itgb1.S integrin subunit beta 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: itgb1.S
Official Full Name: integrin subunit beta 1 S homeolog
Primary source: Xenbase:XB-GENE-6253896
Locus tag: XELAEV_18032868mg
See related: EnsemblRapid:ENSXLAG00005028190 AllianceGenome:Xenbase:XB-GENE-6253896
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: cd29; fnrb; mdf2; vlab; gpiia; itgb1; msk12; itgb1-a; itgb1-b; vla-beta
Summary: Predicted to enable several functions, including C-X3-C chemokine binding activity; cell adhesion molecule binding activity; and fibronectin binding activity. Predicted to act upstream of or within myoblast differentiation and myoblast fusion. Predicted to be located in several cellular components, including focal adhesion; melanosome; and ruffle membrane. Predicted to be part of integrin complex. Is expressed in urinary system. Orthologous to human ITGB1 (integrin subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6S

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6S	NC_054382.1 (16334489..16368551)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6S	NC_030735.1 (15970372..16003115)

Chromosome 6S - NC_054382.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein .
Title: Bidirectional remodeling of β1-integrin adhesions during chemotropic regulation of nerve growth.
Findings identify beta(1)-integrin as an important functional cargo during Ca(2+)-dependent rapid endocytosis stimulated by a diffusible guidance cue in Xenopus spinal neurons.
Title: Asymmetric endocytosis and remodeling of beta1-integrin adhesions during growth cone chemorepulsion by MAG.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables C-X3-C chemokine binding	IEA Inferred from Electronic Annotation more info
enables collagen binding involved in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
enables fibronectin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables laminin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
part_of integrin complex	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin beta-1-B

Names: Beta 1 integrin; integrin beta 1; integrin beta-1*; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090862.1 → NP_001084331.1 integrin beta-1-B precursor

See identical proteins and their annotated locations for NP_001084331.1

Status: PROVISIONAL

Source sequence(s)

BC073688

UniProtKB/Swiss-Prot

P12607

UniProtKB/TrEMBL

Q6GN32

Related

ENSXLAP00005084183.1, ENSXLAT00005085828.1

Conserved Domains (4) summary

pfam00362
Location:35 → 464

Integrin_beta; Integrin, beta chain

pfam07965
Location:640 → 727

Integrin_B_tail; Integrin beta tail domain

pfam07974
Location:599 → 630

EGF_2; EGF-like domain

pfam08725
Location:757 → 795

Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

16334489..16368551

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041567111.1 → XP_041423045.1 integrin beta-1-B isoform X2

UniProtKB/TrEMBL

A0A8J1L390, A0A974CIT9

Related

ENSXLAP00005084764.1, ENSXLAT00005086425.1

Conserved Domains (1) summary

smart00187
Location:151 → 580

INB; Integrin beta subunits (N-terminal portion of extracellular region)
XM_041567110.1 → XP_041423044.1 integrin beta-1-B isoform X1

UniProtKB/TrEMBL

A0A8J1L213, A0A974CIT9

Conserved Domains (1) summary

smart00187
Location:151 → 580

INB; Integrin beta subunits (N-terminal portion of extracellular region)
XM_018268655.2 → XP_018124144.1 integrin beta-1-B isoform X3

UniProtKB/TrEMBL

A0A1L8FQM9, A0A974CI83, A0A974CIT9

Related

ENSXLAP00005084676.1, ENSXLAT00005086331.1