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    PLAUR plasminogen activator, urokinase receptor [ Homo sapiens (human) ]

    Gene ID: 5329, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PLAURprovided by HGNC
    Official Full Name
    plasminogen activator, urokinase receptorprovided by HGNC
    Primary source
    HGNC:HGNC:9053
    See related
    Ensembl:ENSG00000011422 MIM:173391; AllianceGenome:HGNC:9053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD87; UPAR; URKR; U-PAR
    Summary
    This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 100.8), gall bladder (RPKM 18.1) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PLAUR in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43646095..43670169, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46467757..46492325, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44150247..44174321, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44123140-44123790 Neighboring gene uncharacterized LOC105372411 Neighboring gene serine/arginine repetitive matrix 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44127716-44128216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44128217-44128717 Neighboring gene cell adhesion molecule 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10725 Neighboring gene RNA, 7SL, cytoplasmic 368, pseudogene Neighboring gene uncharacterized LOC124904724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14732 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44183469-44183968 Neighboring gene phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44204596-44205096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44220201-44220701 Neighboring gene immunity related GTPase cinema

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene Association Study of the Urokinase Plasminogen Activator and Its Receptor Gene in Alzheimer's Disease.
      Title: Gene Association Study of the Urokinase Plasminogen Activator and Its Receptor Gene in Alzheimer's Disease.
    2. uPAR (PLAUR) Marks Two Intra-Tumoral Subtypes of Glioblastoma: Insights from Single-Cell RNA Sequencing.
      Title: uPAR (PLAUR) Marks Two Intra-Tumoral Subtypes of Glioblastoma: Insights from Single-Cell RNA Sequencing.
    3. Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response.
      Title: Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response.
    4. Soluble urokinase plasminogen activator receptor (suPAR) in bronchoalveolar fluid and blood in critically ill patients-a prospective cohort study.
      Title: Soluble urokinase plasminogen activator receptor (suPAR) in bronchoalveolar fluid and blood in critically ill patients-a prospective cohort study.
    5. Soluble urokinase plasminogen activator receptor, platelet aggregation, and carotid plaque thickness in diabetes: A cross-sectional analysis.
      Title: Soluble urokinase plasminogen activator receptor, platelet aggregation, and carotid plaque thickness in diabetes: A cross-sectional analysis.
    6. Soluble urokinase plasminogen activator receptor in vaginally collected amniotic fluid predicting fetal inflammatory response syndrome: a prospective cohort study.
      Title: Soluble urokinase plasminogen activator receptor in vaginally collected amniotic fluid predicting fetal inflammatory response syndrome: a prospective cohort study.
    7. A case of mosaic deletion of paternally-inherited PLAGL1 and two cases of upd(6)mat add to evidence for PLAGL1 under-expression as a cause of growth restriction.
      Title: A case of mosaic deletion of paternally-inherited PLAGL1 and two cases of upd(6)mat add to evidence for PLAGL1 under-expression as a cause of growth restriction.
    8. Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression.
      Title: Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression.
    9. Plasma IL-6, TREM1, uPAR, and IL6/IL8 biomarkers increment further witnessing the chronic inflammation in type 2 diabetes.
      Title: Plasma IL-6, TREM1, uPAR, and IL6/IL8 biomarkers increment further witnessing the chronic inflammation in type 2 diabetes.
    10. SuPAR mediates viral response proteinuria by rapidly changing podocyte function.
      Title: SuPAR mediates viral response proteinuria by rapidly changing podocyte function.
    Submit: New GeneRIF Correction See all GeneRIFs (558)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of plasminogen activator, urokinase receptor (PLAUR) in human B cells PubMed
    capsid gag A peptide (Ch7) derived from HIV-1 Capsid (amino acids 232-238) has been shown to have immunosuppressive effects through a possible interaction with the Plasminogen Receptor, indicating a role for Capsid in the immunosuppressive effects of HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables urokinase plasminogen activator receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of homotypic cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of fibrinolysis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of plasminogen activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of proteolysis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in urokinase plasminogen activator signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in external side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extrinsic component of membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in focal adhesion HDA PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of protein complex involved in cell-matrix adhesion IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of serine-type endopeptidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    urokinase plasminogen activator surface receptor
    Names
    monocyte activation antigen Mo3
    u-plasminogen activator receptor form 2
    urokinase-type plasminogen activator (uPA) receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032898.1 RefSeqGene

      Range
      5178..26768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_637

    mRNA and Protein(s)

    1. NM_001005376.3 → NP_001005376.1  urokinase plasminogen activator surface receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001005376.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1. Variant 2 encodes the shortest isoform (2), also called suPLAUR, which is the soluble form of this protein. Isoform 2 lacks one of three LU (Ly-6 antigen/uPA receptor-like) domains, compared to isoform 1.
      Source sequence(s)
      AI801128, AI912302, CA495321, X74039
      Consensus CDS
      CCDS33041.1
      UniProtKB/TrEMBL
      Q9UPI5
      Related
      ENSP00000342049.2, ENST00000339082.7
      Conserved Domains (2) summary
      smart00134
      Location:115 → 202
      LU; Ly-6 antigen / uPA receptor -like domain
      cl10471
      Location:23 → 101
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    2. NM_001005377.3 → NP_001005377.1  urokinase plasminogen activator surface receptor isoform 3 precursor

      See identical proteins and their annotated locations for NP_001005377.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks one exon in the coding region and encodes an isoleucine rather than a valine following the splice site, compared to variant 1. Variant 3 encodes isoform 3 which is longer and lacks one of three LU (Ly-6 antigen/uPA receptor-like) domains, compared to isoform 2.
      Source sequence(s)
      CD370232, U08839
      Consensus CDS
      CCDS33042.1
      UniProtKB/Swiss-Prot
      Q03405
      Related
      ENSP00000221264.3, ENST00000221264.8
      Conserved Domains (2) summary
      smart00134
      Location:23 → 101
      LU; Ly-6 antigen / uPA receptor -like domain
      cd00117
      Location:170 → 251
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    3. NM_001301037.2 → NP_001287966.1  urokinase plasminogen activator surface receptor isoform 4 precursor

      See identical proteins and their annotated locations for NP_001287966.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 4, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK290774, BY996586, CA495321, CF126152
      Consensus CDS
      CCDS74386.1
      UniProtKB/TrEMBL
      M0R1I2
      Related
      ENSP00000471881.1, ENST00000601723.5
      Conserved Domains (2) summary
      smart00134
      Location:115 → 202
      LU; Ly-6 antigen / uPA receptor -like domain
      pfam00021
      Location:25 → 99
      UPAR_LY6; u-PAR/Ly-6 domain

    4. NM_002659.4 → NP_002650.1  urokinase plasminogen activator surface receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_002650.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1) which contains three LU (Ly-6 antigen/uPA receptor-like) domains.
      Source sequence(s)
      BC002788, CD370232
      Consensus CDS
      CCDS12628.1
      UniProtKB/Swiss-Prot
      A8K409, Q03405, Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0
      Related
      ENSP00000339328.3, ENST00000340093.8
      Conserved Domains (3) summary
      smart00134
      Location:115 → 202
      LU; Ly-6 antigen / uPA receptor -like domain
      cd00117
      Location:215 → 296
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
      cl10471
      Location:25 → 99
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43646095..43670169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438937.1 → XP_047294893.1  urokinase plasminogen activator surface receptor isoform X14

    2. XM_047438933.1 → XP_047294889.1  urokinase plasminogen activator surface receptor isoform X10

    3. XM_047438936.1 → XP_047294892.1  urokinase plasminogen activator surface receptor isoform X13

    4. XM_047438927.1 → XP_047294883.1  urokinase plasminogen activator surface receptor isoform X4

      Conserved Domains (2) summary
      smart00134
      Location:67 → 154
      LU; Ly-6 antigen / uPA receptor -like domain
      cd00117
      Location:167 → 248
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    5. XM_047438934.1 → XP_047294890.1  urokinase plasminogen activator surface receptor isoform X11

    6. XM_047438935.1 → XP_047294891.1  urokinase plasminogen activator surface receptor isoform X12

    7. XM_047438926.1 → XP_047294882.1  urokinase plasminogen activator surface receptor isoform X3

    8. XM_047438928.1 → XP_047294884.1  urokinase plasminogen activator surface receptor isoform X5

      UniProtKB/TrEMBL
      M0R1I2
      Conserved Domains (2) summary
      smart00134
      Location:115 → 202
      LU; Ly-6 antigen / uPA receptor -like domain
      pfam00021
      Location:25 → 99
      UPAR_LY6; u-PAR/Ly-6 domain

    9. XM_047438925.1 → XP_047294881.1  urokinase plasminogen activator surface receptor isoform X1

      UniProtKB/Swiss-Prot
      A8K409, Q03405, Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0

    10. XM_047438929.1 → XP_047294885.1  urokinase plasminogen activator surface receptor isoform X6

    11. XM_047438930.1 → XP_047294886.1  urokinase plasminogen activator surface receptor isoform X7

    12. XM_047438931.1 → XP_047294887.1  urokinase plasminogen activator surface receptor isoform X8

    13. XM_017026872.3 → XP_016882361.1  urokinase plasminogen activator surface receptor isoform X2

    14. XM_047438932.1 → XP_047294888.1  urokinase plasminogen activator surface receptor isoform X9

      Related
      ENSP00000470029.1, ENST00000599892.5
      Conserved Domains (2) summary
      smart00134
      Location:115 → 203
      LU; Ly-6 antigen / uPA receptor -like domain
      pfam00021
      Location:25 → 99
      UPAR_LY6; u-PAR/Ly-6 domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46467757..46492325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321218.1 → XP_054177193.1  urokinase plasminogen activator surface receptor isoform X14

    2. XM_054321214.1 → XP_054177189.1  urokinase plasminogen activator surface receptor isoform X10

    3. XM_054321217.1 → XP_054177192.1  urokinase plasminogen activator surface receptor isoform X13

    4. XM_054321208.1 → XP_054177183.1  urokinase plasminogen activator surface receptor isoform X4

    5. XM_054321215.1 → XP_054177190.1  urokinase plasminogen activator surface receptor isoform X11

    6. XM_054321216.1 → XP_054177191.1  urokinase plasminogen activator surface receptor isoform X12

    7. XM_054321207.1 → XP_054177182.1  urokinase plasminogen activator surface receptor isoform X3

    8. XM_054321209.1 → XP_054177184.1  urokinase plasminogen activator surface receptor isoform X5

      UniProtKB/TrEMBL
      M0R1I2

    9. XM_054321205.1 → XP_054177180.1  urokinase plasminogen activator surface receptor isoform X1

      UniProtKB/Swiss-Prot
      A8K409, Q03405, Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0

    10. XM_054321206.1 → XP_054177181.1  urokinase plasminogen activator surface receptor isoform X2

    11. XM_054321210.1 → XP_054177185.1  urokinase plasminogen activator surface receptor isoform X6

    12. XM_054321211.1 → XP_054177186.1  urokinase plasminogen activator surface receptor isoform X7

    13. XM_054321212.1 → XP_054177187.1  urokinase plasminogen activator surface receptor isoform X8

    14. XM_054321213.1 → XP_054177188.1  urokinase plasminogen activator surface receptor isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03405.1 GenPept UniProtKB/Swiss-Prot:Q03405

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