txid10090[Organism] - GEO DataSets

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Select item 2002815721.

HuR coordinates systemic aging through platelet infiltration

(Submitter supplied) Aging involves morphological and functional changes across different organs, but how these changes are linked among the different organs remains to be elucidated. Here, we uncover a central role of platelets in sys temic aging. In aged mice, the levels of platelet secreted pro inflammatory factors (PSPF) increased greatly in the serum and platelets, leading to a diffuse increase of platelet infiltration in brain, liver, lung, kidney, and aortic root. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28330
18 Samples

Download data: MTX, TSV

Series

Accession:: GSE281572

ID:: 200281572

Select item 2002819422.

Bioenergetic programs of cancellous and cortical bone are distinct and differ with age and mechanical loading

(Submitter supplied) Mechanical loading induces bone formation in young rodents, but mechanoresponsiveness is reduced with age. Glycolytic activity and mitochondrial dysfunction increase with age and may change bone mechanotransduction. To evaluate load-induced changes to bioenergetic activity in young and adult animals, we loaded the tibia of 10-wk and 26-wk female mice and examined transcriptomic responses at the mid-diaphysis, metaphyseal cortical shell, and cancellous core. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
150 Samples

Download data: XLSX

Series

Accession:: GSE281942

ID:: 200281942

Select item 2002818553.

Systems level analysis of lipid metabolism in oxygen-induced retinopathy [retina_RNAseq]

(Submitter supplied) Activation of anaplerosis takes away glutamine from the biosynthetic pathway to the energy-producing TCA cycle. Especially, induction of hyperoxia driven anaplerosis in neurovascular tissues such as the retina during early stages of development could deplete biosynthetic precursors from newly proliferating endothelial cells impeding physiological angiogenesis and leading to vasoobliteration. Using an oxygen-induced retinopathy (OIR) mouse model, we investigated the metabolic differences between OIR-resistant BALB/cByJ and OIR susceptible C57BL/6J strains at system levels to understand the molecular underpinnings that potentially contribute to hyperoxia-induced vascular abnormalities in the neural retina. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
16 Samples

Download data: XLSX

Series

Accession:: GSE281855

ID:: 200281855

Select item 2002818544.

Systems level analysis of lipid metabolism in oxygen-induced retinopathy [liver RNA-Seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
15 Samples

Download data: XLSX

Series

Accession:: GSE281854

ID:: 200281854

Select item 2002816255.

Transcriptomic changes in ER-HOXB8 mouse cell line on Phf6 knockout

(Submitter supplied) PHF6 is a transcriptional regulator mutated in 3-5% of acute myeloid leukemia. To understand the effect of loss and clinical mutation of PHF6 on the transcriptome of myeloid cells we generated multiple wildtype and Phf6 knockout clones. We observed that loss of PHF6 upregulated genes related to stemness and downregulates genes related to myeloid differentiation.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
7 Samples

Download data: TXT

Series

Accession:: GSE281625

ID:: 200281625

Select item 2002816086.

CREBH Regulates Mitochondrial Unfolded Protein Response to Maintain Energy Homeostasis

(Submitter supplied) The Mitochondrial Unfolded Protein Response (UPRmt), a mitochondria-originated stress response to altered mitochondrial proteostasis, plays important roles in various pathophysiological processes. In this study, we revealed that the endoplasmic reticulum (ER)-tethered stress sensor CREBH regulates UPRmt to maintain mitochondrial homeostasis and function in the liver. CREBH is enriched in and required for hepatic Mitochondria-Associated Membrane (MAM) expansion induced by energy demands. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
6 Samples

Download data: TXT

Series

Accession:: GSE281608

ID:: 200281608

Select item 2002813977.

Interspecies comparison receals Hmga1 as driver of cardiac regeneration [Mnase-seq]

(Submitter supplied) The prospect of repairing the heart after a myocardial infarction by promoting cardiomyocyte proliferation has gained momentum from studies showing the heart's regenerative ability in fish, amphibians and neonatal mammals. Despite evidence of varying cardiomyocyte proliferation rates among species, the molecular mechanisms driving cardiomyocyte cell cycle re-entry remain insufficiently understood. In this study, we employed spatial transcriptomics and identified high-mobility group AT-hook 1a (Hmga1a) as being upregulated in cardiomyocytes of the injury border zone in zebrafish, but not in mice. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL30172
7 Samples

Download data: BIGWIG

Series

Accession:: GSE281397

ID:: 200281397

Select item 2002813228.

N-acetyl-tryptophan in acute kidney injury after cardiac surgery

(Submitter supplied) The transcriptome sequencing, surface plasmon resonance and protein mutation were employed to explore the mechanism of N-acetyl-tryptophan on the kidney.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28457
15 Samples

Download data: TXT

Series

Accession:: GSE281322

ID:: 200281322

Select item 2002811569.

Gastric Hypoplasia in mice lacking Fibroblast Growth Factor 9

(Submitter supplied) To determine the role of Fgf9 in gastric development, we collected E15.5 Fgf9 KO (Fgf9LacZ/LacZ) and Het (Fgf9LacZ/+) stomachs for RNA-seq analysis. 3 stomachs were pooled for each RNA-seq sample.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: TXT

Series

Accession:: GSE281156

ID:: 200281156

Select item 20028099810.

Gene expression profile of Purkinje cells in Kcnd3 F227del mice

(Submitter supplied) Spinocerebellar ataxia type 22 (SCA22) caused by KCND3 mutations is an autosomal dominant disorder. We establish a mouse model carrying the Kcnd3 F227del mutation to study the molecular pathogenesis. Four findings are pinpointed. Firstly, the heterozygous mice exhibit an early onset of defects in motor coordination and balance, which mirror the SCA22 patients. The degeneration and a minor loss of Purkinje cells together with the concurrent presence of neuroinflammation, as well as the previous finding on electrophysiological changes, may all contribute to the development of the SCA22 ataxia phenotype in mice carrying the Kcnd3 F227del mutant protein. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
9 Samples

Download data: TXT

Series

Accession:: GSE280998

ID:: 200280998

Select item 20028030511.

LSK immunophenotype hematopoietic stem cells after irradiation at day points in 3 weeks

(Submitter supplied) In this study, we aimed to investigate the differentiation dynamics of LSK (Lin-Sca1+c-Kit+) cells following radiation injury. LSK cells, which are a critical component of the hematopoietic stem and progenitor cell population, play a vital role in the regeneration and repair of the hematopoietic system after damage. By utilizing these cells, we sought to understand the mechanisms underlying their response to radiation, focusing on their capacity for self-renewal and differentiation into various blood cell lineages.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
4 Samples

Download data: LOOM

Series

Accession:: GSE280305

ID:: 200280305

Select item 20027876512.

Identification of cathepsin L as an inter-organ target to mitigate cachexia while enhancing tumor suppression by anti-PD-L1 [scRNA-seq]

(Submitter supplied) Immune checkpoint inhibitors (ICIs) can induce immune-related adverse events (irAEs) due to an overly activated immune system, despite their anti-cancer effects. Here, we observe that ICI treatment is associated with body weight loss in cancer patients. Similarly, anti-PD-L1 exacerbates muscle wasting in cancer cachexia (CAC) mice, despite its tumor suppressive effects, suggesting muscle atrophy as a potential irAE. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30215
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE278765

ID:: 200278765

Select item 20027828913.

Single nucleus RNA sequencing of mosiac Pax2 and Pax8 mutant proximal tubules

(Submitter supplied) Pax2 and Pax8 are homologous transcription factors required for kidney development and medullary urine concentration. However, their function in proximal tubule homeostasis and response to acute kidney injury is unknown. Mice with proximal tubules consisting of a mosaic of wild-type and Pax2/8 mutant proximal tubules cells were generated. Gene expression of mutant and wild-type proximal tubule cells was compared under homeostatic conditions using single-nucleus RNA sequencing.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
3 Samples

Download data: TAR

Series

Accession:: GSE278289

ID:: 200278289

Select item 20027730314.

Transcriptional profiling of the flow-sorted mouse blood monocyte subsets

(Submitter supplied) Classical monocytes (CMs) can be converted into conventional dominant Nr4a1-dependent nonclassical monocytes (N-NCMs). Upon activation of Nod2 signaling, CM also can be converted into noncanonical Nod2-dependent inducible NCMs (I-NCMs). The transcriptional profiles and typical markers specific for those two NCM subsets yet to be determined. To transcriptionally characterize N-NCM and I-NCM, we performed transcriptional profiling analysis using RNAseq data obtained from the flow-sorted NCM subsets. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
42 Samples

Download data: TXT

Series

Accession:: GSE277303

ID:: 200277303

Select item 20026370115.

The miR-22-5p/Clec4e axis has therapeutic potential in fructose-induced nonalcoholic fatty liver disease

(Submitter supplied) Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease.MicroRNAs play roles in the onset and progression of the disease. This study aimed to screen microRNA profiles and potential RNA networks for the diagnosis and treatment of NAFLD. Mice were high-fructose diet (HFrD) fed to induce NAFLD. MicroRNA expression profiles of the livers in HFrD mice and chow-diet fed mice were analyzed by RNA-seq. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: XLSX

Series

Accession:: GSE263701

ID:: 200263701

Select item 20026316716.

Gene expression in bone marrow-derived dendritic cells obtained from wild-type mice or 3BP2 DL/DL mice stimulated with or without curdlan

(Submitter supplied) C-type lectin dectin-1 is known to recognize beta-glucans such as curdlan and propagate intracellular signaling for activation of NF-kappa B to induce anti-fungal immunity. Recently, we found that adaptor protein 3BP2 is required for the dectin-1-induced activation of NF-kappa B. In this study, we performed microarray analysis to identify genes of which expression is regulated by dectin-1 and 3BP2.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
10 Samples

Download data: CEL, CHP

Series

Accession:: GSE263167

ID:: 200263167

PubMed Analyze with GEO2R

Select item 20026258017.

High-resolution, noninvasive single-cell lineage tracing in mice and humans based on DNA methylation epimutations

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other

Platforms:: GPL24676 GPL24247
697 Samples

Download data: TSV

Series

Accession:: GSE262580

ID:: 200262580

Select item 20026176718.

BPDCN MYB Fusions Regulate Cell Cycle Genes, Impair Differentiation and Induce Myeloid-Dendritic Cell Leukemia [HoxRNASeq]

(Submitter supplied) MYB fusions are recurrently found in select cancers, including blastic plasmacytoid dendritic cell neoplasm (BPDCN), an acute leukemia with poor prognosis. They are markedly enriched in BPDCN compared to other blood cancers, and in some patients are the only obvious somatic mutation detected. This suggests they may alone be sufficient to drive dendritic cell transformation. MYB fusions are hypothesized to alter the normal transcription factor activity of MYB, but mechanistically how they promote leukemogenesis is poorly understood. more...