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Conserved domains on  [gi|1039768955|ref|XP_017175925|]
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sodium/potassium/calcium exchanger 2 isoform X6 [Mus musculus]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 99-667 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 724.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955   99 TPQP---PASQEDQaensteHTQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 175
Cdd:TIGR00927  423 SPSPsalPPGQPDL------HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  176 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLIT 255
Cdd:TIGR00927  497 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  256 FFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMISRNNVIKV---------TVPEAQAKSP-TAGDKDGPTLPV 325
Cdd:TIGR00927  577 FFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVmalgdlskgDVAEAEHTGErTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  326 GSSSAACSCTSE-----ECVAESK-----PRLQRG-----GSSASLHNSLMRNSIFQLMIHTLDPLAEGRFREKASILHK 390
Cdd:TIGR00927  657 GENGEESGGEAEqegetETKGENEsegeiPAERKGeqegeGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  391 IAKKKCQVDENERQNGAANHVE----KIELPNSTSTE---------------------------VEMTPSSEASEPVQNG 439
Cdd:TIGR00927  737 EGEEVEDEGEGEAEGKHEVETEgdrkETEHEGETEAEgkededegeiqagedgemkgdegaegkVEHEGETEAGEKDEHE 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  440 NLSHNI---------------------EAADAPKAT-------------------------------ETAEEEDDQPLSL 467
Cdd:TIGR00927  817 GQSETQaddtevkdetgeqelnaenqgEAKQDEKGVdggggsdggdseeeeeeeeeeeeeeeeeeeeEEEEEENEEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  468 SWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILA 547
Cdd:TIGR00927  897 EWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  548 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSI 627
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSI 1056

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 1039768955  628 ALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKVLVCPVSI 667
Cdd:TIGR00927 1057 ASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 99-667 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 724.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955   99 TPQP---PASQEDQaensteHTQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 175
Cdd:TIGR00927  423 SPSPsalPPGQPDL------HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  176 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLIT 255
Cdd:TIGR00927  497 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  256 FFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMISRNNVIKV---------TVPEAQAKSP-TAGDKDGPTLPV 325
Cdd:TIGR00927  577 FFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVmalgdlskgDVAEAEHTGErTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  326 GSSSAACSCTSE-----ECVAESK-----PRLQRG-----GSSASLHNSLMRNSIFQLMIHTLDPLAEGRFREKASILHK 390
Cdd:TIGR00927  657 GENGEESGGEAEqegetETKGENEsegeiPAERKGeqegeGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  391 IAKKKCQVDENERQNGAANHVE----KIELPNSTSTE---------------------------VEMTPSSEASEPVQNG 439
Cdd:TIGR00927  737 EGEEVEDEGEGEAEGKHEVETEgdrkETEHEGETEAEgkededegeiqagedgemkgdegaegkVEHEGETEAGEKDEHE 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  440 NLSHNI---------------------EAADAPKAT-------------------------------ETAEEEDDQPLSL 467
Cdd:TIGR00927  817 GQSETQaddtevkdetgeqelnaenqgEAKQDEKGVdggggsdggdseeeeeeeeeeeeeeeeeeeeEEEEEENEEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  468 SWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILA 547
Cdd:TIGR00927  897 EWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  548 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSI 627
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSI 1056

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 1039768955  628 ALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKVLVCPVSI 667
Cdd:TIGR00927 1057 ASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
156-652 1.83e-39

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 146.82  E-value: 1.83e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 156 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 235
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 236 WWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMkfnvqverwvkqmisrnnvikvtvpeaqakspta 315
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 316 gdkdgptlpvgsssaacsctseecvaeskprlqrggssaslhnslmrnsifqlmihtldplaegrFREkasilhkiakkk 395
Cdd:COG0530   126 -----------------------------------------------------------------IRR------------ 128

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 396 cqvdenerqngaanhvekielpnststevemtpsseasepvqngnlshnieAADAPKATETAEEEDDQPlslswPTNTRK 475
Cdd:COG0530   129 ---------------------------------------------------ARKEPAWEEVEEELEEKP-----KMSLWK 152

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 476 QATFLIVfpivfplwitlpdvrkpasrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDL 555
Cdd:COG0530   153 ALLLLVL-----------------------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPEL 203

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 556 ITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFSPVTVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRM 634
Cdd:COG0530   204 ATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRI 274

                         490
                  ....*....|....*...
gi 1039768955 635 NKILGFIMFGLYFVFLVV 652
Cdd:COG0530   275 GRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 139-283 2.60e-32

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 121.94  E-value: 2.60e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 139 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 218
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039768955 219 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKF 283
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 535-652 1.25e-14

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 75.45  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 535 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytiihrfSPVTVSSnglfcaiv 614
Cdd:PRK10734  205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI-------SPGEINP-------- 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1039768955 615 LLF-----IMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 652
Cdd:PRK10734  270 LAFsrdywVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 99-667 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 724.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955   99 TPQP---PASQEDQaensteHTQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 175
Cdd:TIGR00927  423 SPSPsalPPGQPDL------HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  176 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLIT 255
Cdd:TIGR00927  497 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  256 FFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMISRNNVIKV---------TVPEAQAKSP-TAGDKDGPTLPV 325
Cdd:TIGR00927  577 FFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVmalgdlskgDVAEAEHTGErTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  326 GSSSAACSCTSE-----ECVAESK-----PRLQRG-----GSSASLHNSLMRNSIFQLMIHTLDPLAEGRFREKASILHK 390
Cdd:TIGR00927  657 GENGEESGGEAEqegetETKGENEsegeiPAERKGeqegeGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  391 IAKKKCQVDENERQNGAANHVE----KIELPNSTSTE---------------------------VEMTPSSEASEPVQNG 439
Cdd:TIGR00927  737 EGEEVEDEGEGEAEGKHEVETEgdrkETEHEGETEAEgkededegeiqagedgemkgdegaegkVEHEGETEAGEKDEHE 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  440 NLSHNI---------------------EAADAPKAT-------------------------------ETAEEEDDQPLSL 467
Cdd:TIGR00927  817 GQSETQaddtevkdetgeqelnaenqgEAKQDEKGVdggggsdggdseeeeeeeeeeeeeeeeeeeeEEEEEENEEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  468 SWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILA 547
Cdd:TIGR00927  897 EWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  548 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSI 627
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSI 1056

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 1039768955  628 ALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKVLVCPVSI 667
Cdd:TIGR00927 1057 ASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 138-649 4.01e-91

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 285.37  E-value: 4.01e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 138 LHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNI 217
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 218 LFVIGMCALFSrEILNLTWWpLFRDVSFYIVDLLMLITFFLDNVimwWESLLLLTAYFAYVVFMKFNVQVERWVKQmisr 297
Cdd:TIGR00367  81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQ---ISRIDGVVLLILYIVYLLFLVKNERWVKY---- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 298 nnvikvtvpeaqaksptagdkdgptlpvgsssaacsctseecvaeskprlqrggssaslhnslmrnsifqlmihtldpla 377
Cdd:TIGR00367     --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 378 EGRFREkasilhkiakkkcQVDENERqngaanhvekielpnststevemtpsseasepvqngnlshnieaadapkateta 457
Cdd:TIGR00367 152 DTYTEE-------------NLDENNR------------------------------------------------------ 164

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 458 eeeddqplslswptntRKQATFLIVFPIVFplwitlpdvrkpasrkffpitffgsITWIAVFSYLMVWWAHQVGETIGIS 537
Cdd:TIGR00367 165 ----------------RPQIFFSLVLLIIG-------------------------LIGLVVGSRLLVDGAVKIAEILGIS 203

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 538 EEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIihRFSPVTVSSNGLFCAIVLLF 617
Cdd:TIGR00367 204 EKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPI--PVEPLAYNLDAPVMVIVTLL 281

                         490       500       510
                  ....*....|....*....|....*....|..
gi 1039768955 618 IMLLFVIlSIALCKWrmnkiLGFIMFGLYFVF 649
Cdd:TIGR00367 282 LMLFFKT-SMKLGRW-----EGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
156-652 1.83e-39

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 146.82  E-value: 1.83e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 156 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 235
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 236 WWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMkfnvqverwvkqmisrnnvikvtvpeaqakspta 315
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 316 gdkdgptlpvgsssaacsctseecvaeskprlqrggssaslhnslmrnsifqlmihtldplaegrFREkasilhkiakkk 395
Cdd:COG0530   126 -----------------------------------------------------------------IRR------------ 128

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 396 cqvdenerqngaanhvekielpnststevemtpsseasepvqngnlshnieAADAPKATETAEEEDDQPlslswPTNTRK 475
Cdd:COG0530   129 ---------------------------------------------------ARKEPAWEEVEEELEEKP-----KMSLWK 152

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 476 QATFLIVfpivfplwitlpdvrkpasrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDL 555
Cdd:COG0530   153 ALLLLVL-----------------------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPEL 203

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 556 ITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFSPVTVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRM 634
Cdd:COG0530   204 ATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRI 274

                         490
                  ....*....|....*...
gi 1039768955 635 NKILGFIMFGLYFVFLVV 652
Cdd:COG0530   275 GRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 139-283 2.60e-32

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 121.94  E-value: 2.60e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 139 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 218
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039768955 219 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKF 283
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 504-655 4.69e-31

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 118.47  E-value: 4.69e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 504 FFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 583
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039768955 584 VGLPLPWLLyTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSIALckWRMNKILGFIMFGLYFVFLVVSVL 655
Cdd:pfam01699  81 LVLGLSALI-GPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPLF--GRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
115-281 4.15e-22

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 97.13  E-value: 4.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 115 EHTQGDYPKDIFSLEERRKGAIILHVIGMIymfiALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSL 194
Cdd:COG0530   132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 195 IGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLTWWPLFRDVSFYIVDLLMLITFFL-DNVIMWWESLLLLTA 273
Cdd:COG0530   208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLAL 285


                  ....*...
gi 1039768955 274 YFAYVVFM 281
Cdd:COG0530   286 YLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
527-654 5.04e-18

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 85.18  E-value: 5.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 527 AHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFSPVTVSS 606
Cdd:COG0530     8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAAL-------IRPLAVDR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1039768955 607 NGLFCAI-VLLFIMLLFVILSIALckwRMNKILGFIMFGLYFVFLVVSV 654
Cdd:COG0530    81 RVLRRDLpFLLLASLLLLALLLDG---TLSRIDGVILLLLYVLYLYYLI 126
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 130-277 9.03e-16

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 78.52  E-value: 9.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 130 ERRKG---AIILHVIGMIYMFIALAIvcdefFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGI 206
Cdd:TIGR00367 163 NRRPQiffSLVLLIIGLIGLVVGSRL-----LVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAV 237

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039768955 207 GTIVGSAVFNILFVIGMCALFSR-EILNLTwwpLFRDVSF-YIVDLLMLITFFLDNVIMWWESLLLLTAYFAY 277
Cdd:TIGR00367 238 GNVIGSNIFNILVGLGVPSLFMPiPVEPLA---YNLDAPVmVIVTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 97-278 4.18e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 79.07  E-value: 4.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955  97 DYTPQPPASQEdqAENSTEHTQGDY------------PKDIfSLEERRKGAIILHVIgMIYMFIALAIVCDEFfVPSLTV 164
Cdd:TIGR00845  28 DHARALTEASS--SGSNTGECTGSYyckegvilpiwePQNP-SVGDKIARATVYFVA-MVYMFLGVSIIADRF-MASIEV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 165 ITEK-----------------LGI-SDDVAGATFMAAGGSAPELFTSLIGV----FIAhSNVGIGTIVGSAVFNILFVIG 222
Cdd:TIGR00845 103 ITSQekeitikkpngettvttVRIwNETVSNLTLMALGSSAPEILLSVIEVcghnFEA-GDLGPSTIVGSAAFNMFIIIA 181

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039768955 223 MCALF-----SREILNL------TWWPLFRDVSFYIVdllmlITFFLDNVIMWWESLLLL-----TAYFAYV 278
Cdd:TIGR00845 182 ICVYVipdgeTRKIKHLrvffvtAAWSVFAYVWLYLI-----LAVFSPGVVEVWEGLLTFfffplCVVFAWV 248
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 530-660 1.01e-14

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 75.44  E-value: 1.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 530 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFSPVTVSSNGL 609
Cdd:TIGR00367  28 IARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAI-------FSPIIVDKDWL 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039768955 610 FCAIvlLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKV 660
Cdd:TIGR00367 101 RRDI--LFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNERWV 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 535-652 1.25e-14

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 75.45  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 535 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytiihrfSPVTVSSnglfcaiv 614
Cdd:PRK10734  205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI-------SPGEINP-------- 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1039768955 615 LLF-----IMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 652
Cdd:PRK10734  270 LAFsrdywVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 140-228 5.52e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 61.20  E-value: 5.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 140 VIGMIYMFIALAIVCDeffvpSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILF 219
Cdd:PRK10734  180 GIALIIMPMATRMVID-----NATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254


                  ....*....
gi 1039768955 220 VIGMCALFS 228
Cdd:PRK10734  255 VLGLPALIS 263
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 141-654 1.94e-09

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 60.55  E-value: 1.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 141 IGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSlIGVFIAHS--NVGIGTIVGSAVFNIL 218
Cdd:PLN03151  145 VWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLGGAVFVTC 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 219 FVIGMCAL-FSREILNLTWWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMisR 297
Cdd:PLN03151  224 VVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARRL--K 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 298 NNVIKVTVP-EAQAKSPTAGDKDGPTLPVgsssaacsctSEECVAESKPRLQrggssaslhnslmrNSIFQLMihtldpl 376
Cdd:PLN03151  302 LDVVTPLLPvQGSIFSPSVEEDESMYSPL----------LESDTESDVPRLQ--------------TSLPQWM------- 350

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 377 aegrFREKASILHKIAKKKCQVDENERQNGAANhvEKIELPNSTST--------EVEMTPSSEASEP-VQNGNLSHNIEA 447
Cdd:PLN03151  351 ----WASNVAIYSNHFAKGSVHDEERPPWGWTD--EGAEVESSLFScsklfsllEMPLTIPRRLTIPiVEEDRWSKTYAV 424

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 448 ADAPKAtetaeeeddqPLSLSWPTNTR-------KQATFLIVFPIVFPLWI-----TLPDvrKPASRKFFPIT---FFGS 512
Cdd:PLN03151  425 ASASLA----------PVLLAFLWSSQddvslqaRIAAYFIGVAIGSTLGFlaykyTEPD--RPPRRFLIPWVlggFIMS 492

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 513 ITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGlGD---MAVSSSVGSNIFDITVGLPLP 589
Cdd:PLN03151  493 IVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGMS 571

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039768955 590 WLLYTIIHRFSPVTV-SSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSV 654
Cdd:PLN03151  572 MLLGAWSKSPESYMLpEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 523-637 4.74e-08

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 55.42  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 523 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYtiihrfsPV 602
Cdd:PRK10734   22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIR-------PF 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039768955 603 TVSSN------------GLFCAIVLLFIML-----LFVILSIALCKWRMNKI 637
Cdd:PRK10734   95 TVHSDvlrrelplmllvSVLAGSVLYDGQLsrsdgIFLLLLAVLWLLFIVKI 146
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 508-621 2.96e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 50.56  E-value: 2.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768955 508 TFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSVGSNIFDITVGL 586
Cdd:TIGR00845 758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGI 837

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1039768955 587 PLPWLLYTIIH-------RFSPVTVS-SNGLFCAIVLLFIMLL 621
Cdd:TIGR00845 838 GVAWSIAAIYHaangtqfKVSPGTLAfSVTLFTIFAFICIGVL 880
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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