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Conserved domains on  [gi|755534470|ref|XP_011241729|]
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transducin-like enhancer protein 2 isoform X3 [Mus musculus]

Protein Classification

TLE_N and WD40 domain-containing protein( domain architecture ID 13692432)

TLE_N and WD40 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 17-152 1.78e-80

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


:

Pssm-ID: 461094  Cd Length: 117  Bit Score: 253.89  E-value: 1.78e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470   17 FKFSVLEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMaaphqcpqggtsyphwprlsplqYYEMSYGLNIE 96
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM-----------------------YYEMSYGLNIE 57

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755534470   97 MHKQAEIVKRLSAICAQMVPFLTQEHQQQVLQAVDRAKQVTVGELNSLLGQQNQLQ 152
Cdd:pfam03920  58 MHKQTEIAKRLNAICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQ 113
WD40 COG2319
WD40 repeat [General function prediction only];
461-713 4.03e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.20  E-value: 4.03e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 461 RQLHTL-AHGEVVCAVTISSSTQHVYTGGK-GCVKVWDVGqpgSKTPVAQLDclNRDNYIRSCKLLPDGQSLIVGGEAST 538
Cdd:COG2319  153 KLLRTLtGHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 539 LSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWT 618
Cdd:COG2319  228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 619 GGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVR-KPEKYQLRLHESCVLSLKFASCGR 696
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSPDGR 385

                        250
                 ....*....|....*..
gi 755534470 697 WFVSTGKDNLLNAWRTP 713
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 269-447 1.65e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470  269 PSEPPSPVT--TPCGKAPLCIPARRDLTDSPASLASSLGSPLPRSKDIALNDLPTGTPASRSCGTSPPQDSSTPGPSSAS 346
Cdd:PHA03247 2739 PAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL 2818

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470  347 HLCQLAAQPAAPTDSIALRSPLTLSSPFTSSFSLGSHSTLNGDLSMPGSYvglHLSPQQMAFESHPHLRgssvSLPGIPV 426
Cdd:PHA03247 2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS---RSPAAKPAAPARPPVR----RLARPAV 2891

                         170       180
                  ....*....|....*....|.
gi 755534470  427 AKPAYSFHVSADGQmQPVPFP 447
Cdd:PHA03247 2892 SRSTESFALPPDQP-ERPPQP 2911
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 17-152 1.78e-80

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 253.89  E-value: 1.78e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470   17 FKFSVLEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMaaphqcpqggtsyphwprlsplqYYEMSYGLNIE 96
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM-----------------------YYEMSYGLNIE 57

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755534470   97 MHKQAEIVKRLSAICAQMVPFLTQEHQQQVLQAVDRAKQVTVGELNSLLGQQNQLQ 152
Cdd:pfam03920  58 MHKQTEIAKRLNAICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQ 113
WD40 COG2319
WD40 repeat [General function prediction only];
461-713 4.03e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.20  E-value: 4.03e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 461 RQLHTL-AHGEVVCAVTISSSTQHVYTGGK-GCVKVWDVGqpgSKTPVAQLDclNRDNYIRSCKLLPDGQSLIVGGEAST 538
Cdd:COG2319  153 KLLRTLtGHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 539 LSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWT 618
Cdd:COG2319  228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 619 GGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVR-KPEKYQLRLHESCVLSLKFASCGR 696
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSPDGR 385

                        250
                 ....*....|....*..
gi 755534470 697 WFVSTGKDNLLNAWRTP 713
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 454-711 1.82e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.53  E-value: 1.82e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 454 TGIPRHARQLHTlahGEVVCAVTISSSTQhVYTGGK-GCVKVWDVGQPgsktpvaqlDCLNR----DNYIRSCKLLPDGQ 528
Cdd:cd00200   40 TGELLRTLKGHT---GPVRDVAASADGTY-LASGSSdKTIRLWDLETG---------ECVRTltghTSYVSSVAFSPDGR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 529 SLIVGGEASTLSIWDLaaPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCID 608
Cdd:cd00200  107 ILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 609 ISDYGTRLWTGGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPE-KYQLRLHESCV 686
Cdd:cd00200  185 FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEcVQTLSGHTNSV 264

                        250       260
                 ....*....|....*....|....*
gi 755534470 687 LSLKFASCGRWFVSTGKDNLLNAWR 711
Cdd:cd00200  265 TSLAWSPDGKRLASGSADGTIRIWD 289
PHA03247 PHA03247
large tegument protein UL36; Provisional
 269-447 1.65e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470  269 PSEPPSPVT--TPCGKAPLCIPARRDLTDSPASLASSLGSPLPRSKDIALNDLPTGTPASRSCGTSPPQDSSTPGPSSAS 346
Cdd:PHA03247 2739 PAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL 2818

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470  347 HLCQLAAQPAAPTDSIALRSPLTLSSPFTSSFSLGSHSTLNGDLSMPGSYvglHLSPQQMAFESHPHLRgssvSLPGIPV 426
Cdd:PHA03247 2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS---RSPAAKPAAPARPPVR----RLARPAV 2891

                         170       180
                  ....*....|....*....|.
gi 755534470  427 AKPAYSFHVSADGQmQPVPFP 447
Cdd:PHA03247 2892 SRSTESFALPPDQP-ERPPQP 2911
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 594-629 8.93e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 8.93e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 755534470   594 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 629
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
594-629 1.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.22e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 755534470  594 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 629
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 17-152 1.78e-80

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 253.89  E-value: 1.78e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470   17 FKFSVLEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMaaphqcpqggtsyphwprlsplqYYEMSYGLNIE 96
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM-----------------------YYEMSYGLNIE 57

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755534470   97 MHKQAEIVKRLSAICAQMVPFLTQEHQQQVLQAVDRAKQVTVGELNSLLGQQNQLQ 152
Cdd:pfam03920  58 MHKQTEIAKRLNAICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQ 113
WD40 COG2319
WD40 repeat [General function prediction only];
461-713 4.03e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.20  E-value: 4.03e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 461 RQLHTL-AHGEVVCAVTISSSTQHVYTGGK-GCVKVWDVGqpgSKTPVAQLDclNRDNYIRSCKLLPDGQSLIVGGEAST 538
Cdd:COG2319  153 KLLRTLtGHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 539 LSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWT 618
Cdd:COG2319  228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 619 GGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVR-KPEKYQLRLHESCVLSLKFASCGR 696
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSPDGR 385

                        250
                 ....*....|....*..
gi 755534470 697 WFVSTGKDNLLNAWRTP 713
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
351-715 2.90e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 2.90e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 351 LAAQPAAPTDSIALRSPLTLSSPFTSSFSLGSHSTLNGDLSMPGSYVGLHLSPQQMAFESHPHLRGSSVSLPGIPVAKPA 430
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 431 YSFhvSADGQMQPVPFPSDALVGTGIPRHARQLHTLAHGEVVCAVTISSSTQHVYTGGK-GCVKVWDVGqpgSKTPVAQL 509
Cdd:COG2319   84 VAF--SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA---TGKLLRTL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 510 DclNRDNYIRSCKLLPDGQSLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQ 589
Cdd:COG2319  159 T--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 590 NQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHCPNQDWLAVGMESSHVEV 668
Cdd:COG2319  235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 755534470 669 LHVRKPEK-YQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYG 715
Cdd:COG2319  315 WDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 454-711 1.82e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.53  E-value: 1.82e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 454 TGIPRHARQLHTlahGEVVCAVTISSSTQhVYTGGK-GCVKVWDVGQPgsktpvaqlDCLNR----DNYIRSCKLLPDGQ 528
Cdd:cd00200   40 TGELLRTLKGHT---GPVRDVAASADGTY-LASGSSdKTIRLWDLETG---------ECVRTltghTSYVSSVAFSPDGR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 529 SLIVGGEASTLSIWDLaaPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCID 608
Cdd:cd00200  107 ILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 609 ISDYGTRLWTGGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPE-KYQLRLHESCV 686
Cdd:cd00200  185 FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEcVQTLSGHTNSV 264

                        250       260
                 ....*....|....*....|....*
gi 755534470 687 LSLKFASCGRWFVSTGKDNLLNAWR 711
Cdd:cd00200  265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
414-722 2.42e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 2.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 414 LRGSSVSLPGIPVAKPAYSFHVSADGQMQPVPFPSDALVGTGIPRHARQLHTLAHGEVVCAVTISSSTQHVYTGGK-GCV 492
Cdd:COG2319   23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAdGTV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 493 KVWDVgqpgsKTPVAQLDCLNRDNYIRSCKLLPDGQSLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAVSPDAK 572
Cdd:COG2319  103 RLWDL-----ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGK 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 573 VCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHC 651
Cdd:COG2319  176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTlTGHSGSVRSVAFS 255

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755534470 652 PNQDWLAVGMESSHVEVLHVR-KPEKYQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQVT 722
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 468-712 2.76e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 2.76e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 468 HGEVVCAVTISSSTQHVYTGGK-GCVKVWDV-GQPGSKTPVAQLDClnrdnyIRSCKLLPDGQSLIVGGEASTLSIWDLa 545
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLeTGELLRTLKGHTGP------VRDVAASADGTYLASGSSDKTIRLWDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 546 aPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTV 625
Cdd:cd00200   81 -ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 626 RCWDLREGR---QLQQHDfsSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPE-KYQLRLHESCVLSLKFASCGRWFVST 701
Cdd:cd00200  160 KLWDLRTGKcvaTLTGHT--GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASG 237

                        250
                 ....*....|.
gi 755534470 702 GKDNLLNAWRT 712
Cdd:cd00200  238 SEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
461-590 1.96e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 461 RQLHTLA-HGEVVCAVTISSSTQHVYTGGKGC-VKVWDVGqpgSKTPVAQLDclNRDNYIRSCKLLPDGQSLIVGGEAST 538
Cdd:COG2319  279 ELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755534470 539 LSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQN 590
Cdd:COG2319  354 VRLWDLA--TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 593-715 4.51e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 4.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 593 MVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREG---RQLQQHdfSSQIFSLGHCPNQDWLAVGMESSHVEVL 669
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755534470 670 HVRKPEK-YQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYG 715
Cdd:cd00200   79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125
WD40 COG2319
WD40 repeat [General function prediction only];
523-722 5.69e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 5.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 523 LLPDGQSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPAcyALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTD 602
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVA--SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 603 GASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPEK-YQLR 680
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLT 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 755534470 681 LHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQVT 722
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 201
PHA03247 PHA03247
large tegument protein UL36; Provisional
 269-447 1.65e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470  269 PSEPPSPVT--TPCGKAPLCIPARRDLTDSPASLASSLGSPLPRSKDIALNDLPTGTPASRSCGTSPPQDSSTPGPSSAS 346
Cdd:PHA03247 2739 PAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL 2818

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470  347 HLCQLAAQPAAPTDSIALRSPLTLSSPFTSSFSLGSHSTLNGDLSMPGSYvglHLSPQQMAFESHPHLRgssvSLPGIPV 426
Cdd:PHA03247 2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS---RSPAAKPAAPARPPVR----RLARPAV 2891

                         170       180
                  ....*....|....*....|.
gi 755534470  427 AKPAYSFHVSADGQmQPVPFP 447
Cdd:PHA03247 2892 SRSTESFALPPDQP-ERPPQP 2911
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 594-629 8.93e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 8.93e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 755534470   594 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 629
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
594-629 1.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.22e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 755534470  594 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 629
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
523-630 1.40e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470 523 LLPDGQSLIVGGEAS-TLSIWDLAapTPRIKAEL-TSSAPacYALAVSPDAKVCFSCCSDGN-----IVVWDLQNQAMVR 595
Cdd:COG3391  117 VDPDGGRLYVADSGNgRVSVIDTA--TGKVVATIpVGAGP--HGIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVA 192

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755534470 596 QFQGHtDGASCIDISDYGTRLW--------TGGLDNTVRCWDL 630
Cdd:COG3391  193 TIPVG-GGPVGVAVSPDGRRLYvanrgsntSNGGSNTVSVIDL 234
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 222-430 1.62e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470  222 ESLVEEDHPSSRGGSGKQQRAEDkDLSGP----YDSEEDKSDyNLVVDEDQPSEPPSPVTTPCGKAPLCIPARRDLTDSP 297
Cdd:PHA03307   12 EAAAEGGEFFPRPPATPGDAADD-LLSGSqgqlVSDSAELAA-VTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755534470  298 ASLAS-SLGSPLPRSKDIALNDLPTGTPASR----SCGTSPPQDSSTPGPSSASHLCQLAAQPAAPTDSIAlRSPLTLSS 372
Cdd:PHA03307   90 WSLSTlAPASPAREGSPTPPGPSSPDPPPPTpppaSPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPA-AVASDAAS 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755534470  373 PFTSSFSLGSHSTLNGDLSMPGSYVGlhLSPQQMAFESHPHLRGSSVSLP-GIPVAKPA 430
Cdd:PHA03307  169 SRQAALPLSSPEETARAPSSPPAEPP--PSTPPAAASPRPPRRSSPISASaSSPAPAPG 225
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 548-587 2.02e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 2.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 755534470   548 TPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWD 587
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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