GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE49067 Query DataSets for GSE49067
Status Public on Sep 30, 2013
Title Expression data from responders/nonresponders before/after receiving DLI for relapse of CML s/p BMT
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Increasing evidence across malignancies suggests that infiltrating T cells at the site of disease are crucial to tumor control. We hypothesized that marrow-infiltrating immune populations play a critical role in response to donor lymphocyte infusion (DLI), an established and potentially curative immune therapy whose precise mechanism remains unknown. We therefore analyzed marrow-infiltrating immune populations in 29 patients (22 responders, 7 nonresponders) with relapsed chronic myelogenous leukemia who received CD4+ DLI in the pre-tyrosine kinase inhibitor era.
We used microarrays to detail the global programme of gene expression underlying T cell infiltration into bone marrow of responders and nonresponders to DLI.
Overall design mRNA expression profiling of marrow-infiltrating CD3+ positively selected T cells of 4 responders compared to 2 non-responders, before and after DLI, was performed on Affymetrix microarrays.
Contributor(s) Bachireddy P, Hainz U, Rooney M, Hacohen N, Wu CJ
Citation(s) 24357730
Submission date Jul 21, 2013
Last update date Dec 06, 2018
Contact name Pavan Bachireddy
Organization name Dana-Farber Cancer Institute
Lab Catherine Wu, MD
Street address 77 Avenue Louis Pasteur
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (12)
GSM1193262 marrow CD3 T cells_pre_R1 (responder)
GSM1193263 marrow CD3 T cells_post_R1 (responder)
GSM1193264 marrow CD3 T cells_pre_R2 (responder)
BioProject PRJNA212860

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE49067_RAW.tar 21.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap