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acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 3 [Homo sapiens]
leucine-rich repeat domain-containing protein( domain architecture ID 705725)
leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
LRR_9 super family | cl25994 | Leucine-rich repeat; |
5-98 | 1.67e-09 | |||
Leucine-rich repeat; The actual alignment was detected with superfamily member pfam14580: Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 55.15 E-value: 1.67e-09
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Name | Accession | Description | Interval | E-value | |||
LRR_9 | pfam14580 | Leucine-rich repeat; |
5-98 | 1.67e-09 | |||
Leucine-rich repeat; Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 55.15 E-value: 1.67e-09
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
12-80 | 3.16e-06 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.24 E-value: 3.16e-06
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AMN1 | cd09293 | Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ... |
5-78 | 2.91e-05 | |||
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model. Pssm-ID: 187754 [Multi-domain] Cd Length: 226 Bit Score: 43.47 E-value: 2.91e-05
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
1-72 | 4.17e-03 | |||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 37.91 E-value: 4.17e-03
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Name | Accession | Description | Interval | E-value | |||
LRR_9 | pfam14580 | Leucine-rich repeat; |
5-98 | 1.67e-09 | |||
Leucine-rich repeat; Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 55.15 E-value: 1.67e-09
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
12-80 | 3.16e-06 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.24 E-value: 3.16e-06
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AMN1 | cd09293 | Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ... |
5-78 | 2.91e-05 | |||
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model. Pssm-ID: 187754 [Multi-domain] Cd Length: 226 Bit Score: 43.47 E-value: 2.91e-05
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
12-80 | 1.31e-04 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 42.23 E-value: 1.31e-04
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
40-105 | 2.27e-04 | |||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 2.27e-04
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LRR_8 | pfam13855 | Leucine rich repeat; |
17-77 | 3.10e-04 | |||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.89 E-value: 3.10e-04
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
16-99 | 3.21e-04 | |||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.54 E-value: 3.21e-04
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FBXL18_LRR | pfam19729 | F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from ... |
12-80 | 3.78e-04 | |||
F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from F-box/LRR repeat protein 18 (also known as F-box and leucine-rich repeat protein 18, FBXL18), associated with F-box domains. This protein is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex through its F-box and the LRR motifs mediate the protein-protein interactions required for the binding of the specific substrates by SCFs complexes. Pssm-ID: 466163 [Multi-domain] Cd Length: 594 Bit Score: 40.88 E-value: 3.78e-04
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
12-81 | 4.05e-04 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 40.69 E-value: 4.05e-04
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
40-85 | 8.14e-04 | |||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.07 E-value: 8.14e-04
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
17-72 | 2.27e-03 | |||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 38.23 E-value: 2.27e-03
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
18-105 | 3.92e-03 | |||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 37.85 E-value: 3.92e-03
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
1-72 | 4.17e-03 | |||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 37.91 E-value: 4.17e-03
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
5-72 | 5.69e-03 | |||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 36.69 E-value: 5.69e-03
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
16-98 | 6.28e-03 | |||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 37.08 E-value: 6.28e-03
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Blast search parameters | ||||
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