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Slc24a2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 [ Mus musculus (house mouse) ]

Gene ID: 76376, updated on 18-Sep-2024

Summary

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Official Symbol
Slc24a2provided by MGI
Official Full Name
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2provided by MGI
Primary source
MGI:MGI:1923626
See related
Ensembl:ENSMUSG00000037996 AllianceGenome:MGI:1923626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nckx2; 2810021B17Rik; 6330417K15Rik
Summary
Enables calcium channel activity. Involved in cellular response to high light intensity and cone photoresponse recovery. Acts upstream of or within several processes, including cellular calcium ion homeostasis; learning or memory; and regulation of synaptic plasticity. Located in membrane. Orthologous to human SLC24A2 (solute carrier family 24 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 27.0), cerebellum adult (RPKM 20.2) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Slc24a2 in Genome Data Viewer
Location:
4 C4; 4 40.69 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86901361..87148780, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86983124..87230652, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11244 Neighboring gene STARR-seq mESC enhancer starr_10704 Neighboring gene STARR-seq mESC enhancer starr_10705 Neighboring gene ribosomal protein S6 Neighboring gene alkaline ceramidase 2 Neighboring gene STARR-seq mESC enhancer starr_10707 Neighboring gene STARR-seq mESC enhancer starr_10709 Neighboring gene cadherin-2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:87013999-87014300 Neighboring gene STARR-seq mESC enhancer starr_10712 Neighboring gene STARR-positive B cell enhancer mm9_chr4:87133481-87133782 Neighboring gene predicted gene, 53246 Neighboring gene poly(A) binding protein interacting protein 2B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Na(+)/Ca(2+), K(+) exchanger 2 modulates mammalian cone phototransduction. Sakurai K, et al. Sci Rep, 2016 Sep 1. PMID 27580676, Free PMC Article
  2. Anatomical evidence for a non-synaptic influence of the K+ -dependent Na+/Ca2+ -exchanger, NCKX2, on hippocampal plasticity. Zhang Y, et al. Neuroscience, 2015 Dec 3. PMID 26410028
  3. A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage. Cuomo O, et al. J Neurosci, 2008 Feb 27. PMID 18305240, Free PMC Article
  4. Reduced CaM Kinase II and CaM Kinase IV Activities Underlie Cognitive Deficits in NCKX2 Heterozygous Mice. Moriguchi S, et al. Mol Neurobiol, 2018 May. PMID 28547530
  5. KIF21A-mediated axonal transport and selective endocytosis underlie the polarized targeting of NCKX2. Lee KH, et al. J Neurosci, 2012 Mar 21. PMID 22442075, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. both CaMKII autophosphorylation and CaMKIV phosphorylation significantly decreased in hippocampal CA1 regions of NCKX2+/- relative to control mice.
    Title: Reduced CaM Kinase II and CaM Kinase IV Activities Underlie Cognitive Deficits in NCKX2 Heterozygous Mice.
  2. It has been concluded that NCKX2 is required for the maintenance of efficient Ca2+ extrusion from mouse cones.
    Title: The Na(+)/Ca(2+), K(+) exchanger 2 modulates mammalian cone phototransduction.
  3. Studies describe for the first time the exact location of K(+)-dependent Na(+)/Ca(2)-exchanger (solute carrier family 24, member 2) in the hippocampus of adult mice.
    Title: Anatomical evidence for a non-synaptic influence of the K+ -dependent Na+/Ca2+ -exchanger, NCKX2, on hippocampal plasticity.
  4. non-synonymous single nucleotide polymorphism in SLC24A5 alters a residue that is important for NCKX5 and NCKX2 activity
    Title: SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.
  5. NCKX2 is involved in brain ischemia, and it may represent a new potential target to be investigated in the study of the molecular mechanisms involved in cerebral ischemia.
    Title: A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage.
  6. Mouse ortholog of rat Slc24a2 solute carrier family 24, encoding a potassium-dependent sodium-calcium exchanger (partial cds)
    Title: Molecular cloning of a novel potassium-dependent sodium-calcium exchanger from rat brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium, potassium:sodium antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium, potassium:sodium antiporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion import ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within establishment of localization in cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term synaptic depression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sodium/potassium/calcium exchanger 2
Names
Na(+)/K(+)/Ca(2+)-exchange protein 2
retinal cone Na-Ca+K exchanger
solute carrier family 24 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110240.1 → NP_001103710.1  sodium/potassium/calcium exchanger 2 isoform 2

    See identical proteins and their annotated locations for NP_001103710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and includes an alternate in-frame exon in the 5' coding region, but lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AL807763, AL954377, AW492765, BC115867
    Consensus CDS
    CCDS51220.1
    UniProtKB/TrEMBL
    Q14BI1
    Related
    ENSMUSP00000102776.3, ENSMUST00000107158.9
    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 711
    2A1904; K+-dependent Na+/Ca+ exchanger

  2. NM_172426.2 → NP_766014.1  sodium/potassium/calcium exchanger 2 isoform 1

    See identical proteins and their annotated locations for NP_766014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AK083127, AL807763, AL954377, AW492765, CJ121602
    Consensus CDS
    CCDS18312.1
    UniProtKB/Swiss-Prot
    B1AXF2, B1AXF3, Q14AY1, Q14BI1, Q8BUN9
    Related
    ENSMUSP00000102775.3, ENSMUST00000107157.9
    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 666
    2A1904; K+-dependent Na+/Ca+ exchanger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    86901361..87148780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538346.5 → XP_006538409.1  sodium/potassium/calcium exchanger 2 isoform X4

    See identical proteins and their annotated locations for XP_006538409.1

    UniProtKB/TrEMBL
    Q14BI1
    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 711
    2A1904; K+-dependent Na+/Ca+ exchanger

  2. XM_006538345.4 → XP_006538408.1  sodium/potassium/calcium exchanger 2 isoform X3

    See identical proteins and their annotated locations for XP_006538408.1

    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 728
    2A1904; K+-dependent Na+/Ca+ exchanger

  3. XM_006538344.5 → XP_006538407.1  sodium/potassium/calcium exchanger 2 isoform X2

    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 729
    2A1904; K+-dependent Na+/Ca+ exchanger

  4. XM_006538342.5 → XP_006538405.1  sodium/potassium/calcium exchanger 2 isoform X1

    See identical proteins and their annotated locations for XP_006538405.1

    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 746
    2A1904; K+-dependent Na+/Ca+ exchanger

  5. XM_006538347.5 → XP_006538410.1  sodium/potassium/calcium exchanger 2 isoform X5

    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 684
    2A1904; K+-dependent Na+/Ca+ exchanger

  6. XM_017320436.3 → XP_017175925.1  sodium/potassium/calcium exchanger 2 isoform X6

    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 667
    2A1904; K+-dependent Na+/Ca+ exchanger

  7. XM_006538349.4 → XP_006538412.1  sodium/potassium/calcium exchanger 2 isoform X9

    See identical proteins and their annotated locations for XP_006538412.1

    UniProtKB/TrEMBL
    Q14AY1
    Related
    ENSMUSP00000102773.2, ENSMUST00000107155.8
    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 649
    2A1904; K+-dependent Na+/Ca+ exchanger

  8. XM_036164527.1 → XP_036020420.1  sodium/potassium/calcium exchanger 2 isoform X10

    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 636
    2A1904; K+-dependent Na+/Ca+ exchanger

  9. XM_006538348.4 → XP_006538411.1  sodium/potassium/calcium exchanger 2 isoform X8

    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 653
    2A1904; K+-dependent Na+/Ca+ exchanger

  10. XM_036164526.1 → XP_036020419.1  sodium/potassium/calcium exchanger 2 isoform X9

    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 649
    2A1904; K+-dependent Na+/Ca+ exchanger

  11. XM_036164525.1 → XP_036020418.1  sodium/potassium/calcium exchanger 2 isoform X7

    UniProtKB/Swiss-Prot
    B1AXF2, B1AXF3, Q14AY1, Q14BI1, Q8BUN9
    Related
    ENSMUSP00000043937.5, ENSMUST00000044990.11
    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 666
    2A1904; K+-dependent Na+/Ca+ exchanger

  12. XM_017320435.2 → XP_017175924.1  sodium/potassium/calcium exchanger 2 isoform X5

    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 684
    2A1904; K+-dependent Na+/Ca+ exchanger

  13. XM_030253877.1 → XP_030109737.1  sodium/potassium/calcium exchanger 2 isoform X4

    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 711
    2A1904; K+-dependent Na+/Ca+ exchanger

  14. XM_006538343.4 → XP_006538406.1  sodium/potassium/calcium exchanger 2 isoform X1

    See identical proteins and their annotated locations for XP_006538406.1

    Conserved Domains (1) summary
    TIGR00927
    Location:99 → 746
    2A1904; K+-dependent Na+/Ca+ exchanger
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUN9.1 GenPept UniProtKB/Swiss-Prot:Q8BUN9

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