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Pcdhb14 protocadherin beta 14 [ Mus musculus (house mouse) ]

Gene ID: 93885, updated on 2-Nov-2024

Summary

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Official Symbol
Pcdhb14provided by MGI
Official Full Name
protocadherin beta 14provided by MGI
Primary source
MGI:MGI:2136749
See related
Ensembl:ENSMUSG00000044043 AllianceGenome:MGI:2136749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PcdhbN; 2210006M07Rik
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to be active in plasma membrane. Is expressed in brain. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Pcdhb14 in Genome Data Viewer
Location:
18 B3; 18 19.5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37580710..37584147)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37447657..37451094)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene protocadherin beta 12 Neighboring gene protocadherin beta 13 Neighboring gene protocadherin beta 15 Neighboring gene protocadherin beta 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. Vanhalst K, et al. FEBS Lett, 2001 Apr 20. PMID 11322959
  2. CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. Elbert A, et al. J Neurosci, 2019 Jan 2. PMID 30377227, Free PMC Article
  3. Clustered gamma-protocadherins regulate cortical interneuron programmed cell death. Mancia Leon WR, et al. Elife, 2020 Jul 7. PMID 32633719, Free PMC Article
  4. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Wu Q, et al. Genome Res, 2001 Mar. PMID 11230163, Free PMC Article
  5. A striking organization of a large family of human neural cadherin-like cell adhesion genes. Wu Q, et al. Cell, 1999 Jun 11. PMID 10380929

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protocadherin beta-14
Names
PCDH-beta-14
Protocadherin-betaN
cell-cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053139.3 → NP_444369.3  protocadherin beta-14 precursor

    See identical proteins and their annotated locations for NP_444369.3

    Status: VALIDATED

    Source sequence(s)
    AK083065, AY013775, BB622429
    Consensus CDS
    CCDS29180.1
    UniProtKB/Swiss-Prot
    Q6PB90, Q8CCT0, Q91Y05
    UniProtKB/TrEMBL
    Q8K1H2
    Related
    ENSMUSP00000054111.4, ENSMUST00000052387.5
    Conserved Domains (4) summary
    cd11304
    Location:247 → 343
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:371 → 449
    CA; Cadherin repeats
    pfam08266
    Location:30 → 111
    Cadherin_2; Cadherin-like
    pfam16492
    Location:686 → 768
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    37580710..37584147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PB90.2 GenPept UniProtKB/Swiss-Prot:Q6PB90

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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