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FRYL FRY like transcription coactivator [ Homo sapiens (human) ]

Gene ID: 285527, updated on 3-Nov-2024

Summary

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Official Symbol
FRYLprovided by HGNC
Official Full Name
FRY like transcription coactivatorprovided by HGNC
Primary source
HGNC:HGNC:29127
See related
Ensembl:ENSG00000075539 MIM:620798; AllianceGenome:HGNC:29127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOR2; AF4p12; KIAA0826
Summary
Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon (RPKM 15.9), lymph node (RPKM 5.8) and 24 other tissues See more
Orthologs
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Genomic context

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See FRYL in Genome Data Viewer
Location:
4p11
Exon count:
70
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (48497357..48780279, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (48464386..48746848, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48499374..48782296, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SLAIN motif family member 2 Neighboring gene U6 snRNA-associated Sm-like protein LSm2 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:48491403-48491940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15411 Neighboring gene solute carrier family 10 member 4 Neighboring gene zygote arrest 1 Neighboring gene RNA, U5E small nuclear 3, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3875 Neighboring gene Sharpr-MPRA regulatory region 7734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15412 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15414 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:48832895-48833458 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:48833459-48834021 Neighboring gene OCIA domain containing 1 Neighboring gene OCIAD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15415 Neighboring gene OCIA domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features. Pan X, et al. Am J Hum Genet, 2024 Apr 4. PMID 38479391, Free PMC Article
  2. Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia. Sait SN, et al. Cancer Genet Cytogenet, 2007 Sep. PMID 17854671
  3. AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner. Hayette S, et al. Cancer Res, 2005 Aug 1. PMID 16061630
  4. Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Xiong S, et al. Structure, 2018 Aug 7. PMID 29983373, Free PMC Article
  5. Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome. Robinson BW, et al. Blood, 2008 Apr 1. PMID 18195096, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features.
    Title: De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features.
  2. The activation segment of NDR1 influences interaction with MST1/MST2 and Furry.
    Title: Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
  3. Thus, t(4;11)(p12;q23) with MLL and FRYL involvement represents a new recurring 11q23 translocation, to date seen only in therapy-related acute leukemias.
    Title: Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16177, DKFZp686E205

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein furry homolog-like
Names
ALL1-fused gene from chromosome 4p12 protein
FRY-like
furry homolog-like
furry-like
mor2 cell polarity protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015030.2 → NP_055845.1  protein furry homolog-like

    See identical proteins and their annotated locations for NP_055845.1

    Status: VALIDATED

    Source sequence(s)
    AC068037, AC096952
    Consensus CDS
    CCDS43227.1
    UniProtKB/Swiss-Prot
    O94915, O95640, Q8WTZ5, Q9NT40
    UniProtKB/TrEMBL
    A0A2C9F2R7
    Related
    ENSP00000351113.4, ENST00000358350.9
    Conserved Domains (3) summary
    pfam14222
    Location:117 → 649
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2001 → 2254
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:687 → 1859
    MOR2-PAG1_mid; Cell morphogenesis central region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    48497357..48780279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453991.2 → XP_024309759.1  protein furry homolog-like isoform X9

    UniProtKB/TrEMBL
    A0A2C9F2R7
    Conserved Domains (3) summary
    pfam14222
    Location:117 → 664
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2016 → 2269
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:702 → 1874
    MOR2-PAG1_mid; Cell morphogenesis central region

  2. XM_024453993.2 → XP_024309761.1  protein furry homolog-like isoform X10

    UniProtKB/Swiss-Prot
    O94915, O95640, Q8WTZ5, Q9NT40
    UniProtKB/TrEMBL
    A0A2C9F2R7
    Conserved Domains (3) summary
    pfam14222
    Location:117 → 649
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2001 → 2254
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:687 → 1859
    MOR2-PAG1_mid; Cell morphogenesis central region

  3. XM_011513683.4 → XP_011511985.1  protein furry homolog-like isoform X9

    See identical proteins and their annotated locations for XP_011511985.1

    UniProtKB/TrEMBL
    A0A2C9F2R7
    Conserved Domains (3) summary
    pfam14222
    Location:117 → 664
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2016 → 2269
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:702 → 1874
    MOR2-PAG1_mid; Cell morphogenesis central region

  4. XM_005248090.6 → XP_005248147.1  protein furry homolog-like isoform X9

    See identical proteins and their annotated locations for XP_005248147.1

    UniProtKB/TrEMBL
    A0A2C9F2R7
    Conserved Domains (3) summary
    pfam14222
    Location:117 → 664
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2016 → 2269
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:702 → 1874
    MOR2-PAG1_mid; Cell morphogenesis central region

  5. XM_047450099.1 → XP_047306055.1  protein furry homolog-like isoform X9

  6. XM_047450098.1 → XP_047306054.1  protein furry homolog-like isoform X8

  7. XM_047450097.1 → XP_047306053.1  protein furry homolog-like isoform X6

  8. XM_011513682.4 → XP_011511984.2  protein furry homolog-like isoform X7

    UniProtKB/TrEMBL
    A0A2C9F2R7
    Related
    ENSP00000422408.4, ENST00000507873.8
    Conserved Domains (3) summary
    pfam14222
    Location:209 → 741
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2093 → 2346
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:779 → 1951
    MOR2-PAG1_mid; Cell morphogenesis central region

  9. XM_024453989.2 → XP_024309757.1  protein furry homolog-like isoform X5

    UniProtKB/TrEMBL
    A0A2C9F2R7
    Conserved Domains (3) summary
    pfam14222
    Location:209 → 741
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2093 → 2346
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:779 → 1951
    MOR2-PAG1_mid; Cell morphogenesis central region

  10. XM_047450095.1 → XP_047306051.1  protein furry homolog-like isoform X4

  11. XM_011513680.4 → XP_011511982.2  protein furry homolog-like isoform X2

    UniProtKB/TrEMBL
    A0A2C9F2R7
    Conserved Domains (3) summary
    pfam14222
    Location:209 → 756
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2107 → 2360
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:794 → 1965
    MOR2-PAG1_mid; Cell morphogenesis central region

  12. XM_011513681.4 → XP_011511983.2  protein furry homolog-like isoform X3

    UniProtKB/TrEMBL
    A0A2C9F2R7
    Conserved Domains (3) summary
    pfam14222
    Location:209 → 756
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2108 → 2361
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:794 → 1966
    MOR2-PAG1_mid; Cell morphogenesis central region

  13. XM_024453988.2 → XP_024309756.1  protein furry homolog-like isoform X1

    UniProtKB/TrEMBL
    A0A2C9F2R7
    Conserved Domains (3) summary
    pfam14222
    Location:209 → 756
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2108 → 2361
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:794 → 1966
    MOR2-PAG1_mid; Cell morphogenesis central region

  14. XM_024453992.2 → XP_024309760.1  protein furry homolog-like isoform X9

    UniProtKB/TrEMBL
    A0A2C9F2R7
    Conserved Domains (3) summary
    pfam14222
    Location:117 → 664
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14225
    Location:2016 → 2269
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:702 → 1874
    MOR2-PAG1_mid; Cell morphogenesis central region

  15. XM_047450100.1 → XP_047306056.1  protein furry homolog-like isoform X11

  16. XM_005248093.6 → XP_005248150.1  protein furry homolog-like isoform X12

    See identical proteins and their annotated locations for XP_005248150.1

    Conserved Domains (2) summary
    pfam14225
    Location:1032 → 1285
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:197 → 890
    MOR2-PAG1_mid; Cell morphogenesis central region

  17. XM_011513684.4 → XP_011511986.1  protein furry homolog-like isoform X12

    See identical proteins and their annotated locations for XP_011511986.1

    Conserved Domains (2) summary
    pfam14225
    Location:1032 → 1285
    MOR2-PAG1_C; Cell morphogenesis C-terminal
    pfam14228
    Location:197 → 890
    MOR2-PAG1_mid; Cell morphogenesis central region

  18. XM_047450101.1 → XP_047306057.1  protein furry homolog-like isoform X13

  19. XM_011513685.4 → XP_011511987.2  protein furry homolog-like isoform X14

    UniProtKB/TrEMBL
    F2Z2S2
    Related
    ENSP00000421584.1, ENST00000507711.5
    Conserved Domains (2) summary
    pfam14222
    Location:209 → 756
    MOR2-PAG1_N; Cell morphogenesis N-terminal
    pfam14228
    Location:794 → 1559
    MOR2-PAG1_mid; Cell morphogenesis central region

RNA

  1. XR_007096393.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    48464386..48746848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349746.1 → XP_054205721.1  protein furry homolog-like isoform X9

  2. XM_054349749.1 → XP_054205724.1  protein furry homolog-like isoform X10

    UniProtKB/Swiss-Prot
    O94915, O95640, Q8WTZ5, Q9NT40

  3. XM_054349747.1 → XP_054205722.1  protein furry homolog-like isoform X9

  4. XM_054349745.1 → XP_054205720.1  protein furry homolog-like isoform X9

  5. XM_054349738.1 → XP_054205713.1  protein furry homolog-like isoform X2

  6. XM_054349742.1 → XP_054205717.1  protein furry homolog-like isoform X6

  7. XM_054349737.1 → XP_054205712.1  protein furry homolog-like isoform X1

  8. XM_054349740.1 → XP_054205715.1  protein furry homolog-like isoform X4

  9. XM_054349741.1 → XP_054205716.1  protein furry homolog-like isoform X5

  10. XM_054349744.1 → XP_054205719.1  protein furry homolog-like isoform X8

  11. XM_054349739.1 → XP_054205714.1  protein furry homolog-like isoform X3

  12. XM_054349743.1 → XP_054205718.1  protein furry homolog-like isoform X7

  13. XM_054349748.1 → XP_054205723.1  protein furry homolog-like isoform X9

  14. XM_054349750.1 → XP_054205725.1  protein furry homolog-like isoform X11

  15. XM_054349751.1 → XP_054205726.1  protein furry homolog-like isoform X12

  16. XM_054349752.1 → XP_054205727.1  protein furry homolog-like isoform X12

  17. XM_054349753.1 → XP_054205728.1  protein furry homolog-like isoform X13

  18. XM_054349754.1 → XP_054205729.1  protein furry homolog-like isoform X14

RNA

  1. XR_008486967.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039751.1: Suppressed sequence

    Description
    NM_001039751.1: This RefSeq was temporarily suppressed because it encoded a much smaller protein than the full-length protein. It may represent a valid splicing variant but currently there are not sufficient data to support this tra
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94915.2 GenPept UniProtKB/Swiss-Prot:O94915

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