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Conserved domains on  [gi|1907157708|ref|XP_036020419|]
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sodium/potassium/calcium exchanger 2 isoform X9 [Mus musculus]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 99-649 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 724.48  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708   99 TPQP---PASQEDQaensteHTQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 175
Cdd:TIGR00927  423 SPSPsalPPGQPDL------HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  176 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLIT 255
Cdd:TIGR00927  497 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  256 FFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMISRNNVIKV---------TVPEAQAKSP-TAGDKDGPTLPS 325
Cdd:TIGR00927  577 FFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVmalgdlskgDVAEAEHTGErTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  326 KPRLQRGGSSASL---------------------------------HNSLMRNSIFQLMIHTLDPLAEGRFREKASILHK 372
Cdd:TIGR00927  657 GENGEESGGEAEQegetetkgenesegeipaerkgeqegegeieakEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  373 IAKKKCQVDENERQNGAANHVE----KIELPNSTSTE---------------------------VEMTPSSEASEPVQNG 421
Cdd:TIGR00927  737 EGEEVEDEGEGEAEGKHEVETEgdrkETEHEGETEAEgkededegeiqagedgemkgdegaegkVEHEGETEAGEKDEHE 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  422 NLSHNI---------------------EAADAPKAT-------------------------------ETAEEEDDQPLSL 449
Cdd:TIGR00927  817 GQSETQaddtevkdetgeqelnaenqgEAKQDEKGVdggggsdggdseeeeeeeeeeeeeeeeeeeeEEEEEENEEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  450 SWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILA 529
Cdd:TIGR00927  897 EWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  530 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSI 609
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSI 1056

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 1907157708  610 ALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKVLVCPVSI 649
Cdd:TIGR00927 1057 ASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 99-649 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 724.48  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708   99 TPQP---PASQEDQaensteHTQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 175
Cdd:TIGR00927  423 SPSPsalPPGQPDL------HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  176 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLIT 255
Cdd:TIGR00927  497 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  256 FFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMISRNNVIKV---------TVPEAQAKSP-TAGDKDGPTLPS 325
Cdd:TIGR00927  577 FFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVmalgdlskgDVAEAEHTGErTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  326 KPRLQRGGSSASL---------------------------------HNSLMRNSIFQLMIHTLDPLAEGRFREKASILHK 372
Cdd:TIGR00927  657 GENGEESGGEAEQegetetkgenesegeipaerkgeqegegeieakEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  373 IAKKKCQVDENERQNGAANHVE----KIELPNSTSTE---------------------------VEMTPSSEASEPVQNG 421
Cdd:TIGR00927  737 EGEEVEDEGEGEAEGKHEVETEgdrkETEHEGETEAEgkededegeiqagedgemkgdegaegkVEHEGETEAGEKDEHE 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  422 NLSHNI---------------------EAADAPKAT-------------------------------ETAEEEDDQPLSL 449
Cdd:TIGR00927  817 GQSETQaddtevkdetgeqelnaenqgEAKQDEKGVdggggsdggdseeeeeeeeeeeeeeeeeeeeEEEEEENEEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  450 SWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILA 529
Cdd:TIGR00927  897 EWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  530 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSI 609
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSI 1056

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 1907157708  610 ALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKVLVCPVSI 649
Cdd:TIGR00927 1057 ASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
156-634 7.82e-42

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 153.37  E-value: 7.82e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 156 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 235
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 236 WWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMkfnvqverwvkqmisrnnvikvtvpeaqakspta 315
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 316 gdkdgptlpskprlqrggssaslhnslmrnsifqlmihtldplaegrFREkasilhkiakkkcqvdenerqngaanhvek 395
Cdd:COG0530   126 -----------------------------------------------IRR------------------------------ 128

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 396 ielpnststevemtpsseasepvqngnlshnieAADAPKATETAEEEDDQPlslswPTNTRKQATFLIVfpivfplwitl 475
Cdd:COG0530   129 ---------------------------------ARKEPAWEEVEEELEEKP-----KMSLWKALLLLVL----------- 159

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 476 pdvrkpasrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSS 555
Cdd:COG0530   160 ------------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGN 221

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 556 SVGSNIFDITVGLPLPWLlytiihrFSPVTVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRMNKILGFIMFGLYFVFLVV 634
Cdd:COG0530   222 IIGSNIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 139-283 3.46e-32

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 121.56  E-value: 3.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 139 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 218
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907157708 219 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKF 283
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 517-634 1.39e-14

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 75.07  E-value: 1.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 517 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytiihrfSPVTVSSnglfcaiv 596
Cdd:PRK10734  205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI-------SPGEINP-------- 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907157708 597 LLF-----IMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 634
Cdd:PRK10734  270 LAFsrdywVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 99-649 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 724.48  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708   99 TPQP---PASQEDQaensteHTQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 175
Cdd:TIGR00927  423 SPSPsalPPGQPDL------HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  176 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLIT 255
Cdd:TIGR00927  497 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLIL 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  256 FFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMISRNNVIKV---------TVPEAQAKSP-TAGDKDGPTLPS 325
Cdd:TIGR00927  577 FFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVmalgdlskgDVAEAEHTGErTGEEGERPTEAE 656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  326 KPRLQRGGSSASL---------------------------------HNSLMRNSIFQLMIHTLDPLAEGRFREKASILHK 372
Cdd:TIGR00927  657 GENGEESGGEAEQegetetkgenesegeipaerkgeqegegeieakEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  373 IAKKKCQVDENERQNGAANHVE----KIELPNSTSTE---------------------------VEMTPSSEASEPVQNG 421
Cdd:TIGR00927  737 EGEEVEDEGEGEAEGKHEVETEgdrkETEHEGETEAEgkededegeiqagedgemkgdegaegkVEHEGETEAGEKDEHE 816

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  422 NLSHNI---------------------EAADAPKAT-------------------------------ETAEEEDDQPLSL 449
Cdd:TIGR00927  817 GQSETQaddtevkdetgeqelnaenqgEAKQDEKGVdggggsdggdseeeeeeeeeeeeeeeeeeeeEEEEEENEEPLSL 896

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  450 SWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILA 529
Cdd:TIGR00927  897 EWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILA 976

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  530 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSI 609
Cdd:TIGR00927  977 AGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSI 1056

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 1907157708  610 ALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKVLVCPVSI 649
Cdd:TIGR00927 1057 ASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 138-631 1.31e-93

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 291.15  E-value: 1.31e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 138 LHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNI 217
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 218 LFVIGMCALFSrEILNLTWWpLFRDVSFYIVDLLMLITFFLDNVimwWESLLLLTAYFAYVVFMKFNVQVERWVKQmisr 297
Cdd:TIGR00367  81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQ---ISRIDGVVLLILYIVYLLFLVKNERWVKY---- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 298 nnvikvtvpeaqaksptagdkdgptlpskprlqrggssaslhnslmrnsifqlmihtldplaEGRFREkasilhkiakkk 377
Cdd:TIGR00367 152 --------------------------------------------------------------DTYTEE------------ 157

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 378 cQVDENERqngaanhvekielpnststevemtpsseasepvqngnlshnieaadapkatetaeeeddqplslswptntRK 457
Cdd:TIGR00367 158 -NLDENNR----------------------------------------------------------------------RP 166

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 458 QATFLIVFPIVFplwitlpdvrkpasrkffpitffgsITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDL 537
Cdd:TIGR00367 167 QIFFSLVLLIIG-------------------------LIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPEL 221

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 538 ITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIihRFSPVTVSSNGLFCAIVLLFIMLLFVIlSIALCKWrmn 617
Cdd:TIGR00367 222 VVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPI--PVEPLAYNLDAPVMVIVTLLLMLFFKT-SMKLGRW--- 295

                         490
                  ....*....|....
gi 1907157708 618 kiLGFIMFGLYFVF 631
Cdd:TIGR00367 296 --EGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
156-634 7.82e-42

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 153.37  E-value: 7.82e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 156 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 235
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 236 WWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMkfnvqverwvkqmisrnnvikvtvpeaqakspta 315
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 316 gdkdgptlpskprlqrggssaslhnslmrnsifqlmihtldplaegrFREkasilhkiakkkcqvdenerqngaanhvek 395
Cdd:COG0530   126 -----------------------------------------------IRR------------------------------ 128

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 396 ielpnststevemtpsseasepvqngnlshnieAADAPKATETAEEEDDQPlslswPTNTRKQATFLIVfpivfplwitl 475
Cdd:COG0530   129 ---------------------------------ARKEPAWEEVEEELEEKP-----KMSLWKALLLLVL----------- 159

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 476 pdvrkpasrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSS 555
Cdd:COG0530   160 ------------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGN 221

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 556 SVGSNIFDITVGLPLPWLlytiihrFSPVTVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRMNKILGFIMFGLYFVFLVV 634
Cdd:COG0530   222 IIGSNIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 139-283 3.46e-32

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 121.56  E-value: 3.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 139 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 218
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907157708 219 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKF 283
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 486-637 6.09e-31

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 118.09  E-value: 6.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 486 FFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 565
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907157708 566 VGLPLPWLLyTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVILSIALckWRMNKILGFIMFGLYFVFLVVSVL 637
Cdd:pfam01699  81 LVLGLSALI-GPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPLF--GRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
115-281 4.46e-22

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 96.74  E-value: 4.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 115 EHTQGDYPKDIFSLEERRKGAIILHVIGMIymfiALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSL 194
Cdd:COG0530   132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 195 IGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLTWWPLFRDVSFYIVDLLMLITFFL-DNVIMWWESLLLLTA 273
Cdd:COG0530   208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLAL 285


                  ....*...
gi 1907157708 274 YFAYVVFM 281
Cdd:COG0530   286 YLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
509-636 5.27e-18

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 84.80  E-value: 5.27e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 509 AHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFSPVTVSS 588
Cdd:COG0530     8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAAL-------IRPLAVDR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907157708 589 NGLFCAI-VLLFIMLLFVILSIALckwRMNKILGFIMFGLYFVFLVVSV 636
Cdd:COG0530    81 RVLRRDLpFLLLASLLLLALLLDG---TLSRIDGVILLLLYVLYLYYLI 126
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 130-277 9.70e-16

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 78.52  E-value: 9.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 130 ERRKG---AIILHVIGMIYMFIALAIvcdefFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGI 206
Cdd:TIGR00367 163 NRRPQiffSLVLLIIGLIGLVVGSRL-----LVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAV 237

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907157708 207 GTIVGSAVFNILFVIGMCALFSR-EILNLTwwpLFRDVSF-YIVDLLMLITFFLDNVIMWWESLLLLTAYFAY 277
Cdd:TIGR00367 238 GNVIGSNIFNILVGLGVPSLFMPiPVEPLA---YNLDAPVmVIVTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 97-446 1.13e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 80.99  E-value: 1.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708  97 DYTPQPPASQEdqAENSTEHTQGDY------------PKDIfSLEERRKGAIILHVIgMIYMFIALAIVCDEFfVPSLTV 164
Cdd:TIGR00845  28 DHARALTEASS--SGSNTGECTGSYyckegvilpiwePQNP-SVGDKIARATVYFVA-MVYMFLGVSIIADRF-MASIEV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 165 ITEK-----------------LGI-SDDVAGATFMAAGGSAPELFTSLIGV----FIAhSNVGIGTIVGSAVFNILFVIG 222
Cdd:TIGR00845 103 ITSQekeitikkpngettvttVRIwNETVSNLTLMALGSSAPEILLSVIEVcghnFEA-GDLGPSTIVGSAAFNMFIIIA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 223 MCALF-----SREILNL------TWWPLFRDVSFYIVdllmlITFFLDNVIMWWESLLLL-----TAYFAYV-----VFM 281
Cdd:TIGR00845 182 ICVYVipdgeTRKIKHLrvffvtAAWSVFAYVWLYLI-----LAVFSPGVVEVWEGLLTFfffplCVVFAWVadrrlLFY 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 282 KFNVQVERWVKQmisRNNVIKVtvpEA-QAKSPTAGDKDGPTLpskprlqrggssaslhNSLMRNSIFQLMIHTLDPLAE 360
Cdd:TIGR00845 257 KYVYKRYRAGKQ---RGMIIET---EGdRPKSKTEIEMDGKMV----------------NSHVDNFLDGALVLEVKEFDE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 361 GRfREKASILHKIAKKKCQVDENERQNGAANHVekielpnststeVEMTPSSEASEPVQ-------NGNLSHNIEAADAP 433
Cdd:TIGR00845 315 AR-REMIRILKELKQKHPDKDLEQLEEMANYQV------------LSRQQKSRAFYRIQatrlmtgAGNILKKHAADAAR 381

                         410
                  ....*....|...
gi 1907157708 434 KATETAEEEDDQP 446
Cdd:TIGR00845 382 KAVSMHEVATDDE 394
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 512-642 1.10e-14

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 75.44  E-value: 1.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 512 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFSPVTVSSNGL 591
Cdd:TIGR00367  28 IARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAI-------FSPIIVDKDWL 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907157708 592 FCAIvlLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKV 642
Cdd:TIGR00367 101 RRDI--LFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNERWV 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 517-634 1.39e-14

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 75.07  E-value: 1.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 517 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytiihrfSPVTVSSnglfcaiv 596
Cdd:PRK10734  205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI-------SPGEINP-------- 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907157708 597 LLF-----IMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 634
Cdd:PRK10734  270 LAFsrdywVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 141-636 1.11e-10

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 64.78  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 141 IGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSlIGVFIAHS--NVGIGTIVGSAVFNIL 218
Cdd:PLN03151  145 VWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLGGAVFVTC 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 219 FVIGMCAL-FSREILNLTWWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMisR 297
Cdd:PLN03151  224 VVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARRL--K 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 298 NNVIKVTVPEAQAKSPTAGDKDGPTLPSKPRLQRGGSSASLHNSLMrnsifQLMihtldplaegrFREKASILHKIAKKK 377
Cdd:PLN03151  302 LDVVTPLLPVQGSIFSPSVEEDESMYSPLLESDTESDVPRLQTSLP-----QWM-----------WASNVAIYSNHFAKG 365

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 378 CQVDENERQNGAANhvEKIELPNSTST--------EVEMTPSSEASEP-VQNGNLSHNIEAADAPKAtetaeeeddqPLS 448
Cdd:PLN03151  366 SVHDEERPPWGWTD--EGAEVESSLFScsklfsllEMPLTIPRRLTIPiVEEDRWSKTYAVASASLA----------PVL 433

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 449 LSWPTNTR-------KQATFLIVFPIVFPLWI-----TLPDvrKPASRKFFPIT---FFGSITWIAVFSYLMVWWAHQVG 513
Cdd:PLN03151  434 LAFLWSSQddvslqaRIAAYFIGVAIGSTLGFlaykyTEPD--RPPRRFLIPWVlggFIMSIVWFYMIANELVALLVAFG 511

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 514 ETIGISEEIMGLTILAAGTSIPDLITSVIVARKGlGD---MAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTV-SSN 589
Cdd:PLN03151  512 VIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLpEDS 590

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1907157708 590 GLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSV 636
Cdd:PLN03151  591 SLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 140-228 5.56e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 61.20  E-value: 5.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 140 VIGMIYMFIALAIVCDeffvpSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILF 219
Cdd:PRK10734  180 GIALIIMPMATRMVID-----NATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254


                  ....*....
gi 1907157708 220 VIGMCALFS 228
Cdd:PRK10734  255 VLGLPALIS 263
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 505-619 5.03e-08

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 55.04  E-value: 5.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 505 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYtiihrfsPV 584
Cdd:PRK10734   22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIR-------PF 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907157708 585 TVSSN------------GLFCAIVLLFIML-----LFVILSIALCKWRMNKI 619
Cdd:PRK10734   95 TVHSDvlrrelplmllvSVLAGSVLYDGQLsrsdgIFLLLLAVLWLLFIVKI 146
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 490-603 2.82e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 50.56  E-value: 2.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157708 490 TFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSVGSNIFDITVGL 568
Cdd:TIGR00845 758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGI 837

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1907157708 569 PLPWLLYTIIH-------RFSPVTVS-SNGLFCAIVLLFIMLL 603
Cdd:TIGR00845 838 GVAWSIAAIYHaangtqfKVSPGTLAfSVTLFTIFAFICIGVL 880
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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