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Conserved domains on  [gi|755534466|ref|XP_011241727|]
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transducin-like enhancer protein 2 isoform X1 [Mus musculus]

Protein Classification

TLE_N and WD40 domain-containing protein( domain architecture ID 13692432)

TLE_N and WD40 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 17-152 2.12e-80

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


:

Pssm-ID: 461094  Cd Length: 117  Bit Score: 253.89  E-value: 2.12e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466   17 FKFSVLEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMaaphqcpqggtsyphwprlsplqYYEMSYGLNIE 96
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM-----------------------YYEMSYGLNIE 57

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755534466   97 MHKQAEIVKRLSAICAQMVPFLTQEHQQQVLQAVDRAKQVTVGELNSLLGQQNQLQ 152
Cdd:pfam03920  58 MHKQTEIAKRLNAICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQ 113
WD40 COG2319
WD40 repeat [General function prediction only];
472-724 5.34e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.20  E-value: 5.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 472 RQLHTL-AHGEVVCAVTISSSTQHVYTGGK-GCVKVWDVGqpgSKTPVAQLDclNRDNYIRSCKLLPDGQSLIVGGEAST 549
Cdd:COG2319  153 KLLRTLtGHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 550 LSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWT 629
Cdd:COG2319  228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 630 GGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVR-KPEKYQLRLHESCVLSLKFASCGR 707
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSPDGR 385

                        250
                 ....*....|....*..
gi 755534466 708 WFVSTGKDNLLNAWRTP 724
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 269-458 5.50e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 5.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466  269 PSEPPSPVT--TPCGKAPLCIPARRDLTDSPASLASSLGSPLPRSKDIALNDLPTGTPASRSCGTSPPQDSSTPGPSSAS 346
Cdd:PHA03247 2739 PAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL 2818

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466  347 HLCQLAAQPAAPTDSIALRSPLTLSSPFTSSFSLGSHSTLNGDLSMPGSyvglhlspqvsssvvyGRSPLMAFESHPHLR 426
Cdd:PHA03247 2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPP----------------SRSPAAKPAAPARPP 2882

                         170       180       190
                  ....*....|....*....|....*....|..
gi 755534466  427 GSSVSLPgiPVAKPAYSFHVSADGQmQPVPFP 458
Cdd:PHA03247 2883 VRRLARP--AVSRSTESFALPPDQP-ERPPQP 2911
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 17-152 2.12e-80

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 253.89  E-value: 2.12e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466   17 FKFSVLEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMaaphqcpqggtsyphwprlsplqYYEMSYGLNIE 96
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM-----------------------YYEMSYGLNIE 57

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755534466   97 MHKQAEIVKRLSAICAQMVPFLTQEHQQQVLQAVDRAKQVTVGELNSLLGQQNQLQ 152
Cdd:pfam03920  58 MHKQTEIAKRLNAICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQ 113
WD40 COG2319
WD40 repeat [General function prediction only];
472-724 5.34e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.20  E-value: 5.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 472 RQLHTL-AHGEVVCAVTISSSTQHVYTGGK-GCVKVWDVGqpgSKTPVAQLDclNRDNYIRSCKLLPDGQSLIVGGEAST 549
Cdd:COG2319  153 KLLRTLtGHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 550 LSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWT 629
Cdd:COG2319  228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 630 GGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVR-KPEKYQLRLHESCVLSLKFASCGR 707
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSPDGR 385

                        250
                 ....*....|....*..
gi 755534466 708 WFVSTGKDNLLNAWRTP 724
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 465-722 2.40e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.15  E-value: 2.40e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 465 TGIPRHARQLHTlahGEVVCAVTISSSTQhVYTGGK-GCVKVWDVGQPgsktpvaqlDCLNR----DNYIRSCKLLPDGQ 539
Cdd:cd00200   40 TGELLRTLKGHT---GPVRDVAASADGTY-LASGSSdKTIRLWDLETG---------ECVRTltghTSYVSSVAFSPDGR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 540 SLIVGGEASTLSIWDLaaPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCID 619
Cdd:cd00200  107 ILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 620 ISDYGTRLWTGGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPE-KYQLRLHESCV 697
Cdd:cd00200  185 FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEcVQTLSGHTNSV 264

                        250       260
                 ....*....|....*....|....*
gi 755534466 698 LSLKFASCGRWFVSTGKDNLLNAWR 722
Cdd:cd00200  265 TSLAWSPDGKRLASGSADGTIRIWD 289
PHA03247 PHA03247
large tegument protein UL36; Provisional
 269-458 5.50e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 5.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466  269 PSEPPSPVT--TPCGKAPLCIPARRDLTDSPASLASSLGSPLPRSKDIALNDLPTGTPASRSCGTSPPQDSSTPGPSSAS 346
Cdd:PHA03247 2739 PAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL 2818

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466  347 HLCQLAAQPAAPTDSIALRSPLTLSSPFTSSFSLGSHSTLNGDLSMPGSyvglhlspqvsssvvyGRSPLMAFESHPHLR 426
Cdd:PHA03247 2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPP----------------SRSPAAKPAAPARPP 2882

                         170       180       190
                  ....*....|....*....|....*....|..
gi 755534466  427 GSSVSLPgiPVAKPAYSFHVSADGQmQPVPFP 458
Cdd:PHA03247 2883 VRRLARP--AVSRSTESFALPPDQP-ERPPQP 2911
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 605-640 9.99e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 9.99e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 755534466   605 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 640
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
605-640 1.30e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.30e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 755534466  605 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 640
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 17-152 2.12e-80

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 253.89  E-value: 2.12e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466   17 FKFSVLEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMaaphqcpqggtsyphwprlsplqYYEMSYGLNIE 96
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM-----------------------YYEMSYGLNIE 57

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755534466   97 MHKQAEIVKRLSAICAQMVPFLTQEHQQQVLQAVDRAKQVTVGELNSLLGQQNQLQ 152
Cdd:pfam03920  58 MHKQTEIAKRLNAICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQ 113
WD40 COG2319
WD40 repeat [General function prediction only];
472-724 5.34e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.20  E-value: 5.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 472 RQLHTL-AHGEVVCAVTISSSTQHVYTGGK-GCVKVWDVGqpgSKTPVAQLDclNRDNYIRSCKLLPDGQSLIVGGEAST 549
Cdd:COG2319  153 KLLRTLtGHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 550 LSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWT 629
Cdd:COG2319  228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 630 GGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVR-KPEKYQLRLHESCVLSLKFASCGR 707
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSPDGR 385

                        250
                 ....*....|....*..
gi 755534466 708 WFVSTGKDNLLNAWRTP 724
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
425-726 4.59e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 4.59e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 425 LRGSSVSLPGIPVAKPAYSFHVSADGQMQPVPFPSDALVGTGIPRHARQLHTLAHGEVVCAVTISSSTQHVYTGGK-GCV 503
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAdGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 504 KVWDVGqpgSKTPVAQLDclNRDNYIRSCKLLPDGQSLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAVSPDAK 583
Cdd:COG2319  145 RLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGK 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 584 VCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHC 662
Cdd:COG2319  218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTlTGHSGGVNSVAFS 297

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755534466 663 PNQDWLAVGMESSHVEVLHVRKPEK-YQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYG 726
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 465-722 2.40e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.15  E-value: 2.40e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 465 TGIPRHARQLHTlahGEVVCAVTISSSTQhVYTGGK-GCVKVWDVGQPgsktpvaqlDCLNR----DNYIRSCKLLPDGQ 539
Cdd:cd00200   40 TGELLRTLKGHT---GPVRDVAASADGTY-LASGSSdKTIRLWDLETG---------ECVRTltghTSYVSSVAFSPDGR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 540 SLIVGGEASTLSIWDLaaPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCID 619
Cdd:cd00200  107 ILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 620 ISDYGTRLWTGGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPE-KYQLRLHESCV 697
Cdd:cd00200  185 FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEcVQTLSGHTNSV 264

                        250       260
                 ....*....|....*....|....*
gi 755534466 698 LSLKFASCGRWFVSTGKDNLLNAWR 722
Cdd:cd00200  265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
446-733 3.50e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.65  E-value: 3.50e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 446 VSADGQMQPVPFPSDALVGTGIPRHARQLHTLAHGEVVCAVTISSSTQHVYTGGK-GCVKVWDVgqpgsKTPVAQLDCLN 524
Cdd:COG2319   44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAdGTVRLWDL-----ATGLLLRTLTG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 525 RDNYIRSCKLLPDGQSLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAM 604
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 605 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHCPNQDWLAVGMESSHVEVLHVR 683
Cdd:COG2319  197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755534466 684 -KPEKYQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQVT 733
Cdd:COG2319  277 tGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 479-723 3.47e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.98  E-value: 3.47e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 479 HGEVVCAVTISSSTQHVYTGGK-GCVKVWDV-GQPGSKTPVAQLDClnrdnyIRSCKLLPDGQSLIVGGEASTLSIWDLa 556
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLeTGELLRTLKGHTGP------VRDVAASADGTYLASGSSDKTIRLWDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 557 aPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTV 636
Cdd:cd00200   81 -ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 637 RCWDLREGR---QLQQHDfsSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPE-KYQLRLHESCVLSLKFASCGRWFVST 712
Cdd:cd00200  160 KLWDLRTGKcvaTLTGHT--GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASG 237

                        250
                 ....*....|.
gi 755534466 713 GKDNLLNAWRT 723
Cdd:cd00200  238 SEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
529-723 1.38e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.38e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 529 IRSCKLLPDGQSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPacYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQF 608
Cdd:COG2319   39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV--LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 609 QGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPEK 687
Cdd:COG2319  117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755534466 688 YQ-LRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRT 723
Cdd:COG2319  197 LRtLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
472-601 2.39e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 2.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 472 RQLHTLA-HGEVVCAVTISSSTQHVYTGGKGC-VKVWDVGqpgSKTPVAQLDclNRDNYIRSCKLLPDGQSLIVGGEAST 549
Cdd:COG2319  279 ELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755534466 550 LSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQN 601
Cdd:COG2319  354 VRLWDLA--TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 604-726 5.40e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 5.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 604 MVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREG---RQLQQHdfSSQIFSLGHCPNQDWLAVGMESSHVEVL 680
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755534466 681 HVRKPEK-YQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYG 726
Cdd:cd00200   79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125
WD40 COG2319
WD40 repeat [General function prediction only];
534-733 6.55e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 6.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 534 LLPDGQSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPAcyALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTD 613
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVA--SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 614 GASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPEK-YQLR 691
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLT 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 755534466 692 LHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQVT 733
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 201
PHA03247 PHA03247
large tegument protein UL36; Provisional
 269-458 5.50e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 5.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466  269 PSEPPSPVT--TPCGKAPLCIPARRDLTDSPASLASSLGSPLPRSKDIALNDLPTGTPASRSCGTSPPQDSSTPGPSSAS 346
Cdd:PHA03247 2739 PAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL 2818

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466  347 HLCQLAAQPAAPTDSIALRSPLTLSSPFTSSFSLGSHSTLNGDLSMPGSyvglhlspqvsssvvyGRSPLMAFESHPHLR 426
Cdd:PHA03247 2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPP----------------SRSPAAKPAAPARPP 2882

                         170       180       190
                  ....*....|....*....|....*....|..
gi 755534466  427 GSSVSLPgiPVAKPAYSFHVSADGQmQPVPFP 458
Cdd:PHA03247 2883 VRRLARP--AVSRSTESFALPPDQP-ERPPQP 2911
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 605-640 9.99e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 9.99e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 755534466   605 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 640
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
605-640 1.30e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.30e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 755534466  605 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 640
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
534-641 1.42e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466 534 LLPDGQSLIVGGEAS-TLSIWDLAapTPRIKAEL-TSSAPacYALAVSPDAKVCFSCCSDGN-----IVVWDLQNQAMVR 606
Cdd:COG3391  117 VDPDGGRLYVADSGNgRVSVIDTA--TGKVVATIpVGAGP--HGIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVA 192

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755534466 607 QFQGHtDGASCIDISDYGTRLW--------TGGLDNTVRCWDL 641
Cdd:COG3391  193 TIPVG-GGPVGVAVSPDGRRLYvanrgsntSNGGSNTVSVIDL 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 559-598 2.26e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 2.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 755534466   559 TPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWD 598
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 222-441 5.05e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466  222 ESLVEEDHPSSRGGSGKQQRAEDkDLSGP----YDSEEDKSDyNLVVDEDQPSEPPSPVTTPCGKAPLCIPARRDLTDSP 297
Cdd:PHA03307   12 EAAAEGGEFFPRPPATPGDAADD-LLSGSqgqlVSDSAELAA-VTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466  298 ASLAS-SLGSPLPRSKDIALNDLPTGTPASR----SCGTSPPQDSSTPGPSSASHLCQLAAQPAAPTDSIAlRSPLTLSS 372
Cdd:PHA03307   90 WSLSTlAPASPAREGSPTPPGPSSPDPPPPTpppaSPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPA-AVASDAAS 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534466  373 PFTSSFSlgshstlngdLSMPGSYVglHLSPQVSSSVVyGRSPLMAFESHPHLRGSSVSLP-GIPVAKPA 441
Cdd:PHA03307  169 SRQAALP----------LSSPEETA--RAPSSPPAEPP-PSTPPAAASPRPPRRSSPISASaSSPAPAPG 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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