GEO DataSets

Analysis of gonads from fetal, neonatal and adult C57BL/6 males and females. Events during meiosis I prophase are critical for correct segregation of chromosomes. Defects in these events may contribute to infertility. Results provide insight into molecular mechanisms underlying meiosis I prophase.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 2 tissue sets

Platform:

GPL1261

Series:

GSE35734

6 Samples

Download data: CEL

(Submitter supplied) Prophase I of meiosis involves dynamic chromosome segregation processes including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes responsible for infertility or recurrent pregnancy loss in humans, we performed expression profiling of male and female gonads of mice undergoing meiotic prophase I.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4503

Platform:

GPL1261

6 Samples

Download data: CEL

(Submitter supplied) Prophase I of male meiosis involves dynamic chromosome segregation processes during early spermatogenesis, including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes responsible for infertility in humans, we performed expression profiling of mouse spermatogenic cells undergoing meiotic prophase I.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL340 GPL339

10 Samples

Download data: CEL, CHP

(Submitter supplied) Spo11, a meiosis-specific protein, introduces double strand breaks on chromosomes and initiates meiotic recombination in a wide variety of organisms. Mouse null Spo11 spermatocytes fail to synapse chromosomes and to progress beyond zygotene stage of meiosis. We analyzed gene expression profiles in Spo11-/- adult and juvenile wild type testis to determine genes expressed in different stages of meiosis and spermatogenesis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL977

9 Samples

Download data: GPR

(Submitter supplied) To investigate the genomic distribution of genes with sex- biased expression patterns in mice we analyzed the chromosomal distribution of genes preferentially expressed in sexually dimorphic tissues such as testis and ovary. Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL977

21 Samples

Download data

(Submitter supplied) In meiotic prophase, chromosomes are organized into compacted loop arrays to promote homolog pairing and recombination. Here, we probe the architecture of the mouse spermatocyte genome in early and late meiotic prophase using Hi-C. We show that early-prophase chromosomes are arranged as linear arrays of 0.8-1 Mb loops, which extend to 1.5-2 Mb in late prophase as chromosomes compact and homologs undergo synapsis. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL21103

5 Samples

Download data: HIC

(Submitter supplied) We comprehensively compared the chromatin structures and transcriptomes in successive substages of female and male mouse meiotic prophase by using sisHi-C and RNA-Seq methods. Interestingly, the transcriptional change happened earlier than chromatin structures reprograming that chromatin structures largely maintained the pre-meiotic condition in leptotene. Also, compartments and TADs gradually disappeared and then slowly recovered in both oocytes and spermatocytes. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL21273

44 Samples

Download data: BW, HIC, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17021 GPL11002

46 Samples

Download data: FPKM_TRACKING

(Submitter supplied) Identification of the mouse embryonic germ cell transcriptome

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11002

24 Samples

Download data: FPKM_TRACKING

(Submitter supplied) Identification of the mouse embryonic germ cell Stra8-/- transcriptome

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

6 Samples

Download data: FPKM_TRACKING

(Submitter supplied) Identification of the mouse embryonic germ cell Dazl-/- transcriptome

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

6 Samples

Download data: FPKM_TRACKING

(Submitter supplied) Identification of genes expressed in the anterior and posterior thirds of mouse fetal ovary

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11002

10 Samples

Download data: FPKM_TRACKING

(Submitter supplied) Structural data of genome organization in somatic cells (fibroblasts) and germ cells (primary spermatocytes and round spermatids) from wild mice with Rb fusions from the Barcelona Rb System.

Organism:

Mus musculus domesticus

Type:

Other

Platform:

GPL17637

3 Samples

Download data: H5

(Submitter supplied) Here we generated a high-resolution structural and functional atlas of mouse spermatogenesis by combining in situ Hi-C, RNA-seq and ChIP-seq of CTCF and meiotic cohesins RAD21L and REC8.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL19057 GPL13112

18 Samples

Download data: BW, TSV, TXT