Tle2 transducin-like enhancer of split 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tle2provided by MGI
Official Full Name: transducin-like enhancer of split 2provided by MGI
Primary source: MGI:MGI:104635
See related: Ensembl:ENSMUSG00000034771 AllianceGenome:MGI:104635
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Grg2; Gm32024; mKIAA4188
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of canonical Wnt signaling pathway. Predicted to be located in focal adhesion and nuclear body. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; integumental system; limb; and sensory organ. Orthologous to human TLE2 (TLE family member 2, transcriptional corepressor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal adult (RPKM 114.6), ovary adult (RPKM 111.1) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10; 10 C1

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81410573..81435018)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81574739..81592581)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tle2 (e-PCR), detects polymorphism
- UniSTS:527579

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transducin-like enhancer protein 2

Names: groucho-related protein; transducin-like enhancer of split 2, homolog of Drosophila E(spl)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252401.2 → NP_001239330.1 transducin-like enhancer protein 2 isoform 2

See identical proteins and their annotated locations for NP_001239330.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses different splice sites in two locations in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AC153919, AC159474

Consensus CDS

CCDS56737.1

UniProtKB/TrEMBL

E9PV07, Q3UN01

Related

ENSMUSP00000117453.2, ENSMUST00000135211.8

Conserved Domains (4) summary

COG2319
Location:444 → 730

WD40; WD40 repeat [General function prediction only]

pfam03920
Location:1 → 113

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:449 → 488

7WD40; WD40 repeat [structural motif]

cl02567
Location:445 → 729

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001428852.1 → NP_001415781.1 transducin-like enhancer protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC153919, AC159474
NM_001428853.1 → NP_001415782.1 transducin-like enhancer protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC153919, AC159474
NM_019725.3 → NP_062699.1 transducin-like enhancer protein 2 isoform 1

See identical proteins and their annotated locations for NP_062699.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC153919, AC159474

Consensus CDS

CCDS24063.1

UniProtKB/Swiss-Prot

Q9WVB2

UniProtKB/TrEMBL

E9PV07

Related

ENSMUSP00000121125.2, ENSMUST00000146358.8

Conserved Domains (4) summary

PHA03247
Location:269 → 459

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:484 → 523

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:480 → 764

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

81410573..81435018

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243429.3 → XP_011241731.1 transducin-like enhancer protein 2 isoform X5

See identical proteins and their annotated locations for XP_011241731.1

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:269 → 459

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:484 → 523

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:466 → 723

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243434.3 → XP_011241736.1 transducin-like enhancer protein 2 isoform X8

See identical proteins and their annotated locations for XP_011241736.1

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:246 → 436

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:461 → 500

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 129

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:443 → 700

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155761.1 → XP_036011654.1 transducin-like enhancer protein 2 isoform X13

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:246 → 423

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:448 → 487

7WD40; WD40 repeat [structural motif]

pfam03920
Location:10 → 129

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:430 → 687

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017313923.3 → XP_017169412.1 transducin-like enhancer protein 2 isoform X27

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:269 → 459

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:484 → 523

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:473 → 641

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243425.4 → XP_011241727.1 transducin-like enhancer protein 2 isoform X1

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:269 → 458

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:483 → 522

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:465 → 722

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243427.4 → XP_011241729.1 transducin-like enhancer protein 2 isoform X3

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:269 → 447

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:472 → 511

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:454 → 711

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243428.4 → XP_011241730.1 transducin-like enhancer protein 2 isoform X4

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:269 → 446

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:471 → 510

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:453 → 710

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243426.4 → XP_011241728.1 transducin-like enhancer protein 2 isoform X2

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:268 → 458

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:483 → 522

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 151

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:465 → 722

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243430.4 → XP_011241732.1 transducin-like enhancer protein 2 isoform X6

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:248 → 438

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:463 → 502

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 131

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:445 → 702

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243431.4 → XP_011241733.1 transducin-like enhancer protein 2 isoform X7

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:247 → 437

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:462 → 501

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 130

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:444 → 701

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155764.1 → XP_036011657.1 transducin-like enhancer protein 2 isoform X31

Conserved Domains (2) summary

sd00039
Location:81 → 120

7WD40; WD40 repeat [structural motif]

cl29593
Location:70 → 320

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030245058.2 → XP_030100918.1 transducin-like enhancer protein 2 isoform X32

Conserved Domains (2) summary

sd00039
Location:67 → 106

7WD40; WD40 repeat [structural motif]

cl29593
Location:56 → 306

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243432.4 → XP_011241734.1 transducin-like enhancer protein 2 isoform X8

See identical proteins and their annotated locations for XP_011241734.1

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:246 → 436

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:461 → 500

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 129

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:443 → 700

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030245051.2 → XP_030100911.1 transducin-like enhancer protein 2 isoform X9

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:246 → 435

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:460 → 499

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 129

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:442 → 699

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030245052.2 → XP_030100912.1 transducin-like enhancer protein 2 isoform X12

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:246 → 424

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:449 → 488

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 129

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:431 → 688

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243433.4 → XP_011241735.1 transducin-like enhancer protein 2 isoform X13

UniProtKB/TrEMBL

E9PV07

Related

ENSMUSP00000121173.2, ENSMUST00000146916.8

Conserved Domains (4) summary

PHA03247
Location:246 → 423

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:448 → 487

7WD40; WD40 repeat [structural motif]

pfam03920
Location:10 → 129

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:430 → 687

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017313919.3 → XP_017169408.1 transducin-like enhancer protein 2 isoform X10

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:245 → 435

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:460 → 499

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 128

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:442 → 699

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017313920.3 → XP_017169409.1 transducin-like enhancer protein 2 isoform X11

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:245 → 434

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:459 → 498

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 128

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:441 → 698

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017313921.3 → XP_017169410.1 transducin-like enhancer protein 2 isoform X14

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:245 → 422

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:447 → 486

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 128

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:429 → 686

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155763.1 → XP_036011656.1 transducin-like enhancer protein 2 isoform X30

Conserved Domains (2) summary

sd00039
Location:93 → 132

7WD40; WD40 repeat [structural motif]

cl29593
Location:82 → 332

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243435.4 → XP_011241737.1 transducin-like enhancer protein 2 isoform X15

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:225 → 415

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:440 → 479

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 108

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:422 → 679

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006513584.4 → XP_006513647.1 transducin-like enhancer protein 2 isoform X16

See identical proteins and their annotated locations for XP_006513647.1

UniProtKB/Swiss-Prot

Q9WVB2

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:269 → 459

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:484 → 523

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:480 → 764

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006513585.4 → XP_006513648.1 transducin-like enhancer protein 2 isoform X17

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:269 → 458

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:483 → 522

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:479 → 763

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030245053.2 → XP_030100913.1 transducin-like enhancer protein 2 isoform X18

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:269 → 447

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:472 → 511

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:468 → 752

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017313922.3 → XP_017169411.1 transducin-like enhancer protein 2 isoform X19

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:269 → 446

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:471 → 510

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:467 → 751

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030245059.2 → XP_030100919.1 transducin-like enhancer protein 2 isoform X33

UniProtKB/TrEMBL

Q5DTI7

Related

ENSMUST00000140433.8

Conserved Domains (2) summary

sd00039
Location:93 → 132

7WD40; WD40 repeat [structural motif]

cl29593
Location:89 → 373

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006513589.5 → XP_006513652.1 transducin-like enhancer protein 2 isoform X34

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:246 → 435

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:460 → 499

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 129

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:456 → 740

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030245055.2 → XP_030100915.1 transducin-like enhancer protein 2 isoform X22

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:246 → 424

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:449 → 488

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 129

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:445 → 729

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030245056.2 → XP_030100916.1 transducin-like enhancer protein 2 isoform X23

Conserved Domains (4) summary

PHA03247
Location:246 → 423

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:448 → 487

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 129

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:444 → 728

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243436.4 → XP_011241738.1 transducin-like enhancer protein 2 isoform X21

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:245 → 434

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:459 → 498

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 128

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:455 → 739

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030245057.2 → XP_030100917.1 transducin-like enhancer protein 2 isoform X24

Conserved Domains (4) summary

PHA03247
Location:245 → 422

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:447 → 486

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 128

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:443 → 727

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030245060.2 → XP_030100920.1 transducin-like enhancer protein 2 isoform X35

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:225 → 414

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:439 → 478

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 108

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:435 → 719

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006513586.4 → XP_006513649.1 transducin-like enhancer protein 2 isoform X25

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:269 → 459

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:484 → 523

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:466 → 711

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155762.1 → XP_036011655.1 transducin-like enhancer protein 2 isoform X26

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:269 → 446

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:471 → 510

7WD40; WD40 repeat [structural motif]

pfam03920
Location:10 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:453 → 698

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006513588.5 → XP_006513651.1 transducin-like enhancer protein 2 isoform X28

Conserved Domains (3) summary

smart00320
Location:473 → 508

WD40; WD40 repeats

PHA03247
Location:269 → 460

PHA03247; large tegument protein UL36; Provisional

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017313924.3 → XP_017169413.1 transducin-like enhancer protein 2 isoform X29

Conserved Domains (3) summary

smart00320
Location:472 → 507

WD40; WD40 repeats

PHA03247
Location:269 → 459

PHA03247; large tegument protein UL36; Provisional

pfam03920
Location:1 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_030245054.2 → XP_030100914.1 transducin-like enhancer protein 2 isoform X20

UniProtKB/TrEMBL

E9PV07

Conserved Domains (4) summary

PHA03247
Location:193 → 383

PHA03247; large tegument protein UL36; Provisional

sd00039
Location:408 → 447

7WD40; WD40 repeat [structural motif]

pfam03920
Location:24 → 76

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl29593
Location:390 → 647

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...