NCBI Conserved Domain Search

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 352.30 E-value: 1.20e-111

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  868 NSISLDFTNLVEVTQSLGFYLGNVQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDN 947
Cdd:cd10038     1 NSISLDFSNLVEVTQSLGFYLGNVQPYCNHDWTLCFTGDSKHASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMDN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  948 QVKLEYSANHGLTWHLVQEECLPSMPSCQEFTSASIYHASEFTQWRRVTVVLPQKTWSGATRFRWSQSYYTAQDEWALDN 1027
Cdd:cd10038    81 QVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQDEWALDN 160


                  ....*...
gi 117320554 1028 IYIGQQCP 1035
Cdd:cd10038   161 IYIGQQCP 168

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 352.29 E-value: 1.36e-111

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1606 GFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASSFLQFEMNMGCSKPFSGAHGIQL 1685
Cdd:cd10040     1 GFQDKFDGSVDLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSHSVQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1686 QYSLNNGKDWQLVTEECVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQTNYTVGADSWAIDNVIL 1765
Cdd:cd10040    81 QYSLNNGRDWHLVTEECVPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGADSWAIDNVVL 160

                         170
                  ....*....|
gi 117320554 1766 ASGCPWMCSG 1775
Cdd:cd10040   161 ASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 337.92 E-value: 1.74e-106

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1960 DTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEVGEHSITTRDLSVNENTIIQFEINVGCSTDSSSADP 2039
Cdd:cd10041     4 DTFDFGPNESNWLFYPGGNTGLYCPYQSKGAPEEDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTTESSSADP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2040 VRLEFSRDFGATWHLLLPLCYHsSSLVSSLCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQP 2119
Cdd:cd10041    84 VRLEFSRDFGATWHLLLPLCYG-SSSISSLCSTELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGFHPAGSQP 162

                         170
                  ....*....|..
gi 117320554 2120 VTWAIDNVYIGP 2131
Cdd:cd10041   163 VTWAIDNVYIGP 174

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 336.11 E-value: 3.69e-106

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2323 VLEDDFSTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVTTDIAVNEDSFLQIDFAASCSVTDSCYAIELEYSV 2402
Cdd:cd10042     1 VLEDDFSTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCYAIELEYSV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117320554 2403 DLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPSYTRSQATRFRWHQPAPFDKQQTWAIDNVYIG 2479
Cdd:cd10042    81 DLGLSWHPLLRDCLPTNVECSSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDNVYIG 157

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 335.61 E-value: 6.13e-106

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3267 PSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSPAQTDSC 3346
Cdd:cd10052     1 PSYIKDNFESGSVSELKWSLIQGGGIGSGCGQLAPHAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3347 NSDLSGPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHVEV 3426
Cdd:cd10052    81 NINLSSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNVEV 160


                  .
gi 117320554 3427 V 3427
Cdd:cd10052   161 V 161

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 333.71 E-value: 4.60e-105

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1241 YEKPAFDYPMNQMSVWLMLANEGMAKNDSfCATTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCTSQFSSTAPV 1320
Cdd:cd10039     1 YEKPAFDYPLNQMSVWLMLSNEGMGKNES-CSPTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1321 LLQYSHDAGMSWFLVKEGCFPASAG-KGCEGNSRELSEPTVYYTGDFEEWTRITIAIPRSLASSKTRFRWIQESSSQKNV 1399
Cdd:cd10039    80 LLQYSHDAGLTWSLVREGCYPASPGsKGCEGSSRELREPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNA 159

                         170
                  ....*....|.
gi 117320554 1400 PPFGLDGVYIS 1410
Cdd:cd10039   160 PPFGLDGVYIS 170

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 327.12 E-value: 6.39e-103

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2890 KTFLKERFDSEEIKPDLWMSLEGGSTCTECGVLAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCHRP 2969
Cdd:cd10051     1 KTFLKERFDSEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2970 VCRKEGVLLDFSTDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFVISNGLVVSGVERAQWALDNILI 3049
Cdd:cd10051    81 TCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFTISNGLVVSGTERAQWALDNILI 160


                  ..
gi 117320554 3050 GG 3051
Cdd:cd10051   161 GG 162

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 322.57 E-value: 2.03e-101

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1066 LPSTIMSDFENPSSWESDWQEVIGGEVVKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESAACN 1145
Cdd:cd10046     1 LPSTVMSDFENQDSLETEWQEVIGGEIVKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSASCN 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 1146 KPDSREEGILLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIIIL 1221
Cdd:cd10046    81 YPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIIIL 156

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 322.17 E-value: 5.11e-101

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3056 PSQLVDTFDDEGSSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVGCEAT-SC 3134
Cdd:cd10044     1 PSSLVETFEDEGTSHDENWEFYPNGVRTDEFCGNPSFHLTWPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVsSC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3135 GDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNAVNSSSWKRITIQLPDHVSSSATQFRWIQKGE 3214
Cdd:cd10044    81 GDLHPVMLEYTTDPRSDHWQLVQTECLPSSSNSIDCSPFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTE 160

                         170
                  ....*....|....*.
gi 117320554 3215 ETEKQSWAIDHVYIGE 3230
Cdd:cd10044   161 STEAPSWAIDDVYIGE 176

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 321.11 E-value: 1.03e-100

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2670 VMLDTFSSAPVPQHERSPadagpvgriafemflEDKTSVNENWLFHDDCTVERFCDSPDGVMLCGSH-DGREVYAVTHDL 2748
Cdd:cd10043     1 VLLDTFSSANLPQHERSP---------------EDKTTVNDHWLFHDNCSIERFCDSPDGVMICGSHdDGREVSAVTHDL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2749 TPTENWIMQFKISVGCKVPEKIAQNQIHVQFSTDFGVSWSYLVPQCLPADPKCSGSVSQPSVFFPTEGWKRITYPLPESL 2828
Cdd:cd10043    66 TPTEGWILQFKISVGCKSSEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKCGGSVTQPSVFFPSKGWRRVTIPLPDKL 145

                         170       180
                  ....*....|....*....|....*.
gi 117320554 2829 TGNPVRFRFYQKYSDVQWAIDNFYLG 2854
Cdd:cd10043   146 VGRPIRFRFYQKASDMQWALDNFYIG 171

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 319.46 E-value: 2.11e-100

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1448 HSEMFDRFEGKLSPLWYKITGGQVGTGCGTLNDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRA 1527
Cdd:cd10047     1 PSEFFDRFEGKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554 1528 RNEGLVVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPREAKTPATAFRWWQPQHGKHSAQWALDDVLIG 1598
Cdd:cd10047    81 RNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQWALDDVLIG 151

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 318.73 E-value: 3.43e-100

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  527 VINPELQTPATKFCLRQKSHQGYNRNVWAVDFFHVLPVLPSTMSHMIQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLH 606
Cdd:cd10037     1 PIPPDLQTPATKFCLRQKSHGGHNRNVWAVDFFHLLPVLPSTVTHFAQFSINLGCGSHQPGNSVSLEFSTNHGRSWSLLH 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554  607 TECLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALTRDTRIRWRQTGPILGNMWAIDNVYIG 672
Cdd:cd10037    81 TECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALTSATRFRWRQTGSVVGSMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 317.55 E-value: 7.81e-100

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2515 LPTQLKDNFNRAPSNQNWLTVSGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPSNRNQG 2594
Cdd:cd10050     1 LPTQLKDTFNRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNRNQG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 2595 VLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLIS 2662
Cdd:cd10050    81 VLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLIG 148

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 316.07 E-value: 2.51e-99

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2166 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGCGKGVPDPRSQ 2245
Cdd:cd10049     1 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQ 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2246 PVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2315
Cdd:cd10049    81 PVLLQYSLNGGLTWSLLQEFLFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIG 150

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 311.35 E-value: 1.74e-97

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  709 PMFISESFGSARLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRA 788
Cdd:cd10045     1 PGFLSESFNSSRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554  789 PDQPGEGVLLHYSYDNGITWKLLEHYSYVNYHEPRIISVELPDDARQFGIQFRWWQPYHSSQGEDVWAIDEIVMT 863
Cdd:cd10045    81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 282.54 E-value: 1.55e-87

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1801 LPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTCLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTPERSHS 1880
Cdd:cd10048     1 LPSVLKDDFNGNLRPDLWPEVYGAERGNLNGETIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 1881 ILLQFSVSGGVTWHLMDEFYFPQTTSILFINVPLPYGAQTNATRFRLWQPYNNGKKEE 1938
Cdd:cd10048    81 VLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEE 138

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 259.85 E-value: 1.18e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1070 IMSDFENPSSWESDWQEVIGGEVVkpeQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESAA--CNKP 1147
Cdd:cd08526     2 LKDSFEGSLSSSDNWSLVSGGEVG---TGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTstCNPP 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117320554 1148 DSREEGILLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1220
Cdd:cd08526    79 DSRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILI 151

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 252.39 E-value: 4.92e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  203 LRDDFDSYQQLELNPNIWVECSNCEMGEQCGTIMHGNAVTFCEPYGPRELTTTCLNTTTASVLQFSIGSGSCRFSYSDPS 282
Cdd:cd10036     1 LRDDFDSYPLLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEPYGPRELITVPLNTTTASVLQFAIGSGSCRFSYSDPS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554  283 ITVSYAKNNT-ADWIQLEKIRAPSNVSTVIHILYLPEEAKGESVQFQWKQDSLRVGEVYEACWALDNILVI 352
Cdd:cd10036    81 IIVSYAVNNTsSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEAPNAGEVYESCWALDNVLII 151

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 250.61 E-value: 2.19e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1450 EMFDRFEGKLSP--LWYKITGGQVGTGCGTLNDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRA 1527
Cdd:cd08526     1 FLKDSFEGSLSSsdNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNPPDS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320554 1528 RNEGLVVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDVLIG 1598
Cdd:cd08526    81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHsGKGQDQWALDNILIG 152

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 247.53 E-value: 2.87e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2518 QLKDNFNRAPSN-QNWLTVSGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLIT------PSN 2590
Cdd:cd08526     1 FLKDSFEGSLSSsDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQtstcnpPDS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554 2591 RNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLI 2661
Cdd:cd08526    81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILI 151

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 246.37 E-value: 6.30e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2892 FLKERFDSEEIKPDLWMSLEGGSTCTECGVLAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCHRPVC 2971
Cdd:cd08526     1 FLKDSFEGSLSSSDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNPPDS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 2972 RKEGVLLDFSTDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFvisnglvVSGVERAQWALDNILIG 3050
Cdd:cd08526    81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPS-------HSGKGQDQWALDNILIG 152

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 241.36 E-value: 3.37e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  711 FISESFGSARLSSyHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRAPD 790
Cdd:cd08526     1 FLKDSFEGSLSSS-DNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNPPD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117320554  791 QPGEGVLLHYSYDNGITWKLLEHYSYVNYHEPRIISVELPDDARQFGIQFRWWQPYHSSQGEDVWAIDEIVMT 863
Cdd:cd08526    80 SRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 235.40 E-value: 3.61e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2519 LKDNFNRAPSNQNWLTVSGGKLSTVCGAVASGLALHFSGG-CSRLLVTVDLNLTNAEFIQFYFMYGCLiTPSNRNQGVLL 2597
Cdd:cd08524     1 LKDDFDGYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCS-TPSYSNQPVLL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554 2598 EYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLIS 2662
Cdd:cd08524    80 EYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 235.73 E-value: 4.29e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1606 GFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASSFLQFEMNMGCSKPFSGAHGIQL 1685
Cdd:cd08525     1 VLLDTFDTLPDSNENWFFYPGGVVKNDCGSTDSALVFTENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSSSNSVML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1686 QYSLNNGKDWQLVTEECVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQTNYTVGADSWAIDNVIL 1765
Cdd:cd08525    81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGVQTWAIDNVYI 160


                  .
gi 117320554 1766 A 1766
Cdd:cd08525   161 G 161

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 232.89 E-value: 3.53e-70

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3269 YIKDNFESARVTEANWETIQGGVIGSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSPAQTDSCNS 3348
Cdd:cd08526     1 FLKDSFEGSLSSSDNWSLVSGGEVGTGCGVLA---SGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNP 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 3349 dlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHVEVV 3427
Cdd:cd08526    78 ----PDSRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 231.73 E-value: 9.85e-70

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2169 FLKDDFEGQLES-DRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGCGK-----GVPDP 2242
Cdd:cd08526     1 FLKDSFEGSLSSsDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSqtstcNPPDS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117320554 2243 RSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVgRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2315
Cdd:cd08526    81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEP-RFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 229.18 E-value: 1.01e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2323 VLEDDFSTLDS--RKWLLHPGGTKMPVCGSTGDALVFIEK-ASTRYVVTTDIAVNEDSFLQIDFAASC-SVTDSCYAIEL 2398
Cdd:cd08525     1 VLLDTFDTLPDsnENWFFYPGGVVKNDCGSTDSALVFTENiGGERYAVTRDLTVNEGYMLQFKINVGCsSTFSSSNSVML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2399 EYSVDLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPSYTRSQATRFRWHQPAPFDKQQTWAIDNVYI 2478
Cdd:cd08525    81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGVQTWAIDNVYI 160


                  .
gi 117320554 2479 G 2479
Cdd:cd08525   161 G 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 221.53 E-value: 2.39e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2170 LKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNED-GLRMLVTRDLDLSHARFVQFFMRLGCGKgvPDPRSQPVL 2248
Cdd:cd08524     1 LKDDFDGYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCST--PSYSNQPVL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117320554 2249 LQYSLNGGLSWSLLQEFLFSnSSNVGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2315
Cdd:cd08524    79 LEYSVDNGASWHLLEEIRAD-SFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 218.01 E-value: 7.68e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1960 DTFDFGPRE-DNWFFYPGGNIGLYCPysskgapEEDSAMVFVSNEVGEHSITTRDLSVNENTIIQFEINVGCSTDSSSAD 2038
Cdd:cd08525     4 DTFDTLPDSnENWFFYPGGVVKNDCG-------STDSALVFTENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSSSN 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2039 PVRLEFSRDFGATWHLLLPLCYHSSSLVSslcstEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPagSQ 2118
Cdd:cd08525    77 SVMLEYSTDAGLSWHLVQEECLPSSPGCS-----ELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYT--SG 149

                         170
                  ....*....|..
gi 117320554 2119 PVTWAIDNVYIG 2130
Cdd:cd08525   150 VQTWAIDNVYIG 161

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 216.08 E-value: 3.69e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  869 SISLDFTNLVEVTQSLGFYLGNVQPY--CGHDWTLCFTGDSKlasSMRYVETQSMQIGASYMIQFSLVMGCGqkYTPHMD 946
Cdd:cd08525     1 VLLDTFDTLPDSNENWFFYPGGVVKNdcGSTDSALVFTENIG---GERYAVTRDLTVNEGYMLQFKINVGCS--STFSSS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  947 NQVKLEYSANHGLTWHLVQEECLPSMPSCQEFTSASIYHASEFTQWRRVTVVLPQKTWSGATRFRWSQ-SYYTAQDEWAL 1025
Cdd:cd08525    76 NSVMLEYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQyGYTSGVQTWAI 155


                  ....*.
gi 117320554 1026 DNIYIG 1031
Cdd:cd08525   156 DNVYIG 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 211.90 E-value: 4.98e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1451 MFDRFEGKLSP-LWYKITGGQVGTGCGTLNDGRSLYFNGL-GKREARTVPLDTRNIRLVQFYIQIGSKTsgitcikPRAR 1528
Cdd:cd08524     1 LKDDFDGYPSPdNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCST-------PSYS 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554 1529 NEGLVVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPREAKTPATAFRWWQPQHGK-HSAQWALDDVLIG 1598
Cdd:cd08524    74 NQPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGvYQATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 212.62 E-value: 6.29e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1241 YEKPAFDYPMNQmSVWLMLANEGMAKNDsfCATTPSAMVF-GKSDGDRFAVTRDLTLKPGYVLQFKLNIGCTSQFSSTAP 1319
Cdd:cd08525     1 VLLDTFDTLPDS-NENWFFYPGGVVKND--CGSTDSALVFtENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSSSNS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1320 VLLQYSHDAGMSWFLVKEGCFPASAGKGcegnsrELSEPTVYYTGDFEEWTRITIAIPRSLASSKTRFRWIQESSSQkNV 1399
Cdd:cd08525    78 VMLEYSTDAGLSWHLVQEECLPSSPGCS------ELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTS-GV 150

                         170
                  ....*....|.
gi 117320554 1400 PPFGLDGVYIS 1410
Cdd:cd08525   151 QTWAIDNVYIG 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 208.44 E-value: 8.26e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1960 DTFDFGPREDNWFFYPGGNIGLYCpysskGAPEEDSAMVFVSNEvGEHSITTRDLSVNENTIIQFEINVGCSTDSSSADP 2039
Cdd:cd08524     3 DDFDGYPSPDNWLLCPGGKTGTVC-----GALSSGNALVFNEPY-GPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2040 VRLEFSRDFGATWHLLLplcyhssslvsslcstehhpssTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPaGSQP 2119
Cdd:cd08524    77 VLLEYSVDNGASWHLLE----------------------EIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHR-GVYQ 133

                         170
                  ....*....|.
gi 117320554 2120 VTWAIDNVYIG 2130
Cdd:cd08524   134 ATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 208.38 E-value: 1.96e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3058 QLVDTFDDEGSSHEeNWSFYPNAVRTAgFCGNPSFHLYWPNKKKDktHNALSSRELIIQPGYMMQFKIVVGCEaTSCGDL 3137
Cdd:cd08525     1 VLLDTFDTLPDSNE-NWFFYPGGVVKN-DCGSTDSALVFTENIGG--ERYAVTRDLTVNEGYMLQFKINVGCS-STFSSS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3138 HSVMLEYTKDArSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNavnssSWKRITIQLPDHVSSSATQFRWIQKGEETE 3217
Cdd:cd08525    76 NSVMLEYSTDA-GLSWHLVQEECLPSSPGCSELHPSSVYESSTFN-----GWKRITIPLPNATLSSATRFRWIQYGYTSG 149

                         170
                  ....*....|..
gi 117320554 3218 KQSWAIDHVYIG 3229
Cdd:cd08525   150 VQTWAIDNVYIG 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 201.89 E-value: 2.03e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2324 LEDDFSTLDS-RKWLLHPGGTKMPVCG--STGDALVFIEKASTRYVVTTDIAVNEDSFLQIDFAASCS-VTDSCYAIELE 2399
Cdd:cd08524     1 LKDDFDGYPSpDNWLLCPGGKTGTVCGalSSGNALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCStPSYSNQPVLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2400 YSVDLGLSWHPLvrdclptnvecsryhlqRILVSDTFNKWTRITLPLPSYTRSQATRFRWHQPAPFD-KQQTWAIDNVYI 2478
Cdd:cd08524    81 YSVDNGASWHLL-----------------EEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGvYQATWAIDNVLI 143


                  .
gi 117320554 2479 G 2479
Cdd:cd08524   144 G 144

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 192.83 E-value: 3.04e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1805 LKDDFNGNLHP-DLWPEVYGAERGNLNGEtIKSGTCLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAK-------GTPE 1876
Cdd:cd08526     2 LKDSFEGSLSSsDNWSLVSGGEVGTGCGV-LASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKsqtstcnPPDS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320554 1877 RSHSILLQFSVSGGVTWHLMDEFYFPQTTSILFINVPLPYGAQTNATRFRLWQPYNNGKKEE 1938
Cdd:cd08526    81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQD 142

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 191.04 E-value: 2.10e-55

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  527 VINPELQTP----ATKFCLRQKSHQGY-----NRNVWAV---DFFHVLPVLPSTM-SHMIQFSINLGCG-THQPGNSVSL 592
Cdd:cd08525     1 VLLDTFDTLpdsnENWFFYPGGVVKNDcgstdSALVFTEnigGERYAVTRDLTVNeGYMLQFKINVGCSsTFSSSNSVML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  593 EFSTNHGRSWSLLHTECLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALTRDTRIRWRQTGPILG-NMWAIDNVYI 671
Cdd:cd08525    81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGvQTWAIDNVYI 160


                  .
gi 117320554  672 G 672
Cdd:cd08525   161 G 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 185.71 E-value: 8.54e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  203 LRDDFDSYqqleLNPNIWVECSNCEMGEQCGTIMHGNAVTFCEPYGPRELTTTCLNTTTASVLQFSIGSGSCRFSYSDPS 282
Cdd:cd08524     1 LKDDFDGY----PSPDNWLLCPGGKTGTVCGALSSGNALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  283 ITVSYAKNNTADWIQLEKIRAPSNVSTVIHILYLPEEAKGESVQFQWKQDSLRVgeVYEACWALDNILVI 352
Cdd:cd08524    77 VLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRG--VYQATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 182.18 E-value: 2.35e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2707 SVNENWLFHDDCTVERFC-DSPDGVMLCGSHDGrEVYAVTHDLTPTENWIMQFKISVGCKvPEKIAQNQIHVQFSTDFGV 2785
Cdd:cd08525    11 DSNENWFFYPGGVVKNDCgSTDSALVFTENIGG-ERYAVTRDLTVNEGYMLQFKINVGCS-STFSSSNSVMLEYSTDAGL 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 2786 SWSYLVPQCLPADPKCSG----SVSQPSVFFpteGWKRITYPLPESLTGNPVRFRFYQKYS---DVQWAIDNFYLG 2854
Cdd:cd08525    89 SWHLVQEECLPSSPGCSElhpsSVYESSTFN---GWKRITIPLPNATLSSATRFRWIQYGYtsgVQTWAIDNVYIG 161

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 167.30 E-value: 2.70e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1067 PSTIMSDFENPSSweSDWQEVIGGEVvkpEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESA--AC 1144
Cdd:cd10047     1 PSEFFDRFEGKLS--PLWYKITGGQV---GTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNgeTC 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 1145 NKPDSREEGILLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPvFSGEDYDQWAVDDIII 1220
Cdd:cd10047    76 LRPRSRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQP-QHGKPSAQWALDDVLI 150

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 159.97 E-value: 1.33e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1447 NHSEMFDRFEGKLSPLWYKITGGQVGTGCGTLNDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPR 1526
Cdd:cd10045     3 FLSESFNSSRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPPD 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320554 1527 ARNEGLVVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDVLI 1597
Cdd:cd10045    83 RPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHsGQNQDVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 159.94 E-value: 1.65e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1451 MFDRF--EGKLSPLWYKITGGQVGTGCGTLNDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRAR 1528
Cdd:cd10051     4 LKERFdsEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRPTCR 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 1529 NEGLVVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPREAKTPATAFRWWQP--------QHGKHSAQWALDDVLIG 1598
Cdd:cd10051    84 KEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftisnglvVSGTERAQWALDNILIG 161

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 157.30 E-value: 7.96e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1066 LPSTIMSDFENpSSWESDWQEVIGGevvKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGgesaaCN 1145
Cdd:cd10050     1 LPTQLKDTFNR-APSSSNWLTVVGG---KLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYG-----CL 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 1146 -KPDSREEGILLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1220
Cdd:cd10050    72 iPPSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLI 147

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 154.51 E-value: 7.59e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1073 DFENPSSwESDWQEVIGGevvKPEQGCGVVSSGSSLYF-SKAGKRQLVSWDLDTSWVDFVQFYIQIGgesaaCNKPDSRE 1151
Cdd:cd08524     4 DFDGYPS-PDNWLLCPGG---KTGTVCGALSSGNALVFnEPYGPRELVTTDLNTNEASFLQFYIGSG-----CSTPSYSN 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 1152 EGILLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1220
Cdd:cd08524    75 QPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLI 143

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 151.87 E-value: 9.97e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1453 DRFEGKLSPL--WYKITGGQVGTGCGTLN---DGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITC----I 1523
Cdd:cd10052     6 DNFESGSVSElkWSLIQGGGIGSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSCninlS 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117320554 1524 KPRARNEGLVVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDV 1595
Cdd:cd10052    86 SPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHdGTGHDQWALDNV 158

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 151.22 E-value: 1.95e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  895 CGHDWTLCFTGDSKlasSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPhmDNQVKLEYSANHGLTWHLVQEECLPSMPS 974
Cdd:cd10040    29 LSMDTALMFTENIG---KPRYAETWDFHVSASTFLQFELSMGCSKPYSN--SHSVQLQYSLNNGRDWHLVTEECVPPAIG 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117320554  975 CQEFTSASIYHASEFTQWRRVTVVLPQKTWSGATRFRWSQSYYT-AQDEWALDNIYIGQQCPNMCSG 1040
Cdd:cd10040   104 CLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYApGADSWAIDNVVLASGCPWMCSG 170

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 150.38 E-value: 3.09e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1463 WYKITGGQVGT---GCGTLNDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSgiTCIKPRARNEGLVVQYSND 1539
Cdd:cd10046    19 WQEVIGGEIVKpemGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSA--SCNYPDSREEGVLLQYSNN 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1540 NGILWHLLRELDFMSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDVLIG 1598
Cdd:cd10046    97 GGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFsGEGYDQWALDDIIIL 156

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 149.16 E-value: 9.74e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1082 SDWQEVIGGevvKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGES--AACNKPDSREEGILLQYS 1159
Cdd:cd10051    16 DQWLSLEGG---VTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENnmTLCLRPTCRKEGVLLQYS 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 1160 NNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQP-------VFSGEDYDQWAVDDIII 1220
Cdd:cd10051    93 TDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftisnglVVSGTERAQWALDNILI 160

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 148.46 E-value: 1.25e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2167 PDFLKDDFEGQ--LESDRFLLMSGG--KPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLG-----CGK 2237
Cdd:cd10046     2 PSTVMSDFENQdsLETEWQEVIGGEivKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGggsasCNY 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 2238 gvPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVgRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2315
Cdd:cd10046    82 --PDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKP-RFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIIIL 156

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 144.15 E-value: 5.25e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2516 PTQLKDNF-NRAPSNQNWLTVSGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYG-------CLiT 2587
Cdd:cd10051     1 KTFLKERFdSEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGsennmtlCL-R 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2588 PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQP---RHD----GLDQNDWAIDNVL 2660
Cdd:cd10051    80 PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftiSNGlvvsGTERAQWALDNIL 159


                  ...
gi 117320554 2661 ISG 2663
Cdd:cd10051   160 IGG 162

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 143.03 E-value: 8.99e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2895 ERFdsEEIKPDLWMSLEGGSTCTECGVLAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCHRPVCRKE 2974
Cdd:cd10047     6 DRF--EGKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRSRNE 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 2975 GVLLDFSTDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFVisnglvvsGVERAQWALDNILIG 3050
Cdd:cd10047    84 GIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH--------GKPSAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 142.63 E-value: 1.20e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2516 PTQLKDNFN--RAPSNQNWLTVSGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLIT------ 2587
Cdd:cd10045     1 PGFLSESFNssRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVlgtcpp 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554 2588 PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLIS 2662
Cdd:cd10045    81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 141.49 E-value: 2.99e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  727 FYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRAPDQPGEGVLLHYSYDNGI 806
Cdd:cd10047    16 WYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRSRNEGIIVQYSNDNGI 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554  807 TWKLLEHYSYVNYHEPRIISVELPDDARQFGIQFRWWQPYHSSQGEDvWAIDEIVM 862
Cdd:cd10047    96 TWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQ-WALDDVLI 150

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 140.40 E-value: 6.68e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2515 LPTQLKDNFNRAPSNQNWLTVSGGKLSTVCG-AVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPSnRNQ 2593
Cdd:cd10048     1 LPSVLKDDFNGNLRPDLWPEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPE-RSH 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554 2594 GVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLISGS 2664
Cdd:cd10048    80 SVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 140.42 E-value: 7.22e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2516 PTQLKDNFNRAPSNQNWLTVSGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGC-LITPSNRNQG 2594
Cdd:cd10049     2 PDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCgKGVPDPRSQP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 2595 VLLEYSVNGGITWNLLMEIFYDQYSKPG-FVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLI 2661
Cdd:cd10049    82 VLLQYSLNGGLTWSLLQEFLFSNSSNVGrYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 140.42 E-value: 7.95e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1067 PSTIMSDFENpsSWESD-WQEVIGGevvKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGgesaaCN 1145
Cdd:cd10049     2 PDFLKDDFEG--QLESDrFLLMSGG---KPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-----CG 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 1146 K--PDSREEGILLQYSNNGGIQWHLLAEMYFSDFSK-PRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1220
Cdd:cd10049    72 KgvPDPRSQPVLLQYSLNGGLTWSLLQEFLFSNSSNvGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 139.94 E-value: 1.14e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1089 GGEVvkpEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGES--AACNKPDSREEGILLQYSNNGGIQW 1166
Cdd:cd10045    24 GGEV---GFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSvlGTCPPPDRPGEGVLLHYSCDNGITW 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 117320554 1167 HLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1220
Cdd:cd10045   101 KLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 139.25 E-value: 1.68e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2167 PDFLKDDFEGQLESDRFLLMSGGKPSRKCG-ILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGCgKGVPDpRSQ 2245
Cdd:cd10048     2 PSVLKDDFNGNLRPDLWPEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFIT-KGTPE-RSH 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320554 2246 PVLLQYSLNGGLSWSLLQEFLFSNSSNVgRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIGGN 2317
Cdd:cd10048    80 SVLLQYSINGGITWHLIDEFYFPTTTDV-LFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 138.80 E-value: 2.61e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2516 PTQLKDNFNRAPSNQnWLTVSGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYG-------CLiTP 2588
Cdd:cd10047     1 PSEFFDRFEGKLSPL-WYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGsklngetCL-RP 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117320554 2589 SNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHdGLDQNDWAIDNVLIS 2662
Cdd:cd10047    79 RSRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH-GKPSAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 138.06 E-value: 4.81e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  709 PMFISESFGSARlSSYHNFYSIRGAEVSF---GCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSvlST 785
Cdd:cd10046     2 PSTVMSDFENQD-SLETEWQEVIGGEIVKpemGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGS--AS 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117320554  786 CRAPDQPGEGVLLHYSYDNGITWKLLEHYSYVNYHEPRIISVELPDDARQFGIQFRWWQPYHSSQGEDVWAIDEIVM 862
Cdd:cd10046    79 CNYPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIII 155

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 135.35 E-value: 4.30e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2167 PDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGCgKGVPDPRSQP 2246
Cdd:cd10050     2 PTQLKDTFNRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGC-LIPPSNRNQG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 2247 VLLQYSLNGGLSWSLLQEfLFSNSSNVGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2315
Cdd:cd10050    81 VLLEYSVNGGITWNLLME-IFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLIG 148

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 134.52 E-value: 1.04e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2167 PDFLKDDFEGQ-LESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLG-------CGKg 2238
Cdd:cd10051     1 KTFLKERFDSEeISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGsennmtlCLR- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2239 vPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVGR-YIALemPLKARSGSTRLRWWQP--SENGHFYSP-----WVID 2310
Cdd:cd10051    80 -PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYdYITL--PENARTNSTRLRWWQPftISNGLVVSGteraqWALD 156


                  ....*.
gi 117320554 2311 QILIGG 2316
Cdd:cd10051   157 NILIGG 162

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 134.20 E-value: 1.15e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2530 QNWLTVSGGKLSTV---CGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLIT----PSNRNQGVLLEYSVN 2602
Cdd:cd10046    17 TEWQEVIGGEIVKPemgCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSAscnyPDSREEGVLLQYSNN 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 2603 GGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLI 2661
Cdd:cd10046    97 GGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIII 155

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 129.53 E-value: 6.32e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1067 PSTIMSDFENPSSWESDWQEVIGGEVvkpEQGCGVVS---SGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGG--ES 1141
Cdd:cd10052     1 PSYIKDNFESGSVSELKWSLIQGGGI---GSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSrsQT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1142 AACN----KPDSREEGILLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDD 1217
Cdd:cd10052    78 DSCNinlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDN 157


                  .
gi 117320554 1218 I 1218
Cdd:cd10052   158 V 158

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 129.15 E-value: 9.40e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2516 PTQLKDNFNRAP-SNQNWLTVSGGKLSTVCGAV---ASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYG-------C 2584
Cdd:cd10052     1 PSYIKDNFESGSvSELKWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsC 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 2585 ---LITPSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNV 2659
Cdd:cd10052    81 ninLSSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 128.76 E-value: 1.15e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  709 PMFISESFGSARLSSYhNFYSIRGAEVSFGCGVL---ASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLST 785
Cdd:cd10052     1 PSYIKDNFESGSVSEL-KWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDS 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554  786 CR----APDQPGEGVLLHYSYDNGITWKLLEHYSYVNYHEPRIISVELPDDARQFGIQFRWWQPYHSSQGEDVWAIDEI 860
Cdd:cd10052    80 CNinlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 127.97 E-value: 2.11e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  709 PMFISESFGSARLSSyHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRA 788
Cdd:cd10051     1 KTFLKERFDSEEISS-DQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLR 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554  789 PDQPGEGVLLHYSYDNGITWKLLEHYSYVNYHEPRIISVELPDDARQFGIQFRWWQPYHSSQGEDV-------WAIDEI 860
Cdd:cd10051    80 PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFTISNGLVVsgteraqWALDNI 158

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 127.16 E-value: 2.73e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  720 RLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKD-GRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCrapdqpgEGVLL 798
Cdd:cd08524     7 GYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSN-------QPVLL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320554  799 HYSYDNGITWKLLEHYSYVNYHEPRIISVELPDDARQFGIQFRWWQPYHSSQGEDVWAIDEI 860
Cdd:cd08524    80 EYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNV 141

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 126.86 E-value: 3.33e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3267 PSYIKDNFESARVTEanWETIQGGVIGSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSPAQTDSC 3346
Cdd:cd10047     1 PSEFFDRFEGKLSPL--WYKITGGQVGTGCGVIK---DGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETC 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 3347 NSdlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHnGTGHDQWALDHV 3424
Cdd:cd10047    76 LR----PRSRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH-GKPSAQWALDDV 148

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 125.23 E-value: 1.20e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2893 LKERFDSEEiKPDLWMSLEGGSTCTECGVLAENTALYF-GGSTVRQAITQDLDLRGAKFLQYWGRIGsennmtsCHRPVC 2971
Cdd:cd08524     1 LKDDFDGYP-SPDNWLLCPGGKTGTVCGALSSGNALVFnEPYGPRELVTTDLNTNEASFLQFYIGSG-------CSTPSY 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 2972 RKEGVLLDFSTDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFvisnglvVSGVERAQWALDNILIG 3050
Cdd:cd08524    73 SNQPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPN-------HRGVYQATWAIDNVLIG 144

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 124.56 E-value: 2.02e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1449 SEMFDRFE-GKLSPLWYKITGGQVGTGCGTLNDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGsktsgitC-IKPR 1526
Cdd:cd10050     3 TQLKDTFNrAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYG-------ClIPPS 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117320554 1527 ARNEGLVVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDVLIG 1598
Cdd:cd10050    76 NRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHdGLDQNDWAIDNVLIG 148

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 124.56 E-value: 2.27e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2889 LKTFLKERFDSEEIKpDLWMSLEGGSTCTECGVLAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNmtschr 2968
Cdd:cd10050     1 LPTQLKDTFNRAPSS-SNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIP------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2969 PVCRKEGVLLDFSTDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPfvisnglVVSGVERAQWALDNIL 3048
Cdd:cd10050    74 PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQP-------SHDGLDQNDWAIDNVL 146


                  ..
gi 117320554 3049 IG 3050
Cdd:cd10050   147 IG 148

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 124.19 E-value: 3.49e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2919 CGVLAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENnmTSCHRPVCRKEGVLLDFSTDGGITWTLLHEMDFQK 2998
Cdd:cd10046    34 CGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGS--ASCNYPDSREEGVLLQYSNNGGISWKLLAEMYFSD 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 117320554 2999 YISVRHDYILLPEGALTNTTRLRWWQPfvisnglVVSGVERAQWALDNILIG 3050
Cdd:cd10046   112 FSKPRFVYLELPTAAKTPCTRFRWWQP-------VFSGEGYDQWALDDIIIL 156

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 124.14 E-value: 3.53e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3267 PSYIKDNFESARVT-EANWETIQGGVIGSGCGQLAPyahGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSPAQTDS 3345
Cdd:cd10045     1 PGFLSESFNSSRLSsYHNFSSIRGGEVGFGCGVLAS---GKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGT 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 3346 CNSdlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHV 3424
Cdd:cd10045    78 CPP----PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEI 152

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 124.26 E-value: 5.07e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1627 GQVDIDClSMDTALIFT---ENIGKPRYAETWDFHVSASSFLQFEMNMGCSKPFSGAH--GIQLQYSLNNGKDWQLVTEE 1701
Cdd:cd10038    22 GNVQPYC-NHDWTLCFTgdsKHASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMdnQVKLEYSTNHGLTWHLVQEE 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 1702 CVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQTNYTVGaDSWAIDNVILASGCP 1770
Cdd:cd10038   101 CLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQ-DEWALDNIYIGQQCP 168

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 123.76 E-value: 5.68e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2892 FLKERFDSEEIK-PDLWMSLEGGSTCTECGVLAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCHRPV 2970
Cdd:cd10045     3 FLSESFNSSRLSsYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPPD 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 2971 CRKEGVLLDFSTDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFvisnglvVSGVERAQWALDNILI 3049
Cdd:cd10045    83 RPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPY-------HSGQNQDVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 122.31 E-value: 1.70e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1802 PSILKDDFNGNLHPDLWPEVYGAERGNLNGeTIKSGTCLIFKGEGLRMLISRDLDCTNTMYVQFSLRF-IAKGTPE-RSH 1879
Cdd:cd10049     2 PDFLKDDFEGQLESDRFLLMSGGKPSRKCG-ILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLgCGKGVPDpRSQ 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 1880 SILLQFSVSGGVTWHLMDEFYF-PQTTSILFINVPLPYGAQTNATRFRLWQPYNNGKKEEIWIIDDFII 1947
Cdd:cd10049    81 PVLLQYSLNGGLTWSLLQEFLFsNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 121.48 E-value: 2.37e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3266 LPSYIKDNFESARVTEaNWETIQGGVIGSGCGqlaPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGspaqtds 3345
Cdd:cd10050     1 LPTQLKDTFNRAPSSS-NWLTVVGGKLSTVCG---AVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYG------- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 3346 CNSDlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHV 3424
Cdd:cd10050    70 CLIP---PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNV 145

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 120.77 E-value: 5.23e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  709 PMFISESFgSARLSSYHnFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSvlstcRA 788
Cdd:cd10049     2 PDFLKDDF-EGQLESDR-FLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGK-----GV 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554  789 PDQPGEGVLLHYSYDNGITWKLLEHYSYVNY-HEPRIISVELPDDARQFGIQFRWWQPYHSSQGEDVWAIDEIVM 862
Cdd:cd10049    75 PDPRSQPVLLQYSLNGGLTWSLLQEFLFSNSsNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 120.78 E-value: 9.13e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2336 WLLHPGGTKMPVCGSTGDALVFIEKA-STRYVVTTDIAVNEDSFLQIDFAASCS-VTDSCYAIELEYSVDLGLSWHPLVR 2413
Cdd:cd10040    16 WYRIQGGQVDIDCLSMDTALMFTENIgKPRYAETWDFHVSASTFLQFELSMGCSkPYSNSHSVQLQYSLNNGRDWHLVTE 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554 2414 DCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPSYTRSQATRFRWHQPAPFDKQQTWAIDNVYIGDGCLDMCSG 2488
Cdd:cd10040    96 ECVPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGADSWAIDNVVLASGCPWMCSG 170

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 119.94 E-value: 9.37e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  720 RLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVlstcraPDQPGEGVLLH 799
Cdd:cd10050    11 RAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIP------PSNRNQGVLLE 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117320554  800 YSYDNGITWKLLEHYSYVNYHEPRIISVELPDDARQFGIQFRWWQPYHSSQGEDVWAIDEIVM 862
Cdd:cd10050    85 YSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLI 147

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 119.50 E-value: 1.79e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3267 PSYIKDNFESARVTEANWETIQGGVIGSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSPAQTDSC 3346
Cdd:cd10051     1 KTFLKERFDSEEISSDQWLSLEGGVTCTDCGVLA---EGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLC 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3347 NSdlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQP--RHNGTG-----HDQW 3419
Cdd:cd10051    78 LR----PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftISNGLVvsgteRAQW 153


                  ....*
gi 117320554 3420 ALDHV 3424
Cdd:cd10051   154 ALDNI 158

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 119.14 E-value: 1.92e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2167 PDFLKDDFEGQLES--DRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGcGKGV----- 2239
Cdd:cd10045     1 PGFLSESFNSSRLSsyHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLG-SKSVlgtcp 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 2240 -PDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNvGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILI 2314
Cdd:cd10045    80 pPDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHE-PRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 118.80 E-value: 2.59e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3266 LPSYIKDNFESARVTEANWETIQGGVI---GSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGspAQ 3342
Cdd:cd10046     1 LPSTVMSDFENQDSLETEWQEVIGGEIvkpEMGCGVIS---SGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIG--GG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3343 TDSCNSdlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALD 3422
Cdd:cd10046    76 SASCNY----PDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALD 151


                  ..
gi 117320554 3423 HV 3424
Cdd:cd10046   152 DI 153

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 115.22 E-value: 3.11e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1805 LKDDFNGNLHPDLWPEVYGAERGNLNGeTIKSGTCLIFKG-EGLRMLISRDLDCTNTMYVQFSLRFIAKGTPERSHSILL 1883
Cdd:cd08524     1 LKDDFDGYPSPDNWLLCPGGKTGTVCG-ALSSGNALVFNEpYGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 117320554 1884 QFSVSGGVTWHLMDEFYFPQTTSILFINVPLPYGAQTNATRFRLWQPYNNGKKE 1937
Cdd:cd08524    80 EYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQ 133

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 114.83 E-value: 5.29e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1609 DKFDGSIDLQaNWYRIQGGQVDIDC--LSMDTALIFTENIGkPRYAETWDFHVSASSFLQFEMNMGCSKPFSGAHGIQLQ 1686
Cdd:cd08524     3 DDFDGYPSPD-NWLLCPGGKTGTVCgaLSSGNALVFNEPYG-PRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1687 YSLNNGKDWQLVTEecvpptigcvhytesstYTSERFQNWRRVTVYLPLATNSPRTRFRWIQTNYTVGADS-WAIDNVIL 1765
Cdd:cd08524    81 YSVDNGASWHLLEE-----------------IRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQAtWAIDNVLI 143

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 113.37 E-value: 1.85e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2167 PDFLKDDFEGQLeSDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLG-------CGKgv 2239
Cdd:cd10047     1 PSEFFDRFEGKL-SPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGsklngetCLR-- 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 2240 PDPRSQPVLLQYSLNGGLSWSLLQEFLFSnSSNVGRYIALEMPLKARSGSTRLRWWQPSENGHfYSPWVIDQILIG 2315
Cdd:cd10047    78 PRSRNEGIIVQYSNDNGITWHLLRELDFM-SYLEPQVISIELPREAKTPATAFRWWQPQHGKP-SAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 112.67 E-value: 3.79e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1066 LPSTIMSDFENPSSWESdWQEVIGGEvvKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIggesaACN 1145
Cdd:cd10048     1 LPSVLKDDFNGNLRPDL-WPEVYGAE--RGNLNGETIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF-----ITK 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554 1146 KPDSREEGILLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1220
Cdd:cd10048    73 GTPERSHSVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVI 147

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 111.75 E-value: 6.76e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3270 IKDNFESArVTEANWETIQGGVIGSGCGQLApyaHGDSLYFNGCQ-IRQAATKPLDLTRASKIMFVLQIGSPAQTDSCns 3348
Cdd:cd08524     1 LKDDFDGY-PSPDNWLLCPGGKTGTVCGALS---SGNALVFNEPYgPRELVTTDLNTNEASFLQFYIGSGCSTPSYSN-- 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 3349 dlsgphtvdKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHV 3424
Cdd:cd08524    75 ---------QPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNV 141

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 111.54 E-value: 1.59e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  559 FHVLPvlpstmSHMIQFSINLGCG-THQPGNSVSLEFSTNHGRSWSLLHTECLPEICAGPHLPHSTVYSSENYSGWNRIT 637
Cdd:cd10040    52 FHVSA------STFLQFELSMGCSkPYSNSHSVQLQYSLNNGRDWHLVTEECVPPAIGCLHYTESSVYSSERFQNWKRIT 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 117320554  638 IPLPNAALTRDTRIRWRQTGPILG-NMWAIDNVYIGPSCLKFCSG 681
Cdd:cd10040   126 VYLPPATISPRTRFRWIQPNYAPGaDSWAIDNVVLASGCPWMCSG 170

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 109.89 E-value: 4.30e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2891 TFLKERFDSEEIKPDLWMSLEGGSTCTECGVL---AENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCH 2967
Cdd:cd10052     2 SYIKDNFESGSVSELKWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSCN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2968 ----RPVCRKEGVLLDFSTDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPfvisnglVVSGVERAQWA 3043
Cdd:cd10052    82 inlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQP-------RHDGTGHDQWA 154


                  ....
gi 117320554 3044 LDNI 3047
Cdd:cd10052   155 LDNV 158

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 108.34 E-value: 1.38e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2167 PDFLKDDFE-GQLESDRFLLMSGGKPSRKCGILS---SGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLG-------C 2235
Cdd:cd10052     1 PSYIKDNFEsGSVSELKWSLIQGGGIGSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsC 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 2236 GKGV--PDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNvGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQI 2312
Cdd:cd10052    81 NINLssPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMR-AQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 107.61 E-value: 1.67e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1801 LPSILKDDFNGNLHPDLWPEVYGAERGNLNGEtIKSGTCLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTPE-RSH 1879
Cdd:cd10050     1 LPTQLKDTFNRAPSSSNWLTVVGGKLSTVCGA-VASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSnRNQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 117320554 1880 SILLQFSVSGGVTWHLMDEFYFPQTTSILFINVPLPYGAQTNATRFRLWQPYNNG 1934
Cdd:cd10050    80 GVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDG 134

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 106.90 E-value: 3.76e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1453 DRFEGKL-SPLWYKITGGQVGTGCGTLNDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGsktsgitCIK--PRARN 1529
Cdd:cd10049     7 DDFEGQLeSDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-------CGKgvPDPRS 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554 1530 EGLVVQYSNDNGILWHLLRELDFM-SFLEPQIISIDLPREAKTPATAFRWWQP-QHGKHSAQWALDDVLIG 1598
Cdd:cd10049    80 QPVLLQYSLNGGLTWSLLQEFLFSnSSNVGRYVALEIPLKARSPSTRLRWWQPsENGHFYSPWVIDQILIG 150

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 106.10 E-value: 6.89e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  926 SYMIQFSLVMGCGqkyTPHMDNQVKLEYSANHGLTWHLVQEECLPSMPSCQEFTSASIYHASEFTQWRRVTVVLPQKTWS 1005
Cdd:cd10037    44 THFAQFSINLGCG---SHQPGNSVSLEFSTNHGRSWSLLHTECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALT 120

                          90       100
                  ....*....|....*....|....*.
gi 117320554 1006 GATRFRWSQSYYTAQDEWALDNIYIG 1031
Cdd:cd10037   121 SATRFRWRQTGSVVGSMWAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 106.16 E-value: 1.02e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2327 DFSTL-DSRKWLLHPGGTKMPVCGS------TGDALvfiEKASTRYVVTTDIAVNEDSFLQIDFAASCSVTDSC---YAI 2396
Cdd:cd10038     6 DFSNLvEVTQSLGFYLGNVQPYCNHdwtlcfTGDSK---HASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPhmdNQV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2397 ELEYSVDLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPSYTRSQATRFRWHQpAPFDKQQTWAIDNV 2476
Cdd:cd10038    83 KLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQ-SYYTDQDEWALDNI 161


                  ....*.
gi 117320554 2477 YIGDGC 2482
Cdd:cd10038   162 YIGQQC 167

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 106.41 E-value: 1.04e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1276 SAMVFGKSD-GDRFAVTRDLTLKPGYVLQFKLNIGCTSQFSSTAPVLLQYSHDAGMSWFLVKEGCFpaSAGKGCEGNSRE 1354
Cdd:cd10041    39 SAMVFVSSElGEHSITTRDLDVNENTIIQFEINVGCTTESSSADPVRLEFSRDFGATWHLLLPLCY--GSSSISSLCSTE 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 1355 LSEPTVYYTGDFEEWTRITIAIPRSLASSKTRFRWIQE-SSSQKNVPPFGLDGVYI 1409
Cdd:cd10041   117 LHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGfHPAGSQPVTWAIDNVYI 172

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 104.61 E-value: 3.37e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  570 SHMIQFSINLGCGTH-QPG--NSVSLEFSTNHGRSWSLLHTECLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALT 646
Cdd:cd10038    59 SYMIQFSLVMGCGQQyTPHmdNQVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWS 138

                          90       100
                  ....*....|....*....|....*....
gi 117320554  647 RDTRIRWRQTGPILGNMWAIDNVYIGPSC 675
Cdd:cd10038   139 SATRFRWSQSYYTDQDEWALDNIYIGQQC 167

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 104.61 E-value: 3.99e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1240 FYEKpaFDYPMNQMSVWLMLANegmAKNDSFCATTPSAMVFGKS-DGDRFAVTRDLTLKPGYVLQFKLNIGCTSQFSSTA 1318
Cdd:cd10040     2 FQDK--FDGSVDLQANWYRIQG---GQVDIDCLSMDTALMFTENiGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1319 PVLLQYSHDAGMSWFLVKEGCFPASAgkGCEgnsrELSEPTVYYTGDFEEWTRITIAIPRSLASSKTRFRWIQESSSqKN 1398
Cdd:cd10040    77 SVQLQYSLNNGRDWHLVTEECVPPAI--GCL----HYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYA-PG 149

                         170       180
                  ....*....|....*....|.
gi 117320554 1399 VPPFGLDGVYISEPCPSYCSG 1419
Cdd:cd10040   150 ADSWAIDNVVLASGCPWMCSG 170

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 103.05 E-value: 7.28e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2892 FLKERFDSEeIKPDLWMSLEGGSTCTECGVLAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGsennmtsCHR--P 2969
Cdd:cd10049     4 FLKDDFEGQ-LESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-------CGKgvP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2970 VCRKEGVLLDFSTDGGITWTLLHEMDFQKYISVRHdYILL--PEGALTNTTRLRWWQPfvisnglVVSGVERAQWALDNI 3047
Cdd:cd10049    76 DPRSQPVLLQYSLNGGLTWSLLQEFLFSNSSNVGR-YVALeiPLKARSPSTRLRWWQP-------SENGHFYSPWVIDQI 147


                  ...
gi 117320554 3048 LIG 3050
Cdd:cd10049   148 LIG 150

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 103.76 E-value: 8.44e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1265 AKNDSFCATTPSAMVFGKSDGDRF---AVTRDLTLKPGYVLQFKLNIGC--TSQFSSTAPVLLQYSHDAGM-SWFLVKEG 1338
Cdd:cd10044    26 VRTDEFCGNPSFHLTWPNKKKDKThnaLTTRQLIVQPGYMIQFKIVVGCgsVSSCGDLHPVMLEYTTDPRSdHWQLVQTE 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117320554 1339 CFPASAGK-GCEGNSreLSEPTVYYTGDFEEWTRITIAIPRSLASSKTRFRWIQESSSQKNvPPFGLDGVYISE 1411
Cdd:cd10044   106 CLPSSSNSiDCSPFQ--YHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTESTEA-PSWAIDDVYIGE 176

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 103.06 E-value: 9.30e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  911 SSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHmdnQVKLEYSANHGLTWHLVQEECLPSMPSCQEFTSASIYHASEFT 990
Cdd:cd10042    39 ASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCY---AIELEYSVDLGLSWHPLLRDCLPTNVECSSYHLQRILVSDTFN 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 117320554  991 QWRRVTVVLPQKTWSGATRFRWSQ-SYYTAQDEWALDNIYIG 1031
Cdd:cd10042   116 KWTRVTLPLPHYTRSQATRFRWHQpAPFDKQQTWAIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 102.68 E-value: 2.06e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3061 DTFDdeGSSH-EENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKThnaLSSRELIIQPGYMMQFKIVVGCeATSCGDLHS 3139
Cdd:cd10040     4 DKFD--GSVDlQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRY---AETWDFHVSASTFLQFELSMGC-SKPYSNSHS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3140 VMLEYTKDARSDsWQLVQTQCLPSSsnsIGCSPFQfhEATIYNAVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEKQ 3219
Cdd:cd10040    78 VQLQYSLNNGRD-WHLVTEECVPPA---IGCLHYT--ESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGAD 151

                         170
                  ....*....|....*....
gi 117320554 3220 SWAIDHVYIGEACPKLCSG 3238
Cdd:cd10040   152 SWAIDNVVLASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 101.82 E-value: 3.42e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  914 RYVETQSMQIGASYMIQFSLVMGCGQKYTpHMdNQVKLEYSANHGLTWHLVQEECLPSMPS---CQ----EFTSASIYHA 986
Cdd:cd10039    46 RFAVTRDLTLKPGYVLQFKVNIGCTSEFS-SF-APVLLQYSHDAGLTWSLVREGCYPASPGskgCEgssrELREPTVYHT 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 117320554  987 SEFTQWRRVTVVLPQKTWSGATRFRWSQ--SYYTAQDEWALDNIYIG 1031
Cdd:cd10039   124 GDYEDWTRITIPIPRSLAASKTRFRWIQesSSLKNAPPFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 101.82 E-value: 4.03e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3110 SRELIIQPGYMMQFKIVVGCEATSCGdLHSVMLEYTKDArSDSWQLVQTQCLPSSSNSIGC--SPFQFHEATIYNAVNSS 3187
Cdd:cd10039    50 TRDLTLKPGYVLQFKVNIGCTSEFSS-FAPVLLQYSHDA-GLTWSLVREGCYPASPGSKGCegSSRELREPTVYHTGDYE 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 117320554 3188 SWKRITIQLPDHVSSSATQFRWIQKGE-ETEKQSWAIDHVYIG 3229
Cdd:cd10039   128 DWTRITIPIPRSLAASKTRFRWIQESSsLKNAPPFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 101.14 E-value: 5.06e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1618 QANWYRIQGGQVDIDCLSMDTALIFTENiGKPRYAETWDFHVSASSFLQFEMNMGCSKPFSgAHGIQLQYSLNNGKDWQL 1697
Cdd:cd10042    11 SRKWLLHPGGTKMPVCGSTGDALVFIEK-ASTRYVVTTDIMVNEDSFLQIDFAASCSVTDS-CYAIELEYSVDLGLSWHP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 1698 VTEECVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQTNYTVGADSWAIDNV 1763
Cdd:cd10042    89 LLRDCLPTNVECSSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDNV 154

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 100.69 E-value: 5.42e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1801 LPSILKDDF-NGNLHPDLWPEVYGAE--RGNLNGETIKSGTCLIFKGEGLRMLISRDLDCTNTMYVQFSLRfIAKGTPE- 1876
Cdd:cd10046     1 LPSTVMSDFeNQDSLETEWQEVIGGEivKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQ-IGGGSASc 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117320554 1877 -----RSHSILLQFSVSGGVTWHLMDEFYFPQTTSILFINVPLPYGAQTNATRFRLWQPYNNGKKEE 1938
Cdd:cd10046    80 nypdsREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYD 146

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 100.38 E-value: 1.07e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3108 LSSRELIIQPGYMMQFKIVVGC-EATSCGDLHSVMLEYTKDaRSDSWQLVQTQCLPSSsnsIGCSpfQFHEATIYNAVNS 3186
Cdd:cd10038    49 VETQSMQIGASYMIQFSLVMGCgQQYTPHMDNQVKLEYSTN-HGLTWHLVQEECLPGM---PSCQ--EFTSGSIYHSSEF 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 117320554 3187 SSWKRITIQLPDHVSSSATQFRWIQKgEETEKQSWAIDHVYIGEACP 3233
Cdd:cd10038   123 TEWRRITLPLPQKTWSSATRFRWSQS-YYTDQDEWALDNIYIGQQCP 168

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 100.68 E-value: 1.11e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  892 QPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQVKLEYSAN-HGLTWHLVQEECLP 970
Cdd:cd10044    29 DEFCGNPSFHLTWPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVSSCGDLHPVMLEYTTDpRSDHWQLVQTECLP 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554  971 S---MPSCQEFT--SASIYHASEFTQWRRVTVVLPQKTWSGATRFRWSQ-SYYTAQDEWALDNIYIGQ 1032
Cdd:cd10044   109 SssnSIDCSPFQyhEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQkTESTEAPSWAIDDVYIGE 176

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 99.86 E-value: 1.76e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2709 NENWLFHDDCTVERFC-------DSPDGVMLCGSHDGREVYAVTHDLTPTENWIMQFKISVGCKVpEKIAQNQIHVQFST 2781
Cdd:cd10041    12 ESNWLFYPGGNTGLYCpyqskgaPEEDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTT-ESSSADPVRLEFSR 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2782 DFGVSWSYLVPQCLPADP---KCSGSVSQPSVFFP--TEGWKRITYPLPESLTGNPVRFRFYQKY-----SDVQWAIDNF 2851
Cdd:cd10041    91 DFGATWHLLLPLCYGSSSissLCSTELHPSSVYYTgtTQGWRREVILFGKLHLCGSVRFRWYQGFhpagsQPVTWAIDNV 170


                  ....
gi 117320554 2852 YLGP 2855
Cdd:cd10041   171 YIGP 174

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 97.99 E-value: 1.01e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2326 DDFSTLDSRKWLLHPGGTKMP-VCGSTGDALVFI--EKASTRYVVTT-DIAVNEDSFLQIDFAASCSVTDSC---YAIEL 2398
Cdd:cd10044     9 EDEGTSHDENWEFYPNGVRTDeFCGNPSFHLTWPnkKKDKTHNALTTrQLIVQPGYMIQFKIVVGCGSVSSCgdlHPVML 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2399 EYSVD-LGLSWHPLVRDCLPTNVE---CS--RYHLQRILVSDTFNKWTRITLPLPSYTRSQATRFRWHQPAPFDKQQTWA 2472
Cdd:cd10044    89 EYTTDpRSDHWQLVQTECLPSSSNsidCSpfQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTESTEAPSWA 168


                  ....*...
gi 117320554 2473 IDNVYIGD 2480
Cdd:cd10044   169 IDDVYIGE 176

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 97.30 E-value: 1.42e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2742 YAVTHDLTPTENWIMQFKISVGC-KVPEKIAQNQIHVQFSTDFGVSWSYLVPQCLPADPKCSgSVSQPSVFFPTE--GWK 2818
Cdd:cd10038    48 YVETQSMQIGASYMIQFSLVMGCgQQYTPHMDNQVKLEYSTNHGLTWHLVQEECLPGMPSCQ-EFTSGSIYHSSEftEWR 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 117320554 2819 RITYPLPESLTGNPVRFRFYQKY--SDVQWAIDNFYLGPGC 2857
Cdd:cd10038   127 RITLPLPQKTWSSATRFRWSQSYytDQDEWALDNIYIGQQC 167

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 95.77 E-value: 5.36e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  915 YVETQSMQIGASYMIQFSLVMGCGQKyTPHMDNQVKLEYSANHGLTWHLVQEECLPSMPSC-QEFTSASIYHASEftQWR 993
Cdd:cd10043    59 SAVTHDLTPTEGWILQFKISVGCKSS-EKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKCgGSVTQPSVFFPSK--GWR 135

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 117320554  994 RVTVVLPQKTWSGATRFRWSQSYYTAQdeWALDNIYIG 1031
Cdd:cd10043   136 RVTIPLPDKLVGRPIRFRFYQKASDMQ--WALDNFYIG 171

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 95.23 E-value: 5.53e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1802 PSILKDDF-NGNLHPDLWPEVYGAERGNLNGeTIKSGTCLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTPE---- 1876
Cdd:cd10051     1 KTFLKERFdSEEISSDQWLSLEGGVTCTDCG-VLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTlclr 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 1877 ---RSHSILLQFSVSGGVTWHLMDEFYFPQTTSILFINVPLPYGAQTNATRFRLWQPY 1931
Cdd:cd10051    80 ptcRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPF 137

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 95.37 E-value: 6.60e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1270 FCATTPSAMVFGKSD---GDRFAVTRDLTLKPGYVLQFKLNIGCTSQFSS--TAPVLLQYSHDAGMSWFLVKEGCFPASA 1344
Cdd:cd10038    27 YCNHDWTLCFTGDSKhasSARYVETQSMQIGASYMIQFSLVMGCGQQYTPhmDNQVKLEYSTNHGLTWHLVQEECLPGMP 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1345 GkgCEgnsrELSEPTVYYTGDFEEWTRITIAIPRSLASSKTRFRWIQESSSQKNvpPFGLDGVYISEPCP 1414
Cdd:cd10038   107 S--CQ----EFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQD--EWALDNIYIGQQCP 168

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 94.62 E-value: 1.08e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1270 FCATTPSAMVFGKSDGDR--FAVTRDLTLKPGYVLQFKLNIGC-TSQFSSTAPVLLQYSHDAGMSWFLVKEGCFPASAGK 1346
Cdd:cd10043    39 FCDSPDGVMICGSHDDGRevSAVTHDLTPTEGWILQFKISVGCkSSEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKC 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117320554 1347 GcegnsRELSEPTVYYTgdFEEWTRITIAIPRSLASSKTRFRWIQESSSQKnvppFGLDGVYI 1409
Cdd:cd10043   119 G-----GSVTQPSVFFP--SKGWRRVTIPLPDKLVGRPIRFRFYQKASDMQ----WALDNFYI 170

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 93.73 E-value: 1.47e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1802 PSILKDDFNGNLhPDLWPEVYGAERGNLNGeTIKSGTCLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTPE----- 1876
Cdd:cd10047     1 PSEFFDRFEGKL-SPLWYKITGGQVGTGCG-VIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGEtclrp 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 1877 --RSHSILLQFSVSGGVTWHLMDEFYFPQTTSILFINVPLPYGAQTNATRFRLWQP 1930
Cdd:cd10047    79 rsRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQP 134

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 92.25 E-value: 4.58e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1449 SEMFDRFEGKLSP-LWYKITGGQVGTGCG-TLNDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGitcikpr 1526
Cdd:cd10048     3 SVLKDDFNGNLRPdLWPEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTP------- 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554 1527 ARNEGLVVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDVLIGVN 1600
Cdd:cd10048    76 ERSHSVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNsGKKEEVWILDDLVIDGN 150

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 92.28 E-value: 5.33e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1970 NWFFYPGGNIGLYCpySSKGApeedsAMVFVSNEVGEHSITTrDLSVNENTIIQFEINVGCSTdSSSADPVRLEFSRDFG 2049
Cdd:cd10042    13 KWLLHPGGTKMPVC--GSTGD-----ALVFIEKASTRYVVTT-DIMVNEDSFLQIDFAASCSV-TDSCYAIELEYSVDLG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2050 ATWHLLLPLCYHSSSLVSSlcsteHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQgfyPAGSQP-VTWAIDNVY 2128
Cdd:cd10042    84 LSWHPLLRDCLPTNVECSS-----YHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQ---PAPFDKqQTWAIDNVY 155


                  ..
gi 117320554 2129 IG 2130
Cdd:cd10042   156 IG 157

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 91.72 E-value: 5.61e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  889 GNVQPYCG---HDWTLCFTGDSklasSMRYVETQSMQIGASYMIQFSLVMGCGqkyTPHMDNQ-VKLEYSANHGLTWHLV 964
Cdd:cd08524    20 GKTGTVCGalsSGNALVFNEPY----GPRELVTTDLNTNEASFLQFYIGSGCS---TPSYSNQpVLLEYSVDNGASWHLL 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554  965 QEeclpsmpscqeftsasiYHASEFTQWRRVTVVLPQKTWSGATRFRWSQSYYTAQDE--WALDNIYIG 1031
Cdd:cd08524    93 EE-----------------IRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQatWAIDNVLIG 144

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 91.07 E-value: 9.38e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3119 YMMQFKIVVGCeaTSCGDLHSVMLEYTKDaRSDSWQLVQTQCLPSSsnsigCSPFQFHEATIYNAVNSSSWKRITIQLPD 3198
Cdd:cd10037    45 HFAQFSINLGC--GSHQPGNSVSLEFSTN-HGRSWSLLHTECLPEL-----CAGPHLPHSTVYSSDNYSGWNRITIPLPN 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 117320554 3199 HVSSSATQFRWIQKGEETEKQsWAIDHVYIG 3229
Cdd:cd10037   117 AALTSATRFRWRQTGSVVGSM-WAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 91.81 E-value: 1.17e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1626 GGQVDIDCLSMDTALIFTENIGKpRYAETWDFHVSASSFLQFEMNMGCSKPFSGAHGIQLQYSLNNGKDWQLVTEECVPP 1705
Cdd:cd10039    23 GMGKNESCSPTPSAMVFGKSDGD-RFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPVLLQYSHDAGLTWSLVREGCYPA 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 1706 TIGCVHYT-------ESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQ-TNYTVGADSWAIDNV 1763
Cdd:cd10039   102 SPGSKGCEgssrelrEPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQeSSSLKNAPPFGLDGV 167

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 91.07 E-value: 1.18e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1660 SASSFLQFEMNMGCSKpFSGAHGIQLQYSLNNGKDWQLVTEECVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNS 1739
Cdd:cd10037    42 TVTHFAQFSINLGCGS-HQPGNSVSLEFSTNHGRSWSLLHTECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALT 120

                          90       100
                  ....*....|....*....|....*.
gi 117320554 1740 PRTRFRWIQTNYTVGaDSWAIDNVIL 1765
Cdd:cd10037   121 SATRFRWRQTGSVVG-SMWAIDNVYI 145

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 91.02 E-value: 1.62e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1802 PSILKDDFNGNL--HPDLWPEVYGAERGNLNGeTIKSGTCLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGT----- 1874
Cdd:cd10045     1 PGFLSESFNSSRlsSYHNFSSIRGGEVGFGCG-VLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVlgtcp 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554 1875 -PER-SHSILLQFSVSGGVTWHLMDEFYFPQTTSILFINVPLPYGAQTNATRFRLWQPYNNGKKE 1937
Cdd:cd10045    80 pPDRpGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQ 144

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 91.39 E-value: 1.76e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3059 LVDTFDDegSSHEENWSFYPNavrtagfcGNPSFHLYWPNKKKDKTHNAL------------SSRELIIQPGYMMQFKIV 3126
Cdd:cd10041     2 LLDTFDF--GPNESNWLFYPG--------GNTGLYCPYQSKGAPEEDSAMvfvsselgehsiTTRDLDVNENTIIQFEIN 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3127 VGCEATScGDLHSVMLEYTKDARSdSWQLVQTQCLPSSSNSIGCSpFQFHEATIYNAVNSSSWKRITIQLPDHVSSSATQ 3206
Cdd:cd10041    72 VGCTTES-SSADPVRLEFSRDFGA-TWHLLLPLCYGSSSISSLCS-TELHPSSVYYTGTTQGWRREVILFGKLHLCGSVR 148

                         170       180
                  ....*....|....*....|....*
gi 117320554 3207 FRWIQ--KGEETEKQSWAIDHVYIG 3229
Cdd:cd10041   149 FRWYQgfHPAGSQPVTWAIDNVYIG 173

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 90.33 E-value: 2.03e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  742 LASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRApdqpgegVLLHYSYDNGITWKLLEHYSYVNYHE 821
Cdd:cd10048    34 IKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHS-------VLLQYSINGGITWHLIDEFYFPTTTD 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 117320554  822 PRIISVELPDDARQFGIQFRWWQPYHSSQGEDVWAIDEIVM 862
Cdd:cd10048   107 VLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVI 147

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 90.65 E-value: 3.15e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2723 FCDSP-DGVMLCGSHDGrEVYAVTHDLTPTENWIMQFKISVGCKvPEKIAQNQIHVQFSTDFGVSWSYLVPQCLPADP-- 2799
Cdd:cd10039    28 ESCSPtPSAMVFGKSDG-DRFAVTRDLTLKPGYVLQFKVNIGCT-SEFSSFAPVLLQYSHDAGLTWSLVREGCYPASPgs 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554 2800 -KCSGS---VSQPSVFFPT--EGWKRITYPLPESLTGNPVRFRFYQKYSDVQ----WAIDNFYLG 2854
Cdd:cd10039   106 kGCEGSsreLREPTVYHTGdyEDWTRITIPIPRSLAASKTRFRWIQESSSLKnappFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 90.62 E-value: 3.19e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  916 VETQSMQIGASYMIQFSLVMGCGQKYTPhmDNQVKLEYSANHGLTWHLVQEEC----LPSMPSCQEFTSASIYHASEFTQ 991
Cdd:cd10041    53 ITTRDLDVNENTIIQFEINVGCTTESSS--ADPVRLEFSRDFGATWHLLLPLCygssSISSLCSTELHPSSVYYTGTTQG 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 117320554  992 WRRVTVVLPQKTWSGATRFRWSQSYYTAQDE---WALDNIYIG 1031
Cdd:cd10041   131 WRREVILFGKLHLCGSVRFRWYQGFHPAGSQpvtWAIDNVYIG 173

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 89.19 E-value: 5.67e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3267 PSYIKDNFESArVTEANWETIQGGVIGSGCGQLAPyahGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGspaqtdsC 3346
Cdd:cd10049     2 PDFLKDDFEGQ-LESDRFLLMSGGKPSRKCGILSS---GNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-------C 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 3347 NSdlSGPHTVDKAVLLQYSVNNGITWHVIAQ-HQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHV 3424
Cdd:cd10049    71 GK--GVPDPRSQPVLLQYSLNGGLTWSLLQEfLFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQI 147

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 89.88 E-value: 5.73e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1966 PREDNWFFYPGGNIGLYCPYSSKGapeedSAMVFVSNEvGEHSITTRDLSVNENTIIQFEINVGCSTDSSSADPVRLEFS 2045
Cdd:cd10039    11 NQMSVWLMLSNEGMGKNESCSPTP-----SAMVFGKSD-GDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPVLLQYS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2046 RDFGATWHLLLPLCYHSSSLVSS--LCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQPvTWA 2123
Cdd:cd10039    85 HDAGLTWSLVREGCYPASPGSKGceGSSRELREPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAP-PFG 163


                  ....*..
gi 117320554 2124 IDNVYIG 2130
Cdd:cd10039   164 LDGVYIS 170

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 88.45 E-value: 1.66e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3072 ENWSFYPNAVrTAGFCGNPSfHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDaRSD 3151
Cdd:cd10043    26 DHWLFHDNCS-IERFCDSPD-GVMICGSHDDGREVSAVTHDLTPTEGWILQFKISVGCKSSEKSAQQPVHVQYSTD-FGV 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 3152 SWQLVQTQCLPSSSNSIGcspfQFHEATIYNAvnSSSWKRITIQLPDHVSSSATQFRWIQKGEETEkqsWAIDHVYIG 3229
Cdd:cd10043   103 SWSYVTPQCLPSDPKCGG----SVTQPSVFFP--SKGWRRVTIPLPDKLVGRPIRFRFYQKASDMQ---WALDNFYIG 171

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 87.25 E-value: 2.37e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2889 LKTFLKERFDsEEIKPDLWMSLEGGSTCTECGVLAEN-TALYFGGSTVRQAITQDLDLRGAKFLQYWGRIgsennmtSCH 2967
Cdd:cd10048     1 LPSVLKDDFN-GNLRPDLWPEVYGAERGNLNGETIKSgTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF-------ITK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2968 RPVCRKEGVLLDFSTDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFvisnglvVSGVERAQWALDNI 3047
Cdd:cd10048    73 GTPERSHSVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPY-------NSGKKEEVWILDDL 145


                  ....
gi 117320554 3048 LIGG 3051
Cdd:cd10048   146 VIDG 149

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 87.97 E-value: 2.53e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1960 DTFDFGP--REDNWFFYPGGNIG-LYCpysskGAPEedSAMVFVSNEVG--EHSITTRDLSVNENTIIQFEINVGCSTDS 2034
Cdd:cd10044     6 ETFEDEGtsHDENWEFYPNGVRTdEFC-----GNPS--FHLTWPNKKKDktHNALTTRQLIVQPGYMIQFKIVVGCGSVS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2035 SSAD--PVRLEFSRDFGAT-WHLLLPLCYHSSSLVSSLCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQG 2111
Cdd:cd10044    79 SCGDlhPVMLEYTTDPRSDhWQLVQTECLPSSSNSIDCSPFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQK 158

                         170
                  ....*....|....*....
gi 117320554 2112 FYPAGSQPvtWAIDNVYIG 2130
Cdd:cd10044   159 TESTEAPS--WAIDDVYIG 175

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 86.84 E-value: 2.91e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2374 NEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLVRDCLPTNveCSRYHL--QRILVSDTFNKWTRITLPLPSYTR 2451
Cdd:cd10037    42 TVTHFAQFSINLGCGSHQPGNSVSLEFSTNHGRSWSLLHTECLPEL--CAGPHLphSTVYSSDNYSGWNRITIPLPNAAL 119

                          90       100
                  ....*....|....*....|....*...
gi 117320554 2452 SQATRFRWHQPAPFDKQQtWAIDNVYIG 2479
Cdd:cd10037   120 TSATRFRWRQTGSVVGSM-WAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 87.68 E-value: 2.94e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1969 DNWFFYPGGNIGLYCPysskgapEEDSAMVFVSNEVGEH-SITTRDLSVNENTIIQFEINVGC-STDSSSADPVRLEFSR 2046
Cdd:cd10043    26 DHWLFHDNCSIERFCD-------SPDGVMICGSHDDGREvSAVTHDLTPTEGWILQFKISVGCkSSEKSAQQPVHVQYST 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2047 DFGATWHLLLPLCYhssslvsslcstehhPSSTYYAGT---------TQGWRREVVHFGKLHLCGSVRFRWYQGFypags 2117
Cdd:cd10043    99 DFGVSWSYVTPQCL---------------PSDPKCGGSvtqpsvffpSKGWRRVTIPLPDKLVGRPIRFRFYQKA----- 158

                         170
                  ....*....|...
gi 117320554 2118 QPVTWAIDNVYIG 2130
Cdd:cd10043   159 SDMQWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 87.66 E-value: 3.03e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1960 DTFD-FGPREDNWFFYPGGNIGLYCPYSskgapeeDSAMVFVSNEVGEHSITTRDLSVNENTIIQFEINVGCSTDSSSAD 2038
Cdd:cd10040     4 DKFDgSVDLQANWYRIQGGQVDIDCLSM-------DTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2039 PVRLEFSRDFGATWHLLLPLCyhsssLVSSLCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQ 2118
Cdd:cd10040    77 SVQLQYSLNNGRDWHLVTEEC-----VPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGAD 151

                         170       180
                  ....*....|....*....|.
gi 117320554 2119 pvTWAIDNVYIGPQCEEMCYG 2139
Cdd:cd10040   152 --SWAIDNVVLASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 87.54 E-value: 4.35e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2323 VLEDDFSTL-DSRKWLLHPGGTKMPVC-----GSTGD--ALVFIEKASTRYVVTT-DIAVNEDSFLQIDFAASCSV-TDS 2392
Cdd:cd10041     1 LLLDTFDFGpNESNWLFYPGGNTGLYCpyqskGAPEEdsAMVFVSSELGEHSITTrDLDVNENTIIQFEINVGCTTeSSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2393 CYAIELEYSVDLGLSWHPLVRDCL---PTNVECS-RYHLQRILVSDTFNKWTRITLPLPSYTRSQATRFRWHQ---PAPf 2465
Cdd:cd10041    81 ADPVRLEFSRDFGATWHLLLPLCYgssSISSLCStELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQgfhPAG- 159

                         170
                  ....*....|....
gi 117320554 2466 DKQQTWAIDNVYIG 2479
Cdd:cd10041   160 SQPVTWAIDNVYIG 173

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.

Pssm-ID: 260081 Cd Length: 135 Bit Score: 85.90 E-value: 4.96e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554   49 GDGEQGEVLISLHIAGNptYYVPGQEYHVTIS--TSTFFDGLLVTGLYTSTSIQSSQsiggssaFGFGIMSDHQFGNQFM 126
Cdd:cd08544    12 GDPQTTPSPYSITVSGN--TYKPGQTYTVTLSgsRPTPFRGFLLQARDASSNEPVGT-------FQLPPDSGTKLLTCCP 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 117320554  127 CSVVASHVSHLPTTNLSFVWIAPPAGTGCVNFMATATHRGQVIFKDALAQQLC 179
Cdd:cd08544    83 SGNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKTLC 135

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 87.20 E-value: 5.58e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  571 HMIQFSINLGCGTHQPGN---SVSLEFSTN-HGRSWSLLHTECLP----EICAGPHLPH-STVYSSENYSGWNRITIPLP 641
Cdd:cd10044    64 YMIQFKIVVGCGSVSSCGdlhPVMLEYTTDpRSDHWQLVQTECLPsssnSIDCSPFQYHeASIYSSVNSSVWKRVTIQLP 143

                          90       100       110
                  ....*....|....*....|....*....|..
gi 117320554  642 NAALTRDTRIRWRQ-TGPILGNMWAIDNVYIG 672
Cdd:cd10044   144 DHVSSSATQFRWIQkTESTEAPSWAIDDVYIG 175

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 86.11 E-value: 8.27e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  573 IQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLHTECLPEI--CAGPHLphSTVYSSENYSGWNRITIPLPNAALTRDTR 650
Cdd:cd10042    57 LQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLLRDCLPTNveCSSYHL--QRILVSDTFNKWTRVTLPLPHYTRSQATR 134

                          90       100
                  ....*....|....*....|...
gi 117320554  651 IRWRQTGPI-LGNMWAIDNVYIG 672
Cdd:cd10042   135 FRWHQPAPFdKQQTWAIDNVYIG 157

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 85.50 E-value: 1.54e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2518 QLKDNFNRAP-SNQNWLTVSGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPSNRNQgVL 2596
Cdd:cd08525     1 VLLDTFDTLPdSNENWFFYPGGVVKNDCGSTDSALVFTENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSSSNS-VM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2597 LEYSVNGGITWNLLME----------------IFY-DQYSKPGFVNILLPPDAKEIATRFRWWQPrHDGLDQNDWAIDNV 2659
Cdd:cd08525    80 LEYSTDAGLSWHLVQEeclpsspgcselhpssVYEsSTFNGWKRITIPLPNATLSSATRFRWIQY-GYTSGVQTWAIDNV 158


                  ...
gi 117320554 2660 LIS 2662
Cdd:cd08525   159 YIG 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 84.02 E-value: 2.78e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1276 SAMVFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCTSQFSSTAPVLLQYSHDAGMSWFLVKEgcfpasagkgcegnsrel 1355
Cdd:cd08524    33 NALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLLEYSVDNGASWHLLEE------------------ 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 117320554 1356 septvYYTGDFEEWTRITIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYIS 1410
Cdd:cd08524    95 -----IRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 83.63 E-value: 3.47e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2709 NENWLFHDDCTVERFCDSP---DGVMLCGSHDGREVyaVTHDLTPTENWIMQFKISVGCKVPEKIAQNqIHVQFSTDFGV 2785
Cdd:cd08524    11 PDNWLLCPGGKTGTVCGALssgNALVFNEPYGPREL--VTTDLNTNEASFLQFYIGSGCSTPSYSNQP-VLLEYSVDNGA 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117320554 2786 SWSYLVpqclpadpkcsgsvsqpSVFFPT-EGWKRITYPLPESLTGNPVRFRFYQ----KYSDVQWAIDNFYLG 2854
Cdd:cd08524    88 SWHLLE-----------------EIRADSfSKWRIIILYLPEDAKSGATRFRWWQpnhrGVYQATWAIDNVLIG 144

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 84.60 E-value: 4.37e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2324 LEDDfsTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTR--YVVTTDIAVNEDSFLQIDFAASCSVTD--SCYAIELE 2399
Cdd:cd10043    18 PEDK--TTVNDHWLFHDNCSIERFCDSPDGVMICGSHDDGRevSAVTHDLTPTEGWILQFKISVGCKSSEksAQQPVHVQ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2400 YSVDLGLSWHPLVRDCLPTNVECSRYHLQRIlVSDTFNKWTRITLPLPSYTRSQATRFRWHQPApfdKQQTWAIDNVYIG 2479
Cdd:cd10043    96 YSTDFGVSWSYVTPQCLPSDPKCGGSVTQPS-VFFPSKGWRRVTIPLPDKLVGRPIRFRFYQKA---SDMQWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 83.80 E-value: 5.38e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1271 CATTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCTSQfSSTAPVLLQYSHDAGMSWFLVKEGCFPASAgkgcEG 1350
Cdd:cd10042    26 CGSTGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVT-DSCYAIELEYSVDLGLSWHPLLRDCLPTNV----EC 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 1351 NSRELSEptVYYTGDFEEWTRITIAIPRSLASSKTRFRWIQESSSQKNvPPFGLDGVYI 1409
Cdd:cd10042   101 SSYHLQR--ILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQ-QTWAIDNVYI 156

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 82.58 E-value: 1.85e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1612 DGSIDLQANWYRIQGGQV-DIDCLSMDTALIFT--ENIGKPRYAETWDFHVSASSFLQFEMNMGCSKPFSGA--HGIQLQ 1686
Cdd:cd10044    10 DEGTSHDENWEFYPNGVRtDEFCGNPSFHLTWPnkKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVSSCGdlHPVMLE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1687 YSLNNGKD-WQLVTEECVPPT---IGCV--HYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQTNYTVGADSWAI 1760
Cdd:cd10044    90 YTTDPRSDhWQLVQTECLPSSsnsIDCSpfQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTESTEAPSWAI 169


                  ...
gi 117320554 1761 DNV 1763
Cdd:cd10044   170 DDV 172

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 81.50 E-value: 2.49e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  422 SEEFESQPT----GWDILGAVVGADCGTVESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFVMGG-----ICDPGVSHE 492
Cdd:cd08526     3 KDSFEGSLSssdnWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSksqtsTCNPPDSRS 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554  493 NDIILYAKIEGRKEHIALDTLTYSSYKVPSLVSVVINPELQTPATKFCLRQKSHQGYNRNVWAVD 557
Cdd:cd08526    83 EGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALD 147

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 81.44 E-value: 2.52e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2735 SHDG--REVYAVTH-----DLTPTENWIMQFKISVGCKVPEKiaQNQIHVQFSTDFGVSWSYLVPQCLPAdpKCSGSVSQ 2807
Cdd:cd10037    19 SHGGhnRNVWAVDFfhllpVLPSTVTHFAQFSINLGCGSHQP--GNSVSLEFSTNHGRSWSLLHTECLPE--LCAGPHLP 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 117320554 2808 PSVFFPTE---GWKRITYPLPESLTGNPVRFRFYQKYSDV--QWAIDNFYLG 2854
Cdd:cd10037    95 HSTVYSSDnysGWNRITIPLPNAALTSATRFRWRQTGSVVgsMWAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 81.11 E-value: 3.71e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2702 LEDKTSV--NENWLFHDDCTVERFCDSpDGVMLCGSHDGREVYAVTHDLTPTENWIMQFKISVGCKVPEKIAQnqIHVQF 2779
Cdd:cd10042     2 LEDDFSTldSRKWLLHPGGTKMPVCGS-TGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCYA--IELEY 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554 2780 STDFGVSWSYLVPQCLPADPKCSGSVSQPSVFFPT-EGWKRITYPLPESLTGNPVRFRFYQKYS-DVQ--WAIDNFYLG 2854
Cdd:cd10042    79 SVDLGLSWHPLLRDCLPTNVECSSYHLQRILVSDTfNKWTRVTLPLPHYTRSQATRFRWHQPAPfDKQqtWAIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 81.11 E-value: 4.21e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3064 DDEGSSHEE-NWSFYPNAVRTAgFCGNPSFHLYWpnKKKDKTHNALSSrELIIQPGYMMQFKIVVGCEAT-SCgdlHSVM 3141
Cdd:cd10042     3 EDDFSTLDSrKWLLHPGGTKMP-VCGSTGDALVF--IEKASTRYVVTT-DIMVNEDSFLQIDFAASCSVTdSC---YAIE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3142 LEYTKDArSDSWQLVQTQCLPSSsnsIGCSPFQFHEATIYNAVNSssWKRITIQLPDHVSSSATQFRWIQKGEETEKQSW 3221
Cdd:cd10042    76 LEYSVDL-GLSWHPLLRDCLPTN---VECSSYHLQRILVSDTFNK--WTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTW 149


                  ....*...
gi 117320554 3222 AIDHVYIG 3229
Cdd:cd10042   150 AIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 81.40 E-value: 4.22e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  557 DFFHVLPVLPSTMSHMIQFSINLGCGTHQPG-NSVSLEFSTNHGRSWSLLHTECLP-----EIC--AGPHLPHSTVYSSE 628
Cdd:cd10039    45 DRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSfAPVLLQYSHDAGLTWSLVREGCYPaspgsKGCegSSRELREPTVYHTG 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 117320554  629 NYSGWNRITIPLPNAALTRDTRIRWRQTGPILGNM--WAIDNVYIG 672
Cdd:cd10039   125 DYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAppFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 81.76 E-value: 4.42e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  570 SHMIQFSINLGCGTHQPG-NSVSLEFSTNHGRSWSLLHTEC-----LPEICAGPHLPHSTVYSSENySGWNRITIPLPNA 643
Cdd:cd10041    63 NTIIQFEINVGCTTESSSaDPVRLEFSRDFGATWHLLLPLCygsssISSLCSTELHPSSVYYTGTT-QGWRREVILFGKL 141

                          90       100       110
                  ....*....|....*....|....*....|...
gi 117320554  644 ALTRDTRIRWRQ---TGPILGNMWAIDNVYIGP 673
Cdd:cd10041   142 HLCGSVRFRWYQgfhPAGSQPVTWAIDNVYIGP 174

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 79.96 E-value: 1.34e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1977 GNIGLYCPYSS----KGAPEEDSAMVFVSnevgehsitTRDLSVNENTIIQFEINVGCSTDSSSA--DPVRLEFSRDFGA 2050
Cdd:cd10038    22 GNVQPYCNHDWtlcfTGDSKHASSARYVE---------TQSMQIGASYMIQFSLVMGCGQQYTPHmdNQVKLEYSTNHGL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2051 TWHLLLPLCyhsssLVSSLCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSqpvTWAIDNVYIG 2130
Cdd:cd10038    93 TWHLVQEEC-----LPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQD---EWALDNIYIG 164


                  ...
gi 117320554 2131 PQC 2133
Cdd:cd10038   165 QQC 167

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 79.86 E-value: 1.48e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2341 GGTKMPVCGSTGDALVFIEKASTRYVVTTDIAVNEDSFLQIDFAASCSVTDSCYA-IELEYSVDLGLSWHpLVRD-CLP- 2417
Cdd:cd10039    23 GMGKNESCSPTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFApVLLQYSHDAGLTWS-LVREgCYPa 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554 2418 --TNVEC----------SRYHlqrilvSDTFNKWTRITLPLPSYTRSQATRFRWHQPA-PFDKQQTWAIDNVYIG 2479
Cdd:cd10039   102 spGSKGCegssrelrepTVYH------TGDYEDWTRITIPIPRSLAASKTRFRWIQESsSLKNAPPFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 79.48 E-value: 2.07e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2169 FLKDDFEGQL-ESDRFLLMSGGKPSRKCGILSSGNNLFFNE-DGLRMLVTRDLDLSHARFVQFFMRLGCGKGVPdpRSQP 2246
Cdd:cd10039     1 YEKPAFDYPLnQMSVWLMLSNEGMGKNESCSPTPSAMVFGKsDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFS--SFAP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2247 VLLQYSLNGGLSWSLLQEFLFSNSS------------------NVGRY-----IALEMPLKARSGSTRLRWWQPSENGHF 2303
Cdd:cd10039    79 VLLQYSHDAGLTWSLVREGCYPASPgskgcegssrelreptvyHTGDYedwtrITIPIPRSLAASKTRFRWIQESSSLKN 158

                         170
                  ....*....|..
gi 117320554 2304 YSPWVIDQILIG 2315
Cdd:cd10039   159 APPFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 79.18 E-value: 2.45e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2711 NWLFHDDCTVERFCDSPDGVMLCGSHDGREVYAVTHDLTPTENWIMQFKISVGCKVPEKiAQNQIHVQFSTDFGVSWSYL 2790
Cdd:cd10040    15 NWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYS-NSHSVQLQYSLNNGRDWHLV 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 2791 VPQCLPADPKCSgSVSQPSVFFPT--EGWKRITYPLPESLTGNPVRFRFYQKYSDV---QWAIDNFYLGPGCLDNCGG 2863
Cdd:cd10040    94 TEECVPPAIGCL-HYTESSVYSSErfQNWKRITVYLPPATISPRTRFRWIQPNYAPgadSWAIDNVVLASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 78.80 E-value: 4.36e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2521 DNFNRAPSNQ-NWLTVSGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPSNrNQGVLLEY 2599
Cdd:cd10040     4 DKFDGSVDLQaNWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSN-SHSVQLQY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2600 SVNGGITWNLLME---------IFYDQ---YSKPGFVN-----ILLPPDAKEIATRFRWWQPrHDGLDQNDWAIDNVLIS 2662
Cdd:cd10040    83 SLNNGRDWHLVTEecvppaigcLHYTEssvYSSERFQNwkritVYLPPATISPRTRFRWIQP-NYAPGADSWAIDNVVLA 161

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 77.62 E-value: 5.21e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3266 LPSYIKDNF-ESARVTEanWETIQGGVIGSGCGQlaPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIgspaqtd 3344
Cdd:cd10048     1 LPSVLKDDFnGNLRPDL--WPEVYGAERGNLNGE--TIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF------- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320554 3345 SCNSDLSGPHtvdkAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALD 3422
Cdd:cd10048    70 ITKGTPERSH----SVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILD 143

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 78.44 E-value: 5.59e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  572 MIQFSINLGCG--THQPGNSVSLEFSTNHGRSWSLLHTECLP-EICAGPHLPHSTVYSSENysGWNRITIPLPNAALTRD 648
Cdd:cd10043    72 ILQFKISVGCKssEKSAQQPVHVQYSTDFGVSWSYVTPQCLPsDPKCGGSVTQPSVFFPSK--GWRRVTIPLPDKLVGRP 149

                          90       100
                  ....*....|....*....|....
gi 117320554  649 TRIRWRQTGPILgnMWAIDNVYIG 672
Cdd:cd10043   150 IRFRFYQKASDM--QWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 77.21 E-value: 6.55e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1286 DRFAVTRDLTLKPGYVLQFKLNIGCTSQfSSTAPVLLQYSHDAGMSWFLVKEGCFPASagkgCEGNsrELSEPTVYYTGD 1365
Cdd:cd10037    31 DFFHLLPVLPSTVTHFAQFSINLGCGSH-QPGNSVSLEFSTNHGRSWSLLHTECLPEL----CAGP--HLPHSTVYSSDN 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 117320554 1366 FEEWTRITIAIPRSLASSKTRFRWIQESSSQKNVppFGLDGVYI 1409
Cdd:cd10037   104 YSGWNRITIPLPNAALTSATRFRWRQTGSVVGSM--WAIDNVYI 145

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 78.29 E-value: 6.79e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1608 QDKFD-GSIDlqANWYRIQGGQVDIDCLSM-------DTALIFTENIGKPRYAETWDFHVSASSFLQFEMNMGCSKPFSG 1679
Cdd:cd10041     3 LDTFDfGPNE--SNWLFYPGGNTGLYCPYQskgapeeDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTTESSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1680 AHGIQLQYSLNNGKDWQLVTEECV---PPTIGC-VHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQTNYTVG- 1754
Cdd:cd10041    81 ADPVRLEFSRDFGATWHLLLPLCYgssSISSLCsTELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGFHPAGs 160

                         170
                  ....*....|
gi 117320554 1755 -ADSWAIDNV 1763
Cdd:cd10041   161 qPVTWAIDNV 170

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 76.70 E-value: 9.48e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  573 IQFSINLGCGTHQPGN-SVSLEFSTNHGRSWSLLHTeclpeicagphlphstvYSSENYSGWNRITIPLPNAALTRDTRI 651
Cdd:cd08524    59 LQFYIGSGCSTPSYSNqPVLLEYSVDNGASWHLLEE-----------------IRADSFSKWRIIILYLPEDAKSGATRF 121

                          90       100
                  ....*....|....*....|...
gi 117320554  652 RWRQTGP--ILGNMWAIDNVYIG 672
Cdd:cd08524   122 RWWQPNHrgVYQATWAIDNVLIG 144

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 77.20 E-value: 9.73e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1611 FDGSIDLQANWYRIQGGQV---DIDCLSMDTALIFTENIGKPRYAETWDFHVSASSFLQFEMNMG-----CSKPFSGAHG 1682
Cdd:cd10046     9 FENQDSLETEWQEVIGGEIvkpEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGggsasCNYPDSREEG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1683 IQLQYSLNNGKDWQLVTEecvpptigcVHYtesSTYTSERFqnwrrVTVYLPLATNSPRTRFRWIQTNYT-VGADSWAID 1761
Cdd:cd10046    89 VLLQYSNNGGISWKLLAE---------MYF---SDFSKPRF-----VYLELPTAAKTPCTRFRWWQPVFSgEGYDQWALD 151


                  ....
gi 117320554 1762 NVIL 1765
Cdd:cd10046   152 DIII 155

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 75.59 E-value: 3.18e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1463 WYKITGGQVGTGCGTLNDGRSLYF-NGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITcikprarNEGLVVQYSNDNG 1541
Cdd:cd10036    18 WSECCGCNVGEQCGVIMHGNALTFcEPYGPRELITVPLNTTTASVLQFAIGSGSCRFSYS-------DPSIIVSYAVNNT 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1542 IL-WHLLRELDFMSFLEPQIISIDLPREAKTPATAFRWWQ--PQHGKH-SAQWALDDVLI 1597
Cdd:cd10036    91 SSdWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQeaPNAGEVyESCWALDNVLI 150

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 75.26 E-value: 3.60e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2322 TVLEDDFSTLDS-RKWLLHPGGTKMPVCG--STGDALVFiEKASTRYVVTTDIAVNEDSFLQIDFAASCSVTDSC--YAI 2396
Cdd:cd10050     3 TQLKDTFNRAPSsSNWLTVVGGKLSTVCGavASGTALHF-SGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNrnQGV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2397 ELEYSVDLGLSWHPLVRdclptnvecsryhlqriLVSDTFNKWTRITLPLPSYTRSQATRFRWHQPApFD--KQQTWAID 2474
Cdd:cd10050    82 LLEYSVNGGITWNLLME-----------------IFYDQYSKPGFVNILLPPEARGVGTRFRWWQPS-HDglDQNDWAID 143


                  ....*
gi 117320554 2475 NVYIG 2479
Cdd:cd10050   144 NVLIG 148

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 74.87 E-value: 8.79e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2699 EMFLEDKTSVNENWLFHDDCTV-ERFCDSPDGVMLCGSH--DGREVYAVTHDLTPTENWIMQFKISVGCK-VPEKIAQNQ 2774
Cdd:cd10044     6 ETFEDEGTSHDENWEFYPNGVRtDEFCGNPSFHLTWPNKkkDKTHNALTTRQLIVQPGYMIQFKIVVGCGsVSSCGDLHP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2775 IHVQFSTD-FGVSWSYLVPQCLPAD---PKCSG-SVSQPSVFFPTEG--WKRITYPLPESLTGNPVRFRFYQKYSDV--- 2844
Cdd:cd10044    86 VMLEYTTDpRSDHWQLVQTECLPSSsnsIDCSPfQYHEASIYSSVNSsvWKRVTIQLPDHVSSSATQFRWIQKTESTeap 165

                         170
                  ....*....|
gi 117320554 2845 QWAIDNFYLG 2854
Cdd:cd10044   166 SWAIDDVYIG 175

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 73.33 E-value: 1.74e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1605 TGFQDKFDGSIDLQaNWYRIQGGQVDIDC--LSMDTALIFTEniGKPRYAETWDFHVSASSFLQFEMNMGC-SKPFSGAH 1681
Cdd:cd10050     3 TQLKDTFNRAPSSS-NWLTVVGGKLSTVCgaVASGTALHFSG--GCSRQLVTVDLNLTNAEFVQFYFMYGClIPPSNRNQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1682 GIQLQYSLNNGKDWQLVTEecvpptigcVHYTEsstYTSERFqnwrrVTVYLPLATNSPRTRFRWIQTNYT-VGADSWAI 1760
Cdd:cd10050    80 GVLLEYSVNGGITWNLLME---------IFYDQ---YSKPGF-----VNILLPPEARGVGTRFRWWQPSHDgLDQNDWAI 142


                  ....*.
gi 117320554 1761 DNVILA 1766
Cdd:cd10050   143 DNVLIG 148

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 72.91 E-value: 3.25e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  422 SEEFE-----SQPTGWDILGAVVGADCGTVESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFVMG-----GICDPGVSH 491
Cdd:cd10045     5 SESFNssrlsSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGsksvlGTCPPPDRP 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554  492 ENDIILYAKIEGRKEHIALDTLTYSSYKVPSLVSVVINPELQTPATKFCLRQKSHQGYNRNVWAVD 557
Cdd:cd10045    85 GEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALD 150

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 72.57 E-value: 3.84e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  424 EFESQ----PTGWDILGAVVGAD---CGTVESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFVMGG---ICDPGVSHEN 493
Cdd:cd10046     8 DFENQdsleTEWQEVIGGEIVKPemgCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGgsaSCNYPDSREE 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117320554  494 DIILYAKIEGRKEHIALDTLTYSSYKVPSLVSVVINPELQTPATKFCLRQKSHQGYNRNVWAVD 557
Cdd:cd10046    88 GVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALD 151

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 72.02 E-value: 7.19e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3269 YIKDNFESARVTEANWETIQGGVIGSGCGqlapyAHGDSLYFNGCQI--RQAATKPLDLTRASKIMFVLQIGSPAQTDSC 3346
Cdd:cd08525     1 VLLDTFDTLPDSNENWFFYPGGVVKNDCG-----STDSALVFTENIGgeRYAVTRDLTVNEGYMLQFKINVGCSSTFSSS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3347 NSdlsgphtvdkaVLLQYSVNNGITWHVIAQ-----------------HQPKDFTQAQRVSYNVPLEARMKGVLLRWWQP 3409
Cdd:cd08525    76 NS-----------VMLEYSTDAGLSWHLVQEeclpsspgcselhpssvYESSTFNGWKRITIPLPNATLSSATRFRWIQY 144

                         170
                  ....*....|....*
gi 117320554 3410 RHnGTGHDQWALDHV 3424
Cdd:cd08525   145 GY-TSGVQTWAIDNV 158

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 71.86 E-value: 1.11e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  725 HNFYSIRGAEVSFGCgvLASGKALVFNKDGRRQLITSFLD--SSQSRFLQFTLRLGsksvlstCRAPDQPGEGVLLHYSY 802
Cdd:cd10040    14 ANWYRIQGGQVDIDC--LSMDTALMFTENIGKPRYAETWDfhVSASTFLQFELSMG-------CSKPYSNSHSVQLQYSL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554  803 DNGITWKLLEH-----------------YSYVNYHEPRIISVELPDDARQFGIQFRWWQPYHSSqGEDVWAIDEIVMTS 864
Cdd:cd10040    85 NNGRDWHLVTEecvppaigclhytessvYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAP-GADSWAIDNVVLAS 162

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 70.66 E-value: 1.32e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2017 NENTIIQFEINVGCSTdSSSADPVRLEFSRDFGATWHLL----LP-LCyhssslvsslcSTEHHPSSTYYAGTT-QGWRR 2090
Cdd:cd10037    42 TVTHFAQFSINLGCGS-HQPGNSVSLEFSTNHGRSWSLLhtecLPeLC-----------AGPHLPHSTVYSSDNySGWNR 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 117320554 2091 EVVHFGKLHLCGSVRFRWYQGFYPAGSQpvtWAIDNVYIG 2130
Cdd:cd10037   110 ITIPLPNAALTSATRFRWRQTGSVVGSM---WAIDNVYIG 146

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 70.48 E-value: 2.26e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1073 DFENPSSWESDWQEVIGGEVvkpEQGCGvvSSGSSLYF--SKAGKRQLVSWDLDTSWVDFVQFYIQIGgesaaCNKPDSR 1150
Cdd:cd08525     5 TFDTLPDSNENWFFYPGGVV---KNDCG--STDSALVFteNIGGERYAVTRDLTVNEGYMLQFKINVG-----CSSTFSS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1151 EEGILLQYSNNGGIQWHLLAE-----------------MYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDyDQW 1213
Cdd:cd08525    75 SNSVMLEYSTDAGLSWHLVQEeclpsspgcselhpssvYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGV-QTW 153


                  ....*..
gi 117320554 1214 AVDDIII 1220
Cdd:cd08525   154 AIDNVYI 160

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 69.81 E-value: 2.85e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1073 DFENPSSWESD---WQEVIGGEVvkpEQGCGVVSSGSSLYFSKA-GKRQLVSWDLDTSWVDFVQFYIQIGgesaACnKPD 1148
Cdd:cd10036     4 DFDSYPLLELNnniWSECCGCNV---GEQCGVIMHGNALTFCEPyGPRELITVPLNTTTASVLQFAIGSG----SC-RFS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1149 SREEGILLQYS-NNGGIQWHLLAEMyfsdfSKPRFVY-----LELPAAAKTPCTRFRWWQPVFSGEDYDQ--WAVDDIII 1220
Cdd:cd10036    76 YSDPSIIVSYAvNNTSSDWITLEKI-----RAPSNGStiihiIPLPTDAKQDNVSFRFRQEAPNAGEVYEscWALDNVLI 150


                  .
gi 117320554 1221 L 1221
Cdd:cd10036   151 I 151

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 70.35 E-value: 3.74e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1647 GKPRYAETWDFHVSASSFLQFEMNMGCSKPFSGAHG-IQLQYSLNNGKDWQLVTEECVPPTIGCvhyTESSTYTSERF-- 1723
Cdd:cd10043    55 GREVSAVTHDLTPTEGWILQFKISVGCKSSEKSAQQpVHVQYSTDFGVSWSYVTPQCLPSDPKC---GGSVTQPSVFFps 131

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 117320554 1724 QNWRRVTVYLPLATNSPRTRFRWIQTNYTVgadSWAIDNVIL 1765
Cdd:cd10043   132 KGWRRVTIPLPDKLVGRPIRFRFYQKASDM---QWALDNFYI 170

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 69.85 E-value: 4.52e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2527 PSNQN--WLTVSGGKLSTVCGAVASGLALHF--SGGcSRLLVTVDLNLTNAEFIQFYFMYGCLITPSNRNQgVLLEYSVN 2602
Cdd:cd10039     9 PLNQMsvWLMLSNEGMGKNESCSPTPSAMVFgkSDG-DRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAP-VLLQYSHD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2603 GGITWNLLMEIFY------------------------DQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDN 2658
Cdd:cd10039    87 AGLTWSLVREGCYpaspgskgcegssrelreptvyhtGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAPPFGLDG 166


                  ....
gi 117320554 2659 VLIS 2662
Cdd:cd10039   167 VYIS 170

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 69.55 E-value: 6.12e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1081 ESDWQEVIGGEVvkpEQGCgvVSSGSSLYF-SKAGK-RQLVSWDLDTSWVDFVQFYIQIGgesaaCNKPDSREEGILLQY 1158
Cdd:cd10040    13 QANWYRIQGGQV---DIDC--LSMDTALMFtENIGKpRYAETWDFHVSASTFLQFELSMG-----CSKPYSNSHSVQLQY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1159 SNNGGIQWHLLAEMYF------------SDFSKPRF-----VYLELPAAAKTPCTRFRWWQPVFsGEDYDQWAVDDIIIL 1221
Cdd:cd10040    83 SLNNGRDWHLVTEECVppaigclhytesSVYSSERFqnwkrITVYLPPATISPRTRFRWIQPNY-APGADSWAIDNVVLA 161


                  .
gi 117320554 1222 S 1222
Cdd:cd10040   162 S 162

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 68.41 E-value: 8.91e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  565 LPSTMSHMIQFSINLGCG--------THQPGNSVSLEFSTNHGRSWSLLHteclpeicagpHLPHStvysseNYSGWNRI 636
Cdd:cd08526    52 LDLTNARFVQFYLRIGSKsqtstcnpPDSRSEGVLLQYSVNGGITWHLLQ-----------ELYYD------QYSEPRFV 114

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 117320554  637 TIPLPNAALTRDTRIRWRQTGPILGNM--WAIDNVYIG 672
Cdd:cd08526   115 SIELPLEARTNGTRFRWWQPSHSGKGQdqWALDNILIG 152

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 68.27 E-value: 1.07e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2519 LKDNFNRAP----SNQNWLTVSGGKLSTVCGAVASGLALHFSGGC-SRLLVTVDLNLTNAEFIQFYFMYGClITPSNRNQ 2593
Cdd:cd10036     1 LRDDFDSYPllelNNNIWSECCGCNVGEQCGVIMHGNALTFCEPYgPRELITVPLNTTTASVLQFAIGSGS-CRFSYSDP 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554 2594 GVLLEYSVNGG-ITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQ--PRHDGLDQNDWAIDNVLI 2661
Cdd:cd10036    80 SIIVSYAVNNTsSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQeaPNAGEVYESCWALDNVLI 150

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 68.67 E-value: 1.07e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1802 PSILKDDFNGNLHPDL-WPEVYGAERGNLNGETIK--SGTCLIFKGEGLRMLISRDLDCTNTMYVQFSLRF--------- 1869
Cdd:cd10052     1 PSYIKDNFESGSVSELkWSLIQGGGIGSGCGQLAPhaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIgsrsqtdsc 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117320554 1870 -IAKGTPE-RSHSILLQFSVSGGVTWHLMDE-----FYFPQTtsiLFINVPLPygAQTNATRFRLWQPYNNGK 1935
Cdd:cd10052    81 nINLSSPRaVDKAVLLQYSVNNGITWYLIAQhqpkdFMRAQR---VSYNLPLE--ARTKGVVLRWWQPRHDGT 148

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 67.50 E-value: 2.02e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3271 KDNFESARVTEAN---WETIQGGVIGSGCGQLApyaHGDSLYFngCQI---RQAATKPLDLTRASKIMFVLQIGspaqtd 3344
Cdd:cd10036     2 RDDFDSYPLLELNnniWSECCGCNVGEQCGVIM---HGNALTF--CEPygpRELITVPLNTTTASVLQFAIGSG------ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3345 SCNSDLSGPHTVdkavlLQYSVNNG-ITWHVIAqhQPKDFTQAQRVSYNVPL--EARMKGVLLRWWQPRHNGTGHDQ--W 3419
Cdd:cd10036    71 SCRFSYSDPSII-----VSYAVNNTsSDWITLE--KIRAPSNGSTIIHIIPLptDAKQDNVSFRFRQEAPNAGEVYEscW 143


                  ....*...
gi 117320554 3420 ALDHVEVV 3427
Cdd:cd10036   144 ALDNVLII 151

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 66.08 E-value: 7.70e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2170 LKDDFEgQLESDRFLLMSGGKPSRKCGilSSGNNLFFNEDG-LRMLVTRDLDLSHARFVQFFMRLGCGkgVPDpRSQPVL 2248
Cdd:cd10042     2 LEDDFS-TLDSRKWLLHPGGTKMPVCG--STGDALVFIEKAsTRYVVTTDIMVNEDSFLQIDFAASCS--VTD-SCYAIE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2249 LQYSLNGGLSWS----------------LLQEFLFSNSSNVGRYIALEMPLKARSGSTRLRWWQPS--ENGHfysPWVID 2310
Cdd:cd10042    76 LEYSVDLGLSWHpllrdclptnvecssyHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPApfDKQQ---TWAID 152


                  ....*
gi 117320554 2311 QILIG 2315
Cdd:cd10042   153 NVYIG 157

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 65.14 E-value: 9.84e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3059 LVDTFDdeGSSHEENWSFYPNAvRTAGFCGNPSfhlywpnkkkdkTHNAL------SSRELIIQP-----GYMMQFKIVV 3127
Cdd:cd08524     1 LKDDFD--GYPSPDNWLLCPGG-KTGTVCGALS------------SGNALvfnepyGPRELVTTDlntneASFLQFYIGS 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3128 GCEATSCGDlHSVMLEYTKDArSDSWQLVQTqclpsssnsigcspfqfheatiYNAVNSSSWKRITIQLPDHVSSSATQF 3207
Cdd:cd08524    66 GCSTPSYSN-QPVLLEYSVDN-GASWHLLEE----------------------IRADSFSKWRIIILYLPEDAKSGATRF 121

                         170       180
                  ....*....|....*....|...
gi 117320554 3208 RWIQKGEETEKQS-WAIDHVYIG 3229
Cdd:cd08524   122 RWWQPNHRGVYQAtWAIDNVLIG 144

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 65.57 E-value: 1.08e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1605 TGFQDKFDGSIDLQANWYRIQGGQVDIDC--LSMDTALIFteniGKP--RYAETWDFHVSASSFLQFEMNMG-------C 1673
Cdd:cd10051     2 TFLKERFDSEEISSDQWLSLEGGVTCTDCgvLAEGDALYF----GGSgaRQAVTQDLDLRGAKFVQYWARIGsennmtlC 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1674 SKPFSGAHGIQLQYSLNNGKDWQLVTEecvpptigcVHYtesstytsERFQNWRRVTVYLPLATNSPRTRFRWIQ----T 1749
Cdd:cd10051    78 LRPTCRKEGVLLQYSTDGGISWTLLHE---------LDY--------QKYISVRYDYITLPENARTNSTRLRWWQpftiS 140

                         170       180
                  ....*....|....*....|
gi 117320554 1750 NYTVGADS----WAIDNVIL 1765
Cdd:cd10051   141 NGLVVSGTeraqWALDNILI 160

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 65.20 E-value: 1.64e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  883 SLGFYLGNVQPYcGHDWTLCFTGdsklaSSMRYVETQSMQIGASYMIQFSLVMG-------CGQKYT-PH-MDNQVKLEY 953
Cdd:cd10052    25 GIGSGCGQLAPH-AHGDSLYFNG-----CGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsCNINLSsPRaVDKAVLLQY 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117320554  954 SANHGLTWHLVQEeclpsmpscqeftsasiYHASEFTQWRRVTVVLPQKTWSGATRFRWSQSYY--TAQDEWALDNI 1028
Cdd:cd10052    99 SVNNGITWYLIAQ-----------------HQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHdgTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 64.53 E-value: 2.00e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1608 QDKFDGSIDLQaNWYRIQGGQVDIDC--LSMDTALIFTENigKPRYAETWDFHVSASSFLQFEMNMGCSK--PFSGAHGI 1683
Cdd:cd10049     6 KDDFEGQLESD-RFLLMSGGKPSRKCgiLSSGNNLFFNED--GLRMLVTRDLDLSMARFVQFFMRLGCGKgvPDPRSQPV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1684 QLQYSLNNGKDWQLVTEecvpptigcVHYTESSTYTserfqnwRRVTVYLPLATNSPRTRFRWIQTNYTvGA--DSWAID 1761
Cdd:cd10049    83 LLQYSLNGGLTWSLLQE---------FLFSNSSNVG-------RYVALEIPLKARSPSTRLRWWQPSEN-GHfySPWVID 145


                  ....
gi 117320554 1762 NVIL 1765
Cdd:cd10049   146 QILI 149

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 64.47 E-value: 2.15e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  929 IQFSLVMGCgqKYTPHMDNQ-VKLEYSANHGLTWHLVQEeclpsmpscqeftsasIYHaSEFTQWRRVTVVLPQKTWSGA 1007
Cdd:cd10050    62 VQFYFMYGC--LIPPSNRNQgVLLEYSVNGGITWNLLME----------------IFY-DQYSKPGFVNILLPPEARGVG 122

                          90       100
                  ....*....|....*....|....*.
gi 117320554 1008 TRFRWSQSYYTA--QDEWALDNIYIG 1031
Cdd:cd10050   123 TRFRWWQPSHDGldQNDWAIDNVLIG 148

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 64.93 E-value: 2.68e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1452 FDRFEGK--LSPLWYKITGGQVGTGCGTLNDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGsktsgitCIKPRARN 1529
Cdd:cd10040     3 QDKFDGSvdLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMG-------CSKPYSNS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1530 EGLVVQYSNDNGILWHLLRE------LDFMSFLEPQI-----------ISIDLPREAKTPATAFRWWQPQHGKHSAQWAL 1592
Cdd:cd10040    76 HSVQLQYSLNNGRDWHLVTEecvppaIGCLHYTESSVysserfqnwkrITVYLPPATISPRTRFRWIQPNYAPGADSWAI 155


                  ....*.
gi 117320554 1593 DDVLIG 1598
Cdd:cd10040   156 DNVVLA 161

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 64.17 E-value: 3.00e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  203 LRDDFDSyqQLELNPNiWVECSNCEMGEQCGTIMHGNAVTFCEPyGPRELTTTCLNTTTASVLQFS--IGSGSCRFSYSD 280
Cdd:cd08526     2 LKDSFEG--SLSSSDN-WSLVSGGEVGTGCGVLASGKALYFNGP-GLRQLVTVDLDLTNARFVQFYlrIGSKSQTSTCNP 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117320554  281 P-----SITVSYAKNNTADWIQLEKIrAPSNVSTVIHILY-LPEEAKGESVQFQWKQDSlrVGEVYEACWALDNILV 351
Cdd:cd08526    78 PdsrseGVLLQYSVNGGITWHLLQEL-YYDQYSEPRFVSIeLPLEARTNGTRFRWWQPS--HSGKGQDQWALDNILI 151

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 62.99 E-value: 6.67e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  873 DFTNLVEVTQSLGFYLGNVQPYCGHDWT---LCFTGDSklassMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQV 949
Cdd:cd10049     8 DFEGQLESDRFLLMSGGKPSRKCGILSSgnnLFFNEDG-----LRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQPV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  950 KLEYSANHGLTWHLVQEeclpsmpscQEFTSASiyhasefTQWRRVTVVLPQKTWSGATRFRWSQ-----SYYtaqDEWA 1024
Cdd:cd10049    83 LLQYSLNGGLTWSLLQE---------FLFSNSS-------NVGRYVALEIPLKARSPSTRLRWWQpsengHFY---SPWV 143


                  ....*..
gi 117320554 1025 LDNIYIG 1031
Cdd:cd10049   144 IDQILIG 150

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 63.28 E-value: 7.07e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1607 FQDKFDGSIDLQANWYRIQGGQVDIDCLSMD-----TALIFteNIGKPRYAETWDFHVSASSFLQFEMNMG-------CS 1674
Cdd:cd10052     4 IKDNFESGSVSELKWSLIQGGGIGSGCGQLAphahgDSLYF--NGCGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsCN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1675 KPFSGAH----GIQLQYSLNNGKDWQLVTEEcVPPtigcvHYTESstytserfqnwRRVTVYLPLATNSPRTRFRWIQTN 1750
Cdd:cd10052    82 INLSSPRavdkAVLLQYSVNNGITWYLIAQH-QPK-----DFMRA-----------QRVSYNLPLEARTKGVVLRWWQPR 144

                         170
                  ....*....|....
gi 117320554 1751 YT-VGADSWAIDNV 1763
Cdd:cd10052   145 HDgTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 61.40 E-value: 3.20e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  900 TLCFTGDSKlassmRYVETQSMQIGASYMIQFSLVMGCGQK---YTPHMDNQVKLEYSANHGLTWHLVQEeclpsmpscq 976
Cdd:cd10046    42 SLYFNKDGL-----RQLVSWDLDTTWVDFIQFYIQIGGGSAscnYPDSREEGVLLQYSNNGGISWKLLAE---------- 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 117320554  977 eftsasiYHASEFTQWRRVTVVLPQKTWSGATRFRWSQSYYTAQ--DEWALDNIYIG 1031
Cdd:cd10046   107 -------MYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEgyDQWALDDIIIL 156

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 61.00 E-value: 3.59e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  420 QWSEEFESQPTG--W-DILGAVVGADCGTVESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFVMGGICDPgVSHENDII 496
Cdd:cd10050     4 QLKDTFNRAPSSsnWlTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPP-SNRNQGVL 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554  497 LYAKIEGRKEHIALDTLTYSSYKVPSLVSVVINPELQTPATKFCLRQKSHQGYNRNVWAVD 557
Cdd:cd10050    83 LEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAID 143

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 61.37 E-value: 4.53e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2892 FLKERFDSEEIKPDLWMSLEGGSTCTECGVLAENTALYFGGSTV-RQAITQDLDLRGAKFLQYWGRIGSENNMTSchrpv 2970
Cdd:cd10039     1 YEKPAFDYPLNQMSVWLMLSNEGMGKNESCSPTPSAMVFGKSDGdRFAVTRDLTLKPGYVLQFKVNIGCTSEFSS----- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2971 crKEGVLLDFSTDGGITWTLL---------------------------HEMDFQKYISVrhdYILLPEGALTNTTRLRWW 3023
Cdd:cd10039    76 --FAPVLLQYSHDAGLTWSLVregcypaspgskgcegssrelreptvyHTGDYEDWTRI---TIPIPRSLAASKTRFRWI 150

                         170       180
                  ....*....|....*....|....*..
gi 117320554 3024 QPfvISNGLVVsgverAQWALDNILIG 3050
Cdd:cd10039   151 QE--SSSLKNA-----PPFGLDGVYIS 170

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 60.59 E-value: 5.08e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1620 NWYRIQGGQVDIDC--LSMDTALIFTENiGKpRYAETWDFHVSASSFLQFEMNMG-------CSKPFSGAHGIQLQYSLN 1690
Cdd:cd10045    18 NFSSIRGGEVGFGCgvLASGKALVFNGD-GR-RQLITAPLDSTQSRYLQFTLRLGsksvlgtCPPPDRPGEGVLLHYSCD 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117320554 1691 NGKDWQLVTEecvpptigcvhytesstYTSERFQNWRRVTVYLPLATNSPRTRFRWIQTNYT-VGADSWAIDNVIL 1765
Cdd:cd10045    96 NGITWKLLEH-----------------YSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSgQNQDVWALDEISM 154

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 60.18 E-value: 6.05e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  718 SARLSSYHNFYS-IRGAEVSFGCGVLASGKALVF-NKDGRRQLITSFLDSSQSRFLQFTLRLGsksvlsTCR-APDQPGe 794
Cdd:cd10036     8 YPLLELNNNIWSeCCGCNVGEQCGVIMHGNALTFcEPYGPRELITVPLNTTTASVLQFAIGSG------SCRfSYSDPS- 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117320554  795 gvlLHYSYDNGIT---WKLLEHYSYVNYHEPRIISVELPDDARQFGIQFRWWQ--PYHSSQGEDVWAIDEIVMT 863
Cdd:cd10036    81 ---IIVSYAVNNTssdWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQeaPNAGEVYESCWALDNVLII 151

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 60.96 E-value: 6.71e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2519 LKDNFNRAPSNQNWLTVSGGKLSTVC-----GAVASGLALHFS----GGCSrlLVTVDLNLTNAEFIQFYFMYGClITPS 2589
Cdd:cd10041     2 LLDTFDFGPNESNWLFYPGGNTGLYCpyqskGAPEEDSAMVFVsselGEHS--ITTRDLDVNENTIIQFEINVGC-TTES 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2590 NRNQGVLLEYSVNGGITWNLLM--------------------EIFYDQYSkPGFVN--ILLPPDAKEIATRFRWWQPRHD 2647
Cdd:cd10041    79 SSADPVRLEFSRDFGATWHLLLplcygsssisslcstelhpsSVYYTGTT-QGWRRevILFGKLHLCGSVRFRWYQGFHP 157

                         170
                  ....*....|....*
gi 117320554 2648 -GLDQNDWAIDNVLI 2661
Cdd:cd10041   158 aGSQPVTWAIDNVYI 172

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 60.13 E-value: 7.06e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  423 EEFESQPTG--W-DILGAVVGADCGTVESGLSLVFLKD-GERKLCTPYMDTTGYGNLRFYFvMGGICDPGVSHENDIILY 498
Cdd:cd08524     3 DDFDGYPSPdnWlLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYI-GSGCSTPSYSNQPVLLEY 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 117320554  499 AKIEGRKEHIaLDTLTYSSYKVPSLVSVVINPELQTPATKFCLRQKSHQGYNRNVWAVD 557
Cdd:cd08524    82 SVDNGASWHL-LEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAID 139

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 60.69 E-value: 8.01e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3272 DNFESARVTEANWETIQGGVIGSGCgqlapYAHGDSLYFNG--CQIRQAATKPLDLTRASKIMFVLQIGspaqtdsCNSD 3349
Cdd:cd10040     4 DKFDGSVDLQANWYRIQGGQVDIDC-----LSMDTALMFTEniGKPRYAETWDFHVSASTFLQFELSMG-------CSKP 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3350 LSGPHTVDkavlLQYSVNNGITWHVIAQ-----------------HQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPrHN 3412
Cdd:cd10040    72 YSNSHSVQ----LQYSLNNGRDWHLVTEecvppaigclhytessvYSSERFQNWKRITVYLPPATISPRTRFRWIQP-NY 146

                         170
                  ....*....|..
gi 117320554 3413 GTGHDQWALDHV 3424
Cdd:cd10040   147 APGADSWAIDNV 158

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 59.06 E-value: 1.62e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2326 DDFSTLDSRKWLLHPGGTKMPVCG--STGDALVF----IEKASTRYVVTTDIAVNEdSFLQIdfaASCSVTDSCY----- 2394
Cdd:cd10047     6 DRFEGKLSPLWYKITGGQVGTGCGviKDGKSLYFngpgKREARTVPLDTTNIRLVQ-FYIQI---GSKLNGETCLrprsr 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2395 --AIELEYSVDLGLSWHPLvrdclptnvecsryhlqRILVSDTFNKWTRITLPLPSYTRSQATRFRWHQPAPFDKQQTWA 2472
Cdd:cd10047    82 neGIIVQYSNDNGITWHLL-----------------RELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQWA 144


                  ....*..
gi 117320554 2473 IDNVYIG 2479
Cdd:cd10047   145 LDDVLIG 151

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 59.02 E-value: 1.78e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2893 LKERFDS---EEIKPDLWMSLEGGSTCTECGVLAENTALYFGGST-VRQAITQDLDLRGAKFLQYwgRIGSennmTSChR 2968
Cdd:cd10036     1 LRDDFDSyplLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEPYgPRELITVPLNTTTASVLQF--AIGS----GSC-R 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2969 PVCRKEGVLLDFSTDGG-ITWTLLHEMDFQKYIS-VRHDyILLPEGALTNTTRLRWWQpfvisNGLVVSGVERAQWALDN 3046
Cdd:cd10036    74 FSYSDPSIIVSYAVNNTsSDWITLEKIRAPSNGStIIHI-IPLPTDAKQDNVSFRFRQ-----EAPNAGEVYESCWALDN 147


                  ...
gi 117320554 3047 ILI 3049
Cdd:cd10036   148 VLI 150

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 58.25 E-value: 2.93e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2170 LKDDFE----GQLESDRFLLMSGGKPSRKCGILSSGNNLFFNE-DGLRMLVTRDLDLSHARFVQFfmRLGCGKGVPDPRS 2244
Cdd:cd10036     1 LRDDFDsyplLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEpYGPRELITVPLNTTTASVLQF--AIGSGSCRFSYSD 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117320554 2245 QPVLLQYSLNGG-LSWSLLQEF-LFSNSSNVGRYIALemPLKARSGSTRLRWWQPSENG--HFYSPWVIDQILI 2314
Cdd:cd10036    79 PSIIVSYAVNNTsSDWITLEKIrAPSNGSTIIHIIPL--PTDAKQDNVSFRFRQEAPNAgeVYESCWALDNVLI 150

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 57.21 E-value: 6.51e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1271 CATTPSA-MVFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCTSQFSS--TAPVLLQYSHDAGMSWFLVKEGCFPASAGKG 1347
Cdd:cd10049    30 CGILSSGnNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDprSQPVLLQYSLNGGLTWSLLQEFLFSNSSNVG 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320554 1348 cegnsrelseptvyytgdfeewTRITIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYI 1409
Cdd:cd10049   110 ----------------------RYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 56.73 E-value: 1.11e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2348 CG--STGDALVFiEKASTRYVVTTDIAVNEDSFLQIDF-AASCSVTDSCYA-------IELEYSVDLGLSWHplvrdcLP 2417
Cdd:cd10045    31 CGvlASGKALVF-NGDGRRQLITAPLDSTQSRYLQFTLrLGSKSVLGTCPPpdrpgegVLLHYSCDNGITWK------LL 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320554 2418 TNVECSRYHLQRIlvsdtfnkwtrITLPLPSYTRSQATRFRWHQP-APFDKQQTWAIDNVYI 2478
Cdd:cd10045   104 EHYSYDNYHEPRI-----------VSVELPEDARNFGVQFRWWQPyHSGQNQDVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 56.38 E-value: 1.47e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1960 DTFDFGPREDNWFFYPGGNIGLYCpysskGAPEEDSAMVFVSNevGEHSITTRDLSVNENTIIQFEINVGCSTDSSSADP 2039
Cdd:cd10050     7 DTFNRAPSSSNWLTVVGGKLSTVC-----GAVASGTALHFSGG--CSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNRNQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2040 -VRLEFSRDFGATWHLLLPLCYHSSSLVSSLCSTehHPSSTYYAGTtqgwrrevvhfgklhlcgsvRFRWYQGFYpAGSQ 2118
Cdd:cd10050    80 gVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNIL--LPPEARGVGT--------------------RFRWWQPSH-DGLD 136

                         170
                  ....*....|..
gi 117320554 2119 PVTWAIDNVYIG 2130
Cdd:cd10050   137 QNDWAIDNVLIG 148

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 55.94 E-value: 1.78e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1607 FQDKFDGSIDLQAN---WYRIQGGQVDIDC--LSMDTALIFTENIGkPRYAETWDFHVSASSFLQFEMNMGCSKPFSGAH 1681
Cdd:cd10036     1 LRDDFDSYPLLELNnniWSECCGCNVGEQCgvIMHGNALTFCEPYG-PRELITVPLNTTTASVLQFAIGSGSCRFSYSDP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1682 GIQLQYSLNNGK-DWQLVTEECVPptigcvhyTESSTYTSerfqnwrrvTVYLPLATNSPRTRFRWIQTNYTVGA---DS 1757
Cdd:cd10036    80 SIIVSYAVNNTSsDWITLEKIRAP--------SNGSTIIH---------IIPLPTDAKQDNVSFRFRQEAPNAGEvyeSC 142


                  ....*...
gi 117320554 1758 WAIDNVIL 1765
Cdd:cd10036   143 WALDNVLI 150

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 55.94 E-value: 1.85e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2324 LEDDF-----STLDSRKWLLHPGGTKMPVCG--STGDALVFIEKASTRYVVTTDIAVNEDSFLQIDFAA-SCSVTDSCYA 2395
Cdd:cd10036     1 LRDDFdsyplLELNNNIWSECCGCNVGEQCGviMHGNALTFCEPYGPRELITVPLNTTTASVLQFAIGSgSCRFSYSDPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2396 IELEYSVDLG-LSWHPLVRDCLPTNVECSrYHLqrilvsdtfnkwtritLPLPSYTRSQATRFRWHQPAPFDKQQ---TW 2471
Cdd:cd10036    81 IIVSYAVNNTsSDWITLEKIRAPSNGSTI-IHI----------------IPLPTDAKQDNVSFRFRQEAPNAGEVyesCW 143


                  ....*..
gi 117320554 2472 AIDNVYI 2478
Cdd:cd10036   144 ALDNVLI 150

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 55.64 E-value: 2.05e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2222 SHARFVQFFMRLGCGKGVPdprSQPVLLQYSLNGGLSWSLLQ-EFL--------------FSNSSNVG-RYIALEMPLKA 2285
Cdd:cd10037    42 TVTHFAQFSINLGCGSHQP---GNSVSLEFSTNHGRSWSLLHtECLpelcagphlphstvYSSDNYSGwNRITIPLPNAA 118

                          90       100       110
                  ....*....|....*....|....*....|
gi 117320554 2286 RSGSTRLRWWQPSENGHfySPWVIDQILIG 2315
Cdd:cd10037   119 LTSATRFRWRQTGSVVG--SMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 55.94 E-value: 2.32e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1960 DTFDFGP-REDNWFFYPGGNIGLYCpysskGAPEEDSAMVFVSNevGEHSITTRDLSVNENTIIQFEINVG-------CS 2031
Cdd:cd10051     6 ERFDSEEiSSDQWLSLEGGVTCTDC-----GVLAEGDALYFGGS--GARQAVTQDLDLRGAKFVQYWARIGsennmtlCL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2032 TDSSSADPVRLEFSRDFGATWHLLLPLCYhssslvsslcstEHHPSSTYyagttqgwrrEVVHFGKLHLCGSVRFRWYQ- 2110
Cdd:cd10051    79 RPTCRKEGVLLQYSTDGGISWTLLHELDY------------QKYISVRY----------DYITLPENARTNSTRLRWWQp 136

                         170       180
                  ....*....|....*....|....*
gi 117320554 2111 -----GFYPAGSQPVTWAIDNVYIG 2130
Cdd:cd10051   137 ftisnGLVVSGTERAQWALDNILIG 161

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 55.69 E-value: 3.23e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2210 GLRMLVTRDLDLSHARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLSWSLLQEFL---------FSNSSNVG------ 2274
Cdd:cd10038    45 SARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMDNQVKLEYSTNHGLTWHLVQEEClpgmpscqeFTSGSIYHssefte 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 117320554 2275 -RYIALEMPLKARSGSTRLRWWQpsenGHFYSP--WVIDQILIG 2315
Cdd:cd10038   125 wRRITLPLPQKTWSSATRFRWSQ----SYYTDQdeWALDNIYIG 164

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 55.31 E-value: 4.55e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2552 ALHFSGGCS-----RLLVTVDLNLTNAEFIQFYFMYGC--LITPSNRNQgVLLEYSVNGGITWNLLME------------ 2612
Cdd:cd10038    33 TLCFTGDSKhassaRYVETQSMQIGASYMIQFSLVMGCgqQYTPHMDNQ-VKLEYSTNHGLTWHLVQEeclpgmpscqef 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 117320554 2613 ----IFY-DQYSKPGFVNILLPPDAKEIATRFRWWQPRHDglDQNDWAIDNVLI 2661
Cdd:cd10038   112 tsgsIYHsSEFTEWRRITLPLPQKTWSSATRFRWSQSYYT--DQDEWALDNIYI 163

Reeler domain;

Pssm-ID: 460411 Cd Length: 130 Bit Score: 54.28 E-value: 5.12e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554    62 IAGNPTYYVPGQEYHVTISTSTF---FDGLLVTGlytstsiqSSQSIGGSSAFGFGIMSDHQFGNQFM-CSVVASHVSH- 136
Cdd:pfam02014   22 ITVSSTSYRPGETITVTLSGASGgpsFKGFLLQA--------RDADSGDPDPVGSFSLPDDADTKFLLdCSGKGNAVTHs 93

                           90       100
                   ....*....|....*....|....*..
gi 117320554   137 --LPTTNLSFVWIAPPAGTGCVNFMAT 161
Cdd:pfam02014   94 ntNKKSSVTVTWTAPASGSGCVVFRAT 120

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 54.44 E-value: 6.78e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  422 SEEFE--SQPTGWDILGAVVGADCGTVESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFVMGGI-----CDPGVSHEND 494
Cdd:cd10047     5 FDRFEgkLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKlngetCLRPRSRNEG 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117320554  495 IIL-YAKIEGRKEHIaLDTLTYSSYKVPSLVSVVINPELQTPATKFCLRQKSHqGYNRNVWAVD 557
Cdd:cd10047    85 IIVqYSNDNGITWHL-LRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH-GKPSAQWALD 146

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 54.92 E-value: 7.40e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3297 GQLAPYA-HGDSLYFNG-----CQIRQAATKPLDLTRASKIMFVLQIGspaqtdsCNSDLSgPHtVDKAVLLQYSVNNGI 3370
Cdd:cd10038    22 GNVQPYCnHDWTLCFTGdskhaSSARYVETQSMQIGASYMIQFSLVMG-------CGQQYT-PH-MDNQVKLEYSTNHGL 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117320554 3371 TWHVI-----------------AQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHngTGHDQWALDHVEV 3426
Cdd:cd10038    93 TWHLVqeeclpgmpscqeftsgSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYY--TDQDEWALDNIYI 163

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 53.73 E-value: 1.27e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  929 IQFSLVMGCgqKYTPHMDNQVKLEYSANHGLTWHLVQEEcLPSMPSCQEFtsasiyhaseftqwrrVTVVLPQKTWSGAT 1008
Cdd:cd10048    63 IQFSFKFIT--KGTPERSHSVLLQYSINGGITWHLIDEF-YFPTTTDVLF----------------VNVPLPYTAQTNAT 123

                          90       100
                  ....*....|....*....|....*
gi 117320554 1009 RFRWSQSYYTAQDE--WALDNIYIG 1031
Cdd:cd10048   124 RFRLWQPYNSGKKEevWILDDLVID 148

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 54.02 E-value: 1.62e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2170 LKDDFEGQLESDRFLLMSGGKPSRKCGILSSG-----NNLFF--NEDGLRMLVTRDLDLSHARFVQFFMRLGCGkgVPDP 2242
Cdd:cd10041     2 LLDTFDFGPNESNWLFYPGGNTGLYCPYQSKGapeedSAMVFvsSELGEHSITTRDLDVNENTIIQFEINVGCT--TESS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2243 RSQPVLLQYSLNGGLSWSLLQEFLFSNSS----------NVGRYIALEMPLKARS----------GSTRLRWWQ----PS 2298
Cdd:cd10041    80 SADPVRLEFSRDFGATWHLLLPLCYGSSSisslcstelhPSSVYYTGTTQGWRREvilfgklhlcGSVRFRWYQgfhpAG 159

                         170
                  ....*....|....*..
gi 117320554 2299 ENGHfysPWVIDQILIG 2315
Cdd:cd10041   160 SQPV---TWAIDNVYIG 173

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 52.90 E-value: 2.38e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  214 ELNPNIWVECSNCEMGEQCGTIMHGNAVTFCEPyGPRELTTTCLNTTTASVLQFSIGSGS------C-RFSYSDPSITVS 286
Cdd:cd10047    10 GKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGP-GKREARTVPLDTTNIRLVQFYIQIGSklngetClRPRSRNEGIIVQ 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320554  287 YAKNNTADWIQLEKIRAPSNVSTVIHILYLPEEAKGESVQFQWKQDslRVGEvYEACWALDNILV 351
Cdd:cd10047    89 YSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQP--QHGK-PSAQWALDDVLI 150

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 52.96 E-value: 2.38e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1608 QDKFDGSI--DLQANWYRIQGGQVDIDCLSMDTALIFTENigKPRYAETWDFHVSASSFLQFEMNMGCSKPFSGAHGIQL 1685
Cdd:cd10048     6 KDDFNGNLrpDLWPEVYGAERGNLNGETIKSGTALIFKGE--GLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHSVLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1686 QYSLNNGKDWQLVTEECVPPTigcvhytesstyTSERFQNwrrvtVYLPLATNSPRTRFR-WIQTNYTVGADSWAIDNVI 1764
Cdd:cd10048    84 QYSINGGITWHLIDEFYFPTT------------TDVLFVN-----VPLPYTAQTNATRFRlWQPYNSGKKEEVWILDDLV 146


                  .
gi 117320554 1765 L 1765
Cdd:cd10048   147 I 147

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 51.78 E-value: 5.54e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2976 VLLDFSTDGGITWTLLHE-----------------MDFQKYISVRHDYILLPEGALTNTTRLRWWQPFVISNglvvsgve 3038
Cdd:cd10037    64 VSLEFSTNHGRSWSLLHTeclpelcagphlphstvYSSDNYSGWNRITIPLPNAALTSATRFRWRQTGSVVG-------- 135

                          90
                  ....*....|..
gi 117320554 3039 rAQWALDNILIG 3050
Cdd:cd10037   136 -SMWAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 51.83 E-value: 6.98e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1099 CGvvSSGSSLYF-SKAGKRQLVSWDLDTSWVDFVQFYIqiggeSAACNKPDSREeGILLQYSNNGGIQWH---------- 1167
Cdd:cd10042    26 CG--STGDALVFiEKASTRYVVTTDIMVNEDSFLQIDF-----AASCSVTDSCY-AIELEYSVDLGLSWHpllrdclptn 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554 1168 ------LLAEMYFSD-FSKPRFVYLELPAAAKTPCTRFRWWQPvfSGEDYDQ-WAVDDIII 1220
Cdd:cd10042    98 vecssyHLQRILVSDtFNKWTRVTLPLPHYTRSQATRFRWHQP--APFDKQQtWAIDNVYI 156

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 51.74 E-value: 8.39e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  732 GAEVSFGCGvlASGKALVFNK-DGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTcRAPdqpgegVLLHYSYDNGITWKL 810
Cdd:cd10039    23 GMGKNESCS--PTPSAMVFGKsDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSS-FAP------VLLQYSHDAGLTWSL 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117320554  811 LEHYSYVN------------------------YHEPRIISVELPDDARQFGIQFRWWQPYHSSQGEDVWAIDEI 860
Cdd:cd10039    94 VREGCYPAspgskgcegssrelreptvyhtgdYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAPPFGLDGV 167

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 51.44 E-value: 8.53e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1954 NPVLLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGapeedSAMVFvsNEVGEHSITTRDLSVNENTIIQFEINVGCS-- 2031
Cdd:cd10049     1 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSG-----NNLFF--NEDGLRMLVTRDLDLSMARFVQFFMRLGCGkg 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2032 TDSSSADPVRLEFSRDFGATWHLLLPLCYHSSSLVSSLCSTEHHPSSTyyagttqgwrrevvhfgklhlCGSVRFRWYQg 2111
Cdd:cd10049    74 VPDPRSQPVLLQYSLNGGLTWSLLQEFLFSNSSNVGRYVALEIPLKAR---------------------SPSTRLRWWQ- 131

                         170       180
                  ....*....|....*....|.
gi 117320554 2112 fyPA--GSQPVTWAIDNVYIG 2130
Cdd:cd10049   132 --PSenGHFYSPWVIDQILIG 150

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 51.06 E-value: 1.02e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  739 CGVlaSGKALVF-NKDGRRQLITSFLDSSQSRFLQFTLRLGSkSVLSTCRApdqpgegVLLHYSYDNGITWKLL------ 811
Cdd:cd10042    26 CGS--TGDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAASC-SVTDSCYA-------IELEYSVDLGLSWHPLlrdclp 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  812 EHYSYVNYHEPRI-----------ISVELPDDARQFGIQFRWWQPYHSSQGEDvWAIDEI 860
Cdd:cd10042    96 TNVECSSYHLQRIlvsdtfnkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQT-WAIDNV 154

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 50.95 E-value: 1.29e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2322 TVLEDDF--STLDSRKWLLHPGGTKMPVCGS-----TGDALVFiEKASTRYVVTTDIAVNEDSF----LQIdfaASCSVT 2390
Cdd:cd10052     2 SYIKDNFesGSVSELKWSLIQGGGIGSGCGQlaphaHGDSLYF-NGCGIRQAVTVELDLTRASKimfvLQI---GSRSQT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2391 DSCY-----------AIELEYSVDLGLSWHpLVRDCLPTNvecsryhlqrilvsdtFNKWTRITLPLPSYTRSQATRFRW 2459
Cdd:cd10052    78 DSCNinlsspravdkAVLLQYSVNNGITWY-LIAQHQPKD----------------FMRAQRVSYNLPLEARTKGVVLRW 140

                         170
                  ....*....|....*...
gi 117320554 2460 HQPAPFDK-QQTWAIDNV 2476
Cdd:cd10052   141 WQPRHDGTgHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 50.93 E-value: 1.38e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1277 AMVFGKSdGDRFAVTRDLTLKPGYVLQFKLNIGCTSQFSSTAP-------VLLQYSHDAGMSWFLVKEGcfpasagkgce 1349
Cdd:cd10051    38 ALYFGGS-GARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRptcrkegVLLQYSTDGGISWTLLHEL----------- 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 117320554 1350 gnsrelseptvyytgDFEEWTRIT---IAIPRSLASSKTRFRWIQ 1391
Cdd:cd10051   106 ---------------DYQKYISVRydyITLPENARTNSTRLRWWQ 135

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 50.18 E-value: 1.95e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1277 AMVFGKsDGDRFAVTRDLTLKPGYVLQFKLNIGCTSQFSSTAP-------VLLQYSHDAGMSWFLVKEgcfpasagkgce 1349
Cdd:cd10045    39 ALVFNG-DGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPpdrpgegVLLHYSCDNGITWKLLEH------------ 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554 1350 gnsrelseptvYYTGDFEEWTRITIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYIS 1410
Cdd:cd10045   106 -----------YSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 49.79 E-value: 3.47e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  203 LRDDFDSYQQLELNpniWVECSNCEMGEQCGTIM---HGNAVTF--CepyGPRELTTTCLNTTTASVLQF--SIGS---- 271
Cdd:cd10052     4 IKDNFESGSVSELK---WSLIQGGGIGSGCGQLAphaHGDSLYFngC---GIRQAVTVELDLTRASKIMFvlQIGSrsqt 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  272 GSCRFSYSDP-----SITVSYAKNNTADWiQLEKIRAPSNVSTVIHILY-LPEEAKGESVQFQWKQDslRVGEVYEACWA 345
Cdd:cd10052    78 DSCNINLSSPravdkAVLLQYSVNNGITW-YLIAQHQPKDFMRAQRVSYnLPLEARTKGVVLRWWQP--RHDGTGHDQWA 154


                  ....*..
gi 117320554  346 LDNILVI 352
Cdd:cd10052   155 LDNVEVV 161

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 49.46 E-value: 3.62e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  561 VLPVLPSTMSHMIQFSINLGCGT---HQPG---NSVSLEFSTNHGRSWSLLhteclpeicagphlphSTVYSSEnYSGWN 634
Cdd:cd10046    54 VSWDLDTTWVDFIQFYIQIGGGSascNYPDsreEGVLLQYSNNGGISWKLL----------------AEMYFSD-FSKPR 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 117320554  635 RITIPLPNAALTRDTRIRWRQtgPILG----NMWAIDNVYIG 672
Cdd:cd10046   117 FVYLELPTAAKTPCTRFRWWQ--PVFSgegyDQWALDDIIIL 156

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 48.70 E-value: 5.64e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  763 LDSSQSRFLQFTLRLGSKSvlstcrapDQPGEGVLLHYSYDNGITWKLLEH-----------------YSYVNYHEPRII 825
Cdd:cd10037    39 LPSTVTHFAQFSINLGCGS--------HQPGNSVSLEFSTNHGRSWSLLHTeclpelcagphlphstvYSSDNYSGWNRI 110

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 117320554  826 SVELPDDARQFGIQFRWWQPyHSSQGeDVWAIDEI 860
Cdd:cd10037   111 TIPLPNAALTSATRFRWRQT-GSVVG-SMWAIDNV 143

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 48.62 E-value: 7.18e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  423 EEFESQP-----TGW--DILGAVVGADCGTVESGLSLVFLK-DGERKLCTPYMDTTGYGNLRFYFVMGGiCDPGVSHEND 494
Cdd:cd10036     3 DDFDSYPllelnNNIwsECCGCNVGEQCGVIMHGNALTFCEpYGPRELITVPLNTTTASVLQFAIGSGS-CRFSYSDPSI 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  495 IILYAKIEGRKEHIALDTLtyssyKVPSLVSVVIN-----PELQTPATKFCLRQKSHQGYN--RNVWAVD 557
Cdd:cd10036    82 IVSYAVNNTSSDWITLEKI-----RAPSNGSTIIHiiplpTDAKQDNVSFRFRQEAPNAGEvyESCWALD 146

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 48.75 E-value: 8.87e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2907 WMSLEGGSTCTECgvLAENTALYFGGS--TVRQAITQDLDLRGAKFLQYwgrigsENNMtSCHRPVCRKEGVLLDFSTDG 2984
Cdd:cd10040    16 WYRIQGGQVDIDC--LSMDTALMFTENigKPRYAETWDFHVSASTFLQF------ELSM-GCSKPYSNSHSVQLQYSLNN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2985 GITWTL------------LHEMDFQKYISVRHD-----YILLPEGALTNTTRLRWWQPFVisnglvvsGVERAQWALDNI 3047
Cdd:cd10040    87 GRDWHLvteecvppaigcLHYTESSVYSSERFQnwkriTVYLPPATISPRTRFRWIQPNY--------APGADSWAIDNV 158


                  ...
gi 117320554 3048 LIG 3050
Cdd:cd10040   159 VLA 161

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 48.24 E-value: 9.57e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1805 LKDDFN----GNLHPDLWPEVYGAERGNLNGeTIKSGTCLIFKG-EGLRMLISRDLDCTNTMYVQFSlrfIAKGTPERSH 1879
Cdd:cd10036     1 LRDDFDsyplLELNNNIWSECCGCNVGEQCG-VIMHGNALTFCEpYGPRELITVPLNTTTASVLQFA---IGSGSCRFSY 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320554 1880 ---SILLQFSV-SGGVTWHLMDEFYFPQTTSILFINVPLPYGAQTNATRFRLWQPYNNGKKE 1937
Cdd:cd10036    77 sdpSIIVSYAVnNTSSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEAPNAGEV 138

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 48.25 E-value: 1.21e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1285 GDRFAVTRDLTLKPGYVLQFKLNIG-------CTSQFSSTAP----VLLQYSHDAGMSWFLVKEgcfpasagkgcegnsr 1353
Cdd:cd10052    48 GIRQAVTVELDLTRASKIMFVLQIGsrsqtdsCNINLSSPRAvdkaVLLQYSVNNGITWYLIAQ---------------- 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 117320554 1354 elseptvYYTGDFEEWTRITIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGV 1407
Cdd:cd10052   112 -------HQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 47.95 E-value: 1.32e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  565 LPSTMSHMIQFSINLGC-GTHQPGNSVSLEFSTNHGRSWSLLHTECLPEicagphlPHSTVYssenysgwnrITIPLPNA 643
Cdd:cd10048    55 LDCTHTLYIQFSFKFITkGTPERSHSVLLQYSINGGITWHLIDEFYFPT-------TTDVLF----------VNVPLPYT 117

                          90       100       110
                  ....*....|....*....|....*....|.
gi 117320554  644 ALTRDTRIR-WR-QTGPILGNMWAIDNVYIG 672
Cdd:cd10048   118 AQTNATRFRlWQpYNSGKKEEVWILDDLVID 148

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 47.52 E-value: 1.60e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  565 LPSTMSHMIQFSINLGCGT--HQPGNSVSLEFSTNHGRSWSLLHteclpEIcagphlphstVYSSENYSGWnrITIPLPN 642
Cdd:cd10050    54 LNLTNAEFVQFYFMYGCLIppSNRNQGVLLEYSVNGGITWNLLM-----EI----------FYDQYSKPGF--VNILLPP 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 117320554  643 AALTRDTRIRWRQ---TGPIlGNMWAIDNVYIG 672
Cdd:cd10050   117 EARGVGTRFRWWQpshDGLD-QNDWAIDNVLIG 148

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 47.99 E-value: 1.62e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1469 GQVGTGCgtlNDGRSLYFNGLGKREARTVPLDTRNIR-----LVQFYIQIGSKTsgitciKPRARNEGLV-VQYSNDNGI 1542
Cdd:cd10038    22 GNVQPYC---NHDWTLCFTGDSKHASSARYVETQSMQigasyMIQFSLVMGCGQ------QYTPHMDNQVkLEYSTNHGL 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117320554 1543 LWHLLRE--LDFM----SFLEPQI-----------ISIDLPREAKTPATAFRWWQPQHGKhSAQWALDDVLIG 1598
Cdd:cd10038    93 TWHLVQEecLPGMpscqEFTSGSIyhsseftewrrITLPLPQKTWSSATRFRWSQSYYTD-QDEWALDNIYIG 164

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 48.01 E-value: 1.85e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2191 PSRKCGILSSGNNlffnEDGLRM-LVTRDLDLSHARFVQFFMRLGCGKGVPDPRsQPVLLQYSLNGGLSWSLL-QEFLFS 2268
Cdd:cd10043    40 CDSPDGVMICGSH----DDGREVsAVTHDLTPTEGWILQFKISVGCKSSEKSAQ-QPVHVQYSTDFGVSWSYVtPQCLPS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554 2269 NSSNVG--------------RYIALEMPLKARSGSTRLRWWQpsenGHFYSPWVIDQILIG 2315
Cdd:cd10043   115 DPKCGGsvtqpsvffpskgwRRVTIPLPDKLVGRPIRFRFYQ----KASDMQWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 47.16 E-value: 1.92e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2571 TNAEFIQFYFMYGCLI-TPSNrnqGVLLEYSVNGGITWNLLM---------------EIFY--DQYSKPGFVNILLPPDA 2632
Cdd:cd10037    42 TVTHFAQFSINLGCGShQPGN---SVSLEFSTNHGRSWSLLHteclpelcagphlphSTVYssDNYSGWNRITIPLPNAA 118

                          90       100
                  ....*....|....*....|....*....
gi 117320554 2633 KEIATRFRWWQPRhdGLDQNDWAIDNVLI 2661
Cdd:cd10037   119 LTSATRFRWRQTG--SVVGSMWAIDNVYI 145

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 47.20 E-value: 1.97e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  203 LRDDFDSyqQLELNPniWVECSNCEMGEQCGTIMHGNAVTFCEPyGPRELTTTCLNTTTASVLQFSIGSGsCRFSYSDP- 281
Cdd:cd10049     5 LKDDFEG--QLESDR--FLLMSGGKPSRKCGILSSGNNLFFNED-GLRMLVTRDLDLSMARFVQFFMRLG-CGKGVPDPr 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117320554  282 --SITVSYAKNNTADWIQLEKIRApSNVSTVIHI--LYLPEEAKGESVQFQWKQDSlRVGEVYEAcWALDNILV 351
Cdd:cd10049    79 sqPVLLQYSLNGGLTWSLLQEFLF-SNSSNVGRYvaLEIPLKARSPSTRLRWWQPS-ENGHFYSP-WVIDQILI 149

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 47.53 E-value: 2.80e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2214 LVTRDLDLSHARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGL-SWSLLQE--------------FLF-------SNSS 2271
Cdd:cd10044    53 LTTRQLIVQPGYMIQFKIVVGCGSVSSCGDLHPVMLEYTTDPRSdHWQLVQTeclpsssnsidcspFQYheasiysSVNS 132

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 117320554 2272 NVGRYIALEMPLKARSGSTRLRWWQPSENGhFYSPWVIDQILIG 2315
Cdd:cd10044   133 SVWKRVTIQLPDHVSSSATQFRWIQKTEST-EAPSWAIDDVYIG 175

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 46.72 E-value: 3.04e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  227 EMGEQCGTIMHGNAVTFCEPyGPRELTTTCLNTTTASVLQFS--IGS----GSCRF-SYSDPSITVSYAKNNTADWIQLE 299
Cdd:cd10045    26 EVGFGCGVLASGKALVFNGD-GRRQLITAPLDSTQSRYLQFTlrLGSksvlGTCPPpDRPGEGVLLHYSCDNGITWKLLE 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 117320554  300 KIRAPSNVSTVIHILYLPEEAKGESVQFQWKQDslRVGEVYEACWALDNILV 351
Cdd:cd10045   105 HYSYDNYHEPRIVSVELPEDARNFGVQFRWWQP--YHSGQNQDVWALDEISM 154

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 46.83 E-value: 3.95e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  754 GRRQLITSFLDSSQSRFLQFTLRLGsksvlstCRAPDQPG--EGVLLHYSYDNGITWKLLEH-----------------Y 814
Cdd:cd10038    45 SARYVETQSMQIGASYMIQFSLVMG-------CGQQYTPHmdNQVKLEYSTNHGLTWHLVQEeclpgmpscqeftsgsiY 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 117320554  815 SYVNYHEPRIISVELPDDARQFGIQFRWWQPYHSSQgeDVWAIDEI 860
Cdd:cd10038   118 HSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQ--DEWALDNI 161

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 45.96 E-value: 5.05e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1960 DTFDfGPREDNWFFYPGGNIGLYCpysskGAPEEDSAMVFvsNEVGEHSITTRDLSVNENTIIQFEINVGCSTDSSSADP 2039
Cdd:cd10047     6 DRFE-GKLSPLWYKITGGQVGTGC-----GVIKDGKSLYF--NGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2040 VR-------LEFSRDFGATWHLLLPLCYhsSSLVSSLCSTEHHPSSTYYAGTTqgwrrevvhfgklhlcgsvrFRWYQGF 2112
Cdd:cd10047    78 PRsrnegiiVQYSNDNGITWHLLRELDF--MSYLEPQVISIELPREAKTPATA--------------------FRWWQPQ 135

                         170
                  ....*....|....*...
gi 117320554 2113 YpaGSQPVTWAIDNVYIG 2130
Cdd:cd10047   136 H--GKPSAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 45.64 E-value: 6.62e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1276 SAMVFgKSDGDRFAVTRDLTLKPGYVLQFKLNIGCTSQFSSTAPVLLQYSHDAGMSWFLVKEGCFPASAgkgcegnsrel 1355
Cdd:cd10048    38 TALIF-KGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHSVLLQYSINGGITWHLIDEFYFPTTT----------- 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 117320554 1356 sePTVYytgdfeewtrITIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYI 1409
Cdd:cd10048   106 --DVLF----------VNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVI 147

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 45.16 E-value: 1.15e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  203 LRDDFDSYqqlELNPNIWVECSNCEMGEQCGTIMHGNAVTFCEPyGPRELTTTCLNTTTASVLQF--SIGS----GSCRF 276
Cdd:cd10051     4 LKERFDSE---EISSDQWLSLEGGVTCTDCGVLAEGDALYFGGS-GARQAVTQDLDLRGAKFVQYwaRIGSennmTLCLR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  277 SYS-DPSITVSYAKNNTADWIQLEKIRAPSNVSTVIHILYLPEEAKGESVQFQWKQ-----DSLRVGEVYEACWALDNIL 350
Cdd:cd10051    80 PTCrKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQpftisNGLVVSGTERAQWALDNIL 159


                  .
gi 117320554  351 V 351
Cdd:cd10051   160 I 160

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 45.18 E-value: 1.27e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1973 FYP--GGNIGLYCPYSSKGapeedSAMVFvsNEVGEHSITTRDLSVNENTIIQFEINVGCSTDSSSADP-------VRLE 2043
Cdd:cd10045    19 FSSirGGEVGFGCGVLASG-----KALVF--NGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPpdrpgegVLLH 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2044 FSRDFGATWHLLLPLCYHSSslvsslcsteHHPsstyyagttqgwRREVVHFGKLHLCGSVRFRWYQGFYPAGSQPVtWA 2123
Cdd:cd10045    92 YSCDNGITWKLLEHYSYDNY----------HEP------------RIVSVELPEDARNFGVQFRWWQPYHSGQNQDV-WA 148


                  ....*.
gi 117320554 2124 IDNVYI 2129
Cdd:cd10045   149 LDEISM 154

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 44.87 E-value: 1.31e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2744 VTHDLTPTENWIMQFKISVGCK-VPEKiaQNQIHVQFSTDFGVSWsYLVPQCLPADPkcsgsvsQPSVFFptegwkriTY 2822
Cdd:cd10048    51 VSRDLDCTHTLYIQFSFKFITKgTPER--SHSVLLQYSINGGITW-HLIDEFYFPTT-------TDVLFV--------NV 112

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 117320554 2823 PLPESLTGNPVRFRFYQKYSDVQ----WAIDNFYLG 2854
Cdd:cd10048   113 PLPYTAQTNATRFRLWQPYNSGKkeevWILDDLVID 148

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 45.16 E-value: 1.52e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  584 HQPGNSVSLEFSTNHGRSWSLLHteclpeicagpHLPHstvyssENYSGWNRITIPLPNAALTRDTRIRWRQTGPI---L 660
Cdd:cd10051    81 TCRKEGVLLQYSTDGGISWTLLH-----------ELDY------QKYISVRYDYITLPENARTNSTRLRWWQPFTIsngL 143

                          90
                  ....*....|....*...
gi 117320554  661 GNM------WAIDNVYIG 672
Cdd:cd10051   144 VVSgteraqWALDNILIG 161

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 44.47 E-value: 1.64e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1506 LVQFYIQIGSKTsgitcikpRARNEGLVVQYSNDNGILWHLLR-----ELDFMSFLePQI-------------ISIDLPR 1567
Cdd:cd10037    46 FAQFSINLGCGS--------HQPGNSVSLEFSTNHGRSWSLLHteclpELCAGPHL-PHStvyssdnysgwnrITIPLPN 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 117320554 1568 EAKTPATAFRWWQPqHGKHSAQWALDDVLIG 1598
Cdd:cd10037   117 AALTSATRFRWRQT-GSVVGSMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 44.77 E-value: 2.02e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  423 EEFESQ---PTGWDIL-GAVVGADCGTVESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFVMGG-----ICDPGVSHEN 493
Cdd:cd10051     6 ERFDSEeisSDQWLSLeGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSennmtLCLRPTCRKE 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320554  494 DIILYAKIEGRKEHIALDTLTYSSYKVPSLVSVVINPELQTPATKFCLRQ---KSHQ----GYNRNVWAVD 557
Cdd:cd10051    86 GVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQpftISNGlvvsGTERAQWALD 156

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 44.50 E-value: 2.04e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  436 GAVVGADCGTVESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFVMGgiCDPGVSHEND--IILYAKIEGRKEHIALDTL 513
Cdd:cd10049    23 GGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG--CGKGVPDPRSqpVLLQYSLNGGLTWSLLQEF 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 117320554  514 TYS-SYKVPSLVSVVINPELQTPATKFCLRQKSHQGYNRNVWAVD 557
Cdd:cd10049   101 LFSnSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVID 145

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 44.50 E-value: 2.06e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  568 TMSHMIQFSINLGCGTHQP---GNSVSLEFSTNHGRSWSLLhteclpeicagphlpHSTVYSSENYSGwNRITIPLPNAA 644
Cdd:cd10049    57 SMARFVQFFMRLGCGKGVPdprSQPVLLQYSLNGGLTWSLL---------------QEFLFSNSSNVG-RYVALEIPLKA 120

                          90       100       110
                  ....*....|....*....|....*....|
gi 117320554  645 LTRDTRIRWRQTGPILGNM--WAIDNVYIG 672
Cdd:cd10049   121 RSPSTRLRWWQPSENGHFYspWVIDQILIG 150

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 44.51 E-value: 2.08e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3270 IKDNFESarVTEANWETIQGGVIGSGCGqlapyAHGDSLYF-NGCQIRQAATKPLDLTRASKIMFVLQIGSPAqTDSCns 3348
Cdd:cd10042     2 LEDDFST--LDSRKWLLHPGGTKMPVCG-----STGDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAASCSV-TDSC-- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3349 dlsgphtvdKAVLLQYSVNNGITWH-VIAQHQPKD----------------FTQAQRVSYNVPLEARMKGVLLRWWQPRH 3411
Cdd:cd10042    72 ---------YAIELEYSVDLGLSWHpLLRDCLPTNvecssyhlqrilvsdtFNKWTRVTLPLPHYTRSQATRFRWHQPAP 142

                         170
                  ....*....|...
gi 117320554 3412 NGTGHdQWALDHV 3424
Cdd:cd10042   143 FDKQQ-TWAIDNV 154

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 44.10 E-value: 2.16e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  428 QPTGW-DILGAVVGADCG-TVESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFVMggICDPGVSHENDIILYAKIEGRK 505
Cdd:cd10048    14 RPDLWpEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF--ITKGTPERSHSVLLQYSINGGI 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 117320554  506 EHIALDTLTYSSYKVPSLVSVVINPELQTPATKFCLRQKSHQGYNRNVWAVDFF 559
Cdd:cd10048    92 TWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDL 145

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 44.08 E-value: 2.44e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1130 FVQFYIQIGGESAAcnkPDSreeGILLQYSNNGGIQWHLL----------------AEMYFSD-FSKPRFVYLELPAAAK 1192
Cdd:cd10037    46 FAQFSINLGCGSHQ---PGN---SVSLEFSTNHGRSWSLLhteclpelcagphlphSTVYSSDnYSGWNRITIPLPNAAL 119

                          90       100
                  ....*....|....*....|....*....
gi 117320554 1193 TPCTRFRWWQPvfSGEDYDQWAVDDIIIL 1221
Cdd:cd10037   120 TSATRFRWRQT--GSVVGSMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 44.04 E-value: 2.62e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  565 LPSTMSHMIQFSINLG-------CGTHQPGN-SVSLEFSTNHGRSWSLLHtECLPEICAGPHLphstvyssenysgwnrI 636
Cdd:cd10047    52 LDTTNIRLVQFYIQIGsklngetCLRPRSRNeGIIVQYSNDNGITWHLLR-ELDFMSYLEPQV----------------I 114

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 117320554  637 TIPLPNAALTRDTRIRWRQtgPILGN---MWAIDNVYIG 672
Cdd:cd10047   115 SIELPREAKTPATAFRWWQ--PQHGKpsaQWALDDVLIG 151

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 44.06 E-value: 3.49e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2516 PTQLKDNFNRAP--SNQNWLTVSGGKLST-VCGAVASGL--ALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPS- 2589
Cdd:cd10044     1 PSSLVETFEDEGtsHDENWEFYPNGVRTDeFCGNPSFHLtwPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVSSc 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 2590 NRNQGVLLEYSVNGGIT-WNLLME---------------IFYDQ--YSKPGF-----VNILLPPDAKEIATRFRWWQpRH 2646
Cdd:cd10044    81 GDLHPVMLEYTTDPRSDhWQLVQTeclpsssnsidcspfQYHEAsiYSSVNSsvwkrVTIQLPDHVSSSATQFRWIQ-KT 159

                         170
                  ....*....|....*
gi 117320554 2647 DGLDQNDWAIDNVLI 2661
Cdd:cd10044   160 ESTEAPSWAIDDVYI 174

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 43.74 E-value: 4.12e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1804 ILKDDFNGN------LHPdlwpevyGAERGNLNGETiksGTCLIF-KGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTpE 1876
Cdd:cd10042     1 VLEDDFSTLdsrkwlLHP-------GGTKMPVCGST---GDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAASCSVT-D 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1877 RSHSILLQFSVSGGVTWHLMDEFYFP--------QTTSILF---------INVPLPYGAQTNATRFRLWQPYNNGKKEEi 1939
Cdd:cd10042    70 SCYAIELEYSVDLGLSWHPLLRDCLPtnvecssyHLQRILVsdtfnkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQT- 148


                  ....*...
gi 117320554 1940 WIIDDFII 1947
Cdd:cd10042   149 WAIDNVYI 156

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 42.92 E-value: 6.72e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1858 TNTMYVQFSLRfIAKGTPERSHSILLQFSVSGGVTWHLMDEFYFPQTTSILF-----------------INVPLPYGAQT 1920
Cdd:cd10037    42 TVTHFAQFSIN-LGCGSHQPGNSVSLEFSTNHGRSWSLLHTECLPELCAGPHlphstvyssdnysgwnrITIPLPNAALT 120

                          90
                  ....*....|...
gi 117320554 1921 NATRFRLWQPYNN 1933
Cdd:cd10037   121 SATRFRWRQTGSV 133

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.25 E-value: 8.24e-04

                           10        20
                   ....*....|....*....|....*
gi 117320554  2137 CYGHGSCINGT-KCICDPGYSGPTC 2160
Cdd:pfam07974    2 CSGRGTCVNQCgKCVCDSGYQGATC 26

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 9.27e-04

                           10        20
                   ....*....|....*....|....*
gi 117320554  1038 CSGHGSCDH--GVCRCDQGYQGTEC 1060
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 42.10 E-value: 1.17e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554  565 LPSTMSHMIQFSINLG----CGT----HQPGNSVSLEFSTNHGRSWSLLHteclpeicagphlphstVYSSENYSGWNRI 636
Cdd:cd10045    55 LDSTQSRYLQFTLRLGsksvLGTcpppDRPGEGVLLHYSCDNGITWKLLE-----------------HYSYDNYHEPRIV 117

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 117320554  637 TIPLPNAALTRDTRIRWRQTGPILGN--MWAIDNVYI 671
Cdd:cd10045   118 SVELPEDARNFGVQFRWWQPYHSGQNqdVWALDEISM 154

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.43 E-value: 1.36e-03

                           10        20
                   ....*....|....*....|....*....
gi 117320554  3232 CPKLCSGHGYCTTGAvCICDESFQGDDCS 3260
Cdd:pfam18720    2 CPLGCSSRGVCVDGQ-CICDSEYSGDDCS 29

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 42.21 E-value: 1.49e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1840 LIFKGE-----GLRMLISRDLDCTNTMYVQFSLRFIA--KGTPERSHSILLQFSVSGGVTWHLMDEFYFP---------- 1902
Cdd:cd10038    34 LCFTGDskhasSARYVETQSMQIGASYMIQFSLVMGCgqQYTPHMDNQVKLEYSTNHGLTWHLVQEECLPgmpscqefts 113

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 117320554 1903 -------QTTSILFINVPLPYGAQTNATRFRLWQPY 1931
Cdd:cd10038   114 gsiyhssEFTEWRRITLPLPQKTWSSATRFRWSQSY 149

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.61e-03

                           10        20
                   ....*....|....*....|....*
gi 117320554  1773 CSGRGICDS--GRCVCDRGFGGPFC 1795
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 41.74 E-value: 1.65e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3056 PSQLVDTFDDEGSSHeeNWSFYpNAVRTAGFCGNPSFHLYWPNKKKdkthnalSSRELIIQP-----GYMMQFKIVVGCE 3130
Cdd:cd10050     2 PTQLKDTFNRAPSSS--NWLTV-VGGKLSTVCGAVASGTALHFSGG-------CSRQLVTVDlnltnAEFVQFYFMYGCL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3131 ATSCGDLHSVMLEYTKDArSDSWQLVqtqclpsssnsigcspfqfheATIYNAVNSSSwKRITIQLPDHVSSSATQFRWI 3210
Cdd:cd10050    72 IPPSNRNQGVLLEYSVNG-GITWNLL---------------------MEIFYDQYSKP-GFVNILLPPEARGVGTRFRWW 128

                         170       180
                  ....*....|....*....|
gi 117320554 3211 QKGEETEKQS-WAIDHVYIG 3229
Cdd:cd10050   129 QPSHDGLDQNdWAIDNVLIG 148

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 41.31 E-value: 2.86e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 3272 DNFESARVtEANWETIQGGVIGSGCGQLAPYAHGD--SLYFNGCQIRQAA--TKPLDLTRASKIMFVLQIGspaqtdsCN 3347
Cdd:cd10041     4 DTFDFGPN-ESNWLFYPGGNTGLYCPYQSKGAPEEdsAMVFVSSELGEHSitTRDLDVNENTIIQFEINVG-------CT 75

                          90       100
                  ....*....|....*....|....*...
gi 117320554 3348 SDLSGPHTVDkavlLQYSVNNGITWHVI 3375
Cdd:cd10041    76 TESSSADPVR----LEFSRDFGATWHLL 99

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.66 E-value: 2.90e-03

                           10        20
                   ....*....|....*....|....*..
gi 117320554  1769 CPWMCSGRGICDSGRCVCDRGFGGPFC 1795
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.62 E-value: 3.89e-03

                          10        20        30
                  ....*....|....*....|....*....|....
gi 117320554 2133 CEEM--CYGHGSCIN---GTKCICDPGYSGPTCK 2161
Cdd:cd00054     5 CASGnpCQNGGTCVNtvgSYRCSCPPGYTGRNCE 38

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 40.66 E-value: 4.77e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320554 1531 GLVVQYSNDNGILWH-LLRE-----LDFMSFLEPQI-----------ISIDLPREAKTPATAFRWWQPQHGKHSAQWALD 1593
Cdd:cd10042    73 AIELEYSVDLGLSWHpLLRDclptnVECSSYHLQRIlvsdtfnkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAID 152


                  ....*
gi 117320554 1594 DVLIG 1598
Cdd:cd10042   153 NVYIG 157

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 5.22e-03

                           10        20
                   ....*....|....*....|....*.
gi 117320554  3235 LCSGHGYC-TTGAVCICDESFQGDDC 3259
Cdd:pfam07974    1 ICSGRGTCvNQCGKCVCDSGYQGATC 26

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.56 E-value: 5.82e-03

                           10        20
                   ....*....|....*....|....*
gi 117320554  2861 CGGHGDCLKE--QCICDPGYSGPNC 2883
Cdd:pfam07974    2 CSGRGTCVNQcgKCVCDSGYQGATC 26

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 40.59 E-value: 6.16e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117320554 1535 QYSNDNGILWhllreldfmsflepQIISIDLPREAKTPATAFRWWQPQHGKHSAQWALDDVLIG 1598
Cdd:cd10044   126 IYSSVNSSVW--------------KRVTIQLPDHVSSSATQFRWIQKTESTEAPSWAIDDVYIG 175