GEO DataSets

Comparison of gene expression in 12 pediatric rhabdomyosarcomas (RMS) to that in 11 pediatric Ewing's sarcomas (EWS). 3 embryonic and 9 alveolar RMS tumors examined. RMS and EWS appear similar in routine histology. Results identify expression profiles that distinguish RMS from EWS.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL91

Series:

GSE967

23 Samples

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(Submitter supplied) Affymetrx U95Av2 GeneChip hybridizations, RNA extracted from primary human pediatric alveolar (aRMS) and embryonal (eRMS) rhabdomyosarcoma, plus primary pediatric Ewing's sarcoma (EWS) Keywords = pediatric sarcoma Keywords = Ewing's sarcoma Keywords = rhabdomyosarcoma Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS971

Platform:

GPL91

23 Samples

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(Submitter supplied) The molecular hallmark of the Ewing family of tumors is the presence of balanced chromosomal translocations leading to the formation of chimerical transcription factors (i.e. EWS/FLI1) that play a pivotal role in the pathogenesis of Ewing tumors by deregulating gene expression. We have recently demonstrated that DAX1 (NR0B1), an orphan nuclear receptor which was not previously implicated in cancer, is induced by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors, suggesting that DAX1 is a biologically relevant target of EWS/FLI1-mediated oncogenesis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2895

12 Samples

Download data: TXT

(Submitter supplied) V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2; synonyms HER2, NEU) encodes a transmembrane glycoprotein with tyrosine kinase-specific activity that acts as a major switch in different signal-transduction processes. ERBB2 amplification and overexpression have been found in a number of human cancers, including breast, ovary and kidney carcinoma. Our aim was to detect ERBB2- regulated target genes that contribute to its tumorigenic effect on a genomewide scale. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL3697

4 Samples

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(Submitter supplied) Group of 5 experiments (including 2 independent cell preparations and 2 dye swaps) of Erbbr (Her2, Neu) transfected fibroblasts versus normal cells Keywords: parallel sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1216

5 Samples

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(Submitter supplied) We create an experimental model of EWS cells that are chemoresistant and unable to give metastasis in mice and identify a molecular signature of potential prognostic value in EWS patients Keywords: cell type comparison

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL876

4 Samples

Download data: TXT

(Submitter supplied) Rhabdomyosarcoma (RMS) is the most common paediatric soft-tissue sarcoma and resembles developing skeletal muscle. Specific genomic alterations including translocations, deletions and amplification events have been associated with the alveolar and embryonal subtypes of RMS. Characterizing these changes has led to increased understanding of the underlying molecular biology. However, further aberrations and their significance remain to be defined. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

13 Samples

Download data: CEL, CHP

(Submitter supplied) Liverpool2 is a spotted cDNA array for approximately 10,000 nonredundant genes expressed in embryonic, adult, and/or cancerous liver.

Organism:

Homo sapiens

2 Series

189 Samples

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(Submitter supplied) Liverpool is a nylon array of complementary DNA (cDNA) probes for approximately 10,000 nonredundant genes expressed in embryonic, adult, and/or cancerous liver.

Organism:

Homo sapiens

1 Series

42 Samples

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(Submitter supplied) By using high-density DNA microarrays, we analyzed the gene-expression profile of Hodgkin's lymphoma cell lines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

3 Samples

Download data: CEL

(Submitter supplied) Comparison of gene expression profiles between neuroblastoma samples and Ewing family tumor samples. RNA from native tumor samples was processed for DNA-microarray analysis using Affymetrix HG-U133A microarrays. Primary image analysis was performed using MAS 5.0 and data were scaled to an target intesity of 500. Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1713

Platform:

GPL96

10 Samples

Download data: CEL, TXT

(Submitter supplied) Gene expression analysis of cell lines initially established as neuroblastoma cell lines. Cells were harvested and processed for DNA-microarray analysis using Affymetrix HG-U133A microarrays. Primary image analysis was performed using MAS 5.0 and data were scaled to an target intesity of 500. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1548

Platform:

GPL96

4 Samples

Download data: CEL

Analysis of Ewing family tumor (EFT) and neuroblastoma (NB) samples. Distinguishing EFTs from other small round blue cell tumors (SRBCTs), such as NBs, by histologic methods is often difficult. Results identify EF-associated genes that enable molecular discrimination between EFTs and other SRBCTs.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL96

Series:

GSE1825

10 Samples

Download data: CEL

Analysis of four cell lines initially established as neuroblastomas. Results indicate that the SK-N-MC cell line expresses all of the Ewing Family Tumor (EFT) signature genes. EFTs are small round blue cell tumors that show features of neuroectodermal differentiation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 cell line, 2 disease state sets

Platform:

GPL96

Series:

GSE1824

4 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL20712 GPL23159

127 Samples

Download data: CEL, TXT

(Submitter supplied) Adolescents and young adults (AYA) with rhabdomyosarcoma (RMS) form a subgroup of patients whose optimal clinical management and best possible access to care remain a challenge and survival lacks behind that of children while diagnosed with histologically similar tumors. Understanding the tumor biology that differentiate children from AYA-RMS could provide critical information and drive new initiatives to improve their final outcome. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL20712

64 Samples

Download data: TXT

(Submitter supplied) Adolescents and young adults (AYA) with rhabdomyosarcoma (RMS) form a subgroup of patients whose optimal clinical management and best possible access to care remain a challenge and survival lacks behind that of children while diagnosed with histologically similar tumors. Understanding the tumor biology that differentiate children from AYA-RMS could provide critical information and drive new initiatives to improve their final outcome. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23159

63 Samples

Download data: CEL

(Submitter supplied) Cardiac hypertrophy was induced by aortic banding (6, 12, 16, and 30 weeks), myocardial infarction (3 and 9 weeks), an av-fistula (aorta abd. to v. cava inf.. 3 and 8 weeks), or hormone infusion (two weeks either angiotensin 2 or a thyroxin analogue). Sham operated or saline infused animals served as controls. Gene expression was determined by Affymetrix RGU34A GeneChip's to identify genes with common regulation in the different models of cardiac hypertrophy. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS598

Platform:

GPL85

46 Samples

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Analysis of heart left ventricle tissue in several models of cardiac hypertrophy. Hypertrophy induced by aortic banding, myocardial infarction, an arteriovenous fistula, or hormone (angiotensin 2 or thyroxin analog) infusion.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state, 10 protocol, 9 time sets

Platform:

GPL85

Series:

GSE738

46 Samples

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