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Conserved domains on  [gi|546231978|ref|NP_001271190|]
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WD repeat-containing protein 86 isoform 3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-123 5.86e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 5.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   3 REFRGHRNCVLTLAYSAPwdlpstpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:cd00200  171 ATLTGHTGEVNSVAFSPD--------------GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 546231978  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLA 123
Cdd:cd00200  237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 138-269 3.40e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978  138 SGATHSSSTASRCTARCSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATrwAAPPRPCSRPDPAGPLQTPAQTPS 217
Cdd:PHA03247 2561 PAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP--SPLPPDTHAPDPPPPSPSPAANEP 2638

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 546231978  218 GSQSAPPCYPRWWRPMAGEGRGARKPGREESPSQASGFSlVARRRWERECSP 269
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRRAAR 2689
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-123 5.86e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 5.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   3 REFRGHRNCVLTLAYSAPwdlpstpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:cd00200  171 ATLTGHTGEVNSVAFSPD--------------GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 546231978  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLA 123
Cdd:cd00200  237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277
WD40 COG2319
WD40 repeat [General function prediction only];
3-125 7.57e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 7.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   3 REFRGHRNCVLTLAYSApwDlpstpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  240 RTLTGHSGSVRSVAFSP--D------------GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 546231978  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLAPG 125
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASG 348
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-93 7.63e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 7.63e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 546231978    54 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
55-93 3.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 546231978   55 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 138-269 3.40e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978  138 SGATHSSSTASRCTARCSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATrwAAPPRPCSRPDPAGPLQTPAQTPS 217
Cdd:PHA03247 2561 PAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP--SPLPPDTHAPDPPPPSPSPAANEP 2638

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 546231978  218 GSQSAPPCYPRWWRPMAGEGRGARKPGREESPSQASGFSlVARRRWERECSP 269
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRRAAR 2689
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-123 5.86e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 5.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   3 REFRGHRNCVLTLAYSAPwdlpstpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:cd00200  171 ATLTGHTGEVNSVAFSPD--------------GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 546231978  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLA 123
Cdd:cd00200  237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-113 4.99e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 4.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:cd00200   45 RTLKGHTGPVRDVAASA--------------DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSS 110

                         90       100       110
                 ....*....|....*....|....*....|.
gi 546231978  83 GSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:cd00200  111 SSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-116 1.59e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 1.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   1 MSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA 80
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSP--------------DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 546231978  81 FTGSTDATIRAWDILSGEQLRVFREHRGSVICLECS 116
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFS 186
WD40 COG2319
WD40 repeat [General function prediction only];
3-125 7.57e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 7.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   3 REFRGHRNCVLTLAYSApwDlpstpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  240 RTLTGHSGSVRSVAFSP--D------------GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 546231978  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLAPG 125
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
3-123 8.10e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 8.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  156 RTLTGHSGAVTSVAFSP--------------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 546231978  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLA 123
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-113 8.42e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 8.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   1 MSREFRGHRNCVLTLAYSAPwdlpstpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA 80
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD--------------GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL 66

                         90       100       110
                 ....*....|....*....|....*....|...
gi 546231978  81 FTGSTDATIRAWDILSGEQLRVFREHRGSVICL 113
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSV 99
WD40 COG2319
WD40 repeat [General function prediction only];
3-123 1.20e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 1.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  114 RTLTGHTGAVRSVAFSP--------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 546231978  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLA 123
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220
WD40 COG2319
WD40 repeat [General function prediction only];
3-123 1.18e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.88  E-value: 1.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   3 REFRGHRNCVLTLAYSApwDlpstpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  282 RTLTGHSGGVNSVAFSP--D------------GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 546231978  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLA 123
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388
WD40 COG2319
WD40 repeat [General function prediction only];
3-123 3.30e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 3.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  198 RTLTGHTGAVRSVAFSP--------------DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 546231978  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLA 123
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLA 304
WD40 COG2319
WD40 repeat [General function prediction only];
32-116 1.80e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 1.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978  32 AAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 111
Cdd:COG2319   87 SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT 166


                 ....*
gi 546231978 112 CLECS 116
Cdd:COG2319  167 SVAFS 171
WD40 COG2319
WD40 repeat [General function prediction only];
3-94 3.53e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 3.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  324 RTLTGHTGAVRSVAFSP--------------DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         90
                 ....*....|..
gi 546231978  83 GSTDATIRAWDI 94
Cdd:COG2319  390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-93 2.34e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 2.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978   5 FRGHRNCVLTLAYSapwdlPStpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGS 84
Cdd:cd00200  215 LRGHENGVNSVAFS-----PD---------GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                 ....*....
gi 546231978  85 TDATIRAWD 93
Cdd:cd00200  281 ADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-123 3.38e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 3.38e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 546231978  57 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLA 123
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLA 67
WD40 COG2319
WD40 repeat [General function prediction only];
32-123 6.97e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 6.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978  32 AAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 111
Cdd:COG2319   45 SPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVR 124

                         90
                 ....*....|..
gi 546231978 112 CLECSRAAGTLA 123
Cdd:COG2319  125 SVAFSPDGKTLA 136
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-93 7.63e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 7.63e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 546231978    54 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
55-93 3.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 546231978   55 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 138-269 3.40e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978  138 SGATHSSSTASRCTARCSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATrwAAPPRPCSRPDPAGPLQTPAQTPS 217
Cdd:PHA03247 2561 PAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP--SPLPPDTHAPDPPPPSPSPAANEP 2638

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 546231978  218 GSQSAPPCYPRWWRPMAGEGRGARKPGREESPSQASGFSlVARRRWERECSP 269
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRRAAR 2689
PHA03247 PHA03247
large tegument protein UL36; Provisional
 123-227 5.34e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 5.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978  123 APGPSTRSLESCGGCSGATHSSSTASRCTA--RCSTPPRTTAPcaSGTCAGSEVPRGPLRPCAASRGSSATRWAAPPRPC 200
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPApgRVSRPRRARRL--GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP 2705

                          90       100
                  ....*....|....*....|....*...
gi 546231978  201 SRPDPAGPLQTPA-QTPSGSQSAPPCYP 227
Cdd:PHA03247 2706 PTPEPAPHALVSAtPLPPGPAAARQASP 2733
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 3-50 3.16e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 3.16e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 546231978     3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVW 50
Cdd:smart00320   6 KTLKGHTGPVTSVAFSP--------------DGKYLASGSDDGTIKLW 39
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 155-256 4.40e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 38.51  E-value: 4.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978 155 STPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATRWAAPP---RPCSRPDPAGPLQTPAQTPSGSQSAPpcyprwwR 231
Cdd:PRK14959 379 SAPSGSAAEGPASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPatpAPSAAPSPRVPWDDAPPAPPRSGIPP-------R 451

                         90       100
                 ....*....|....*....|....*
gi 546231978 232 PMAGEGRGARKPGREESPSQASGFS 256
Cdd:PRK14959 452 PAPRMPEASPVPGAPDSVASASDAP 476
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 131-263 6.71e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 37.66  E-value: 6.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978 131 LESCGGCSGAThSSSTASRCTARcSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSA----TRWAAPPRPCSRPDPA 206
Cdd:PRK07764 381 LERRLGVAGGA-GAPAAAAPSAA-AAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPApappSPAGNAPAGGAPSPPP 458

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 546231978 207 GPLQTPAQTPSGSQSAPPCYPRWWRPMAG-EGRGARKPGREESPSQASGFSLVARRRW 263
Cdd:PRK07764 459 AAAPSAQPAPAPAAAPEPTAAPAPAPPAApAPAAAPAAPAAPAAPAGADDAATLRERW 516
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 112-227 7.13e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 37.15  E-value: 7.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978 112 CLECSRAAGTLAPGPStrslesCGGCSGATHSSSTASRCTAR-CSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSA 190
Cdd:PHA02682  72 CMQRPSGQSPLAPSPA------CAAPAPACPACAPAAPAPAVtCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTR 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 546231978 191 TRWAAPPRPCSRPDPAG----------PLQTPAQTPSGSQSAPPCYP 227
Cdd:PHA02682 146 QCPPAPPLPTPKPAPAAkpiflhnqlpPPDYPAASCPTIETAPAASP 192
WD40 pfam00400
WD domain, G-beta repeat;
3-50 8.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 8.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 546231978    3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVW 50
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP--------------DGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
3-54 8.60e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.20  E-value: 8.60e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 546231978   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVAS 54
Cdd:COG2319  366 RTLTGHTGAVTSVAFSP--------------DGRTLASGSADGTVRLWDLAT 403
PHA03247 PHA03247
large tegument protein UL36; Provisional
 118-276 8.72e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 37.61  E-value: 8.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978  118 AAGTLAPGPSTRSLESCGGCSGATHSSSTASRCTARCSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATRWAAPP 197
Cdd:PHA03247 2727 AARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231978  198 RPCSRP----------DPAGPLQTPAQTPSGSQSAPPCYPRWWRPMAGE----GRGARKPGREESPSQASGFSLVARRRW 263
Cdd:PHA03247 2807 PPAAVLapaaalppaaSPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvapgGDVRRRPPSRSPAAKPAAPARPPVRRL 2886

                         170
                  ....*....|...
gi 546231978  264 ERECSPWGPPPFP 276
Cdd:PHA03247 2887 ARPAVSRSTESFA 2899
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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