GEO DataSets

Analysis of peripheral blood mononuclear cells from 8 nickel refinery workers. Occupational exposure to nickel is associated with an increased risk of lung and nasal cancers. Results provide insight into molecular mechanisms underlying nickel carcinogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 stress sets

Platform:

GPL6244

Series:

GSE40392

18 Samples

Download data: CEL

(Submitter supplied) Up to date the studies examining the gene expression profiles in response to exposure to nickel compounds have only been conducted using in vitro tissue culture systems. Here, we have compared the gene expression profiles in peripheral blood mononuclear cells (PMCs) of eight nickel refinery workers in Jinchang, China to the expression profiles of referent subjects with only environmental exposure.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4974

Platform:

GPL6244

18 Samples

Download data: CEL

(Submitter supplied) Wegener’s granulomatosis (WG) is a systemic inflammatory disease that can lead to substantial morbidity. This study seeks to further understanding of the biology underlying WG, and to discover markers of disease activity useful in prognosis and treatment guidance.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6104

127 Samples

Download data: TXT

(Submitter supplied) The effect of benzene exposure on peripheral blood mononuclear cell (PBMC) gene expression was examined in a population of shoe-factory workers with well-characterized occupational exposures to benzene. We compared data from two microarray platforms (Illumina and Affymetrix). Keywords: occupational exposure

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3559 GDS3560 GDS3561

Platforms:

GPL97 GPL96 GPL2700

48 Samples

Download data: CEL, XLS

Analysis of peripheral blood mononuclear cells from shoe factory workers exposed to benzene. Benzene is a leukemogen. Results provide insight into molecular mechanisms of benzene carcinogenicity.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL2700

Series:

GSE9569

16 Samples

Download data

Analysis of peripheral blood mononuclear cells from shoe factory workers exposed to benzene. Benzene is a leukemogen. Results provide insight into molecular mechanisms of benzene carcinogenicity.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL97

Series:

GSE9569

16 Samples

Download data: CEL

Analysis of peripheral blood mononuclear cells from shoe factory workers exposed to benzene. Benzene is a leukemogen. Results provide insight into molecular mechanisms of benzene carcinogenicity.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL96

Series:

GSE9569

16 Samples

Download data: CEL

(Submitter supplied) Bovine tuberculosis (BTB) caused by Mycobacterium bovis continues to cause substantial losses to global agriculture and has significant repercussions for human health. The advent of high throughput genomics has facilitated large scale gene expression analyses that present a novel opportunity for revealing the molecular mechanisms underlying chronic mycobacterial infection. Using this approach, we have previously shown that innate immune genes in peripheral blood mononuclear cells (PBMC) from BTB-infected animals are repressed in vivo in the absence of exogenous stimulation. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL5751

36 Samples

Download data: GPR

(Submitter supplied) The aim of the study is to identify the global messenger RNA (mRNA) and long noncoding RNA (lncRNA) expression profiling in peripheral blood from thirty patients with Obsessive Compulsive Disorders (OCD) and thirty paired normal controls.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL19612

60 Samples

Download data: TXT

(Submitter supplied) Type 1 diabetes mellitus (T1D) is a common autoimmune disease mediated by autoimmune attack against pancreatic b cells.Dys-regualtion of the component of peripheral blood mononuclear cells (PBMCs), including T-cells and B-cells, and smaller amounts of NK cells and dendritic cells, have all been implicated in this process This study sought to identify T1D associated differently expressed genes in the peripheral blood mononuclear cell (PBMC).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

22 Samples

Download data: CEL

(Submitter supplied) Hypersensitivity reactions to medications constitute a growing problem in the clinical practice. In order to study the molecular basis underlying the pathogenesis of non-immediate hypersensitivity reactions to drugs, we characterized the gene expression profiles of PBMCs isolated from patients during the acute phase and upon resolution of the clinical symptoms using a cDNA array technology. Eighty five genes were found to be differentially expressed during the acute phase of drug-induced delayed hypersensitivity reactions. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL7328

26 Samples

Download data: TXT

(Submitter supplied) We compared PBMC genomic response to exercise in both early (EB) and late-pubertal boys (LB) Keywords: stress response

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

40 Samples

Download data: CEL

(Submitter supplied) Previously, using microarrays and mRNA-Sequencing (mRNA-Seq) we found that occupational exposure to a range of benzene levels perturbed gene expression in peripheral blood mononuclear cells. In the current study, we sought to identify gene expression biomarkers predictive of benzene exposure below 1 part per million (ppm), the occupational standard in the U.S. First, we used the nCounter platform to validate altered expression of 30 genes in 33 unexposed controls and 57 subjects exposed to benzene (<1 to ≥5 ppm). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25533

96 Samples

Download data: XLSX