GEO DataSets

Analysis of skeletal muscle from metabolic syndrome (MS) female patients before and after 6 months of exercise training. MS is associated with insulin resistance. Results provide insight into the molecular mechanisms underlying insulin-resistant skeletal muscle in MS patients.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 12 individual, 2 protocol sets

Platform:

GPL6244

Series:

GSE43760

24 Samples

Download data: CEL

(Submitter supplied) We assessed vastus lateralis muscle gene expression levels of 12 women with the metabolic syndrome before and after a 6 month exercise training program

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4909

Platform:

GPL6244

24 Samples

Download data: CEL

(Submitter supplied) Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). Using the HG-U133 Plus 2.0 expression array from Affymetrix, we analyzed gene expression in skeletal muscle from obese women with PCOS (n=16) and age- and body mass index-matched control women (n=13) metabolically characterized by euglycemic-hyperinsulinemic clamp and indirect calorimetry. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3104

Platform:

GPL570

29 Samples

Download data: CEL

Analysis of vastus lateralis muscles from women with insulin-resistant polycystic ovary syndrome (PCOS). Insulin resistance in skeletal muscles is a risk factor for the development of type 2 diabetes in women with PCOS. Results provide insight into the pathogenesis of insulin resistance in PCOS.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL570

Series:

GSE6798

29 Samples

Download data: CEL

(Submitter supplied) The aim of the study was to investigate how short-term fasting affects whole-body energy homeostasis and skeletal muscle energy/nutrient-sensing pathways and transcriptome in humans. For this purpose, twelve young healthy men were studied during a 24-hour fast. Skeletal muscle biopsies were collected and analyzed at baseline and after 4, 10 and 24h of fasting. As expected, fasting induced a time-dependent decrease in plasma insulin and leptin levels, whereas levels of ketone bodies and free fatty acids increased. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5473

Platform:

GPL10558

48 Samples

Download data: TXT

Analysis of skeletal muscle biopsies collected at 1.5, 4, 10, and 24hr post-meal time from healthy young men subjected to a 24hr fast. Results provide insight into the molecular mechanisms underlying metabolic adaptation to fasting in healthy humans.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 12 individual, 4 time sets

Platform:

GPL10558

Series:

GSE55924

48 Samples

Download data

(Submitter supplied) Skeletal muscle aging is characterized by a progressive decline in muscle mass and function, which is referred to as sarcopenia. Aging is also a primary risk factor for metabolic syndrome (SX), which is a cluster of risk factors for cardiovascular diseases and type 2 diabetes. However, the molecular mechanisms implicated in sarcopenia and changes in muscle proteome associated with SX in elderly men remain unclear. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

30 Samples

Download data: CEL