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Conserved domains on  [gi|53829381|ref|NP_001005377|]
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urokinase plasminogen activator surface receptor isoform 3 precursor [Homo sapiens]

Protein Classification

urokinase plasminogen activator surface receptor family protein( domain architecture ID 10298020)

urokinase plasminogen activator surface receptor (PLAUR/UPAR) plays a role in localizing and promoting plasmin formation; but contains only two LU (Ly-6 antigen/uPA receptor-like) domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 162-252 1.03e-31

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


:

Pssm-ID: 467088  Cd Length: 93  Bit Score: 113.26  E-value: 1.03e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381 162 ENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGT--HEPKNQSYMVRGCATASMCQHAHLGDAFSMNHID 239
Cdd:cd23558   1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTtaHGGKNQSYMVKGCATPSMCQSTALSLNQVLNSAD 80

                        90
                ....*....|...
gi 53829381 240 VSCCTKSGCNHPD 252
Cdd:cd23558  81 VRCCNGSLCNNGD 93
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 23-100 2.18e-20

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


:

Pssm-ID: 467086  Cd Length: 79  Bit Score: 82.89  E-value: 2.18e-20
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53829381  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQ 100
Cdd:cd23556   1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEGEELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 162-252 1.03e-31

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 113.26  E-value: 1.03e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381 162 ENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGT--HEPKNQSYMVRGCATASMCQHAHLGDAFSMNHID 239
Cdd:cd23558   1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTtaHGGKNQSYMVKGCATPSMCQSTALSLNQVLNSAD 80

                        90
                ....*....|...
gi 53829381 240 VSCCTKSGCNHPD 252
Cdd:cd23558  81 VRCCNGSLCNNGD 93
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 23-100 2.18e-20

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 82.89  E-value: 2.18e-20
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53829381  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQ 100
Cdd:cd23556   1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEGEELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 169-251 3.49e-16

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 72.18  E-value: 3.49e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381    169 RQCYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTHEPKN-QSYMVRGCATASMCQHAHLGDAFSMNH-IDVSCCTKS 246
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDSrGSVVYKGCATSPICPGSHGYEINLTIAfLKVSCCQTD 76


                   ....*
gi 53829381    247 GCNHP 251
Cdd:smart00134  77 LCNAA 81
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 171-249 5.82e-12

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 60.25  E-value: 5.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381   171 CYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTHEPKNQ--SYMVRGCATaSMCQhAHLGDAFSMNHIDV--SCCTKS 246
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVT----CPLSDGQCVTTTLELPEGNLrgTVVSKGCAR-SSCP-RLLSDFINGGIISVseSCCQSD 74


                  ...
gi 53829381   247 GCN 249
Cdd:pfam00021  75 LCN 77
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 25-99 1.10e-07

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 48.30  E-value: 1.10e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 53829381    25 CMQCK--TNGDCRVE-ECALGQDLCRTTIVRLWEEGEELELVEKSCTHSeKTNRTLSYRTGLKITSLTEVVCGLDLCN 99
Cdd:pfam00021   1 CYSCLgvSNEDCLSEvTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARS-SCPRLLSDFINGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 23-101 4.84e-07

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 46.76  E-value: 4.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381     23 LRCMQCKTNGD--CRVEE-CALGQDLCRTTIVRlWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCN 99
Cdd:smart00134   1 LQCYSCTGNPDssCSSEEeCRSPDDVCLTVVAE-VISDSRGSVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTDLCN 79


                   ..
gi 53829381    100 QG 101
Cdd:smart00134  80 AA 81
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 162-252 1.03e-31

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 113.26  E-value: 1.03e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381 162 ENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGT--HEPKNQSYMVRGCATASMCQHAHLGDAFSMNHID 239
Cdd:cd23558   1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTtaHGGKNQSYMVKGCATPSMCQSTALSLNQVLNSAD 80

                        90
                ....*....|...
gi 53829381 240 VSCCTKSGCNHPD 252
Cdd:cd23558  81 VRCCNGSLCNNGD 93
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 23-100 2.18e-20

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 82.89  E-value: 2.18e-20
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53829381  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQ 100
Cdd:cd23556   1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEGEELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 111-249 6.90e-18

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 76.59  E-value: 6.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381 111 RSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQegeevlelenlpqngrqcysckgnsthgcsseetfli 190
Cdd:cd23557   1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSL------------------------------------- 43

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 53829381 191 dcrgpmnqclvatgthEPKNQSYMVRGCATASMCQHAHLGDAFSMnHIDVSCCTKSGCN 249
Cdd:cd23557  44 ----------------ERPKSERRLKGCGTLPGCPGSLGFHNNDT-FHLLKCCNSSLCN 85
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 169-251 3.49e-16

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 72.18  E-value: 3.49e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381    169 RQCYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTHEPKN-QSYMVRGCATASMCQHAHLGDAFSMNH-IDVSCCTKS 246
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDSrGSVVYKGCATSPICPGSHGYEINLTIAfLKVSCCQTD 76


                   ....*
gi 53829381    247 GCNHP 251
Cdd:smart00134  77 LCNAA 81
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 171-249 5.82e-12

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 60.25  E-value: 5.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381   171 CYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTHEPKNQ--SYMVRGCATaSMCQhAHLGDAFSMNHIDV--SCCTKS 246
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVT----CPLSDGQCVTTTLELPEGNLrgTVVSKGCAR-SSCP-RLLSDFINGGIISVseSCCQSD 74


                  ...
gi 53829381   247 GCN 249
Cdd:pfam00021  75 LCN 77
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 167-241 1.88e-09

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 53.20  E-value: 1.88e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 53829381 167 NGRQCYSCKGNSTHGCSSEETflIDCRGPMNQCLVATGTH--EPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVS 241
Cdd:cd23572   1 NGLQCPACYSEGSDSCKSEET--VNCTGEETQCIEFSGTIsgGGSSVKFAMKGCATESACDLGKGSLPFGGTSVNIT 75
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 25-99 1.10e-07

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 48.30  E-value: 1.10e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 53829381    25 CMQCK--TNGDCRVE-ECALGQDLCRTTIVRLWEEGEELELVEKSCTHSeKTNRTLSYRTGLKITSLTEVVCGLDLCN 99
Cdd:pfam00021   1 CYSCLgvSNEDCLSEvTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARS-SCPRLLSDFINGGIISVSESCCQSDLCN 77
TFP_LU_ECD_LYPD5_rpt2 cd23566
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 165-252 3.56e-07

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467096  Cd Length: 96  Bit Score: 47.40  E-value: 3.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381 165 PQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKN----QSYMVRGCATASMCQHAHLGDAFSMNHIDV 240
Cdd:cd23566   5 TPNGMECYACLSFSPDDCSPENAEKVKCHGDMTRCYEGNGTVTIGNdnfsVPIYIKTCQAPSCTTPGSTSPWTAIISQQG 84

                        90
                ....*....|..
gi 53829381 241 SCCTKSGCNHPD 252
Cdd:cd23566  85 SCCSGSLCNGPS 96
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 23-101 4.84e-07

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 46.76  E-value: 4.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381     23 LRCMQCKTNGD--CRVEE-CALGQDLCRTTIVRlWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCN 99
Cdd:smart00134   1 LQCYSCTGNPDssCSSEEeCRSPDDVCLTVVAE-VISDSRGSVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTDLCN 79


                   ..
gi 53829381    100 QG 101
Cdd:smart00134  80 AA 81
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 170-249 6.67e-06

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 43.63  E-value: 6.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381 170 QCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHePKNQSYMVRGCATASMCQHAHLGDAFSMNHIDV-SCCTKSGC 248
Cdd:cd00117   2 KCYQCNSSNDPNCCNSSPTLVTCSSPETFCRKIVGKV-GGGETLVIRGCATECECGCTECCSGTGTSGTTCtSCCDTDLC 80


                .
gi 53829381 249 N 249
Cdd:cd00117  81 N 81
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 167-250 1.43e-04

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 39.75  E-value: 1.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829381 167 NGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYM--VRGCATASMCQHAHLGDAfSMNhIDVSCCT 244
Cdd:cd23563   2 NGVECYSCVGNSRGACSPSNAPVVRCYGAYSGCFDGNVTLTIGNVTLSlpVKGCVQDGDCTRESKGGA-SVT-LKGSCCS 79


                ....*.
gi 53829381 245 KSGCNH 250
Cdd:cd23563  80 GNLCNS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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