GEO DataSets

Analysis of sporadic medulloblastomas (MB), tumor grade IV from pediatric patients. Medulloblastoma is a highly malignant brain tumor occurring predominantly in children. Results provide insight into the molecular mechanisms underlying the pathogenesis of MB.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 age, 3 disease state, 2 gender sets

Platform:

GPL6244

Series:

GSE41842

19 Samples

Download data: CEL

(Submitter supplied) Medulloblastoma is a malignant brain tumor that occurs predominantly in children. Current risk stratification based on the clinical parameters is inadequate for accurate prognostication. In order to get a better understanding of medulloblastoma biology, miRNA profiling of medulloblastomas was carried out in parallel with the expression profiling of protein- coding genes. miRNA profiling of medulloblastomas was carried out using Taqman Low Density Density Aarray v 1.0 having 365 human microRNAs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4469

Platform:

GPL6244

19 Samples

Download data: CEL

(Submitter supplied) Purpose Integrated genomics approaches have identified at least four distinct biological variants in medulloblastoma: WNT, SHH, group C, and group D. Non-WNT/Non-SHH tumors are associated with metastatic dissemination and an unfavorable prognosis. Additional markers may enhance outcome prediction in Non-WNT/Non-SHH medulloblastomas. Experimental Design We combined transcriptomic and DNA copy-number analyses for 64 primary medulloblastomas. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

64 Samples

Download data: TXT

(Submitter supplied) Medulloblastoma is the most frequent malignant pediatric brain tumor. Considerable efforts are dedicated to identify markers that help to refine treatment strategies. The activation of the Wnt/beta-catenin pathway occurs in 10-15% of medulloblastomas and has been recently described as a marker for favorable patient outcome. We report a series of 72 pediatric medulloblastomas evaluated for beta-catenin immunostaining, CTNNB1 mutations, and studied by comparative genomic hybridization. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

40 Samples

Download data: CEL