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Links from GEO DataSets

Items: 13

1.
Full record GDS5656

Forkhead box O 1,3,4 muscle-specific knockout effect on fasted gastrocnemius muscle

Analysis of gastrocnemius muscle from starved males with muscle-specific deletion of Forkhead Box O transcription factors 1, 3 and 4 (FoxO1,3,4-/-). Results provide insight into the collective roles of FoxOs during muscle atrophy.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 stress sets
Platform:
GPL1261
Series:
GSE52667
4 Samples
Download data: CEL
2.

The FoxO signature in protein breakdown

(Submitter supplied) Under stress conditions mammalian cells activate compensatory mechanisms to survive and maintain cellular function. During catabolic conditions, such as low nutrients, systemic inflammation, cancer or infections, protein breakdown is enhanced and aminoacids are released from muscles to sustain liver gluconeogenesis and tissues protein synthesis. Proteolysis in muscle is orchestrated by a set of genes named atrophy-related genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5656
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE52667
ID:
200052667
3.

FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy

(Submitter supplied) Insulin deficiency and uncontrolled diabetes lead to a catabolic state with decreased muscle strength, contributing to disease-related morbidity. FoxO transcription factors are suppressed by insulin and thus are key mediators of insulin action. To study their role in diabetic muscle wasting, we created mice with muscle-specific triple knockout of FoxO1/3/4 and induced diabetes in these M-FoxO-TKO mice with streptozotocin (STZ). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
21 Samples
Download data: CSV
Series
Accession:
GSE136948
ID:
200136948
4.

Sestrin prevents skeletal muscle atrophy

(Submitter supplied) We identify sestrins, a family of stress-inducible metabolic regulators, as protective factors against muscle wasting. Sestrin expression decreases during inactivity and its genetic deficiency exacerbates muscle wasting; conversely, sestrin overexpression suffices to prevent atrophy.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
42 Samples
Download data: TXT
Series
Accession:
GSE136866
ID:
200136866
5.

Regulation of Glucose Uptake and Inflammation by FOXO1 and FOXO3 in Skeletal Muscle

(Submitter supplied) Forkhead box class O (FoxO) transcription factors regulate whole body energy metabolism, skeletal muscle mass and substrate switching. To elucidate the role of FOXO in skeletal muscle, dominant negative (dn) constructs for FOXO1 (FOXO1dn) or FOXO3 (FOXO3dn) were transfected by electroporation into mouse tibialis anterior muscle and glucose uptake, signal transduction, and glucose stimulated gene expression profiles were assessed. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
24 Samples
Download data: CEL
Series
Accession:
GSE105778
ID:
200105778
6.

Effect of endophilin A deficiency in mouse hippocampus

(Submitter supplied) We tested how complete or partial loss of endophilin A1, A2 and A3 affects gene expression in mouse hippocampus. Total loss of endophilin (triple knock-outs, TKO) was assessed in newborn mice, since the TKO mice only survive only several hours after birth. Partial loss of endophilin (endoA1,A2 double knock-out, DKO) was assessed between
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
49 Samples
Download data: XLS, XLSX
Series
Accession:
GSE85702
ID:
200085702
7.

Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging

(Submitter supplied) Sarcopenia is a degenerative condition that consists in the age-induced atrophy and functional decline of skeletal muscle cells (myofibers). A common hypothesis is that inducing myofiber hypertrophy should also reinstate myofiber contractile function but such model has not been extensively tested. Here, we find that the levels of the ubiquitin ligase UBR4 increase in skeletal muscle with aging, and that muscle-specific UBR4 loss rescues age-associated myofiber atrophy in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9185
16 Samples
Download data: TXT
Series
Accession:
GSE149637
ID:
200149637
8.

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle [CR data set]

(Submitter supplied) As global life expectancy continues to climb, maintaining skeletal muscle function is increasingly essential to ensure a good life quality for aging populations. Calorie restriction (CR) is the most potent and reproducible intervention to extend health and lifespan, but is largely unachievable in humans. Therefore, identification of “CR mimetics” has received much attention. Since CR targets nutrient-sensing pathways centering on mTORC1, rapamycin, the allosteric inhibitor of mTORC1, has been proposed as a potential CR mimetic and counteracts age-related muscle loss. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
24 Samples
Download data: TXT
Series
Accession:
GSE171322
ID:
200171322
9.

Muscle response to aging and aging-modulating interventions.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL19057 GPL17021
167 Samples
Download data
Series
Accession:
GSE139214
ID:
200139214
10.

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia [TSCmKO data set].

(Submitter supplied) Purpose: Sustained muscle fiber-specific mTORC1 activity, through deletion of the mTORC1 upstream inhibitor Tsc1, drives progressive muscle wasting and weakness reminiscent of sarcopenia. We aimed to characterise gene expression changes coinciding with the development of sarcopenia-like features in TSCmKO mice. Methods: Extensorum digitorum longus (EDL) muscles from 3- (weak phenotype) and 9-month-old (severe phenotype) TSCmKO and littermate control mice (Tsc1 floxed, HSA-Cre negative) treated with either vehicle or rapamycin (8 mg.kg.min-1) for 3 days were processed and sequenced. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
40 Samples
Download data: TXT
Series
Accession:
GSE139213
ID:
200139213
11.

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia [NMJ data set].

(Submitter supplied) Purpose: To investigate whether our signatures of mTORC1-driven sarcopenia originate from cells residing at the neuromuscular junction (NMJ), we followed laser-capture microdissection with RNA-seq from adult and sarcopenic tibialis anterior (TA) muscles. Methods: TA muscles were incubated in solution containing fluorescently-labeled bungarotoxin, which binds to post-synaptic AChRs and thereby marks NMJ regions. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
32 Samples
Download data: TXT
Series
Accession:
GSE139209
ID:
200139209
12.

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia [Aging-Rapamycin data set].

(Submitter supplied) Purpose: Despite demonstrating that the overall effect of long-term rapamycin-treatment is overwhelmingly positive in aging skeletal muscle, we observed muscle-specificity in the responsiveness to rapamycin, leading us to hypothesize that the primary drivers of age-related muscle loss and therefore effective intervention strategies may differ between muscles. To address this question and dissect the key signaling nodes associated with mTORC1-driven muscle aging, we created a comprehensive multi-muscle gene expression atlas in adult, sarcopenic and rapamycin-treated mice using RNA-seq. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
71 Samples
Download data: TXT
Series
Accession:
GSE139204
ID:
200139204
13.

RNAseq of GFP-FOXR1 and GFP-FOXR1 M280L vs GFP CTL

(Submitter supplied) The forkhead box (Fox) family of transcription factors are highly conserved and play essential roles in a wide range of cellular and developmental processes. We report an individual with severe neurological symptoms including postnatal microcephaly, progressive brain atrophy and global developmental delay associated with a de novo missense variant (M280L) in the FOXR1 gene. At the protein level, M280L impaired FOXR1 expression and induced a nuclear aggregate phenotype due to protein misfolding and proteolysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
7 Samples
Download data: TXT
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