Reln reelin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Relnprovided by MGI
Official Full Name: reelinprovided by MGI
Primary source: MGI:MGI:103022
See related: Ensembl:ENSMUSG00000042453 AllianceGenome:MGI:103022
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: rl; reeler
Summary: Enables receptor ligand activity; serine-type peptidase activity; and very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; positive regulation of cell communication; and regulation of neurotransmitter receptor activity. Acts upstream of or within several processes, including nervous system development; peptidyl-tyrosine phosphorylation; and thyroid hormone metabolic process. Located in cytoplasm; dendrite; and extracellular matrix. Is active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; and familial temporal lobe epilepsy 7. Orthologous to human RELN (reelin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 15.8), CNS E18 (RPKM 13.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 9.98 cM

Exon count:: 65

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (22089452..22549703, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (21884454..22344705, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development.
Title: Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development.
De novo monoallelic Reelin missense variants cause dominant neuronal migration disorders via a dominant-negative mechanism.
Title: De novo monoallelic Reelin missense variants cause dominant neuronal migration disorders via a dominant-negative mechanism.
Reelin differentially shapes dendrite morphology of medial entorhinal cortical ocean and island cells.
Title: Reelin differentially shapes dendrite morphology of medial entorhinal cortical ocean and island cells.
Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair.
Title: Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair.
Co-cultures of cerebellar slices from mice with different reelin genetic backgrounds as a model to study cortical lamination.
Title: Co-cultures of cerebellar slices from mice with different reelin genetic backgrounds as a model to study cortical lamination.
Central repeat fragment of reelin leads to active reelin intracellular signaling and rescues cognitive deficits in a mouse model of reelin deficiency.
Title: Central repeat fragment of reelin leads to active reelin intracellular signaling and rescues cognitive deficits in a mouse model of reelin deficiency.
Postnatal injection of Reelin protein into the cerebellum ameliorates the motor functions in reeler mouse.
Title: Postnatal injection of Reelin protein into the cerebellum ameliorates the motor functions in reeler mouse.
Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation.
Title: Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation.
Specific contribution of Reelin expressed by Cajal-Retzius cells or GABAergic interneurons to cortical lamination.
Title: Specific contribution of Reelin expressed by Cajal-Retzius cells or GABAergic interneurons to cortical lamination.
New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction.
Title: New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction.

Submit: New GeneRIF Correction See all GeneRIFs (220)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (4) 1 citation
Chemically induced (other) (2) 1 citation
Endonuclease-mediated (4) 1 citation
Spontaneous (7) 1 citation
Targeted (5) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Reln (e-PCR), detects polymorphism
- UniSTS:530698

NoName (e-PCR)
- UniSTS:225306

Reln (e-PCR), detects polymorphism
- UniSTS:516124

D5Mit72 (e-PCR), detects polymorphism
- UniSTS:130611

Reln (e-PCR), detects polymorphism
- UniSTS:507189

D5Mit227 (e-PCR), detects polymorphism
- UniSTS:130359

RH118282 (e-PCR)
- UniSTS:160941

PMC30678P1 (e-PCR)
- UniSTS:272576

U24703 (e-PCR)
- UniSTS:179142

Reln (e-PCR), detects polymorphism
- UniSTS:516555

Reln (e-PCR), detects polymorphism
- UniSTS:144341

Reln (e-PCR), detects polymorphism
- UniSTS:144342

Reln (e-PCR), detects polymorphism
- UniSTS:144343

Reln (e-PCR), detects polymorphism
- UniSTS:144344

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables lipoprotein particle receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipoprotein particle receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables very-low-density lipoprotein particle receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NMDA glutamate receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in associative learning	IDA Inferred from Direct Assay more info	PubMed
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex tangential migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendrite development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dentate gyrus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippocampus development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within interneuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral motor column neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in layer formation in cerebral cortex	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within layer formation in cerebral cortex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	IDA Inferred from Direct Assay more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of AMPA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CREB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TOR signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lateral motor column neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of small GTPase mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic density protein 95 clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in receptor localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reelin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in reelin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of NMDA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of neuron migration	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic activity	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thyroid hormone metabolic process	IMP Inferred from Mutant Phenotype more info
involved_in ventral spinal cord development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of reelin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: reelin

Names: extracellular matrix serine protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310464.1 → NP_001297393.1 reelin isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC113028, AC116404, AC119906, AC121878

Consensus CDS

CCDS80217.1

UniProtKB/Swiss-Prot

Q60841

Related

ENSMUSP00000058025.8, ENSMUST00000062372.14

Conserved Domains (20) summary

cd10036
Location:203 → 352

Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin

cd10037
Location:527 → 672

Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10038
Location:868 → 1035

Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10039
Location:1241 → 1410

Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10040
Location:1606 → 1775

Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10041
Location:1960 → 2131

Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10042
Location:2323 → 2479

Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10043
Location:2670 → 2854

Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10044
Location:3056 → 3230

Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cd10045
Location:709 → 863

Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10046
Location:1066 → 1221

Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10047
Location:1448 → 1598

Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10048
Location:1801 → 1938

Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10049
Location:2166 → 2315

Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10050
Location:2515 → 2662

Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10051
Location:2890 → 3051

Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10052
Location:3267 → 3427

Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cl15240
Location:422 → 557

Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins

cd08544
Location:49 → 179

Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins

pfam07974
Location:2131 → 2160

EGF_2; EGF-like domain
NM_011261.2 → NP_035391.2 reelin isoform 1 precursor

See identical proteins and their annotated locations for NP_035391.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC113028, AC116404, AC119906, AC121878

Consensus CDS

CCDS39023.1

UniProtKB/Swiss-Prot

E9PZ78, Q60841, Q9CUA6

Related

ENSMUSP00000124052.2, ENSMUST00000161356.8

Conserved Domains (20) summary

cd10036
Location:203 → 352

Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin

cd10037
Location:527 → 672

Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10038
Location:868 → 1035

Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10039
Location:1241 → 1410

Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10040
Location:1606 → 1775

Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10041
Location:1960 → 2131

Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10042
Location:2323 → 2479

Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10043
Location:2670 → 2854

Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10044
Location:3056 → 3230

Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cd10045
Location:709 → 863

Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10046
Location:1066 → 1221

Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10047
Location:1448 → 1598

Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10048
Location:1801 → 1938

Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10049
Location:2166 → 2315

Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10050
Location:2515 → 2662

Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10051
Location:2890 → 3051

Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10052
Location:3267 → 3427

Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cl15240
Location:422 → 557

Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins

cd08544
Location:49 → 179

Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins

pfam07974
Location:2131 → 2160

EGF_2; EGF-like domain