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    WDR86 WD repeat domain 86 [ Homo sapiens (human) ]

    Gene ID: 349136, updated on 17-Sep-2024

    Summary

    Official Symbol
    WDR86provided by HGNC
    Official Full Name
    WD repeat domain 86provided by HGNC
    Primary source
    HGNC:HGNC:28020
    See related
    Ensembl:ENSG00000187260 AllianceGenome:HGNC:28020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in spleen (RPKM 5.6), endometrium (RPKM 5.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See WDR86 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (151368955..151410712, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (152550820..152583552, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151078210..151107798, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:150936637-150937836 Neighboring gene uncharacterized LOC124901779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150938593-150939094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150941724-150942298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150942299-150942872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150942873-150943447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150943448-150944021 Neighboring gene Sharpr-MPRA regulatory region 13648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150949301-150950210 Neighboring gene chondroitin polymerizing factor 2 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150953220-150953720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150953721-150954221 Neighboring gene microRNA 671 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150971756-150972555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150974709-150975418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151000420-151001278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26858 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:151038519-151039020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26859 Neighboring gene negative regulator of ubiquitin like proteins 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151084439-151085101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151107690-151108322 Neighboring gene WDR86 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151125597-151126116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26861 Neighboring gene uncharacterized LOC124901780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151134795-151135644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151136006-151136506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151136507-151137007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:151137719-151138255 Neighboring gene Sharpr-MPRA regulatory region 6092 Neighboring gene microRNA 3907 Neighboring gene crystallin gamma N Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:151153164-151154036 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:151154037-151154909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151155634-151156302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:151157640-151158307 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:151159408-151159959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:151161805-151162306 Neighboring gene RNA, 7SL, cytoplasmic 76, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    WD repeat-containing protein 86

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284260.2NP_001271189.1  WD repeat-containing protein 86 isoform 1

      See identical proteins and their annotated locations for NP_001271189.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC005486, AC005996, AK296049, BC047921
      Consensus CDS
      CCDS64806.1
      UniProtKB/Swiss-Prot
      Q86TI4
      Related
      ENSP00000419162.2, ENST00000469830.2
      Conserved Domains (3) summary
      COG2319
      Location:3234
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4241
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:6195
      7WD40; WD40 repeat [structural motif]
    2. NM_001284261.2NP_001271190.1  WD repeat-containing protein 86 isoform 3

      See identical proteins and their annotated locations for NP_001271190.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC005486, AC005996, AK125347, BC047921
      Consensus CDS
      CCDS64805.1
      UniProtKB/TrEMBL
      A0A090N7X3
      Related
      ENSP00000417512.1, ENST00000477459.5
      Conserved Domains (3) summary
      COG2319
      Location:35128
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1262
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:3123
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001284262.2NP_001271191.1  WD repeat-containing protein 86 isoform 4

      See identical proteins and their annotated locations for NP_001271191.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC005996, BC047921, BC107125
      Consensus CDS
      CCDS75680.1
      UniProtKB/TrEMBL
      A0A0C4DGX6
      Related
      ENSP00000482209.1, ENST00000621812.2
      Conserved Domains (2) summary
      cd00200
      Location:3215
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:1262
      7WD40; WD40 repeat [structural motif]
    4. NM_198285.3NP_938026.2  WD repeat-containing protein 86 isoform 2

      See identical proteins and their annotated locations for NP_938026.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC005996, BC047921, BC107125, BI757623, BX338490, BX390499, DA267732
      Consensus CDS
      CCDS5925.2
      UniProtKB/Swiss-Prot
      B4DJF1, C9JAJ5, C9JXE3, Q3KNT1, Q6ZUS8, Q86TI4
      Related
      ENSP00000335522.7, ENST00000334493.11
      Conserved Domains (4) summary
      smart00320
      Location:543
      WD40; WD40 repeats
      COG2319
      Location:24346
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:53341
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:101135
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      151368955..151410712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420328.1XP_047276284.1  WD repeat-containing protein 86 isoform X12

    2. XM_047420327.1XP_047276283.1  WD repeat-containing protein 86 isoform X13

    3. XM_011516151.4XP_011514453.1  WD repeat-containing protein 86 isoform X9

      Conserved Domains (3) summary
      COG2319
      Location:3244
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4251
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:1955
      7WD40; WD40 repeat [structural motif]
    4. XM_011516147.4XP_011514449.1  WD repeat-containing protein 86 isoform X5

      Conserved Domains (3) summary
      COG2319
      Location:3244
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4251
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:1955
      7WD40; WD40 repeat [structural motif]
    5. XM_011516145.4XP_011514447.1  WD repeat-containing protein 86 isoform X2

      Conserved Domains (3) summary
      COG2319
      Location:3234
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4241
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:6195
      7WD40; WD40 repeat [structural motif]
    6. XM_011516144.4XP_011514446.1  WD repeat-containing protein 86 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:3234
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4241
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:6195
      7WD40; WD40 repeat [structural motif]
    7. XM_005249990.6XP_005250047.1  WD repeat-containing protein 86 isoform X8

      Conserved Domains (3) summary
      COG2319
      Location:3311
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:8301
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:6195
      7WD40; WD40 repeat [structural motif]
    8. XM_011516146.4XP_011514448.1  WD repeat-containing protein 86 isoform X4

      Conserved Domains (4) summary
      smart00320
      Location:543
      WD40; WD40 repeats
      COG2319
      Location:24346
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:53341
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:101135
      7WD40; WD40 repeat [structural motif]
    9. XM_011516148.2XP_011514450.1  WD repeat-containing protein 86 isoform X6

      See identical proteins and their annotated locations for XP_011514450.1

      Conserved Domains (3) summary
      COG2319
      Location:35113
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1262
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:3113
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    10. XM_005249989.5XP_005250046.1  WD repeat-containing protein 86 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:3244
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4251
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:1955
      7WD40; WD40 repeat [structural motif]
    11. XM_011516150.2XP_011514452.1  WD repeat-containing protein 86 isoform X6

      See identical proteins and their annotated locations for XP_011514452.1

      Conserved Domains (3) summary
      COG2319
      Location:35113
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1262
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:3113
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    12. XM_006715966.4XP_006716029.1  WD repeat-containing protein 86 isoform X7

      Conserved Domains (3) summary
      COG2319
      Location:3284
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:8292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:6195
      7WD40; WD40 repeat [structural motif]
    13. XM_011516152.3XP_011514454.1  WD repeat-containing protein 86 isoform X10

      Conserved Domains (3) summary
      COG2319
      Location:3234
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:4241
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:6195
      7WD40; WD40 repeat [structural motif]
    14. XM_047420326.1XP_047276282.1  WD repeat-containing protein 86 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      152550820..152583552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358132.1XP_054214107.1  WD repeat-containing protein 86 isoform X12

    2. XM_054358129.1XP_054214104.1  WD repeat-containing protein 86 isoform X9

    3. XM_054358124.1XP_054214099.1  WD repeat-containing protein 86 isoform X5

    4. XM_054358121.1XP_054214096.1  WD repeat-containing protein 86 isoform X2

    5. XM_054358120.1XP_054214095.1  WD repeat-containing protein 86 isoform X1

    6. XM_054358128.1XP_054214103.1  WD repeat-containing protein 86 isoform X8

    7. XM_054358123.1XP_054214098.1  WD repeat-containing protein 86 isoform X4

    8. XM_054358125.1XP_054214100.1  WD repeat-containing protein 86 isoform X6

    9. XM_054358122.1XP_054214097.1  WD repeat-containing protein 86 isoform X3

    10. XM_054358126.1XP_054214101.1  WD repeat-containing protein 86 isoform X6

    11. XM_054358127.1XP_054214102.1  WD repeat-containing protein 86 isoform X7

    12. XM_054358130.1XP_054214105.1  WD repeat-containing protein 86 isoform X10

    13. XM_054358131.1XP_054214106.1  WD repeat-containing protein 86 isoform X11