GEO DataSet Links for SRA (Select 6131934) - GEO DataSets

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Items: 2

Select item 3033263801.

PT089_P9_B05_S113

Organism:: Homo sapiens

Source name:: breast

Platform:: GPL9052
Series:: GSE118389 GSE118390

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Accession:: GSM3326380

ID:: 303326380

SRA Run Selector

Select item 2001183892.

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq [RNA-Seq]

(Submitter supplied) Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conduct single-cell RNA- sequencing (scRNA-seq) of >1500 cells from six primary TNBC. Intercellular heterogeneity of gene expression programs within each tumor was variable and largely correlated with clonality of inferred genomic copy number changes, suggesting that genotype drives the gene expression phenotype of individual subpopulations. more...