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Conserved domains on  [gi|1246145998|ref|XP_022425610|]
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mannan-binding lectin serine protease 1 isoform X4 [Delphinapterus leucas]

Protein Classification

CUB domain-containing protein( domain architecture ID 10806469)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein similar to CUB domain-containing protein 2 (CDCP2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 449-641 2.07e-57

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 194.42  E-value: 2.07e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 449 IFSGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSKWIVTAAHCLHQLldsedatlhgldllSPSAFKIIMGKHWRYRSDE 528
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 529 NEQSLSVKQIFLHPLYNPNTFENDVALVELSKSPVLNDFVMPICLPQG--PPQEGAMVIVSGWGK-QFLQRFPETLMEIE 605
Cdd:cd00190    67 GGQVIKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSgyNLPAGTTCTVSGWGRtSEGGPLPDVLQEVN 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1246145998 606 IPVVDHRICQEAYtPLKKKVTRDMICAGEKEGK-------SGG 641
Cdd:cd00190   147 VPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGkdacqgdSGG 188
CUB pfam00431
CUB domain;
185-294 9.02e-38

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 136.27  E-value: 9.02e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 185 CSDNlFTQRTGVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPEvsCPYDYIKIKTGPK----VLGPFC 260
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGPSasspLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1246145998 261 GEKAPEPINTQSHSVQILFRSDNSGENRGWKLLY 294
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 28-137 6.97e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 116.74  E-value: 6.97e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998  28 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEEQVLATFCGRETTdteqtpg 103
Cdd:cd00041    10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1246145998 104 qEVVLSPGSFMSITFRSDFSNeeRFTGFEAHYMA 137
Cdd:cd00041    83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
Sushi pfam00084
Sushi repeat (SCR repeat);
301-362 7.12e-11

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 57.89  E-value: 7.12e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246145998 301 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDGTWSNKIPTC 362
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 153-181 9.51e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.47  E-value: 9.51e-09
                          10        20
                  ....*....|....*....|....*....
gi 1246145998 153 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 181
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 367-432 6.85e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.99  E-value: 6.85e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246145998 367 CGAPAELENGLVTFSTRNnlTTYKSEIRYSCqQPYYQMLHSitDVYTCSAQGVWMNEvlgrsQPTC 432
Cdd:cd00033     1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGS--STITCTENGGWSPP-----PPTC 56
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 449-641 2.07e-57

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 194.42  E-value: 2.07e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 449 IFSGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSKWIVTAAHCLHQLldsedatlhgldllSPSAFKIIMGKHWRYRSDE 528
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 529 NEQSLSVKQIFLHPLYNPNTFENDVALVELSKSPVLNDFVMPICLPQG--PPQEGAMVIVSGWGK-QFLQRFPETLMEIE 605
Cdd:cd00190    67 GGQVIKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSgyNLPAGTTCTVSGWGRtSEGGPLPDVLQEVN 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1246145998 606 IPVVDHRICQEAYtPLKKKVTRDMICAGEKEGK-------SGG 641
Cdd:cd00190   147 VPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGkdacqgdSGG 188
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 448-641 2.23e-56

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 191.74  E-value: 2.23e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998  448 RIFSGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSKWIVTAAHCLHQLldsedatlhgldllSPSAFKIIMGKHWRyRSD 527
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRHFCGGSLISPRWVLTAAHCVRGS--------------DPSNIRVRLGSHDL-SSG 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998  528 ENEQSLSVKQIFLHPLYNPNTFENDVALVELSKSPVLNDFVMPICLPQG--PPQEGAMVIVSGWGKQFL--QRFPETLME 603
Cdd:smart00020  66 EEGQVIKVSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSnyNVPAGTTCTVSGWGRTSEgaGSLPDTLQE 145

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1246145998  604 IEIPVVDHRICQEAYtPLKKKVTRDMICAGEKEGK-------SGG 641
Cdd:smart00020 146 VNVPIVSNATCRRAY-SGGGAITDNMLCAGGLEGGkdacqgdSGG 189
Trypsin pfam00089
Trypsin;
449-641 5.38e-52

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 179.56  E-value: 5.38e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 449 IFSGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSKWIVTAAHCLHqlldsedatlhgldllSPSAFKIIMGKHWRYRSDE 528
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGKHFCGGSLISENWVLTAAHCVS----------------GASDVKVVLGAHNIVLREG 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 529 NEQSLSVKQIFLHPLYNPNTFENDVALVELSKSPVLNDFVMPICLPQ--GPPQEGAMVIVSGWGKQFLQRFPETLMEIEI 606
Cdd:pfam00089  65 GEQKFDVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDasSDLPVGTTCTVSGWGNTKTLGPSDTLQEVTV 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1246145998 607 PVVDHRICQEAYtplKKKVTRDMICAGEK-----EGKSGG 641
Cdd:pfam00089 145 PVVSRETCRSAY---GGTVTDTMICAGAGgkdacQGDSGG 181
CUB pfam00431
CUB domain;
185-294 9.02e-38

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 136.27  E-value: 9.02e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 185 CSDNlFTQRTGVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPEvsCPYDYIKIKTGPK----VLGPFC 260
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGPSasspLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1246145998 261 GEKAPEPINTQSHSVQILFRSDNSGENRGWKLLY 294
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 447-641 3.97e-37

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 139.78  E-value: 3.97e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 447 ARIFSGRPAQKGTTPWIAMLSHLNG--QPFCGGSLLGSKWIVTAAHClhqlldsedatlhgLDLLSPSAFKIIMGKHWry 524
Cdd:COG5640    29 PAIVGGTPATVGEYPWMVALQSSNGpsGQFCGGTLIAPRWVLTAAHC--------------VDGDGPSDLRVVIGSTD-- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 525 RSDENEQSLSVKQIFLHPLYNPNTFENDVALVELSkSPVlnDFVMPICLPQGP--PQEGAMVIVSGWGK--QFLQRFPET 600
Cdd:COG5640    93 LSTSGGTVVKVARIVVHPDYDPATPGNDIALLKLA-TPV--PGVAPAPLATSAdaAAPGTPATVAGWGRtsEGPGSQSGT 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1246145998 601 LMEIEIPVVDHRICQeAYTPLkkkVTRDMICAGEKEGK-------SGG 641
Cdd:COG5640   170 LRKADVPVVSDATCA-AYGGF---DGGTMLCAGYPEGGkdacqgdSGG 213
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 185-296 1.47e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 130.22  E-value: 1.47e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 185 CSDNLFTQRTGVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPevSCPYDYIKIKTGP----KVLGPFC 260
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSP--NCSYDYLEIYDGPstssPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1246145998 261 GEKAPEPINTQSHSVQILFRSDNSGENRGWKLLYRA 296
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 28-137 6.97e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 116.74  E-value: 6.97e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998  28 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEEQVLATFCGRETTdteqtpg 103
Cdd:cd00041    10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1246145998 104 qEVVLSPGSFMSITFRSDFSNeeRFTGFEAHYMA 137
Cdd:cd00041    83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 195-294 8.72e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 115.95  E-value: 8.72e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998  195 GVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPEvsCPYDYIKIKTGP----KVLGPFCGEKAPEPINT 270
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGPsassPLLGRFCGSEAPPPVIS 77

                           90       100
                   ....*....|....*....|....*
gi 1246145998  271 -QSHSVQILFRSDNSGENRGWKLLY 294
Cdd:smart00042  78 sSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 29-135 1.00e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 115.95  E-value: 1.00e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998   29 GQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEEQVLATFCGREttdteqtPGQ 104
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1246145998  105 EVVLSPGSFMSITFRSDFSNEERftGFEAHY 135
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
CUB pfam00431
CUB domain;
23-135 9.41e-23

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 93.51  E-value: 9.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998  23 ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEEQVLATFCGREttdt 98
Cdd:pfam00431   4 VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGSG---- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1246145998  99 eqtpGQEVVLSPGSFMSITFRSDFSNEERftGFEAHY 135
Cdd:pfam00431  80 ----IPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
Sushi pfam00084
Sushi repeat (SCR repeat);
301-362 7.12e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 57.89  E-value: 7.12e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246145998 301 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDGTWSNKIPTC 362
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 301-363 1.59e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 1.59e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246145998 301 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNvemdtfQIECLKDGTWSNKIPTCK 363
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSS------TITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 301-362 7.08e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.14  E-value: 7.08e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246145998  301 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDGTWSNKIPTC 362
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 153-181 9.51e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.47  E-value: 9.51e-09
                          10        20
                  ....*....|....*....|....*....
gi 1246145998 153 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 181
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 279-382 6.80e-06

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 48.54  E-value: 6.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 279 FRSDNSGENRGWKLLYRATGNECPKLQPPvHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDgTWsNK 358
Cdd:PHA02954  108 FRCEEKNGNTSWNDTVTCPNAECQPLQLE-HGSCQPVKEKYSFGEHITINCDVGYEVIGASY------ISCTAN-SW-NV 178

                          90       100
                  ....*....|....*....|....
gi 1246145998 359 IPTCKiVDCGAPAeLENGLVTFST 382
Cdd:PHA02954  179 IPSCQ-QKCDIPS-LSNGLISGST 200
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 367-432 6.85e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.99  E-value: 6.85e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246145998 367 CGAPAELENGLVTFSTRNnlTTYKSEIRYSCqQPYYQMLHSitDVYTCSAQGVWMNEvlgrsQPTC 432
Cdd:cd00033     1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGS--STITCTENGGWSPP-----PPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 300-433 9.00e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 48.12  E-value: 9.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 300 ECPKLQPPVHGNIEPLQAKYFFKDQVLISCDTgHKVLKDNVeMDTFQIECLKDGTWSNKIPTCKIVDCGAPAeLENGLVT 379
Cdd:PHA02639   84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNE-HKGVQYSL-VGNEKITCIQDKSWKPDPPICKMINCRFPA-LQNGYIN 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1246145998 380 FSTRNNLTTYKSEIRYSCQQPYYQMLHSITdvyTCSAQGVWMNEVlgrsqPTCL 433
Cdd:PHA02639  161 GIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFPSI-----PTCV 206
PHA02817 PHA02817
EEV Host range protein; Provisional
 347-398 1.55e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.86  E-value: 1.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246145998 347 IECLKDGTWSNKIPTCKIVDCGAPAeLENGLVTFSTRNNLTTYKSEIRYSCQ 398
Cdd:PHA02817   69 IICEKDGKWNKEFPVCKIIRCRFPA-LQNGFVNGIPDSKKFYYESEVSFSCK 119
EGF_CA smart00179
Calcium-binding EGF-like domain;
139-181 6.03e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 6.03e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1246145998  139 DVDECMEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 181
Cdd:smart00179   1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 367-432 8.89e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.59  E-value: 8.89e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246145998  367 CGAPAELENGLVTFSTRNnlTTYKSEIRYSCQQPYYQmlhSITDVYTCSAQGVWMNEVlgrsqPTC 432
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPGYTL---IGSSTITCLENGTWSPPP-----PTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 139-176 1.36e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1246145998 139 DVDECmereDEELSCDHY--CHNYIGGYYCSCRFGYILHT 176
Cdd:cd00054     1 DIDEC----ASGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 449-641 2.07e-57

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 194.42  E-value: 2.07e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 449 IFSGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSKWIVTAAHCLHQLldsedatlhgldllSPSAFKIIMGKHWRYRSDE 528
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 529 NEQSLSVKQIFLHPLYNPNTFENDVALVELSKSPVLNDFVMPICLPQG--PPQEGAMVIVSGWGK-QFLQRFPETLMEIE 605
Cdd:cd00190    67 GGQVIKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSgyNLPAGTTCTVSGWGRtSEGGPLPDVLQEVN 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1246145998 606 IPVVDHRICQEAYtPLKKKVTRDMICAGEKEGK-------SGG 641
Cdd:cd00190   147 VPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGkdacqgdSGG 188
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 448-641 2.23e-56

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 191.74  E-value: 2.23e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998  448 RIFSGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSKWIVTAAHCLHQLldsedatlhgldllSPSAFKIIMGKHWRyRSD 527
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRHFCGGSLISPRWVLTAAHCVRGS--------------DPSNIRVRLGSHDL-SSG 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998  528 ENEQSLSVKQIFLHPLYNPNTFENDVALVELSKSPVLNDFVMPICLPQG--PPQEGAMVIVSGWGKQFL--QRFPETLME 603
Cdd:smart00020  66 EEGQVIKVSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSnyNVPAGTTCTVSGWGRTSEgaGSLPDTLQE 145

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1246145998  604 IEIPVVDHRICQEAYtPLKKKVTRDMICAGEKEGK-------SGG 641
Cdd:smart00020 146 VNVPIVSNATCRRAY-SGGGAITDNMLCAGGLEGGkdacqgdSGG 189
Trypsin pfam00089
Trypsin;
449-641 5.38e-52

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 179.56  E-value: 5.38e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 449 IFSGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSKWIVTAAHCLHqlldsedatlhgldllSPSAFKIIMGKHWRYRSDE 528
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGKHFCGGSLISENWVLTAAHCVS----------------GASDVKVVLGAHNIVLREG 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 529 NEQSLSVKQIFLHPLYNPNTFENDVALVELSKSPVLNDFVMPICLPQ--GPPQEGAMVIVSGWGKQFLQRFPETLMEIEI 606
Cdd:pfam00089  65 GEQKFDVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDasSDLPVGTTCTVSGWGNTKTLGPSDTLQEVTV 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1246145998 607 PVVDHRICQEAYtplKKKVTRDMICAGEK-----EGKSGG 641
Cdd:pfam00089 145 PVVSRETCRSAY---GGTVTDTMICAGAGgkdacQGDSGG 181
CUB pfam00431
CUB domain;
185-294 9.02e-38

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 136.27  E-value: 9.02e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 185 CSDNlFTQRTGVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPEvsCPYDYIKIKTGPK----VLGPFC 260
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGPSasspLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1246145998 261 GEKAPEPINTQSHSVQILFRSDNSGENRGWKLLY 294
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 447-641 3.97e-37

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 139.78  E-value: 3.97e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 447 ARIFSGRPAQKGTTPWIAMLSHLNG--QPFCGGSLLGSKWIVTAAHClhqlldsedatlhgLDLLSPSAFKIIMGKHWry 524
Cdd:COG5640    29 PAIVGGTPATVGEYPWMVALQSSNGpsGQFCGGTLIAPRWVLTAAHC--------------VDGDGPSDLRVVIGSTD-- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 525 RSDENEQSLSVKQIFLHPLYNPNTFENDVALVELSkSPVlnDFVMPICLPQGP--PQEGAMVIVSGWGK--QFLQRFPET 600
Cdd:COG5640    93 LSTSGGTVVKVARIVVHPDYDPATPGNDIALLKLA-TPV--PGVAPAPLATSAdaAAPGTPATVAGWGRtsEGPGSQSGT 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1246145998 601 LMEIEIPVVDHRICQeAYTPLkkkVTRDMICAGEKEGK-------SGG 641
Cdd:COG5640   170 LRKADVPVVSDATCA-AYGGF---DGGTMLCAGYPEGGkdacqgdSGG 213
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 185-296 1.47e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 130.22  E-value: 1.47e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 185 CSDNLFTQRTGVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPevSCPYDYIKIKTGP----KVLGPFC 260
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSP--NCSYDYLEIYDGPstssPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1246145998 261 GEKAPEPINTQSHSVQILFRSDNSGENRGWKLLYRA 296
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 28-137 6.97e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 116.74  E-value: 6.97e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998  28 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEEQVLATFCGRETTdteqtpg 103
Cdd:cd00041    10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1246145998 104 qEVVLSPGSFMSITFRSDFSNeeRFTGFEAHYMA 137
Cdd:cd00041    83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 195-294 8.72e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 115.95  E-value: 8.72e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998  195 GVITSPDFPSPYPKSSECVYTIELEEGFMISLQFEDiFDIEDHPEvsCPYDYIKIKTGP----KVLGPFCGEKAPEPINT 270
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGPsassPLLGRFCGSEAPPPVIS 77

                           90       100
                   ....*....|....*....|....*
gi 1246145998  271 -QSHSVQILFRSDNSGENRGWKLLY 294
Cdd:smart00042  78 sSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 29-135 1.00e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 115.95  E-value: 1.00e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998   29 GQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEEQVLATFCGREttdteqtPGQ 104
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1246145998  105 EVVLSPGSFMSITFRSDFSNEERftGFEAHY 135
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
CUB pfam00431
CUB domain;
23-135 9.41e-23

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 93.51  E-value: 9.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998  23 ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEEQVLATFCGREttdt 98
Cdd:pfam00431   4 VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGSG---- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1246145998  99 eqtpGQEVVLSPGSFMSITFRSDFSNEERftGFEAHY 135
Cdd:pfam00431  80 ----IPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
Sushi pfam00084
Sushi repeat (SCR repeat);
301-362 7.12e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 57.89  E-value: 7.12e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246145998 301 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDGTWSNKIPTC 362
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 301-363 1.59e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 1.59e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246145998 301 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNvemdtfQIECLKDGTWSNKIPTCK 363
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSS------TITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 301-362 7.08e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.14  E-value: 7.08e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246145998  301 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDGTWSNKIPTC 362
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 153-181 9.51e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.47  E-value: 9.51e-09
                          10        20
                  ....*....|....*....|....*....
gi 1246145998 153 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 181
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 463-590 1.74e-06

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 48.90  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 463 IAMLSHLNGQPFCGGSLLGSKWIVTAAHCLHqllDSEDATLhgldllsPSAFKIIMGkhwryRSDENEQSLSVKQIFLHP 542
Cdd:COG3591     2 VGRLETDGGGGVCTGTLIGPNLVLTAGHCVY---DGAGGGW-------ATNIVFVPG-----YNGGPYGTATATRFRVPP 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1246145998 543 LYNPNT-FENDVALVELSKSPVLNDFVMPIcLPQGPPQEGAMVIVSGWG 590
Cdd:COG3591    67 GWVASGdAGYDYALLRLDEPLGDTTGWLGL-AFNDAPLAGEPVTIIGYP 114
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 279-382 6.80e-06

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 48.54  E-value: 6.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 279 FRSDNSGENRGWKLLYRATGNECPKLQPPvHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVemdtfqIECLKDgTWsNK 358
Cdd:PHA02954  108 FRCEEKNGNTSWNDTVTCPNAECQPLQLE-HGSCQPVKEKYSFGEHITINCDVGYEVIGASY------ISCTAN-SW-NV 178

                          90       100
                  ....*....|....*....|....
gi 1246145998 359 IPTCKiVDCGAPAeLENGLVTFST 382
Cdd:PHA02954  179 IPSCQ-QKCDIPS-LSNGLISGST 200
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 367-432 6.85e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.99  E-value: 6.85e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246145998 367 CGAPAELENGLVTFSTRNnlTTYKSEIRYSCqQPYYQMLHSitDVYTCSAQGVWMNEvlgrsQPTC 432
Cdd:cd00033     1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGS--STITCTENGGWSPP-----PPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 300-433 9.00e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 48.12  E-value: 9.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 300 ECPKLQPPVHGNIEPLQAKYFFKDQVLISCDTgHKVLKDNVeMDTFQIECLKDGTWSNKIPTCKIVDCGAPAeLENGLVT 379
Cdd:PHA02639   84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNE-HKGVQYSL-VGNEKITCIQDKSWKPDPPICKMINCRFPA-LQNGYIN 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1246145998 380 FSTRNNLTTYKSEIRYSCQQPYYQMLHSITdvyTCSAQGVWMNEVlgrsqPTCL 433
Cdd:PHA02639  161 GIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFPSI-----PTCV 206
PHA02817 PHA02817
EEV Host range protein; Provisional
 347-398 1.55e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.86  E-value: 1.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246145998 347 IECLKDGTWSNKIPTCKIVDCGAPAeLENGLVTFSTRNNLTTYKSEIRYSCQ 398
Cdd:PHA02817   69 IICEKDGKWNKEFPVCKIIRCRFPA-LQNGFVNGIPDSKKFYYESEVSFSCK 119
EGF_CA smart00179
Calcium-binding EGF-like domain;
139-181 6.03e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 6.03e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1246145998  139 DVDECMEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 181
Cdd:smart00179   1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 367-432 8.89e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.59  E-value: 8.89e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246145998  367 CGAPAELENGLVTFSTRNnlTTYKSEIRYSCQQPYYQmlhSITDVYTCSAQGVWMNEVlgrsqPTC 432
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPGYTL---IGSSTITCLENGTWSPPP-----PTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 139-176 1.36e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1246145998 139 DVDECmereDEELSCDHY--CHNYIGGYYCSCRFGYILHT 176
Cdd:cd00054     1 DIDEC----ASGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
PHA02831 PHA02831
EEV host range protein; Provisional
 308-420 8.49e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 41.90  E-value: 8.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 308 VHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVEMDTfqIECLkDGTWSNKIPTCKIVDCGAPAeLENG-LVTFSTRnnl 386
Cdd:PHA02831   85 LNGYIKNKKDQYSFGDSVTYACKVNKLEKYSIVGNET--VKCI-NKQWVPKYPVCKLIRCKYPA-LQNGfLNVFEKK--- 157

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1246145998 387 TTYKSEIRYSCQQPyYQMLHSITDvyTCSAQGVW 420
Cdd:PHA02831  158 FYYGDIVNFKCKKG-FILLGSSVS--TCDINSIW 188
PHA02639 PHA02639
EEV host range protein; Provisional
 301-399 2.08e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 40.80  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 301 CPKLQPPVHGNIEPLQAKYFFKDQVLISCDTGHKVLKDNVEMdtfqieCLKD---GTWSNKIPTCKIVDCGAPAELENGL 377
Cdd:PHA02639   22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRT------CIKDknnAIWSNKAPFCMLKECNDPPSIINGK 95

                          90       100
                  ....*....|....*....|....
gi 1246145998 378 VTfstrNNLTTYK--SEIRYSCQQ 399
Cdd:PHA02639   96 IY----NKREMYKvgDEIYYVCNE 115
EGF_CA pfam07645
Calcium-binding EGF domain;
139-171 2.91e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 2.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1246145998 139 DVDECmerEDEELSCDH--YCHNYIGGYYCSCRFG 171
Cdd:pfam07645   1 DVDEC---ATGTHNCPAntVCVNTIGSFECRCPDG 32
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 289-450 2.98e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 40.02  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 289 GWKLLYRATGNECPKLQPPVHGNIEPLQAKyfFKDQVLISCDTGHKVLKDNveMDTFQIECLKDGTWSNKIPTCKIVDCG 368
Cdd:PHA02927   74 GWTLFNQCIKRRCPSPRDIDNGQLDIGGVD--FGSSITYSCNSGYQLIGES--KSYCELGSTGSMVWNPEAPICESVKCQ 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 369 APAELENGlvTFSTRNNLTTYKSEIRYSCQQPYYQMLHSITdvyTCSAqGVWMNEvlgrsqPTCLPV-CGIPKFSRNLMA 447
Cdd:PHA02927  150 SPPSISNG--RHNGYEDFYTDGSVVTYSCNSGYSLIGNSGV---LCSG-GEWSDP------PTCQIVkCPHPTISNGYLS 217


                  ...
gi 1246145998 448 RIF 450
Cdd:PHA02927  218 SGF 220
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 121-180 7.01e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 38.52  E-value: 7.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246145998 121 DFSNEERFTGFEAHYMAVDVDECMEredEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
Cdd:cd01475   168 DFSTIEELTKKFQGKICVVPDLCAT---LSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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