NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|546231463|ref|NP_001271191|]
View 

WD repeat-containing protein 86 isoform 4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-215 1.83e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.35  E-value: 1.83e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:cd00200   45 RTLKGHTGPVRDVAASA--------------DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA--G 158
Cdd:cd00200  111 SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPdgE 190

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 546231463 159 TLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWDVR 215
Cdd:cd00200  191 KLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSpdGYLLASGSEDGTIRVWDLR 249
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-215 1.83e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.35  E-value: 1.83e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:cd00200   45 RTLKGHTGPVRDVAASA--------------DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA--G 158
Cdd:cd00200  111 SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPdgE 190

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 546231463 159 TLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWDVR 215
Cdd:cd00200  191 KLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSpdGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
3-218 1.30e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 1.30e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  156 RTLTGHSGAVTSVAFSP--------------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG-- 158
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgk 301

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 546231463 159 TLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWDVRGLR 218
Cdd:COG2319  302 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATGE 363
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-93 1.75e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 1.75e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 546231463    54 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
55-93 6.42e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 6.42e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 546231463   55 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 86-214 1.30e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  86 DATIRAWDILSGEQLRVFREHRGSVICLELVN---RLVYSGSADRTVKCWLADTGECVRTFTAhRRNVSALKYHAGT--- 159
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESgrs 632

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 546231463 160 LFTGSGDACARAFDAQSGELRR-VFRGHTFIINCIQ-VHGQVLYTASHDGALRLWDV 214
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRfVDSSTLVSSSTDNTLKLWDL 689
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-215 1.83e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.35  E-value: 1.83e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:cd00200   45 RTLKGHTGPVRDVAASA--------------DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA--G 158
Cdd:cd00200  111 SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPdgE 190

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 546231463 159 TLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWDVR 215
Cdd:cd00200  191 KLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSpdGYLLASGSEDGTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-215 9.71e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 156.73  E-value: 9.71e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463   1 MSREFRGHRNCVLTLAYSAPwdlpstpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA 80
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD--------------GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  81 FTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH-- 156
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSpdGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSpd 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 546231463 157 AGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWDVR 215
Cdd:cd00200  147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
3-218 1.30e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 1.30e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  156 RTLTGHSGAVTSVAFSP--------------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG-- 158
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgk 301

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 546231463 159 TLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWDVRGLR 218
Cdd:COG2319  302 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-213 1.86e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 150.95  E-value: 1.86e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463   1 MSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA 80
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSP--------------DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  81 FTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG 158
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVnsVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 546231463 159 T--LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 213
Cdd:cd00200  231 GylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
3-218 8.99e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.99  E-value: 8.99e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  114 RTLTGHTGAVRSVAFSP--------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG-- 158
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgr 259

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 546231463 159 TLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWDVRGLR 218
Cdd:COG2319  260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGK 321
WD40 COG2319
WD40 repeat [General function prediction only];
3-216 3.39e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.83  E-value: 3.39e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463   3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFT 82
Cdd:COG2319  198 RTLTGHTGAVRSVAFSP--------------DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  83 GSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA--G 158
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgK 343

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463 159 TLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWDVRG 216
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
32-216 7.17e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 7.17e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  32 AAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 111
Cdd:COG2319   87 SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463 112 CLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG--TLFTGSGDACARAFDAQSGELRRVFRGHT 187
Cdd:COG2319  167 SVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                        170       180       190
                 ....*....|....*....|....*....|.
gi 546231463 188 FIINCIQVH--GQVLYTASHDGALRLWDVRG 216
Cdd:COG2319  247 GSVRSVAFSpdGRLLASGSADGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-218 9.14e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.92  E-value: 9.14e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  57 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCWLA 134
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463 135 DTGECVRTFTAHRRNVSALKYHAGT--LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALR 210
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSpdGTFVASSSQDGTIK 160


                 ....*...
gi 546231463 211 LWDVRGLR 218
Cdd:cd00200  161 LWDLRTGK 168
WD40 COG2319
WD40 repeat [General function prediction only];
32-216 1.28e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 1.28e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  32 AAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 111
Cdd:COG2319   45 SPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVR 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463 112 CLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG--TLFTGSGDACARAFDAQSGELRRVFRGHT 187
Cdd:COG2319  125 SVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHT 204

                        170       180       190
                 ....*....|....*....|....*....|.
gi 546231463 188 FIINCIQVH--GQVLYTASHDGALRLWDVRG 216
Cdd:COG2319  205 GAVRSVAFSpdGKLLASGSADGTVRLWDLAT 235
WD40 COG2319
WD40 repeat [General function prediction only];
32-215 3.14e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 3.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  32 AAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 111
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463 112 CLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA--GTLFTGSGDACARAFDAQSGELRRVFRGHT 187
Cdd:COG2319   83 SVAFspDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                        170       180       190
                 ....*....|....*....|....*....|
gi 546231463 188 FIINCIQVH--GQVLYTASHDGALRLWDVR 215
Cdd:COG2319  163 GAVTSVAFSpdGKLLASGSDDGTVRLWDLA 192
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-93 1.75e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 1.75e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 546231463    54 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 176-213 2.41e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.41e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 546231463   176 SGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 213
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
55-93 6.42e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 6.42e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 546231463   55 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 93
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 86-214 1.30e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  86 DATIRAWDILSGEQLRVFREHRGSVICLELVN---RLVYSGSADRTVKCWLADTGECVRTFTAhRRNVSALKYHAGT--- 159
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESgrs 632

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 546231463 160 LFTGSGDACARAFDAQSGELRR-VFRGHTFIINCIQ-VHGQVLYTASHDGALRLWDV 214
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRfVDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
177-213 2.01e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 546231463  177 GELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 213
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 4-164 3.16e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 3.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463   4 EFRGHRNCVLTLAYSApwdlpstpcaeeaAAGGLLVTGSTDGTAKVWQVASGCCHQTLRghTGAVLCLVL---DTPGHTA 80
Cdd:PLN00181 570 EMKEHEKRVWSIDYSS-------------ADPTLLASGSDDGSVKLWSINQGVSIGTIK--TKANICCVQfpsESGRSLA 634

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231463  81 FtGSTDATIRAWDILSGE-QLRVFREHRGSVICLELVN-RLVYSGSADRTVKCW---LADTG---ECVRTFTAHR--RNV 150
Cdd:PLN00181 635 F-GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDsSTLVSSSTDNTLKLWdlsMSISGineTPLHSFMGHTnvKNF 713

                        170
                 ....*....|....
gi 546231463 151 SALKYHAGTLFTGS 164
Cdd:PLN00181 714 VGLSVSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-132 3.99e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 3.99e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 546231463    96 SGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW 132
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
97-132 1.16e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.16e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 546231463   97 GEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW 132
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 3-50 7.79e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.44  E-value: 7.79e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 546231463     3 REFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVW 50
Cdd:smart00320   6 KTLKGHTGPVTSVAFSP--------------DGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH