GEO DataSets

(Submitter supplied) The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL11154

3 Samples

Download data: TXT

(Submitter supplied) Human primary keratinocytes were collected at 0, 1, 3, 6, 12, 24 and 48 hours after addition of 1.8mM Calcium and RNA was extracted.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5454

Platform:

GPL6244

14 Samples

Download data: CEL, CHP

(Submitter supplied) Human primary keratinocytes were depleted of MLL2 by siRNA and induced to differentiated for 2 days by addition of Calcium

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5452

Platform:

GPL6244

4 Samples

Download data: CEL, CHP

(Submitter supplied) Human primary keratinocytes were depleted of GRHL3 by siRNA and induced to differentiated for 2 days by addition of Calcium

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5453

Platform:

GPL6244

6 Samples

Download data: CEL, CHP

Analysis of neonatal epidermal keratinocytes treated with 1.8 mM calcium for up to 48 hours. Results provide insight into the molecular mechanisms underlying the differentiation of epidermal keratinocytes.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 7 time sets

Platform:

GPL6244

Series:

GSE38628

14 Samples

Download data: CEL, CHP

Analysis of Grainyhead like 3 (GRHL3)-depleted neonatal epidermal keratinocytes following treatment with 1.8 mM calcium for 24 hours to induce differentiation. GRHL3 encodes a transcription factor. Results provide insight into the role of GRHL3 in keratinocyte differentiation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL6244

Series:

GSE37049

6 Samples

Download data: CEL, CHP

Analysis of MLL2-depleted neonatal epidermal keratinocytes following treatment with 1.8 mM calcium for 24 hours to induce differentiation. Histone H3K4 methyltransferase MLL2 is a trithorax group protein. Results provide insight into the role of MLL2 in keratinocyte differentiation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL6244

Series:

GSE37570

4 Samples

Download data: CEL, CHP