GEO DataSet Links for SRA (Select 7094512) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Links from SRA

Items: 2

Select item 3035664931.

HAP1_RNA-seq_WT_Control_r6

Organism:: Homo sapiens

Source name:: cell line

Platform:: GPL20301
Series:: GSE125219 GSE125221

Download data

Sample

Accession:: GSM3566493

ID:: 303566493

SRA Run Selector

Select item 2001252192.

Histone chaperone CAF-1 is a synthetic lethal vulnerability in the context of ARID1A deficiencies [RNA-Seq]

(Submitter supplied) Mutations in the BAF chromatin remodeling complex rank among the most frequent genetic alterations in human cancers, many of which result in a loss of function of the respective subunits. Recent genomic and chemical screens have revealed synthetic lethal interactions of BAF complex subunits with each other as well as with further chromatin modifiers. Using an epigenome-focused shRNA library, we identified loss of the histone chaperone complex CAF-1 (chromatin assembly factor 1) as a synthetic lethal vulnerability of ARID1A-deficient cells that is enhanced by the androgen receptor agonist testosterone. more...