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Items: 1 to 20 of 2453742

1.

Molecular mechanisms of the Xiao-chai-hu-tang on chronic stress-induced colorectal cancer growth based on an integrated network pharmacology and RNA sequencing approach with experimental validation

(Submitter supplied) XCHT significantly inhibited CRC growth under chronic stress in a dose-dependent manner. Mechanistically, XCHT suppressed the expression levels of glycolysis associated enzymes and inflammatory factors caused by chronic stress. Moreover, XCHT significantly mitigated the activity of the JAK2/STAT3 signaling which was activated by chronic stress induced IL-6.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23479
12 Samples
Download data: TXT
Series
Accession:
GSE276601
ID:
200276601

2.

TGFβ primes alveolar-like macrophages to induce type I IFN following TLR2 activation.

(Submitter supplied) Alveolar macrophages (AMs) are key mediators of lung function and are potential targets for therapies during respiratory infections. TGFb is an important regulator of AM differentiation and maintenance but, how TGFb directly modulates the innate immune responses of AMs remains unclear. This shortcoming prevents effective targeting of AMs to improve lung function in health and disease. Here we leveraged an optimized ex vivo AM model system, fetal-liver derived alveolar-like macrophages (FLAMs), to dissect the role of TGFb in AMs. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
12 Samples
Download data: CSV
Series
Accession:
GSE276577
ID:
200276577

3.

Detect IGF1R function in postnatal bone marrow mesenchymal stem cell

(Submitter supplied) 1. IGF1R signaling pathway is highly enriched in P0.5 BMMSC compared to adult BMMSC; 2. Niche factors are highly expressed in PDGFRa+Sca1+ (PaS) cells. 3. Knockout IGF1R in Prx1+ BMMSC significantly impaired niche factors expression in P0.5 BMMSC.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
11 Samples
Download data: CSV
Series
Accession:
GSE276419
ID:
200276419

4.

Purification of mitochondria from skeletal muscle tissue for transcriptomic analyses reveals localization of nuclear-encoded non-coding RNAs [SMvsMT]

(Submitter supplied) Mitochondria are central to cellular function, particularly in metabolically active tissues such as skeletal muscle. Nuclear-encoded RNAs typically localise within the nucleus and cytosol but a small population may also translocate to subcellular compartments such as mitochondria. We aimed to investigate the nuclear-encoded RNAs that localise within the mitochondria of skeletal muscle tissue. Intact mitochondria were isolated via immunoprecipitation (IP) followed by enzymatic treatments (RNase-A and proteinase-K) optimised to remove transcripts located exterior to mitochondria, making it amenable for high-throughput transcriptomic sequencing. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
12 Samples
Download data: CSV
Series
Accession:
GSE276307
ID:
200276307

5.

Purification of mitochondria from skeletal muscle tissue for transcriptomic analyses reveals localization of nuclear-encoded non-coding RNAs [Mitoplasts]

(Submitter supplied) Mitochondria are central to cellular function, particularly in metabolically active tissues such as skeletal muscle. Nuclear-encoded RNAs typically localise within the nucleus and cytosol but a small population may also translocate to subcellular compartments such as mitochondria. We aimed to investigate the nuclear-encoded RNAs that localise within the mitochondria of skeletal muscle cells and tissue. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
12 Samples
Download data: CSV
Series
Accession:
GSE276306
ID:
200276306

6.

Purification of mitochondria from skeletal muscle tissue for transcriptomic analyses reveals localization of nuclear-encoded non-coding RNAs [L6 mito]

(Submitter supplied) MiRNAs are non-coding RNAs that regulate gene expression. MiRNAs mostly localise within the cytosol but are also found in the mitochondria where they can regulate the expression of mitochondrial-encoded transcripts. Small RNA library preparation protocols are well described when using total cellular RNA as the template, however, these methods are not directly applicable to total RNA extracted from fractionated cells, such as isolated mitochondria. more...
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL19052
12 Samples
Download data: CSV
Series
Accession:
GSE276303
ID:
200276303

7.

Post-transcriptional regulation by the gut microbiota decoded by nanopore direct RNA sequencing [RNA methylation]

(Submitter supplied) It has been widely recognized that the microbiota has the capacity to shape host gene expression and physiological functions. However, there remains a paucity of comprehensive study revealing host transcriptional landscape regulated by the microbiota. Here, we comprehensively examined mRNA landscapes in mouse tissues (brain and cecum) from specific pathogen free (SPF) and germ-free mouse (GF) using Nanopore direct RNA sequencing. more...
Organism:
Mus musculus; Homo sapiens
Type:
Other
Platforms:
GPL24676 GPL24247
14 Samples
Download data: BED
Series
Accession:
GSE261724
ID:
200261724

8.

Post-transcriptional regulation by the gut microbiota decoded by nanopore direct RNA sequencing

(Submitter supplied) It has been widely recognized that the microbiota has the capacity to shape host gene expression and physiological functions. However, there remains a paucity of comprehensive study revealing host transcriptional landscape regulated by the microbiota. Here, we comprehensively examined mRNA landscapes in mouse tissues (brain and cecum) from specific pathogen free (SPF) and germ-free mouse (GF) using Nanopore direct RNA sequencing. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
4 related Platforms
16 Samples
Download data: TSV
Series
Accession:
GSE261301
ID:
200261301

9.

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platform:
GPL24247
70 Samples
Download data: BED, BW, COV, TXT
Series
Accession:
GSE247855
ID:
200247855

10.

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma [HiChIP]

(Submitter supplied) The ability of cancer cells to alter their identity is essential for tumor survival and progression. Loss of the pulmonary lineage specifier NKX2-1 within KRAS-driven lung adenocarcinoma (LUAD) enhances tumor progression and results in a pulmonary-to-gastric lineage switch that is dependent upon the activity of pioneer factors FoxA1 and FoxA2; however, the underlying mechanism remains largely unknown. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24247
2 Samples
Download data: TXT
Series
Accession:
GSE247854
ID:
200247854

11.

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma [Bisulfite-Seq]

(Submitter supplied) The ability of cancer cells to alter their identity is essential for tumor survival and progression. Loss of the pulmonary lineage specifier NKX2-1 within KRAS-driven lung adenocarcinoma (LUAD) enhances tumor progression and results in a pulmonary-to-gastric lineage switch that is dependent upon the activity of pioneer factors FoxA1 and FoxA2; however, the underlying mechanism remains largely unknown. more...
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL24247
20 Samples
Download data: BW, COV
Series
Accession:
GSE247853
ID:
200247853

12.

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma [ChIP-seq]

(Submitter supplied) The ability of cancer cells to alter their identity is essential for tumor survival and progression. Loss of the pulmonary lineage specifier NKX2-1 within KRAS-driven lung adenocarcinoma (LUAD) enhances tumor progression and results in a pulmonary-to-gastric lineage switch that is dependent upon the activity of pioneer factors FoxA1 and FoxA2; however, the underlying mechanism remains largely unknown. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24247
28 Samples
Download data: BED, BW
Series
Accession:
GSE247851
ID:
200247851

13.

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma [RNA-Seq]

(Submitter supplied) The ability of cancer cells to alter their identity is essential for tumor survival and progression. Loss of the pulmonary lineage specifier NKX2-1 within KRAS-driven lung adenocarcinoma (LUAD) enhances tumor progression and results in a pulmonary-to-gastric lineage switch that is dependent upon the activity of pioneer factors FoxA1 and FoxA2; however, the underlying mechanism remains largely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
20 Samples
Download data: TXT
Series
Accession:
GSE247845
ID:
200247845

14.

Acyl-coA Binding Protein neutralization improves cancer immunosurveillance

(Submitter supplied) The plasma concentrations of acyl coenzyme A binding protein (ACBP, also known as diazepam-binding inhibitor, DBI, or ‘endozepine’) increase with age and obesity, two parameters that are also the most important risk factors for cancer. In mice bearing MCA205 fibrosarcoma, antibody mediated ACBP/DBI neutralization enhanced the anticancer T-cell response in the context of chemoimmunotherapy. T-cells infiltrating MCA205 tumors were sorted and submitting to single-cell TCR sequencing and single-cell RNA sequencing (scRNAseq) to identify the mechanisms driving this improvement.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL24247
12 Samples
Download data: CSV, MTX, TSV
Series
Accession:
GSE242119
ID:
200242119

15.

Effect of Zbtb24-depletion on gene expressions during the activation of peritoneal B1 cells

(Submitter supplied) ZBTB24-null ICF2 patients suffer from recurrent infections associated with antibody defects, implying a pivitol role of ZBTB24 in B cell biology. We thus generated B-cell specific Zbtb24 knockout mice and investigated its intrinsic role in B cell development and function both in vitro and in vivo. In accordance with findings obtained in ICF2 patients, Zbtb24 is dispensable for B cell developent and maintenance in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23479
4 Samples
Download data: TXT
Series
Accession:
GSE241747
ID:
200241747

16.

Effect of Zbtb24-depletion on gene expressions during the activation of total splenic B cells

(Submitter supplied) ZBTB24-null ICF2 patients suffer from recurrent infections associated with antibody defects, implying a pivitol role of ZBTB24 in B cell biology. We thus generated B-cell specific Zbtb24 knockout mice and investigated its intrinsic role in B cell development and function both in vitro and in vivo. In accordance with findings obtained in ICF2 patients, Zbtb24 is dispensable for B cell developent and maintenance in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23479
18 Samples
Download data: TXT
Series
Accession:
GSE241746
ID:
200241746

17.

RNA-seq analysis of mouse bone marrow hematopoietic progenitors after bone marrow transplant

(Submitter supplied) RNA-seq analysis of differentially expressed genes in wild-type, NFAT5-deficient, IFNAR1-deficient and double deficient (NFAT5 and IFNAR1) hematopoietic stem cells (HSC) and multipotent progenitors (MPP)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
8 Samples
Download data: TXT
Series
Accession:
GSE228634
ID:
200228634

18.

Effect of isolated neutrophils from Cd177 knockout mice post-SCI on microglia in a co-culture system

(Submitter supplied) To investigate the transcriptional effects of CD177+ neutrophils on microglia in spinal cord injuries (SCI), we adapted a co-culture system containing isolated neutrophils from Cd177 WT or KO mice post-SCI and isolated microglia. Each group had a biological repeat (n=3).
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE276429
ID:
200276429

19.

Effect of isolated neutrophils from Cd177 knockout mice post-SCI on macrophages in a co-culture system

(Submitter supplied) To investigate the transcriptional effects of CD177+ neutrophils on macrophages in spinal cord injuries (SCI), we adapted a co-culture system containing isolated neutrophils from Cd177 WT or KO mice post-SCI and bone marrow-derived macrophages (BMDMs). Each group had a biological repeat (n=3).
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE276427
ID:
200276427

20.

PD1-mediated microglia assisted cerebrovascular pruning during vascular development.

(Submitter supplied) To further explore the mechanism of cerebrovascular pruning by PD1 in microglia, we analyzed RNA isolated from Pd1fl/fl and Pd1cKO-Cx3 cerebral cortical microglia at P11 using RNA-seq to identify genome-wide changes.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: XLS
Series
Accession:
GSE276402
ID:
200276402

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