GEO DataSets

Analysis of bladder cancer specimens from a high-risk population of patients who underwent radical cystectomy (Memorial Sloan-Kettering Cancer Center cohort). Results provide insight into the prediction of survival in high-risk urothelial carcinoma of the urinary bladder.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 5 specimen sets

Platform:

GPL570

Series:

GSE31684

93 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array; Genome variation profiling by genome tiling array

Platforms:

GPL10150 GPL15793

128 Samples

Download data: CEL, TXT

(Submitter supplied) Metastatic urothelial carcinoma (UC) of the bladder is associated with multiple somatic copy number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic UC treated with platinum chemotherapy.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL10150

94 Samples

Download data: BED, PDF, TXT

(Submitter supplied) Metastatic urothelial carcinoma (UC) of the bladder is associated with multiple somatic copy number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic UC treated with platinum chemotherapy.

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL15793

34 Samples

Download data: BED, CEL, PDF, TXT

(Submitter supplied) Urothelial carcinoma of the bladder is characterized by significant variability in clinical outcomes depending on stage and grade. The addition of molecular information may improve our understanding of such heterogeneity and enhance prognostic prediction. The purpose of this study was to validate and improve published prognostic signatures for high-risk bladder cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4456

Platform:

GPL570

93 Samples

Download data: CEL, TXT

(Submitter supplied) Purpose: Selecting muscle-invasive bladder cancer patients for adjuvant therapy is currently based on clinical variables with limited power. We hypothesized that genomic-based signatures can outperform clinical models to identify patients at higher risk. Method:Transcriptome-wide expression profiles were generated using 1.4 million feature-arrays on archival tumors from 225 patients who underwent radical cystectomy and had muscle-invasive and/or node-positive bladder cancer. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5188

199 Samples

Download data: CEL

(Submitter supplied) We sought to test the hypothesis that ascertainment of genome-wide copy number alterations in bladder cancer may have value for clinical management. We performed a genome wide analysis of 164 bladder cancer samples and 27 bladder cancer cell lines to identify genetic changes associated with disease characteristics. Multiplex inversion probe (MIP) analysis, a newly developed genomic technique, was used to study 80 bladder cancers to identify mutations and copy number changes. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL13270

80 Samples

Download data: CEL

(Submitter supplied) Full title: Predictive Gene Signatures as Strong Prognostic Indicators of the Effectiveness of Bacillus Calmette–Guérin (BCG) Immunotherapy in Primary pT1 Bladder Cancers Intravesical BCG immunotherapy is effective in prevention of recurrence and progression in many cases of non-muscle invasive bladder cancer, but many patients fail to respond. This study identified predictive gene signatures in primary pT1 bladder cancer with BCG immunotherapy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

48 Samples

Download data: TXT, XLS

(Submitter supplied) This study aimed to identify the genetic signatures associated with disease prognosis in bladder cancer. We used 165 primary bladder cancer samples, 23 recurrent non-muscle invasive tumor tissues, 58 normal looking bladder mucosae surrounding cancer and 10 normal bladder mucosae for microarray analysis. Hierarchical clustering was used to stratify the prognosis-related gene classifiers. For validation, real-time reverse-transcriptase polymerase chain reaction (RT-PCR) of top-ranked 14 genes was performed. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

256 Samples

Download data: TXT, XLS

(Submitter supplied) Background Clinically useful molecular markers predicting the clinical course of patients diagnosed with non-muscle invasive bladder cancer are needed to improve treatment outcome. Methods We used custom designed oligonucleotide microarrays to validate four previously reported gene expression signatures for molecular diagnosis of disease stage and carcinoma in situ, and for predicting disease recurrence and progression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4060

808 Samples

Download data: TXT

(Submitter supplied) Background: Bladder-sparing trimodality therapy (TMT) is an alternative to radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC), and biomarkers to inform therapy selection are needed. Objective: To evaluate immune and stromal signatures in MIBC treated with TMT.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL22995

136 Samples

Download data: CEL

(Submitter supplied) Primary tumors from a series of breast cancer patients evaluated for the presence of tumor cells in bone marrow. Samples were taken at primary surgery, RNA isolated from fresh frozen tumors, amplified and hybridized to 42k cDNA arrays. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc.

Organism:

Homo sapiens

Type:

Expression profiling by array

6 related Platforms

123 Samples

Download data

(Submitter supplied) validation of the survival outcomes from MVAC-Avastin treated tumors

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14951

49 Samples

Download data: TXT

(Submitter supplied) A prognostic gene expression signature in chemotherapy-naïve bladder cancer is predictive of clinical outcomes from neoadjuvant chemotherapy

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14951

61 Samples

Download data: TXT

(Submitter supplied) In this study we applied differential gene expression analysis to exfoliated human urothelia obtained from patients of known bladder disease status. Selected targets from the microarray data were validated in an independent set of samples using a quantitative PCR approach.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

92 Samples

Download data: CEL, CHP

(Submitter supplied) Pancreatic cancer is the fourth leading cancer-related death in United States. The clinical relevance of genomic imbalances in pancreatic cancer is uncertain. We performed array-comparative genomic hybridization (aCGH) in 44 resected pancreatic cancer specimens from a Korean cohort. We observed recurrent copy number gains were observed in chromosome 1q, 11q, 18q11.1-11.2, and 20q13.13; and losses in chromosome 2p, 9p, 10q, 14q, 15q, 18q12.2-23, 19q, 20q11.1, 21p, and 22q. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL4093

44 Samples

Download data: TXT

(Submitter supplied) We aimed to provide a molecular description of Lynch syndrome-associated urothelial cancer in relation to molecular subtypes of sporadic bladder cancer. Whole genome mRNA expression profiles of 41 tumors and immunohistochemical stainings against FGFR3, KRT5, CCNB1, RB1, and CDKN2A (p16) of 37 tumors from Lynch syndrome patients were generated. Pathological data, microsatellite instability, anatomic location, and overall survival data was analyzed and compared with data from sporadic bladder cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

41 Samples

Download data: CEL