itgb5 integrin, beta 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itgb5provided by ZNC
Official Full Name: integrin, beta 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6022
See related: Ensembl:ENSDARG00000012942 AllianceGenome:ZFIN:ZDB-GENE-030131-6022
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fi30h12
Summary: Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell surface receptor signaling pathway; and stress fiber assembly. Predicted to act upstream of or within cell adhesion. Predicted to be located in plasma membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface and focal adhesion. Is expressed in margin. Orthologous to human ITGB5 (integrin subunit beta 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (22677503..22748014)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (22866618..22937146)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fi39e01.x1 (e-PCR)
- UniSTS:197444

fi30h12.x1 (e-PCR)
- UniSTS:197251

AW174985 (e-PCR)
- UniSTS:205791

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin beta-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082836.1 → NP_001076305.1 integrin beta-5 precursor

See identical proteins and their annotated locations for NP_001076305.1

Status: PROVISIONAL

Source sequence(s)

AL974314

UniProtKB/TrEMBL

A0A8M1NC23, Q1MSX8

Related

ENSDARP00000074455.4, ENSDART00000080005.6

Conserved Domains (3) summary

pfam00362
Location:60 → 489

Integrin_beta; Integrin, beta chain

pfam07965
Location:661 → 744

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:771 → 804

Integrin_b_cyt; Integrin beta cytoplasmic domain