GEO DataSets

Analysis of PBMCs from patients with active pulmonary tuberculosis (PTB) up to 6 months after initiation of anti-tuberculosis chemotherapy treatment. Results provide insight into the molecular mechanisms associated with PTB.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 9 individual, 3 time sets

Platform:

GPL570

Series:

GSE54992

27 Samples

Download data: CEL

(Submitter supplied) C1q expression increases significantly in the peripheral blood of patients with active tuberculosis compared to healthy controls and individuals with latent TB infection. The percentage of C1q-expressing CD14 positive cells is significantly increased in active TB patients. C1q expression in the peripheral blood correlates with sputum smear positivity in tuberculosis patients and is reduced after anti-tuberculosis chemotherapy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4966 GDS5030

Platform:

GPL570

39 Samples

Download data: CEL

Analysis of PBMCs isolated from patients with active pulmonary tuberculosis (PTB) and latent TB infection (LTBI). Results provide insight into identifying potential biomarkers that can distinguish individuals with PTB from LTBI.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 21 individual sets

Platform:

GPL570

Series:

GSE54992

21 Samples

Download data: CEL

(Submitter supplied) Comprehensively compare the transcriptional difference in PPD stimulated PBMCs from individuals with different tuberculosis infectious status: tuberculosis patients, latent infectious individuals and healthy controls using the microarray analysis.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6848

12 Samples

Download data: TXT

(Submitter supplied) We report a study about differentially expressed small non-coding RNAs in the blood of humans harboring a latent (LTBI) or active tuberculosis (TB) infection in comparison with exposed controls (ExC) and treated LTBI (LTBItt). All non-TB subjects enrolled in this study were recent close contacts (rCt) of a newly diagnosed contagious TB cases enrolled in Rio de Janeiro, Brazil. The detailed methodology is described below. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL16791

49 Samples

Download data: TXT

(Submitter supplied) Tuberculosis (TB) is a serious infectious disease, but current methods of detection require improvement in sensitivity, efficiency or specificity. We conducted a microarray experiment, comparing the gene expression profiles in peripheral blood mononuclear cells among individuals with active TB, latent infection, and healthy conditions in a Taiwanese population. These differentially expressed genes may be potential biomarkers that can differentiate between active TB and latent infection.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16951

42 Samples

Download data: GPR

(Submitter supplied) The knowledge of circRNAs in tuberculosis (TB) remains limited. Aim of the present study was to characterize the expression profiles and potential function of circRNAs in human peripheral blood mononuclear cells (PBMCs) from patients with active TB.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL21825

6 Samples

Download data: TXT

(Submitter supplied) For further identify the differentiation between latent and clinical tuberculosis (TB), we employed whole genome microarray expression profiling to study genes with significant expression change in peripheral CD4+T cells between healthy control, latent tuberculosis (LTB) and clinical tuberculosis (TB). Our experiment included 4 groups: healthy donor (HD), latent TB1 (LTB1) with low IFN-gamma release level, latent TB2 (LTB2) with high IFN-gamma release level, and tuberculosis (TB) with high IFN-gamma release level. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

4 Samples

Download data: TXT

(Submitter supplied) To further understand the host immune factors involved in the progression from latent tuberculosis infection (LTBI) to active tuberculosis (TB) and identify the potential signatures for discriminating TB from LTBI, the genome-wide transcriptional profile of the Mycobacterium.Tuberculosis (M.TB)–specific antigens stimulated peripheral blood mononuclear cells (PBMCs) from active TB, LTBI and health controls (HCs) were performed. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

12 Samples

Download data: TXT