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Links from GEO DataSets

Items: 3

1.
Full record GDS4871

Donor lymphocyte infusion effect on bone marrow-infiltrating CD3+ T cells of patients with relapsed chronic myelogenous leukemia

Analysis of marrow-infiltrating CD3+ T cells isolated from relapsed chronic myelogenous leukemia (CML) patients following donor lymphocyte infusion (DLI) therapy. Four patients were DLI-responsive, two were DLI-nonresponsive. Results provide mechanistic insights into DLI response in relapsed CML.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 individual, 2 protocol sets
Platform:
GPL571
Series:
GSE49067
12 Samples
Download data: CEL
2.

Expression data from responders/nonresponders before/after receiving DLI for relapse of CML s/p BMT

(Submitter supplied) Increasing evidence across malignancies suggests that infiltrating T cells at the site of disease are crucial to tumor control. We hypothesized that marrow-infiltrating immune populations play a critical role in response to donor lymphocyte infusion (DLI), an established and potentially curative immune therapy whose precise mechanism remains unknown. We therefore analyzed marrow-infiltrating immune populations in 29 patients (22 responders, 7 nonresponders) with relapsed chronic myelogenous leukemia who received CD4+ DLI in the pre-tyrosine kinase inhibitor era. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4871
Platform:
GPL571
12 Samples
Download data: CEL
Series
Accession:
GSE49067
ID:
200049067
3.

Discovery of the targets of the immune response to chronic myeloid leukemia in 3 patients using protein microarrays

(Submitter supplied) Three patients who had relapsed chronic myeloid leukemia after allogeneic bone marrow transplant and received an immunotherapeutic intervention (donor lymphocyte infusion, or DLI) without further treatment were studied. The binding of serum immunoglobulins to proteins after immunotherapy was compared to before in two patients using Invitrogen ProtoArrays from a single lot. For a third patient, comparison was made between two timepoints after immunotherapy against one timepoint before using Invitrogen ProtoArrays from a separate lot. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platforms:
GPL6896 GPL6895
7 Samples
Download data: GPR
Series
Accession:
GSE11565
ID:
200011565
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