GEO DataSet Links for SRA (Select 4624812) - GEO DataSets

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Items: 2

Select item 3028234891.

R6/2_HD_Cortex_Male_Vehicle_replicate2

Organism:: Mus musculus

Source name:: R6/2, Cortex, Vehicle

Platform:: GPL13112
Series:: GSE105158

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Accession:: GSM2823489

ID:: 302823489

SRA Run Selector

Select item 2001051582.

RNA-Seq data on KMO inhibitor (CHDI-00340246) subchronic treated R6/2 mice.

(Submitter supplied) Dysregulation of the kynurenine (Kyn) pathway has been associated with the progression of Huntington's disease (HD). In particular, elevated levels of the kynurenine metabolites 3-hydroxy kynurenine (3-OH-Kyn) and quinolinic acid (Quin), have been reported in the brains of HD patients as well as in rodent models of HD. The production of these metabolites is controlled by the activity of kynurenine mono-oxygenase (KMO), a mitochondrial outer membrane enzyme which catalyzes the synthesis of 3-OH-Kyn from Kyn. more...