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MASP1 MBL associated serine protease 1 [ Delphinapterus leucas (beluga whale) ]

Gene ID: 111172796, updated on 15-Mar-2024

Summary

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Gene symbol
MASP1
Gene description
MBL associated serine protease 1
See related
Ensembl:ENSDLEG00000014231
Gene type
protein coding
RefSeq status
MODEL
Organism
Delphinapterus leucas
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Monodontidae; Delphinapterus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
19
Annotation release Status Assembly Chr Location
101 current ASM228892v3 (GCF_002288925.2) Unplaced Scaffold NW_022098104.1 (91607620..91879653)
100 previous assembly ASM228892v2 (GCF_002288925.1) Unplaced Scaffold NW_019160855.1 (67497635..67769672)

NW_022098104.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene somatostatin Neighboring gene uncharacterized LOC111172824 Neighboring gene olfactory receptor 8K5-like Neighboring gene receptor transporter protein 4 Neighboring gene elongation factor 1-alpha 1 pseudogene Neighboring gene receptor transporter protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mannan-binding lectin serine protease 1
Names
mannan binding lectin serine peptidase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Delphinapterus leucas Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM228892v3 Primary Assembly

Genomic

  1. NW_022098104.1 Reference ASM228892v3 Primary Assembly

    Range
    91607620..91879653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030760955.1 → XP_030616815.1  mannan-binding lectin serine protease 1 isoform X3

    UniProtKB/TrEMBL
    A0A7F8K895
    Conserved Domains (6) summary
    cd00033
    Location:378 → 443
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd00041
    Location:39 → 148
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:460 → 705
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:312 → 373
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:196 → 305
    CUB; CUB domain
    pfam14670
    Location:164 → 192
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_022569876.2 → XP_022425584.1  mannan-binding lectin serine protease 1 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9MT43
    Related
    ENSDLEP00000019550.1, ENSDLET00000021547.1
    Conserved Domains (6) summary
    cd00033
    Location:378 → 443
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:460 → 722
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:39 → 148
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:196 → 305
    CUB; CUB domain
    pfam00084
    Location:312 → 373
    Sushi; Sushi repeat (SCR repeat)
    pfam14670
    Location:164 → 192
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_022569911.1 → XP_022425619.1  mannan-binding lectin serine protease 1 isoform X5

    UniProtKB/TrEMBL
    A0A2Y9MT70
    Conserved Domains (6) summary
    cd00033
    Location:367 → 432
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:449 → 694
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:185 → 294
    CUB; CUB domain
    pfam00084
    Location:301 → 362
    Sushi; Sushi repeat (SCR repeat)
    pfam14670
    Location:153 → 181
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  4. XM_022569902.1 → XP_022425610.1  mannan-binding lectin serine protease 1 isoform X4

    UniProtKB/TrEMBL
    A0A2Y9MUK6
    Conserved Domains (7) summary
    cd00033
    Location:367 → 432
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:449 → 641
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:185 → 294
    CUB; CUB domain
    pfam04569
    Location:633 → 691
    DUF591; Protein of unknown function
    pfam00084
    Location:301 → 362
    Sushi; Sushi repeat (SCR repeat)
    pfam14670
    Location:153 → 181
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  5. XM_022569885.1 → XP_022425593.1  mannan-binding lectin serine protease 1 isoform X2

    UniProtKB/TrEMBL
    A0A2Y9N8M0
    Related
    ENSDLEP00000019535.1, ENSDLET00000021531.1
    Conserved Domains (6) summary
    cd00033
    Location:367 → 432
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:449 → 711
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:185 → 294
    CUB; CUB domain
    pfam00084
    Location:301 → 362
    Sushi; Sushi repeat (SCR repeat)
    pfam14670
    Location:153 → 181
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  6. XM_022569928.1 → XP_022425636.1  mannan-binding lectin serine protease 1 isoform X7

    UniProtKB/TrEMBL
    A0A2Y9MXK9
    Conserved Domains (4) summary
    cd00041
    Location:28 → 137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00431
    Location:185 → 294
    CUB; CUB domain
    pfam00084
    Location:301 → 362
    Sushi; Sushi repeat (SCR repeat)
    pfam14670
    Location:153 → 181
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  7. XM_022569918.2 → XP_022425626.1  mannan-binding lectin serine protease 1 isoform X6

    UniProtKB/TrEMBL
    A0A2Y9MXK0
    Conserved Domains (6) summary
    cd00033
    Location:334 → 399
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:416 → 678
    Tryp_SPc; Trypsin-like serine protease
    pfam00431
    Location:152 → 261
    CUB; CUB domain
    cl00049
    Location:48 → 104
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00084
    Location:268 → 329
    Sushi; Sushi repeat (SCR repeat)
    pfam14670
    Location:120 → 148
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version

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