GEO DataSets

Analysis of osteoclasts lacking the transcription factor NFATc1. Osteoclasts cultured in the presence of M-CSF and RANKL to induce differentiation. Results identify gene targets of NFATc1 in osteoclastogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL8321

Series:

GSE37219

4 Samples

Download data: CEL

(Submitter supplied) Genetic deletion of Nfatc1 in mice results in profound osteoclast-poor osteopetrosis, a high bone mass state caused by a lack of osteoclast activity. We hypothesized that the family of NFATc1 regulated transcripts in the osteoclast would be enriched for genes associated with osteoclast function. We used microarrays profile gene expression in wild-type and NFATc1-deficient osteoclasts generated in vitro to identify NFATc1-dependent transcripts in osteoclasts.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5464

Platform:

GPL8321

4 Samples

Download data: CEL

(Submitter supplied) To screen for altered gene expression during osteoclastogenesis, BMM cells treated with RANKL or RANKL+LEA were subjected to gene expression profiling.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

6 Samples

Download data: XLSX