Conserved Protein Domain Family
Cadherin_C_2
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pfam16492: Cadherin_C_2 (this model, PSSM-Id:293101 is obsolete and has been replaced by 465139)
Cadherin cytoplasmic C-terminal
Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.
Links
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Statistics
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PSSM-Id: 293101
Aligned: 147 rows
Threshold Bit Score: 31.2966
Created: 24-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5DRB1        688 DLTLYLVVAVAVVSCVFLTFVITLLALRLRHWHSSHLLRATSdglagvptSHFVGV----------DGVRAFLQTYSQEF 757  chimpanzee
ETE67654     1517 tLTKYLVICLAAVSFVFLVCIVVFIVVKVFKKDPQSHFTAAV--------PHFPPAnvdtqencadSQNGSLSRTYRYDV 1588 king cobra
XP_007078010 1553 DLTLYLIVALAAISLLSLVTFTFLSAKCLRGHtdedgggg---qccrhqdSPSRDFykqsspnlqvSSDGTLKYM---EV 1626 Amur tiger
NP_001163983  688 DITMYLIISLVAISLVSFITFVILLVKCLKRDlhspgw-------cckneYESKYYsepcqptlhlNSDGTLKYM---EV 757  western clawe...
ETE59223     2273 NLTLYLIISLVAISLVSCVMMIIVGARCFKSGfcipnw------iishwcSRRTDRkstinisgypNPEGFIRYL---EV 2343 king cobra
XP_004913214  688 NLTLYLIISLVAISVVSLITFIILLVKCLKRDsygsscg-----lcfsskYQANNYtdqykptlylNADGTLKYM---EV 759  western clawe...
XP_012814691  688 NLTLYLIISLVAISLVSLITFLILLVKCLKRDnygrgcg-----fcfsskYQTTHYtdqykptlylNTDGTLKYM---EV 759  western clawe...
XP_006632074 1486 KITFYLILALASVSVISFLTFVILAVKCVRNSrgaac-----------ccvkrADKnpqrnlqlqlNTDGPIKYI---EV 1551 spotted gar
XP_003970359  690 rITLYLIVSLASVSVLSLLTFLILVVKCIRNSrssgsc-------cmrrsDCDDYKnpnrnlqiqlNTDGPIKYV---EV 759  torafugu
XP_006632078 1251 KLTFYLTISLASVSVVSFLTFVILGVKCIRNWkcssf--------fcvrgHDSGNKnqsrnlqlqlNTDGPIKYI---EV 1319 spotted gar

Q5DRB1        758 SLTA-DSRKSHLI---------FPQ 772  chimpanzee
ETE67654     1589 CLTG-GSLSSEFR---------FLK 1603 king cobra
XP_007078010 1627 TLRPtDSQSHCYrtcfspasdgsdf 1651 Amur tiger
NP_001163983  758 RMAPtEAQGQCYrscfstlsdkndi 782  western clawed frog
ETE59223     2344 SGAGaQNYKSCFSpmseqgdffFVK 2368 king cobra
XP_004913214  760 RMAPpESQGQCYqacfpsateknyf 784  western clawed frog
XP_012814691  760 RMVPpDSQGQCYqacfpsasennds 784  western clawed frog
XP_006632074 1552 LGGDmLSQSQSFRscfspmseisdf 1576 spotted gar
XP_003970359  760 LGGDmMSQSQSFRscmspmseysdf 784  torafugu
XP_006632078 1320 LGGDmLSQSQSFRscfspvseisdf 1344 spotted gar
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