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Conserved domains on  [gi|2217321585|ref|XP_047294883|]
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urokinase plasminogen activator surface receptor isoform X4 [Homo sapiens]

Protein Classification

urokinase plasminogen activator surface receptor family protein( domain architecture ID 10639048)

urokinase plasminogen activator surface receptor (PLAUR/UPAR) plays a role in localizing and promoting plasmin formation; but contains only two LU (Ly-6 antigen/uPA receptor-like) domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 63-151 1.30e-34

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467087  Cd Length: 85  Bit Score: 120.50  E-value: 1.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585  63 RSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQegeeGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFL 142
Cdd:cd23557     1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSL----ERPKSERRLKGCGTLPGCPGSLGFHNNDTFHLL 76


                  ....*....
gi 2217321585 143 KCCNTTKCN 151
Cdd:cd23557    77 KCCNSSLCN 85
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 159-249 4.49e-32

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


:

Pssm-ID: 467088  Cd Length: 93  Bit Score: 114.03  E-value: 4.49e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585 159 ENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGT--HEPKNQSYMVRGCATASMCQHAHLGDAFSMNHID 236
Cdd:cd23558     1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTtaHGGKNQSYMVKGCATPSMCQSTALSLNQVLNSAD 80

                          90
                  ....*....|...
gi 2217321585 237 VSCCTKSGCNHPD 249
Cdd:cd23558    81 VRCCNGSLCNNGD 93
TFP super family cl45932
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 23-55 3.00e-07

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


The actual alignment was detected with superfamily member cd23556:

Pssm-ID: 480272  Cd Length: 79  Bit Score: 47.07  E-value: 3.00e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217321585  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWE 55
Cdd:cd23556     1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWE 34
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 63-151 1.30e-34

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 120.50  E-value: 1.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585  63 RSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQegeeGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFL 142
Cdd:cd23557     1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSL----ERPKSERRLKGCGTLPGCPGSLGFHNNDTFHLL 76


                  ....*....
gi 2217321585 143 KCCNTTKCN 151
Cdd:cd23557    77 KCCNSSLCN 85
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 159-249 4.49e-32

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 114.03  E-value: 4.49e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585 159 ENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGT--HEPKNQSYMVRGCATASMCQHAHLGDAFSMNHID 236
Cdd:cd23558     1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTtaHGGKNQSYMVKGCATPSMCQSTALSLNQVLNSAD 80

                          90
                  ....*....|...
gi 2217321585 237 VSCCTKSGCNHPD 249
Cdd:cd23558    81 VRCCNGSLCNNGD 93
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 166-248 2.68e-16

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 72.18  E-value: 2.68e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585  166 RQCYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTHEPKN-QSYMVRGCATASMCQHAHLGDAFSMNH-IDVSCCTKS 243
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDSrGSVVYKGCATSPICPGSHGYEINLTIAfLKVSCCQTD 76


                   ....*
gi 2217321585  244 GCNHP 248
Cdd:smart00134  77 LCNAA 81
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 67-154 1.14e-15

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 70.64  E-value: 1.14e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585   67 LECISC-GSSDMSCERGRHqslqCRSPEEQCLDVVTHWIQEGeegrpKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLK-- 143
Cdd:smart00134   1 LQCYSCtGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDS-----RGSVVYKGCATSPICPGSHGYEINLTIAFLKvs 71

                           90
                   ....*....|.
gi 2217321585  144 CCNTTKCNEGP 154
Cdd:smart00134  72 CCQTDLCNAAG 82
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 168-246 2.53e-12

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 61.40  E-value: 2.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585 168 CYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTHEPKNQ--SYMVRGCATaSMCQhAHLGDAFSMNHIDV--SCCTKS 243
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVT----CPLSDGQCVTTTLELPEGNLrgTVVSKGCAR-SSCP-RLLSDFINGGIISVseSCCQSD 74


                  ...
gi 2217321585 244 GCN 246
Cdd:pfam00021  75 LCN 77
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 23-55 3.00e-07

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 47.07  E-value: 3.00e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217321585  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWE 55
Cdd:cd23556     1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWE 34
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 63-151 1.30e-34

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 120.50  E-value: 1.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585  63 RSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQegeeGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFL 142
Cdd:cd23557     1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSL----ERPKSERRLKGCGTLPGCPGSLGFHNNDTFHLL 76


                  ....*....
gi 2217321585 143 KCCNTTKCN 151
Cdd:cd23557    77 KCCNSSLCN 85
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 159-249 4.49e-32

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 114.03  E-value: 4.49e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585 159 ENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGT--HEPKNQSYMVRGCATASMCQHAHLGDAFSMNHID 236
Cdd:cd23558     1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTtaHGGKNQSYMVKGCATPSMCQSTALSLNQVLNSAD 80

                          90
                  ....*....|...
gi 2217321585 237 VSCCTKSGCNHPD 249
Cdd:cd23558    81 VRCCNGSLCNNGD 93
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 166-248 2.68e-16

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 72.18  E-value: 2.68e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585  166 RQCYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTHEPKN-QSYMVRGCATASMCQHAHLGDAFSMNH-IDVSCCTKS 243
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDSrGSVVYKGCATSPICPGSHGYEINLTIAfLKVSCCQTD 76


                   ....*
gi 2217321585  244 GCNHP 248
Cdd:smart00134  77 LCNAA 81
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 67-154 1.14e-15

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 70.64  E-value: 1.14e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585   67 LECISC-GSSDMSCERGRHqslqCRSPEEQCLDVVTHWIQEGeegrpKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLK-- 143
Cdd:smart00134   1 LQCYSCtGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDS-----RGSVVYKGCATSPICPGSHGYEINLTIAFLKvs 71

                           90
                   ....*....|.
gi 2217321585  144 CCNTTKCNEGP 154
Cdd:smart00134  72 CCQTDLCNAAG 82
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 168-246 2.53e-12

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 61.40  E-value: 2.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585 168 CYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTHEPKNQ--SYMVRGCATaSMCQhAHLGDAFSMNHIDV--SCCTKS 243
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVT----CPLSDGQCVTTTLELPEGNLrgTVVSKGCAR-SSCP-RLLSDFINGGIISVseSCCQSD 74


                  ...
gi 2217321585 244 GCN 246
Cdd:pfam00021  75 LCN 77
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 164-238 1.29e-09

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 53.97  E-value: 1.29e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217321585 164 NGRQCYSCKGNSTHGCSSEETflIDCRGPMNQCLVATGTH--EPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVS 238
Cdd:cd23572     1 NGLQCPACYSEGSDSCKSEET--VNCTGEETQCIEFSGTIsgGGSSVKFAMKGCATESACDLGKGSLPFGGTSVNIT 75
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 23-55 3.00e-07

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 47.07  E-value: 3.00e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217321585  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWE 55
Cdd:cd23556     1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWE 34
TFP_LU_ECD_LYPD5_rpt2 cd23566
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 162-249 3.40e-07

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467096  Cd Length: 96  Bit Score: 47.40  E-value: 3.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585 162 PQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKN----QSYMVRGCATASMCQHAHLGDAFSMNHIDV 237
Cdd:cd23566     5 TPNGMECYACLSFSPDDCSPENAEKVKCHGDMTRCYEGNGTVTIGNdnfsVPIYIKTCQAPSCTTPGSTSPWTAIISQQG 84

                          90
                  ....*....|..
gi 2217321585 238 SCCTKSGCNHPD 249
Cdd:cd23566    85 SCCSGSLCNGPS 96
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 167-246 6.21e-06

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 43.63  E-value: 6.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585 167 QCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHePKNQSYMVRGCATASMCQHAHLGDAFSMNHIDV-SCCTKSGC 245
Cdd:cd00117     2 KCYQCNSSNDPNCCNSSPTLVTCSSPETFCRKIVGKV-GGGETLVIRGCATECECGCTECCSGTGTSGTTCtSCCDTDLC 80


                  .
gi 2217321585 246 N 246
Cdd:cd00117    81 N 81
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 164-247 1.55e-04

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 39.75  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321585 164 NGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYM--VRGCATASMCQHAHLGDAfSMNhIDVSCCT 241
Cdd:cd23563     2 NGVECYSCVGNSRGACSPSNAPVVRCYGAYSGCFDGNVTLTIGNVTLSlpVKGCVQDGDCTRESKGGA-SVT-LKGSCCS 79


                  ....*.
gi 2217321585 242 KSGCNH 247
Cdd:cd23563    80 GNLCNS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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