Cadm2 cell adhesion molecule 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cadm2provided by RGD
Official Full Name: cell adhesion molecule 2provided by RGD
Primary source: RGD:1305678
See related: EnsemblRapid:ENSRNOG00000074750 AllianceGenome:RGD:1305678
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Igsf4d; Necl-3; SynCAM 2
Summary: Involved in synaptic membrane adhesion. Located in axon and neuronal cell body membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 310.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 11p12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (17994856..18971895, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (4548367..5525420, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (4175078..4397335, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of miR125a reduced the level of Cadm2 expression in PC12 cell injury induced by free-serum. In contrast, inhibition of miR125a using miR125a inhibitors significantly resulted in higher levels of Cadm2 expression. In conclusion, miR125a is involved in the behavioral disorder of animal models of MCAO by regulation of Cadm2.
Title: MicroRNA-125a-3p is involved in early behavioral disorders in stroke-afflicted rats through the regulation of Cadm2.
We show that Necl-3/SynCAM-2 is a plasma membrane protein that accumulates in several tissues, including those of the central and peripheral nervous system.
Title: The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137821 (e-PCR)
- UniSTS:219908

AU048452 (e-PCR)
- UniSTS:144902

D11Got5 (e-PCR)
- UniSTS:115774

D11Got1 (e-PCR)
- UniSTS:112710

D0Mco65 (e-PCR)
- UniSTS:518997

BF386655 (e-PCR)
- UniSTS:243804

AU047486 (e-PCR)
- UniSTS:110461

BF387497 (e-PCR)
- UniSTS:244369

BF387017 (e-PCR)
- UniSTS:244162

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
NOT located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cell adhesion molecule 2

Names: immunoglobulin superfamily member 4D; immunoglobulin superfamily, member 4; nectin-like protein 3; synaptic cell adhesion molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047102.2 → NP_001040567.1 cell adhesion molecule 2 precursor

See identical proteins and their annotated locations for NP_001040567.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q1WIM2

UniProtKB/TrEMBL

A0A8I6A950

Conserved Domains (4) summary

smart00294
Location:348 → 366

4.1m; putative band 4.1 homologues' binding motif

smart00408
Location:240 → 303

IGc2; Immunoglobulin C-2 Type

cd05884
Location:141 → 223

Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))

cd07701
Location:26 → 120

Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

17994856..18971895 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088453.2 → XP_038944381.1 cell adhesion molecule 2 isoform X2

UniProtKB/Swiss-Prot

Q1WIM2

UniProtKB/TrEMBL

A0A8I5ZY73

Related

ENSRNOP00000108195.1, ENSRNOT00000144814.1

Conserved Domains (5) summary

smart00294
Location:388 → 406

4.1m; putative band 4.1 homologues' binding motif

smart00408
Location:240 → 303

IGc2; Immunoglobulin C-2 Type

cd00096
Location:242 → 251

Ig; Ig strand B [structural motif]

cd05884
Location:120 → 223

IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains

cd07701
Location:26 → 121

IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains
XM_039088451.2 → XP_038944379.1 cell adhesion molecule 2 isoform X1

UniProtKB/Swiss-Prot

Q1WIM2

Conserved Domains (5) summary

smart00294
Location:397 → 415

4.1m; putative band 4.1 homologues' binding motif

smart00408
Location:249 → 312

IGc2; Immunoglobulin C-2 Type

cd00096
Location:251 → 260

Ig; Ig strand B [structural motif]

cd05884
Location:129 → 232

IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains

cd07701
Location:35 → 130

IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains
XM_039088454.1 → XP_038944382.1 cell adhesion molecule 2 isoform X3

UniProtKB/Swiss-Prot

Q1WIM2

UniProtKB/TrEMBL

A0A0A0MY16

Related

ENSRNOP00000099794.1, ENSRNOT00000148613.1

Conserved Domains (5) summary

smart00294
Location:357 → 375

4.1m; putative band 4.1 homologues' binding motif

smart00408
Location:249 → 312

IGc2; Immunoglobulin C-2 Type

cd00096
Location:251 → 260

Ig; Ig strand B [structural motif]

cd05884
Location:129 → 232

IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains

cd07701
Location:35 → 130

IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains
XM_039088456.2 → XP_038944384.1 cell adhesion molecule 2 isoform X4

UniProtKB/TrEMBL

A0A0G2K5U6

Related

ENSRNOP00000109645.1, ENSRNOT00000124799.1

Conserved Domains (4) summary

smart00294
Location:280 → 298

4.1m; putative band 4.1 homologues' binding motif

smart00408
Location:132 → 195

IGc2; Immunoglobulin C-2 Type

cd00096
Location:134 → 143

Ig; Ig strand B [structural motif]

cd05884
Location:12 → 115

IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
XM_063270608.1 → XP_063126678.1 cell adhesion molecule 2 isoform X5
XM_039088455.2 → XP_038944383.1 cell adhesion molecule 2 isoform X4

UniProtKB/TrEMBL

A0A0G2K5U6

Conserved Domains (4) summary

smart00294
Location:280 → 298

4.1m; putative band 4.1 homologues' binding motif

smart00408
Location:132 → 195

IGc2; Immunoglobulin C-2 Type

cd00096
Location:134 → 143

Ig; Ig strand B [structural motif]

cd05884
Location:12 → 115

IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains