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    TIA1 TIA1 cytotoxic granule associated RNA binding protein [ Homo sapiens (human) ]

    Gene ID: 7072, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TIA1provided by HGNC
    Official Full Name
    TIA1 cytotoxic granule associated RNA binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:11802
    See related
    Ensembl:ENSG00000116001 MIM:603518; AllianceGenome:HGNC:11802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WDM; ALS26; TIA-1
    Summary
    The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
    Expression
    Ubiquitous expression in endometrium (RPKM 25.4), ovary (RPKM 18.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TIA1 in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (70209444..70248793, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (70221187..70260535, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70436576..70475925, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70350937-70351742 Neighboring gene Sharpr-MPRA regulatory region 3961 Neighboring gene long intergenic non-protein coding RNA 1816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:70365403-70365944 Neighboring gene Sharpr-MPRA regulatory region 12614 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70368111-70368650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70376065-70376594 Neighboring gene chromosome 2 open reading frame 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:70418013-70418598 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70474526-70475341 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70475342-70476156 Neighboring gene tRNA-Gly (anticodon CCC) 2-1 Neighboring gene microRNA 1285-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Welander distal myopathy caused by an ancient founder mutation in TIA1 associated with perturbed splicing. Klar J, et al. Hum Mutat, 2013 Apr. PMID 23348830
    2. Single-nucleotide polymorphism in the human TIA1 gene interacts with stressful life events to predict the development of pathological anxiety symptoms in a Swedish population. Rayman JB, et al. J Affect Disord, 2020 Jan 1. PMID 31541970
    3. No supportive evidence for TIA1 gene mutations in a European cohort of ALS-FTD spectrum patients. Baradaran-Heravi Y, et al. Neurobiol Aging, 2018 Sep. PMID 29886022
    4. Mutation screening of the TIA1 gene in Chinese patients with amyotrophic lateral sclerosis/frontotemporal dementia. Gu X, et al. Neurobiol Aging, 2018 Aug. PMID 29773329
    5. Genetic analysis of TIA1 gene in Chinese patients with amyotrophic lateral sclerosis. Zhang K, et al. Neurobiol Aging, 2018 Jul. PMID 29699721

    See all (154) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Defining the landscape of TIA1 and SQSTM1 digenic myopathy.
      Title: Defining the landscape of TIA1 and SQSTM1 digenic myopathy.
    2. The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics.
      Title: The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics.
    3. RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer.
      Title: RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer.
    4. Distal myopathy due to digenic inheritance of TIA1 and SQSTM1 variants in two unrelated Spanish patients.
      Title: Distal myopathy due to digenic inheritance of TIA1 and SQSTM1 variants in two unrelated Spanish patients.
    5. Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein.
      Title: Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein.
    6. The role of peritumoral CD8 + /TIA1 + lymphocytes in hepatocellular carcinoma aggressiveness and recurrence after surgical resection.
      Title: The role of peritumoral CD8 + /TIA1 + lymphocytes in hepatocellular carcinoma aggressiveness and recurrence after surgical resection.
    7. ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures.
      Title: ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures.
    8. Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling.
      Title: Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling.
    9. Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1.
      Title: Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1.
    10. The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease.
      Title: The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease.
    Submit: New GeneRIF Correction See all GeneRIFs (80)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia
    MedGen: C5436882 OMIM: 619133 GeneReviews: Not available
    		not available
    Welander distal myopathy
    MedGen: C0221054 OMIM: 604454 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat co-localizes with TIA1 in cytoplasmic stress granules under stress conditions PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR AU-rich region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables poly(A) binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of epithelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to cytoplasmic stress granule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in stress granule assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytotoxic granule associated RNA binding protein TIA1
    Names
    T-cell-restricted intracellular antigen-1
    p40-TIA-1 (containing p15-TIA-1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029967.1 RefSeqGene

      Range
      5020..44204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001351508.2 → NP_001338437.1  cytotoxic granule associated RNA binding protein TIA1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC016700
      Consensus CDS
      CCDS86847.1
      UniProtKB/TrEMBL
      F8W8I6, Q59G98
      Related
      ENSP00000282574.4, ENST00000282574.8
      Conserved Domains (3) summary
      cd12620
      Location:214 → 286
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12615
      Location:8 → 81
      RRM1_TIA1; RNA recognition motif 1 (RRM1) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12618
      Location:104 → 181
      RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

    2. NM_001351509.2 → NP_001338438.1  cytotoxic granule associated RNA binding protein TIA1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC016700
      UniProtKB/TrEMBL
      Q59G98
      Conserved Domains (3) summary
      cd12618
      Location:96 → 175
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12621
      Location:205 → 278
      RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cl17169
      Location:8 → 83
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001351510.2 → NP_001338439.1  cytotoxic granule associated RNA binding protein TIA1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC016700
      UniProtKB/TrEMBL
      Q59G98
      Conserved Domains (3) summary
      cd12620
      Location:203 → 275
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12615
      Location:8 → 81
      RRM1_TIA1; RNA recognition motif 1 (RRM1) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12618
      Location:93 → 170
      RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

    4. NM_001351511.1 → NP_001338440.1  cytotoxic granule associated RNA binding protein TIA1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC016700
      Conserved Domains (3) summary
      TIGR01628
      Location:11 → 342
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12620
      Location:177 → 249
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12618
      Location:67 → 144
      RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

    5. NM_001351512.1 → NP_001338441.1  cytotoxic granule associated RNA binding protein TIA1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC016700
      Conserved Domains (3) summary
      cd12618
      Location:59 → 138
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12621
      Location:168 → 241
      RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cl25887
      Location:13 → 333
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    6. NM_001351513.1 → NP_001338442.1  cytotoxic granule associated RNA binding protein TIA1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC016700
      Conserved Domains (3) summary
      cd12618
      Location:57 → 136
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12621
      Location:166 → 239
      RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cl25887
      Location:11 → 331
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    7. NM_001351514.2 → NP_001338443.1  cytotoxic granule associated RNA binding protein TIA1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC016700
      Conserved Domains (3) summary
      cd12618
      Location:29 → 108
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12621
      Location:138 → 211
      RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cl17169
      Location:1 → 23
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. NM_001351515.2 → NP_001338444.1  cytotoxic granule associated RNA binding protein TIA1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC016700
      Conserved Domains (2) summary
      cd12620
      Location:113 → 185
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12618
      Location:3 → 80
      RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

    9. NM_001351516.2 → NP_001338445.1  cytotoxic granule associated RNA binding protein TIA1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC016700
      UniProtKB/TrEMBL
      C9JTN7
      Related
      ENSP00000399567.1, ENST00000445587.5
      Conserved Domains (2) summary
      cd12618
      Location:105 → 184
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cl17169
      Location:8 → 81
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. NM_001351517.2 → NP_001338446.1  cytotoxic granule associated RNA binding protein TIA1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC016700
      Conserved Domains (2) summary
      cl17169
      Location:74 → 147
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl25887
      Location:4 → 238
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    11. NM_001351518.2 → NP_001338447.1  cytotoxic granule associated RNA binding protein TIA1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC016700, BC015944
      Consensus CDS
      CCDS86846.1
      Related
      ENSP00000413751.2, ENST00000416149.6
      Conserved Domains (2) summary
      cd12618
      Location:105 → 184
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cl17169
      Location:8 → 81
      RRM_SF; RNA recognition motif (RRM) superfamily

    12. NM_001351519.2 → NP_001338448.1  cytotoxic granule associated RNA binding protein TIA1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC016700
      UniProtKB/TrEMBL
      H7BY49
      Conserved Domains (1) summary
      TIGR01628
      Location:9 → 156
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    13. NM_001351520.2 → NP_001338449.1  cytotoxic granule associated RNA binding protein TIA1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC016700
      Related
      ENST00000477044.6
      Conserved Domains (1) summary
      cl17169
      Location:8 → 83
      RRM_SF; RNA recognition motif (RRM) superfamily

    14. NM_001351521.2 → NP_001338450.1  cytotoxic granule associated RNA binding protein TIA1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC016700
      UniProtKB/TrEMBL
      H7BY49
      Related
      ENSP00000354838.4, ENST00000361692.4
      Conserved Domains (1) summary
      cl17169
      Location:8 → 81
      RRM_SF; RNA recognition motif (RRM) superfamily

    15. NM_001351522.2 → NP_001338451.1  cytotoxic granule associated RNA binding protein TIA1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC016700
      Consensus CDS
      CCDS86848.1
      UniProtKB/TrEMBL
      E5RGV5
      Related
      ENSP00000430969.1, ENST00000474809.6
      Conserved Domains (2) summary
      cd12615
      Location:8 → 81
      RRM1_TIA1; RNA recognition motif 1 (RRM1) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cl17169
      Location:104 → 133
      RRM_SF; RNA recognition motif (RRM) superfamily

    16. NM_001351523.2 → NP_001338452.1  cytotoxic granule associated RNA binding protein TIA1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC016700
      Conserved Domains (1) summary
      cl17169
      Location:29 → 82
      RRM_SF; RNA recognition motif (RRM) superfamily

    17. NM_001351524.2 → NP_001338453.1  cytotoxic granule associated RNA binding protein TIA1 isoform 19

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variant 20, encodes isoform 19.
      Source sequence(s)
      AC016700
      Conserved Domains (3) summary
      TIGR01628
      Location:4 → 239
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12620
      Location:74 → 146
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:1 → 41
      RRM_SF; RNA recognition motif (RRM) superfamily

    18. NM_001351525.2 → NP_001338454.1  cytotoxic granule associated RNA binding protein TIA1 isoform 19

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variant 19, encodes isoform 19.
      Source sequence(s)
      AC016700
      Conserved Domains (3) summary
      TIGR01628
      Location:4 → 239
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12620
      Location:74 → 146
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:1 → 41
      RRM_SF; RNA recognition motif (RRM) superfamily

    19. NM_022037.4 → NP_071320.2  cytotoxic granule associated RNA binding protein TIA1 isoform 1

      See identical proteins and their annotated locations for NP_071320.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is missing exon 5, which is included in transcript variant 2, resulting in the shorter isoform (1).
      Source sequence(s)
      AC016700
      Consensus CDS
      CCDS1900.1
      UniProtKB/TrEMBL
      Q59G98
      Related
      ENSP00000404023.2, ENST00000415783.6
      Conserved Domains (3) summary
      cd12620
      Location:203 → 275
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12615
      Location:8 → 81
      RRM1_TIA1; RNA recognition motif 1 (RRM1) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12618
      Location:93 → 170
      RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

    20. NM_022173.4 → NP_071505.2  cytotoxic granule associated RNA binding protein TIA1 isoform 2

      See identical proteins and their annotated locations for NP_071505.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes exon 5, which is missing in transcript variant 1, resulting in the longer isoform (2).
      Source sequence(s)
      AC016700
      Consensus CDS
      CCDS1901.1
      UniProtKB/Swiss-Prot
      P31483, Q53SS9, Q96B58
      UniProtKB/TrEMBL
      Q59G98
      Related
      ENSP00000401371.2, ENST00000433529.7
      Conserved Domains (3) summary
      cd12620
      Location:214 → 286
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12615
      Location:8 → 81
      RRM1_TIA1; RNA recognition motif 1 (RRM1) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12618
      Location:104 → 181
      RRM2_TIA1; RNA recognition motif 2 (RRM2) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

    RNA

    1. NR_147216.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    2. NR_147217.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    3. NR_147218.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    4. NR_147219.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    5. NR_147220.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    6. NR_147221.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    7. NR_147222.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    8. NR_147223.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    9. NR_147224.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    10. NR_147225.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    11. NR_147226.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    12. NR_147227.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    13. NR_147228.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    14. NR_147229.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    15. NR_147230.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    16. NR_147231.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    17. NR_147232.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016700

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      70209444..70248793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264528.6 → XP_005264585.1  cytotoxic granule associated RNA binding protein TIA1 isoform X1

      See identical proteins and their annotated locations for XP_005264585.1

      Conserved Domains (3) summary
      cd12618
      Location:40 → 119
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12621
      Location:149 → 222
      RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cl17169
      Location:1 → 23
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_047445625.1 → XP_047301581.1  cytotoxic granule associated RNA binding protein TIA1 isoform X2

    3. XM_047445630.1 → XP_047301586.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

    4. XM_047445628.1 → XP_047301584.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

    5. XM_047445626.1 → XP_047301582.1  cytotoxic granule associated RNA binding protein TIA1 isoform X2

    6. XM_047445632.1 → XP_047301588.1  cytotoxic granule associated RNA binding protein TIA1 isoform X6

    7. XM_047445631.1 → XP_047301587.1  cytotoxic granule associated RNA binding protein TIA1 isoform X6

    8. XM_047445627.1 → XP_047301583.1  cytotoxic granule associated RNA binding protein TIA1 isoform X3

    9. XM_047445629.1 → XP_047301585.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

    10. XM_047445634.1 → XP_047301590.1  cytotoxic granule associated RNA binding protein TIA1 isoform X7

    11. XM_047445633.1 → XP_047301589.1  cytotoxic granule associated RNA binding protein TIA1 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      70221187..70260535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343587.1 → XP_054199562.1  cytotoxic granule associated RNA binding protein TIA1 isoform X1

    2. XM_054343588.1 → XP_054199563.1  cytotoxic granule associated RNA binding protein TIA1 isoform X2

    3. XM_054343593.1 → XP_054199568.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

    4. XM_054343591.1 → XP_054199566.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

    5. XM_054343589.1 → XP_054199564.1  cytotoxic granule associated RNA binding protein TIA1 isoform X2

    6. XM_054343595.1 → XP_054199570.1  cytotoxic granule associated RNA binding protein TIA1 isoform X6

    7. XM_054343594.1 → XP_054199569.1  cytotoxic granule associated RNA binding protein TIA1 isoform X6

    8. XM_054343590.1 → XP_054199565.1  cytotoxic granule associated RNA binding protein TIA1 isoform X3

    9. XM_054343592.1 → XP_054199567.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

    10. XM_054343597.1 → XP_054199572.1  cytotoxic granule associated RNA binding protein TIA1 isoform X7

    11. XM_054343596.1 → XP_054199571.1  cytotoxic granule associated RNA binding protein TIA1 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31483.3 GenPept UniProtKB/Swiss-Prot:P31483

    Gene LinkOut

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