U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TERF2 telomeric repeat binding factor 2 [ Gallus gallus (chicken) ]

Gene ID: 395598, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Symbol
TERF2provided by CGNC
Full Name
telomeric repeat binding factor 2provided by CGNC
Primary source
CGNC:415
See related
Ensembl:ENSGALG00010008246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TRF2
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TERF2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 11 NC_052542.1 (18585718..18593531, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 11 NC_052583.1 (18933676..18941488, complement)

Chromosome 11 - NC_052542.1Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 8 Neighboring gene NIP7, nucleolar pre-rRNA processing protein Neighboring gene transmembrane p24 trafficking protein 6 Neighboring gene cytochrome b5 type B Neighboring gene nuclear factor of activated T-cells 5 Neighboring gene uncharacterized LOC124417145

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning and characterisation of the chicken gene encoding the telomeric protein TRF2. Konrad JP, et al. Gene, 1999 Oct 18. PMID 10571037
  2. The telomeric protein Rap1 is conserved in vertebrates and is expressed from a bidirectional promoter positioned between the Rap1 and KARS genes. Tan M, et al. Gene, 2003 Dec 24. PMID 14659874
  3. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G-rich strand telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables telomerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of telomere maintenance via recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of telomeric D-loop disassembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protection from non-homologous end joining at telomere IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomeric D-loop disassembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomeric loop formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of shelterin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
telomeric repeat-binding factor 2
Names
TTAGGG-repeat binding factor 2 TRF2
telomeric DNA-binding protein
telomeric repeat binding factor a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271892.2 → NP_001258821.2  telomeric repeat-binding factor 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000248
    UniProtKB/Swiss-Prot
    Q9PU53
    UniProtKB/TrEMBL
    A0A8V0XZ26
    Related
    ENSGALP00010011279.1, ENSGALT00010019731.1
    Conserved Domains (4) summary
    cd11654
    Location:494 → 535
    TRF2_RBM; RAP1 binding motif of telomere repeat binding factor
    cd11660
    Location:666 → 714
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    PHA03247
    Location:220 → 566
    PHA03247; large tegument protein UL36; Provisional
    cd00280
    Location:20 → 219
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052542.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    18585718..18593531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040707005.2 → XP_040562939.1  telomeric repeat-binding factor 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9PU53
    Conserved Domains (3) summary
    PTZ00449
    Location:169 → 491
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd11660
    Location:585 → 633
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cl02779
    Location:20 → 190
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

  2. XM_015292545.4 → XP_015148031.2  telomeric repeat-binding factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9PU53
    Conserved Domains (4) summary
    cd11654
    Location:465 → 506
    TRF2_RBM; RAP1 binding motif of telomere repeat binding factor
    cd11660
    Location:637 → 685
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    PHA03247
    Location:191 → 537
    PHA03247; large tegument protein UL36; Provisional
    cl02779
    Location:20 → 190
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

  3. XM_015292546.4 → XP_015148032.2  telomeric repeat-binding factor 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9PU53
    Conserved Domains (3) summary
    PTZ00449
    Location:198 → 520
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd11660
    Location:614 → 662
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cd00280
    Location:20 → 219
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052583.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    18933676..18941488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046925358.1 → XP_046781314.1  telomeric repeat-binding factor 2 isoform X3

  2. XM_046925356.1 → XP_046781312.1  telomeric repeat-binding factor 2 isoform X1

  3. XM_046925357.1 → XP_046781313.1  telomeric repeat-binding factor 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9PU53.2 GenPept UniProtKB/Swiss-Prot:Q9PU53

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.