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Conserved domains on  [gi|1246146002|ref|XP_022425626|]
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mannan-binding lectin serine protease 1 isoform X6 [Delphinapterus leucas]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 416-678 7.51e-82

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


:

Pssm-ID: 214473  Cd Length: 229  Bit Score: 258.76  E-value: 7.51e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  416 RIIGGRNAEPGLFPWQALIvvedtsRVPNDKWFGSGALLSESWILTAAHVLRSQRRDNtvtpvskehVTVYLGLHDVRDK 495
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSL------QYGGGRHFCGGSLISPRWVLTAAHCVRGSDPSN---------IRVRLGSHDLSSG 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  496 SGAVNSSAARVVLHPDFDIQNYNHDIALVQLREPVPLGPHIMPVCLPRPEpEGPAPHMLGLVAGWGisnpnvtvdeIISS 575
Cdd:smart00020  66 EEGQVIKVSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSN-YNVPAGTTCTVSGWG----------RTSE 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  576 GTRTLSDVLQYVKLPVVPHAECKTSYesrSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVILDDssqRWVAQGLVSWGG 655
Cdd:smart00020 135 GAGSLPDTLQEVNVPIVSNATCRRAY---SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGS 208

                          250       260
                   ....*....|....*....|...
gi 1246146002  656 PeeCGSKQVYGVYTKVSNYVDWV 678
Cdd:smart00020 209 G--CARPGKPGVYTRVSSYLDWI 229
CUB pfam00431
CUB domain;
152-261 1.23e-37

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 135.89  E-value: 1.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 152 CSDNlFTQRTGVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPEvsCPYDYIKIKTGPK----VLGPFC 227
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGPSasspLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1246146002 228 GEKAPEPINTQSHSVQILFRSDNSGENRGWKLLY 261
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
Sushi pfam00084
Sushi repeat (SCR repeat);
268-329 1.30e-10

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 57.12  E-value: 1.30e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246146002 268 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDGTWSNKIPTC 329
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 120-148 8.72e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.47  E-value: 8.72e-09
                          10        20
                  ....*....|....*....|....*....
gi 1246146002 120 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 148
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 334-399 1.04e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.22  E-value: 1.04e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246146002 334 CGAPAELENGLVTFSTRNnlTTYKSEIRYSCqQPYYQMLHSitDVYTCSAQGVWMNEvlgrsQPTC 399
Cdd:cd00033     1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGS--STITCTENGGWSPP-----PPTC 56
CUB super family cl00049
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 48-104 2.88e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


The actual alignment was detected with superfamily member cd00041:

Pssm-ID: 412131 [Multi-domain]  Cd Length: 113  Bit Score: 43.56  E-value: 2.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1246146002  48 ETEEQVLATFCGRETTdteqtpgqEVVLSPGSFMSITFRSDFSNeeRFTGFEAHYMA 104
Cdd:cd00041    67 STSSPLLGRFCGSTLP--------PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 416-678 7.51e-82

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 258.76  E-value: 7.51e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  416 RIIGGRNAEPGLFPWQALIvvedtsRVPNDKWFGSGALLSESWILTAAHVLRSQRRDNtvtpvskehVTVYLGLHDVRDK 495
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSL------QYGGGRHFCGGSLISPRWVLTAAHCVRGSDPSN---------IRVRLGSHDLSSG 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  496 SGAVNSSAARVVLHPDFDIQNYNHDIALVQLREPVPLGPHIMPVCLPRPEpEGPAPHMLGLVAGWGisnpnvtvdeIISS 575
Cdd:smart00020  66 EEGQVIKVSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSN-YNVPAGTTCTVSGWG----------RTSE 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  576 GTRTLSDVLQYVKLPVVPHAECKTSYesrSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVILDDssqRWVAQGLVSWGG 655
Cdd:smart00020 135 GAGSLPDTLQEVNVPIVSNATCRRAY---SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGS 208

                          250       260
                   ....*....|....*....|...
gi 1246146002  656 PeeCGSKQVYGVYTKVSNYVDWV 678
Cdd:smart00020 209 G--CARPGKPGVYTRVSSYLDWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 417-678 1.93e-80

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 255.28  E-value: 1.93e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 417 IIGGRNAEPGLFPWQALIvvedtsRVPNDKWFGSGALLSESWILTAAHVLRSQRRDNtvtpvskehVTVYLGLHDV-RDK 495
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSL------QYTGGRHFCGGSLISPRWVLTAAHCVYSSAPSN---------YTVRLGSHDLsSNE 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 496 SGAVNSSAARVVLHPDFDIQNYNHDIALVQLREPVPLGPHIMPVCLPRPEPEgPAPHMLGLVAGWGISNPNVtvdeiiss 575
Cdd:cd00190    66 GGGQVIKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYN-LPAGTTCTVSGWGRTSEGG-------- 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 576 gtrTLSDVLQYVKLPVVPHAECKTSYesrSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVILDDSsqRWVAQGLVSWGg 655
Cdd:cd00190   137 ---PLPDVLQEVNVPIVSNAECKRAY---SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNG--RGVLVGIVSWG- 207

                         250       260
                  ....*....|....*....|...
gi 1246146002 656 pEECGSKQVYGVYTKVSNYVDWV 678
Cdd:cd00190   208 -SGCARPNYPGVYTRVSSYLDWI 229
Trypsin pfam00089
Trypsin;
417-678 1.15e-59

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 199.98  E-value: 1.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 417 IIGGRNAEPGLFPWQALIVVEdtsrvpNDKWFGSGALLSESWILTAAHVLRSQRRdntvtpvskehVTVYLGLHDVRDKS 496
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLS------SGKHFCGGSLISENWVLTAAHCVSGASD-----------VKVVLGAHNIVLRE 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 497 GAVNS-SAARVVLHPDFDIQNYNHDIALVQLREPVPLGPHIMPVCLPRPEPEGPAPHMlGLVAGWGISNPNVTvdeiiss 575
Cdd:pfam00089  64 GGEQKfDVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGTT-CTVSGWGNTKTLGP------- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 576 gtrtlSDVLQYVKLPVVPHAECKTSYesrsgNYSVTENMFCAGYyeGGKDTCLGDSGGAFVILDDssqrwVAQGLVSWGG 655
Cdd:pfam00089 136 -----SDTLQEVTVPVVSRETCRSAY-----GGTVTDTMICAGA--GGKDACQGDSGGPLVCSDG-----ELIGIVSWGY 198

                         250       260
                  ....*....|....*....|...
gi 1246146002 656 PeeCGSKQVYGVYTKVSNYVDWV 678
Cdd:pfam00089 199 G--CASGNYPGVYTPVSSYLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 416-685 1.18e-57

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 196.02  E-value: 1.18e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 416 RIIGGRNAEPGLFPWQALIVVEDTSRvpndKWFGSGALLSESWILTAAHvlrsqrrdnTVTPVSKEHVTVYLGLHDVRDK 495
Cdd:COG5640    30 AIVGGTPATVGEYPWMVALQSSNGPS----GQFCGGTLIAPRWVLTAAH---------CVDGDGPSDLRVVIGSTDLSTS 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 496 SGAVnSSAARVVLHPDFDIQNYNHDIALVQLREPVPLGPhimPVCLPRPEPEGPAPHMLgLVAGWGIsnpnvtvdeiISS 575
Cdd:COG5640    97 GGTV-VKVARIVVHPDYDPATPGNDIALLKLATPVPGVA---PAPLATSADAAAPGTPA-TVAGWGR----------TSE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 576 GTRTLSDVLQYVKLPVVPHAECktsyesRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVILDDSsqRWVAQGLVSWGG 655
Cdd:COG5640   162 GPGSQSGTLRKADVPVVSDATC------AAYGGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDGG--GWVLVGVVSWGG 233

                         250       260       270
                  ....*....|....*....|....*....|
gi 1246146002 656 pEECGsKQVYGVYTKVSNYVDWVWEQIGSP 685
Cdd:COG5640   234 -GPCA-AGYPGVYTRVSAYRDWIKSTAGGL 261
CUB pfam00431
CUB domain;
152-261 1.23e-37

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 135.89  E-value: 1.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 152 CSDNlFTQRTGVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPEvsCPYDYIKIKTGPK----VLGPFC 227
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGPSasspLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1246146002 228 GEKAPEPINTQSHSVQILFRSDNSGENRGWKLLY 261
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 152-263 1.33e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 130.22  E-value: 1.33e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 152 CSDNLFTQRTGVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPevSCPYDYIKIKTGP----KVLGPFC 227
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSP--NCSYDYLEIYDGPstssPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1246146002 228 GEKAPEPINTQSHSVQILFRSDNSGENRGWKLLYRA 263
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 162-261 6.35e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 116.34  E-value: 6.35e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  162 GVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPEvsCPYDYIKIKTGP----KVLGPFCGEKAPEPINT 237
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGPsassPLLGRFCGSEAPPPVIS 77

                           90       100
                   ....*....|....*....|....*
gi 1246146002  238 -QSHSVQILFRSDNSGENRGWKLLY 261
Cdd:smart00042  78 sSSNSLTLTFVSDSSVQKRGFSARY 102
Sushi pfam00084
Sushi repeat (SCR repeat);
268-329 1.30e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 57.12  E-value: 1.30e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246146002 268 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDGTWSNKIPTC 329
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 268-330 2.42e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 2.42e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246146002 268 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNvemdtfQIECLKDGTWSNKIPTCK 330
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSS------TITCTENGGWSPPPPTCE 57
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 120-148 8.72e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.47  E-value: 8.72e-09
                          10        20
                  ....*....|....*....|....*....
gi 1246146002 120 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 148
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 268-329 9.89e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 51.76  E-value: 9.89e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246146002  268 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDGTWSNKIPTC 329
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 334-399 1.04e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.22  E-value: 1.04e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246146002 334 CGAPAELENGLVTFSTRNnlTTYKSEIRYSCqQPYYQMLHSitDVYTCSAQGVWMNEvlgrsQPTC 399
Cdd:cd00033     1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGS--STITCTENGGWSPP-----PPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 267-400 1.04e-05

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 47.74  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 267 ECPKLQPPVHGNIEPLQAKYFFKDQVLISCDTgHKVLKDNVeMDTFQIECLKDGTWSNKIPTCKIVDCGAPAeLENGLVT 346
Cdd:PHA02639   84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNE-HKGVQYSL-VGNEKITCIQDKSWKPDPPICKMINCRFPA-LQNGYIN 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1246146002 347 FSTRNNLTTYKSEIRYSCQQPYYQMLHSITdvyTCSAQGVWMNEVlgrsqPTCL 400
Cdd:PHA02639  161 GIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFPSI-----PTCV 206
PHA02817 PHA02817
EEV Host range protein; Provisional
 314-365 1.26e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.86  E-value: 1.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246146002 314 IECLKDGTWSNKIPTCKIVDCGAPAeLENGLVTFSTRNNLTTYKSEIRYSCQ 365
Cdd:PHA02817   69 IICEKDGKWNKEFPVCKIIRCRFPA-LQNGFVNGIPDSKKFYYESEVSFSCK 119
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 246-349 1.34e-05

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 47.77  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 246 FRSDNSGENRGWKLLYRATGNECPKLQPPvHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDgTWsNK 325
Cdd:PHA02954  108 FRCEEKNGNTSWNDTVTCPNAECQPLQLE-HGSCQPVKEKYSFGEHITINCDVGYEVIGASY------ISCTAN-SW-NV 178

                          90       100
                  ....*....|....*....|....
gi 1246146002 326 IPTCKiVDCGAPAeLENGLVTFST 349
Cdd:PHA02954  179 IPSCQ-QKCDIPS-LSNGLISGST 200
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 48-104 2.88e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 43.56  E-value: 2.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1246146002  48 ETEEQVLATFCGRETTdteqtpgqEVVLSPGSFMSITFRSDFSNeeRFTGFEAHYMA 104
Cdd:cd00041    67 STSSPLLGRFCGSTLP--------PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
EGF_CA smart00179
Calcium-binding EGF-like domain;
106-148 6.34e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 6.34e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1246146002  106 DVDECMEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 148
Cdd:smart00179   1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 52-102 7.43e-05

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 42.38  E-value: 7.43e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1246146002   52 QVLATFCGREttdteqtPGQEVVLSPGSFMSITFRSDFSNEERftGFEAHY 102
Cdd:smart00042  61 PLLGRFCGSE-------APPPVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 334-399 1.32e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.20  E-value: 1.32e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246146002  334 CGAPAELENGLVTFSTRNnlTTYKSEIRYSCQQPYYQmlhSITDVYTCSAQGVWMNEVlgrsqPTC 399
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPGYTL---IGSSTITCLENGTWSPPP-----PTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 106-143 1.33e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1246146002 106 DVDECmereDEELSCDHY--CHNYIGGYYCSCRFGYILHT 143
Cdd:cd00054     1 DIDEC----ASGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 416-678 7.51e-82

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 258.76  E-value: 7.51e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  416 RIIGGRNAEPGLFPWQALIvvedtsRVPNDKWFGSGALLSESWILTAAHVLRSQRRDNtvtpvskehVTVYLGLHDVRDK 495
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSL------QYGGGRHFCGGSLISPRWVLTAAHCVRGSDPSN---------IRVRLGSHDLSSG 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  496 SGAVNSSAARVVLHPDFDIQNYNHDIALVQLREPVPLGPHIMPVCLPRPEpEGPAPHMLGLVAGWGisnpnvtvdeIISS 575
Cdd:smart00020  66 EEGQVIKVSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSN-YNVPAGTTCTVSGWG----------RTSE 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  576 GTRTLSDVLQYVKLPVVPHAECKTSYesrSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVILDDssqRWVAQGLVSWGG 655
Cdd:smart00020 135 GAGSLPDTLQEVNVPIVSNATCRRAY---SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGS 208

                          250       260
                   ....*....|....*....|...
gi 1246146002  656 PeeCGSKQVYGVYTKVSNYVDWV 678
Cdd:smart00020 209 G--CARPGKPGVYTRVSSYLDWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 417-678 1.93e-80

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 255.28  E-value: 1.93e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 417 IIGGRNAEPGLFPWQALIvvedtsRVPNDKWFGSGALLSESWILTAAHVLRSQRRDNtvtpvskehVTVYLGLHDV-RDK 495
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSL------QYTGGRHFCGGSLISPRWVLTAAHCVYSSAPSN---------YTVRLGSHDLsSNE 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 496 SGAVNSSAARVVLHPDFDIQNYNHDIALVQLREPVPLGPHIMPVCLPRPEPEgPAPHMLGLVAGWGISNPNVtvdeiiss 575
Cdd:cd00190    66 GGGQVIKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYN-LPAGTTCTVSGWGRTSEGG-------- 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 576 gtrTLSDVLQYVKLPVVPHAECKTSYesrSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVILDDSsqRWVAQGLVSWGg 655
Cdd:cd00190   137 ---PLPDVLQEVNVPIVSNAECKRAY---SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNG--RGVLVGIVSWG- 207

                         250       260
                  ....*....|....*....|...
gi 1246146002 656 pEECGSKQVYGVYTKVSNYVDWV 678
Cdd:cd00190   208 -SGCARPNYPGVYTRVSSYLDWI 229
Trypsin pfam00089
Trypsin;
417-678 1.15e-59

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 199.98  E-value: 1.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 417 IIGGRNAEPGLFPWQALIVVEdtsrvpNDKWFGSGALLSESWILTAAHVLRSQRRdntvtpvskehVTVYLGLHDVRDKS 496
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLS------SGKHFCGGSLISENWVLTAAHCVSGASD-----------VKVVLGAHNIVLRE 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 497 GAVNS-SAARVVLHPDFDIQNYNHDIALVQLREPVPLGPHIMPVCLPRPEPEGPAPHMlGLVAGWGISNPNVTvdeiiss 575
Cdd:pfam00089  64 GGEQKfDVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGTT-CTVSGWGNTKTLGP------- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 576 gtrtlSDVLQYVKLPVVPHAECKTSYesrsgNYSVTENMFCAGYyeGGKDTCLGDSGGAFVILDDssqrwVAQGLVSWGG 655
Cdd:pfam00089 136 -----SDTLQEVTVPVVSRETCRSAY-----GGTVTDTMICAGA--GGKDACQGDSGGPLVCSDG-----ELIGIVSWGY 198

                         250       260
                  ....*....|....*....|...
gi 1246146002 656 PeeCGSKQVYGVYTKVSNYVDWV 678
Cdd:pfam00089 199 G--CASGNYPGVYTPVSSYLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 416-685 1.18e-57

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 196.02  E-value: 1.18e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 416 RIIGGRNAEPGLFPWQALIVVEDTSRvpndKWFGSGALLSESWILTAAHvlrsqrrdnTVTPVSKEHVTVYLGLHDVRDK 495
Cdd:COG5640    30 AIVGGTPATVGEYPWMVALQSSNGPS----GQFCGGTLIAPRWVLTAAH---------CVDGDGPSDLRVVIGSTDLSTS 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 496 SGAVnSSAARVVLHPDFDIQNYNHDIALVQLREPVPLGPhimPVCLPRPEPEGPAPHMLgLVAGWGIsnpnvtvdeiISS 575
Cdd:COG5640    97 GGTV-VKVARIVVHPDYDPATPGNDIALLKLATPVPGVA---PAPLATSADAAAPGTPA-TVAGWGR----------TSE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 576 GTRTLSDVLQYVKLPVVPHAECktsyesRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVILDDSsqRWVAQGLVSWGG 655
Cdd:COG5640   162 GPGSQSGTLRKADVPVVSDATC------AAYGGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDGG--GWVLVGVVSWGG 233

                         250       260       270
                  ....*....|....*....|....*....|
gi 1246146002 656 pEECGsKQVYGVYTKVSNYVDWVWEQIGSP 685
Cdd:COG5640   234 -GPCA-AGYPGVYTRVSAYRDWIKSTAGGL 261
CUB pfam00431
CUB domain;
152-261 1.23e-37

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 135.89  E-value: 1.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 152 CSDNlFTQRTGVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPEvsCPYDYIKIKTGPK----VLGPFC 227
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGPSasspLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1246146002 228 GEKAPEPINTQSHSVQILFRSDNSGENRGWKLLY 261
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 152-263 1.33e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 130.22  E-value: 1.33e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 152 CSDNLFTQRTGVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPevSCPYDYIKIKTGP----KVLGPFC 227
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSP--NCSYDYLEIYDGPstssPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1246146002 228 GEKAPEPINTQSHSVQILFRSDNSGENRGWKLLYRA 263
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 162-261 6.35e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 116.34  E-value: 6.35e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  162 GVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPEvsCPYDYIKIKTGP----KVLGPFCGEKAPEPINT 237
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGPsassPLLGRFCGSEAPPPVIS 77

                           90       100
                   ....*....|....*....|....*
gi 1246146002  238 -QSHSVQILFRSDNSGENRGWKLLY 261
Cdd:smart00042  78 sSSNSLTLTFVSDSSVQKRGFSARY 102
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 443-657 8.94e-11

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 61.62  E-value: 8.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 443 PNDKWFGSGALLSESWILTAAHVLRSQRRDNTVTpvskeHVTVYLGlhdvRDKSGAVNSSAARVVLHPDFDIQ-NYNHDI 521
Cdd:COG3591     8 DGGGGVCTGTLIGPNLVLTAGHCVYDGAGGGWAT-----NIVFVPG----YNGGPYGTATATRFRVPPGWVASgDAGYDY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 522 ALVQLREPVplgphimpvclprPEPEGPAPhmlglvagwgisnpnVTVDEIISSGTRTlsDVLQYvklpvvPHAECKTSY 601
Cdd:COG3591    79 ALLRLDEPL-------------GDTTGWLG---------------LAFNDAPLAGEPV--TIIGY------PGDRPKDLS 122

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1246146002 602 ESRSGN-YSVTENMFcagYYEGgkDTCLGDSGGAfvILDDSSQRWVAQGLVSWGGPE 657
Cdd:COG3591   123 LDCSGRvTGVQGNRL---SYDC--DTTGGSSGSP--VLDDSDGGGRVVGVHSAGGAD 172
Sushi pfam00084
Sushi repeat (SCR repeat);
268-329 1.30e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 57.12  E-value: 1.30e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246146002 268 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDGTWSNKIPTC 329
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 268-330 2.42e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 2.42e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246146002 268 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNvemdtfQIECLKDGTWSNKIPTCK 330
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSS------TITCTENGGWSPPPPTCE 57
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 120-148 8.72e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.47  E-value: 8.72e-09
                          10        20
                  ....*....|....*....|....*....
gi 1246146002 120 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 148
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 268-329 9.89e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 51.76  E-value: 9.89e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246146002  268 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDGTWSNKIPTC 329
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 334-399 1.04e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.22  E-value: 1.04e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246146002 334 CGAPAELENGLVTFSTRNnlTTYKSEIRYSCqQPYYQMLHSitDVYTCSAQGVWMNEvlgrsQPTC 399
Cdd:cd00033     1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGS--STITCTENGGWSPP-----PPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 267-400 1.04e-05

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 47.74  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 267 ECPKLQPPVHGNIEPLQAKYFFKDQVLISCDTgHKVLKDNVeMDTFQIECLKDGTWSNKIPTCKIVDCGAPAeLENGLVT 346
Cdd:PHA02639   84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNE-HKGVQYSL-VGNEKITCIQDKSWKPDPPICKMINCRFPA-LQNGYIN 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1246146002 347 FSTRNNLTTYKSEIRYSCQQPYYQMLHSITdvyTCSAQGVWMNEVlgrsqPTCL 400
Cdd:PHA02639  161 GIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFPSI-----PTCV 206
PHA02817 PHA02817
EEV Host range protein; Provisional
 314-365 1.26e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.86  E-value: 1.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246146002 314 IECLKDGTWSNKIPTCKIVDCGAPAeLENGLVTFSTRNNLTTYKSEIRYSCQ 365
Cdd:PHA02817   69 IICEKDGKWNKEFPVCKIIRCRFPA-LQNGFVNGIPDSKKFYYESEVSFSCK 119
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 246-349 1.34e-05

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 47.77  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 246 FRSDNSGENRGWKLLYRATGNECPKLQPPvHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDgTWsNK 325
Cdd:PHA02954  108 FRCEEKNGNTSWNDTVTCPNAECQPLQLE-HGSCQPVKEKYSFGEHITINCDVGYEVIGASY------ISCTAN-SW-NV 178

                          90       100
                  ....*....|....*....|....
gi 1246146002 326 IPTCKiVDCGAPAeLENGLVTFST 349
Cdd:PHA02954  179 IPSCQ-QKCDIPS-LSNGLISGST 200
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 48-104 2.88e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 43.56  E-value: 2.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1246146002  48 ETEEQVLATFCGRETTdteqtpgqEVVLSPGSFMSITFRSDFSNeeRFTGFEAHYMA 104
Cdd:cd00041    67 STSSPLLGRFCGSTLP--------PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
EGF_CA smart00179
Calcium-binding EGF-like domain;
106-148 6.34e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 6.34e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1246146002  106 DVDECMEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 148
Cdd:smart00179   1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 52-102 7.43e-05

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 42.38  E-value: 7.43e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1246146002   52 QVLATFCGREttdteqtPGQEVVLSPGSFMSITFRSDFSNEERftGFEAHY 102
Cdd:smart00042  61 PLLGRFCGSE-------APPPVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 334-399 1.32e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.20  E-value: 1.32e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246146002  334 CGAPAELENGLVTFSTRNnlTTYKSEIRYSCQQPYYQmlhSITDVYTCSAQGVWMNEVlgrsqPTC 399
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPGYTL---IGSSTITCLENGTWSPPP-----PTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 106-143 1.33e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1246146002 106 DVDECmereDEELSCDHY--CHNYIGGYYCSCRFGYILHT 143
Cdd:cd00054     1 DIDEC----ASGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
PHA02831 PHA02831
EEV host range protein; Provisional
 275-387 8.40e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 41.90  E-value: 8.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 275 VHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVEMDTfqIECLkDGTWSNKIPTCKIVDCGAPAeLENG-LVTFSTRnnl 353
Cdd:PHA02831   85 LNGYIKNKKDQYSFGDSVTYACKVNKLEKYSIVGNET--VKCI-NKQWVPKYPVCKLIRCKYPA-LQNGfLNVFEKK--- 157

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1246146002 354 TTYKSEIRYSCQQPyYQMLHSITDvyTCSAQGVW 387
Cdd:PHA02831  158 FYYGDIVNFKCKKG-FILLGSSVS--TCDINSIW 188
PHA02639 PHA02639
EEV host range protein; Provisional
 268-366 2.43e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 40.42  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 268 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVEMdtfqieCLKD---GTWSNKIPTCKIVDCGAPAELENGL 344
Cdd:PHA02639   22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRT------CIKDknnAIWSNKAPFCMLKECNDPPSIINGK 95

                          90       100
                  ....*....|....*....|....
gi 1246146002 345 VTfstrNNLTTYK--SEIRYSCQQ 366
Cdd:PHA02639   96 IY----NKREMYKvgDEIYYVCNE 115
EGF_CA pfam07645
Calcium-binding EGF domain;
106-138 3.58e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 3.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1246146002 106 DVDECmerEDEELSCDH--YCHNYIGGYYCSCRFG 138
Cdd:pfam07645   1 DVDEC---ATGTHNCPAntVCVNTIGSFECRCPDG 32
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 256-407 3.89e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 39.64  E-value: 3.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 256 GWKLLYRATGNECPKLQPPVHGNIEPLQAKyfFKDQVLISCDTGHKVLKDNveMDTFQIECLKDGTWSNKIPTCKIVDCG 335
Cdd:PHA02927   74 GWTLFNQCIKRRCPSPRDIDNGQLDIGGVD--FGSSITYSCNSGYQLIGES--KSYCELGSTGSMVWNPEAPICESVKCQ 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246146002 336 APAELENGlvTFSTRNNLTTYKSEIRYSCQQPYYQMLHSITdvyTCSAqGVWMNEvlgrsqPTC-LPACGQPS 407
Cdd:PHA02927  150 SPPSISNG--RHNGYEDFYTDGSVVTYSCNSGYSLIGNSGV---LCSG-GEWSDP------PTCqIVKCPHPT 210
Trypsin_2 pfam13365
Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.
 449-539 6.74e-03

Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.


Pssm-ID: 433149 [Multi-domain]  Cd Length: 142  Bit Score: 37.40  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002 449 GSGALLSES-WILTAAHVLRSQRRDNtvtpvskeHVTVYLGLHDVRdksgavnsSAARVVLHPDFDiqnynHDIALVQLR 527
Cdd:pfam13365   1 GTGFVVSSDgLVLTNAHVVDDAEEAA--------VELVSVVLADGR--------EYPATVVARDPD-----LDLALLRVS 59

                          90
                  ....*....|....*...
gi 1246146002 528 ------EPVPLGPHIMPV 539
Cdd:pfam13365  60 gdgrglPPLPLGDSEPLV 77
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 88-147 6.94e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 38.52  E-value: 6.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246146002  88 DFSNEERFTGFEAHYMAVDVDECMEredEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 147
Cdd:cd01475   168 DFSTIEELTKKFQGKICVVPDLCAT---LSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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