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Conserved domains on  [gi|530376644|ref|XP_005248150|]
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protein furry homolog-like isoform X12 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
1315-2044 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


:

Pssm-ID: 466072  Cd Length: 633  Bit Score: 1049.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1315 VSKELPGKTLDFHFDISETPIIGNKYGDQHSAAGRNGKPKVIAVTRSTSSTSSGSNSNALVPVSWKRPQLSQRRTREKLM 1394
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1395 NVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDINQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEGESM 1474
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1475 DNFNWGVRRRSLDSIDKGDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAaLTASQILSRTQMLNSDSATDEtiPDHPD 1554
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1555 LLLQSEDSTGSitTEEVLqiRDETPTLEASLdnansrlPEDTtsvlkeehvttfedegsyiiqeqqeslvcqgildleet 1634
Cdd:pfam19421  236 SLSQSQDSSSA--DEESL--RAETPSLEVSL-------PEDA-------------------------------------- 266
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1635 empeplapesypesvceedvtlalkelderceeeeadfsglssqdeeEQDGFPEVQTSPLPSPFLSAIIAAFQPVAYDDE 1714
Cdd:pfam19421  267 -----------------------------------------------SARGFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1715 EEAWRCHVNQMLSDTDGSSAVFTFHVFSRLFQTIQRKFGEITNEAVSFLGDSLQRIGTKFKSSLEVMMLCSECPTVFVDA 1794
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1795 ETLMSCGLLETLKFGVLELQEHLDTYNVKREAAEQWLDDCKRTFGAK--EDMYRINTDAQQMeilAELELCRRLYKLHFQ 1872
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFPRGsgDGVITCQPADQEE---KQLELCQRLYKLHFQ 456
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1873 LLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLESILKE-----AESASENEEIDISKAAQTTIETAIHSLIETLKNKE 1947
Cdd:pfam19421  457 LLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLRNKE 536
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1948 FISAVAQVKAFRSLWPSDIFGSCEDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMVQSY 2027
Cdd:pfam19421  537 FSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGY 616
                          730
                   ....*....|....*..
gi 530376644  2028 QLLAQAKPMGNMVSTGF 2044
Cdd:pfam19421  617 RALTAFLPDSSVSGSSL 633
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
1032-1285 1.65e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464109  Cd Length: 252  Bit Score: 251.63  E-value: 1.65e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1032 ATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSESREKIENVQSKlKWTN-FPGLQQLFLKGFTSASTQEMTVHL 1110
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1111 LSKLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 1188
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1189 RDCSNWINVVCRYLHDSFS-DTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAKQFNLEIIKIIGKYVQS 1267
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFpDYEFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234
                          250
                   ....*....|....*...
gi 530376644  1268 PYWKEALNILKLVVSRSA 1285
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid super family cl20509
Cell morphogenesis central region; This family is the conserved central region of proteins ...
127-890 2.32e-30

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


The actual alignment was detected with superfamily member pfam14228:

Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 131.68  E-value: 2.32e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   127 DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGYLYKWLDNILD------------------------------SLD 176
Cdd:pfam14228  396 EVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGRVIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGG 474
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   177 KKVHQLGCEAVTL-------LLELNPDqsnLMYWAVDRCYTGSGRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAA 248
Cdd:pfam14228  475 KDRHRGGPLRVHLakvalknLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVV 551
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   249 DSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVLSQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTA 328
Cdd:pfam14228  552 DPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRQLDA 629
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   329 --HPAGRQVmLHYLLPWMNNIELVDLKplptarrhdededDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAK 406
Cdd:pfam14228  630 vdIIAQHQV-LTCMAPWIENLNFLKLW-------------ES-----------------GW-----SERLLKSLYYVTWR 673
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   407 YGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--ICGVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVS 475
Cdd:pfam14228  674 HGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIEDCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVY 751
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   476 EL------QLTDPVSSGVTHMDnppyyrITSSYKIPSVTSGTTSSSNTMVAPtdgNPDNKPikenieesyvhLDIYSGLN 549
Cdd:pfam14228  752 ELaqrmleESVEPSRPSDGAFD------LESSAVLEFSQGPAPVQVAQLLDP---QPHMSP-----------LLVRSSLE 811
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   550 SHLNRQHHRLesryssssGGSYEEEKSDSMPLYSNWRLKVMEHNQGE-------PLPFPPAGGcwsPLV----------- 611
Cdd:pfam14228  812 GPLRNASGSL--------SWRTVTGRSMSGPLNTMPEVVAVDTHTGRsgqlftgSGPLPNMSG---PLMgvrsstgslrs 880
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   612 --------DYVPETSSPG-----------------LPLH-----RCNIAVILLTDliIDHSVKVEWGSYLHLLLHAIFIG 661
Cdd:pfam14228  881 hhvsrdsgDYFIDTPNSVeeiritpvvnaselqsaLQGHqhwlsRADIALILLAE--IAYENDEDFRSHLPLLFHVTFVS 958
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   662 FDHCHPEVYEHCKRLLLHLLIVMGpnsnirtvasvllrnkefnePRVLTVKQVAHLDYnftagindfipdyqpspmtdsg 741
Cdd:pfam14228  959 MDSSEDIVLKHCQHLLVNLLYSLA--------------------GRHLELYDVEHGDG---------------------- 996
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   742 lsssstsssislgnnsaaishlhttilnevdisvEQDGKVKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKH 821
Cdd:pfam14228  997 ----------------------------------EYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLS 1042
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   822 VV-SVFKQSSsegihLEHHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDP 890
Cdd:pfam14228 1043 MVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
1315-2044 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1049.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1315 VSKELPGKTLDFHFDISETPIIGNKYGDQHSAAGRNGKPKVIAVTRSTSSTSSGSNSNALVPVSWKRPQLSQRRTREKLM 1394
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1395 NVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDINQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEGESM 1474
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1475 DNFNWGVRRRSLDSIDKGDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAaLTASQILSRTQMLNSDSATDEtiPDHPD 1554
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1555 LLLQSEDSTGSitTEEVLqiRDETPTLEASLdnansrlPEDTtsvlkeehvttfedegsyiiqeqqeslvcqgildleet 1634
Cdd:pfam19421  236 SLSQSQDSSSA--DEESL--RAETPSLEVSL-------PEDA-------------------------------------- 266
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1635 empeplapesypesvceedvtlalkelderceeeeadfsglssqdeeEQDGFPEVQTSPLPSPFLSAIIAAFQPVAYDDE 1714
Cdd:pfam19421  267 -----------------------------------------------SARGFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1715 EEAWRCHVNQMLSDTDGSSAVFTFHVFSRLFQTIQRKFGEITNEAVSFLGDSLQRIGTKFKSSLEVMMLCSECPTVFVDA 1794
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1795 ETLMSCGLLETLKFGVLELQEHLDTYNVKREAAEQWLDDCKRTFGAK--EDMYRINTDAQQMeilAELELCRRLYKLHFQ 1872
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFPRGsgDGVITCQPADQEE---KQLELCQRLYKLHFQ 456
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1873 LLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLESILKE-----AESASENEEIDISKAAQTTIETAIHSLIETLKNKE 1947
Cdd:pfam19421  457 LLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLRNKE 536
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1948 FISAVAQVKAFRSLWPSDIFGSCEDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMVQSY 2027
Cdd:pfam19421  537 FSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGY 616
                          730
                   ....*....|....*..
gi 530376644  2028 QLLAQAKPMGNMVSTGF 2044
Cdd:pfam19421  617 RALTAFLPDSSVSGSSL 633
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
1032-1285 1.65e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 251.63  E-value: 1.65e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1032 ATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSESREKIENVQSKlKWTN-FPGLQQLFLKGFTSASTQEMTVHL 1110
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1111 LSKLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 1188
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1189 RDCSNWINVVCRYLHDSFS-DTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAKQFNLEIIKIIGKYVQS 1267
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFpDYEFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234
                          250
                   ....*....|....*...
gi 530376644  1268 PYWKEALNILKLVVSRSA 1285
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
127-890 2.32e-30

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 131.68  E-value: 2.32e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   127 DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGYLYKWLDNILD------------------------------SLD 176
Cdd:pfam14228  396 EVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGRVIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGG 474
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   177 KKVHQLGCEAVTL-------LLELNPDqsnLMYWAVDRCYTGSGRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAA 248
Cdd:pfam14228  475 KDRHRGGPLRVHLakvalknLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVV 551
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   249 DSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVLSQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTA 328
Cdd:pfam14228  552 DPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRQLDA 629
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   329 --HPAGRQVmLHYLLPWMNNIELVDLKplptarrhdededDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAK 406
Cdd:pfam14228  630 vdIIAQHQV-LTCMAPWIENLNFLKLW-------------ES-----------------GW-----SERLLKSLYYVTWR 673
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   407 YGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--ICGVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVS 475
Cdd:pfam14228  674 HGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIEDCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVY 751
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   476 EL------QLTDPVSSGVTHMDnppyyrITSSYKIPSVTSGTTSSSNTMVAPtdgNPDNKPikenieesyvhLDIYSGLN 549
Cdd:pfam14228  752 ELaqrmleESVEPSRPSDGAFD------LESSAVLEFSQGPAPVQVAQLLDP---QPHMSP-----------LLVRSSLE 811
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   550 SHLNRQHHRLesryssssGGSYEEEKSDSMPLYSNWRLKVMEHNQGE-------PLPFPPAGGcwsPLV----------- 611
Cdd:pfam14228  812 GPLRNASGSL--------SWRTVTGRSMSGPLNTMPEVVAVDTHTGRsgqlftgSGPLPNMSG---PLMgvrsstgslrs 880
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   612 --------DYVPETSSPG-----------------LPLH-----RCNIAVILLTDliIDHSVKVEWGSYLHLLLHAIFIG 661
Cdd:pfam14228  881 hhvsrdsgDYFIDTPNSVeeiritpvvnaselqsaLQGHqhwlsRADIALILLAE--IAYENDEDFRSHLPLLFHVTFVS 958
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   662 FDHCHPEVYEHCKRLLLHLLIVMGpnsnirtvasvllrnkefnePRVLTVKQVAHLDYnftagindfipdyqpspmtdsg 741
Cdd:pfam14228  959 MDSSEDIVLKHCQHLLVNLLYSLA--------------------GRHLELYDVEHGDG---------------------- 996
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   742 lsssstsssislgnnsaaishlhttilnevdisvEQDGKVKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKH 821
Cdd:pfam14228  997 ----------------------------------EYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLS 1042
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   822 VV-SVFKQSSsegihLEHHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDP 890
Cdd:pfam14228 1043 MVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
1315-2044 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1049.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1315 VSKELPGKTLDFHFDISETPIIGNKYGDQHSAAGRNGKPKVIAVTRSTSSTSSGSNSNALVPVSWKRPQLSQRRTREKLM 1394
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1395 NVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDINQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEGESM 1474
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1475 DNFNWGVRRRSLDSIDKGDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAaLTASQILSRTQMLNSDSATDEtiPDHPD 1554
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1555 LLLQSEDSTGSitTEEVLqiRDETPTLEASLdnansrlPEDTtsvlkeehvttfedegsyiiqeqqeslvcqgildleet 1634
Cdd:pfam19421  236 SLSQSQDSSSA--DEESL--RAETPSLEVSL-------PEDA-------------------------------------- 266
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1635 empeplapesypesvceedvtlalkelderceeeeadfsglssqdeeEQDGFPEVQTSPLPSPFLSAIIAAFQPVAYDDE 1714
Cdd:pfam19421  267 -----------------------------------------------SARGFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1715 EEAWRCHVNQMLSDTDGSSAVFTFHVFSRLFQTIQRKFGEITNEAVSFLGDSLQRIGTKFKSSLEVMMLCSECPTVFVDA 1794
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1795 ETLMSCGLLETLKFGVLELQEHLDTYNVKREAAEQWLDDCKRTFGAK--EDMYRINTDAQQMeilAELELCRRLYKLHFQ 1872
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFPRGsgDGVITCQPADQEE---KQLELCQRLYKLHFQ 456
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1873 LLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLESILKE-----AESASENEEIDISKAAQTTIETAIHSLIETLKNKE 1947
Cdd:pfam19421  457 LLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLRNKE 536
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1948 FISAVAQVKAFRSLWPSDIFGSCEDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMVQSY 2027
Cdd:pfam19421  537 FSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGY 616
                          730
                   ....*....|....*..
gi 530376644  2028 QLLAQAKPMGNMVSTGF 2044
Cdd:pfam19421  617 RALTAFLPDSSVSGSSL 633
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
1032-1285 1.65e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 251.63  E-value: 1.65e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1032 ATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSESREKIENVQSKlKWTN-FPGLQQLFLKGFTSASTQEMTVHL 1110
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1111 LSKLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 1188
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644  1189 RDCSNWINVVCRYLHDSFS-DTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAKQFNLEIIKIIGKYVQS 1267
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFpDYEFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234
                          250
                   ....*....|....*...
gi 530376644  1268 PYWKEALNILKLVVSRSA 1285
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
127-890 2.32e-30

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 131.68  E-value: 2.32e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   127 DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGYLYKWLDNILD------------------------------SLD 176
Cdd:pfam14228  396 EVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGRVIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGG 474
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   177 KKVHQLGCEAVTL-------LLELNPDqsnLMYWAVDRCYTGSGRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAA 248
Cdd:pfam14228  475 KDRHRGGPLRVHLakvalknLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVV 551
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   249 DSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVLSQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTA 328
Cdd:pfam14228  552 DPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRQLDA 629
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   329 --HPAGRQVmLHYLLPWMNNIELVDLKplptarrhdededDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAK 406
Cdd:pfam14228  630 vdIIAQHQV-LTCMAPWIENLNFLKLW-------------ES-----------------GW-----SERLLKSLYYVTWR 673
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   407 YGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--ICGVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVS 475
Cdd:pfam14228  674 HGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIEDCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVY 751
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   476 EL------QLTDPVSSGVTHMDnppyyrITSSYKIPSVTSGTTSSSNTMVAPtdgNPDNKPikenieesyvhLDIYSGLN 549
Cdd:pfam14228  752 ELaqrmleESVEPSRPSDGAFD------LESSAVLEFSQGPAPVQVAQLLDP---QPHMSP-----------LLVRSSLE 811
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   550 SHLNRQHHRLesryssssGGSYEEEKSDSMPLYSNWRLKVMEHNQGE-------PLPFPPAGGcwsPLV----------- 611
Cdd:pfam14228  812 GPLRNASGSL--------SWRTVTGRSMSGPLNTMPEVVAVDTHTGRsgqlftgSGPLPNMSG---PLMgvrsstgslrs 880
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   612 --------DYVPETSSPG-----------------LPLH-----RCNIAVILLTDliIDHSVKVEWGSYLHLLLHAIFIG 661
Cdd:pfam14228  881 hhvsrdsgDYFIDTPNSVeeiritpvvnaselqsaLQGHqhwlsRADIALILLAE--IAYENDEDFRSHLPLLFHVTFVS 958
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   662 FDHCHPEVYEHCKRLLLHLLIVMGpnsnirtvasvllrnkefnePRVLTVKQVAHLDYnftagindfipdyqpspmtdsg 741
Cdd:pfam14228  959 MDSSEDIVLKHCQHLLVNLLYSLA--------------------GRHLELYDVEHGDG---------------------- 996
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   742 lsssstsssislgnnsaaishlhttilnevdisvEQDGKVKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKH 821
Cdd:pfam14228  997 ----------------------------------EYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLS 1042
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376644   822 VV-SVFKQSSsegihLEHHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDP 890
Cdd:pfam14228 1043 MVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLGNP 1107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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