GEO DataSets

Analysis of ventral dentate gyrus from adults subjected to chronic corticosterone (CORT) to induce depression-like behaviors, followed by combined treatment of CORT and selective serotonin reuptake inhibitor fluoxetine. Results provide insight into the molecular basis of antidepressant resistance.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 individual sets

Platform:

GPL1261

Series:

GSE43261

19 Samples

Download data: CEL

(Submitter supplied) Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are the most common treatment for major depression. However, approximately 50% of depressed patients fail to achieve an effective treatment response. Understanding how gene expression systems relate to treatment responses may be critical for understanding antidepressant resistance. Transcriptome profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to utilize this information to determine mechanisms underlying antidepressant treatment responses. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS5307 GDS5308

Platform:

GPL1261

38 Samples

Download data: CEL

Analysis of dorsal dentate gyrus from adults subjected to chronic corticosterone (CORT) to induce depression-like behaviors, followed by combined treatment of CORT and selective serotonin reuptake inhibitor fluoxetine. Results provide insight into the molecular basis of antidepressant resistance.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 individual sets

Platform:

GPL1261

Series:

GSE43261

19 Samples

Download data: CEL

(Submitter supplied) Although regulation of energy metabolism has been linked with multiple disorders, its role in depression and responsiveness to antidepressants is less-known. We found that an epigenetic and energetic agent, acetyl-L-carnitine (LAC, oral administration), rapidly rescued the depressive- and central and systemic metabolic-like phenotype of LAC-deficient Flinders Sensitive Line (FSL) rats. After acute stress during LAC treatment, a subset of FSL continued to respond to LAC (rFSL), whereas the other subset did not respond (nrFSL). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18694

12 Samples

Download data: TXT

(Submitter supplied) Major depression is a multidimensional disorder highly prevalent in modern society. Although several classes of antidepressants (ADs) are currently available to treat depression, the effectiveness of treatment is still limited, as many patients do not show full remission; thus, there is a need to find better patients’ directed therapeutic strategies. Neuroplastic changes in several brain regions, namely in the hippocampal dentate gyrus (DG), are amongst the best correlates of depression and of ADs actions. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

21 Samples

Download data: CEL

(Submitter supplied) We constructed a comprehensive multi-omics map of the molecular effects of fluoxetine (an SSRI antidepressant) in 27 rat brain regions. We profiled gene expression (bulk RNA-seq, 210 datasets) and chromatin state (bulk chromatin immunoprecipitation sequencing (ChIP-seq) for the histone marker H3K27ac, 100 datasets) in a broad, unbiased panel of 27 brain regions across the entire rodent brain, in naive and fluoxetine-treated animals. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL20084 GPL22396

108 Samples

Download data: CSV

(Submitter supplied) We constructed a comprehensive multi-omics map of the molecular effects of fluoxetine (an SSRI antidepressant), in 27 rat brain regions. We profiled gene expression (bulk RNA-seq, 210 datasets) and chromatin state (bulk chromatin immunoprecipitation sequencing (ChIP-seq) for the histone marker H3K27ac, 100 datasets) in a broad, unbiased panel of 27 brain regions across the entire rodent brain, in naive and fluoxetine-treated animals. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18694

212 Samples

Download data: TXT

(Submitter supplied) We constructed a comprehensive multi-omics map of the molecular effects of fluoxetine (an SSRI antidepressant), in 27 rat brain regions. We profiled gene expression (bulk RNA-seq, 210 datasets) and chromatin state (bulk chromatin immunoprecipitation sequencing (ChIP-seq) for the histone marker H3K27ac, 100 datasets) in a broad, unbiased panel of 27 brain regions across the entire rodent brain, in naive and fluoxetine-treated animals. more...

Organism:

Rattus norvegicus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL18694

106 Samples

Download data: BED