Similar studies for GEO DataSets (Select 4339) - GEO DataSets

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Items: 20

Select item 43391.

Dietary saturated fat effect on small intestine

Analysis of small intestine divided into 3 equal parts along the proximal to distal axis (SI 1, SI 2, SI 3) from C57Bl/6J males fed high-fat diets varying in polyunsaturated/saturated fatty acid ratios (P/S). Results provide insight into role of dietary fat type on development of metabolic syndrome.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 agent, 3 tissue sets

Platform:: GPL1261
Series:: GSE18586
9 Samples

Download data: CEL

DataSet

Accession:: GDS4339

ID:: 4339

Select item 2000185862.

Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine

(Submitter supplied) We studied the effect of dietary fat type, varying in polyunsaturated/saturated fatty acid ratio's (P/S) on development of metabolic syndrome. C57Bl/6J mice were fed purified high-fat diets (45E% fat) containing palm oil (HF-PO; P/S 0.4), olive oil (HF-OO; P/S 1.1) or safflower oil (HF-SO; P/S 7.8) for 8 weeks. A low-fat palm oil diet (LF-PO; 10E% fat) was used as a reference. Additionally, we analyzed diet-induced changes in gut microbiota composition and mucosal gene expression. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4339
Platform:: GPL1261
9 Samples

Download data: CEL

Series

Accession:: GSE18586

ID:: 200018586

Select item 2000035123.

Fat-type specific effects of high fat diets

(Submitter supplied) High fat diet (HF) rodent models have contributed significantly to the dissection of the pathophysiology of the insulin resistance syndrome, but their phenotype varies distinctly between different studies. Here, we have analyzed gene expression patterns in livers of animals fed with different HF with varying fatty acid compositions. Keywords: diet-gene interaction

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS1307
Platform:: GPL1355
10 Samples

Download data

Series

Accession:: GSE3512

ID:: 200003512

Select item 13074.

Various high fat diets effect on liver

Expression profiling of liver from Wistar males fed for 12 weeks with one of 4 different high fat diets, each differing in fatty acid composition. The different fat sources used were lard, olive oil, coconut fat, and cod liver oil.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 5 protocol sets

Platform:: GPL1355
Series:: GSE3512
10 Samples

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DataSet

Accession:: GDS1307

ID:: 1307

Select item 2000185815.

Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice

(Submitter supplied) There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3831
Platform:: GPL1261
6 Samples

Download data: CEL, EXP

Series

Accession:: GSE18581

ID:: 200018581

Select item 38316.

Supplementary dietary calcium effect on small-intestinal mucosal cells

Analysis of small intestine (proximal, middle, distal) mucosal cells of C57BL/6J males fed high-fat diets differing in Ca concentration. High-Ca (150mmol/kg) stimulates fecal fat and bile acid excretion. Results provide insight into role of dietary Ca on development of obesity or insulin resistance.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol, 3 tissue sets

Platform:: GPL1261
Series:: GSE18581
6 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS3831

ID:: 3831

Select item 2000034337.

Differential regulation of intestinal lipid metabolism in A/J versus C57BL/6J mice during diet-induced obesity

(Submitter supplied) The effects of high-fat (HF) feeding on the gene expression in the small intestine were examined using obesity-resistant A/J mice and obesity-sensitive C57BL/6J (B6) mice. Both strains of mice were maintained on low-fat (LF, 5% fat) or HF (30% fat) diets for two weeks. Oligonucleotide microarray and semi-quantitative RT-PCR analysis revealed that lipid metabolism-related genes including mitochondrial acyl-CoA thioesterase 1, pyruvate dehydrogenase kinase 4, and NADP+-dependent cytosolic malic enzyme were up-regulated by more than 2-fold in both strains of mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2909
Platform:: GPL339
4 Samples

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Series

Accession:: GSE3433

ID:: 200003433

Select item 29098.

High fat diet effect on the small intestine of an obesity-prone strain

Analysis of small intestines of A/J and C57BL/6J animals on a low or high fat diet. The A/J strain is resistant to obesity, C57BL/6J is prone. Results provide insight into the factors contributing to the susceptibility to obesity.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol, 2 strain sets

Platform:: GPL339
Series:: GSE3433
4 Samples

Download data

DataSet

Accession:: GDS2909

ID:: 2909

Select item 2000331669.

Effect of Concentration and type of Dietary Fatty Acid on Development of Nonalcoholic Fatty Liver Disease

(Submitter supplied) The current study was designed to determine if dietary fatty acid concentration and composition affects the development and progression of nonalcoholic fatty liver disease. Male SD rats were overfed diets low (5%) or high (70%) fat diets via total enteral nutrition where the fat source was olive oil (monounsaturated), or corn oil (polyunsaturated). Overfeeding 5% corn oil produced little steatosis relative to feeding 5% olive oil. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL85
12 Samples

Download data: CEL

Series

Accession:: GSE33166

ID:: 200033166

Select item 20002630010.

Dose-dependent effects of dietary fat on development of obesity in relation to intestinal differential gene expression in C57BL/6J mice

(Submitter supplied) Excessive intake of dietary fat is known to be a contributing factor in the development of obesity. In this study, we determined the dose-dependent effects of dietary fat on the development of this metabolic condition with a focus on changes in gene expression in the small intestine. C57BL/6J mice were fed diets with either 10, 20, 30 or 45 energy% (E%) derived from fat for four weeks (n=10 mice/diet). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7440
120 Samples

Download data: CEL

Series

Accession:: GSE26300

ID:: 200026300

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000852411.

Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice

(Submitter supplied) The prevalence of the metabolic syndrome (MS) is rapidly increasing all over the world. Consequently, there is an urgent need for more effective intervention strategies. Both animal and human studies indicate that lipid oversupply to skeletal muscle can result in insulin resistance which is one of the charecteristices of the MS. C57BL/6J mice were fed a low fat (10 kcal%) palm oil diet or a high fat (45 kcal%; HF) palm oil diet for 3 or 28 days. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3078
Platform:: GPL5766
24 Samples

Download data: CEL

Series

Accession:: GSE8524

ID:: 200008524

Select item 307812.

High fat diet effect on the skeletal muscle: time course

Analysis of skeletal muscles of C57BL/6J animals fed a low or high fat diet for 3 or 28 days. Oversupply of lipid to skeletal muscle can result in insulin resistance, a characteristic of metabolic syndrome (MS). Results provide insight into the molecular events underlying the early onset of MS.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol, 2 time sets

Platform:: GPL5766
Series:: GSE8524
24 Samples

Download data: CEL

DataSet

Accession:: GDS3078

ID:: 3078

Select item 20007319513.

Expression data in liver from germ-free and conventional mice fed lard or fish oil for 11 weeks

(Submitter supplied) Dietary lipids and gut microbiota may both influence adipose tissue physiology. By feeding conventional and germ-free mice high fat diets with different lipid compositon we aimed to investigate how dietary lipids and the gut microbiota interact to influence inflammation and metabolism in the liver

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
24 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE73195

ID:: 200073195

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000858214.

Role of small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice.

(Submitter supplied) Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. To gain more insight in the role of the small intestine in the etiology of these metabolic disorders, a microarray study was performed on small intestines (SI) of C57BL/6J mice that were fed a high fat diet mimicking the fatty acid composition of a Western-style human diet. The mice became obese and developed dietary fat-induced glucose intolerance. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3357
Platform:: GPL1261
18 Samples

Download data: CEL, EXP

Series

Accession:: GSE8582

ID:: 200008582

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 335715.

High dietary fat effect on small intestine: time course

Analysis of small intestines of male C57BL/6J rodents fed a powdered high-fat purified diet for up to 8 weeks. Diet contributes to obesity and insulin resistance (IR) development. Results provide insight into the molecular mechanisms underlying dietary fat-induced obesity and IR pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 3 time, 3 tissue sets

Platform:: GPL1261
Series:: GSE8582
18 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS3357

ID:: 3357

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20006727716.

Liver tissue HELP-tagging cytosine methylation data from C57BL/6J mice receiving high-fat diet with or without lingonberries

(Submitter supplied) The C57BL/6J mouse model develops obesity and pre-diabetes when fed a high-fat diet. In this experiment, DNA methylation was assessed globally at specific CpG sites in liver tissue from mice receiving high-fat diet (45E% from fat) for 13 weeks (Control) or high-fat diet supplemented with 20% (w/w) of freeze-dried lingonberries (n=4). Our findings show that lingonberries prevent development of high-fat induced obesity, hepatic steatosis and low-grade inflammation, and the DNA was hypermethylated in mice receiving lingonberries compared to control.

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TXT

Series

Accession:: GSE67277

ID:: 200067277

PubMed Similar studies SRA Run Selector

Select item 20022206017.

The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis

(Submitter supplied) Dietary lipids can affect metabolic health through gut microbiota-mediated mechanisms, but the influence of lipid-microbiota interaction on liver steatosis is unknown. We investigated the effect of dietary lipid composition on human microbiota in an observational study and combined diet experiments with microbiota transplants to study lipid-microbiota interactions and liver status in mice. In humans, low intake of saturated fatty acids (SFA) was associated with increased microbial diversity independent of fiber intake. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21163
79 Samples

Download data: TXT

Series

Accession:: GSE222060

ID:: 200222060

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004886118.

Microbial RNAseq analysis of cecal and fecal samples collected from mice colonized with the microbiota of human twins discordant for obesity

(Submitter supplied) Microbial RNAseq analysis of cecal and fecal samples collected from mice colonized with the microbiota of human twins discordant for obesity. Samples were colleted at the time of sacrifice, or 15 days after colonization from mice gavaged with uncultured or cultured fecal microbiota from the lean twins or their obese co-twins. Samples were sequenced using Illumina HiSeq technology, with 101 paired end chemistry.

Organism:: mouse gut metagenome

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17443
59 Samples

Download data: TXT

Series

Accession:: GSE48861

ID:: 200048861

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20022030219.

Impact of various high fat diets on intestinal gene expression in mouse

(Submitter supplied) High fat diets (HFDs) are linked to several diseases including obesity, diabetes, insulin resistance, fatty liver, and susceptibility to inflammatory bowel disease (IBD) in both mouse and humans. RNA-seq from male mice (C57BL/6N) fed Vivarium Chow (VIV) or any one of three high fat diets (40% kcal fat) (SO+CO, PL+CO, CO) for 24 weeks was performed on four segments of the intestinal tract (Duodenum, Jejunum, Terminal Ileum and Proximal Colon).

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
60 Samples

Download data: TXT

Series

Accession:: GSE220302

ID:: 200220302

PubMed Full text in PMC Similar studies

Select item 20003789720.

Protein affects gene expression and prevents lipid accumulation in the liver in mice

(Submitter supplied) Obesity and associated increased prevalence of non-alcoholic fatty liver (NAFLD) disease is suggested to be positively modulated by a high protein (HP) diet in humans and rodents. The aim was to detect mechanisms by which a HP diet prevents hepatic lipid accumulation by means of transcriptomics. To study the acute and long term effect of a high protein ingestion on hepatic lipid accumulation under both low and high fat (HF) conditions, mice were fed combinations of high (35%) or low (10%) fat and high (50%) or normal (15%) protein diets for 1 or 12 weeks. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
9 Samples

Download data: CEL

Series

Accession:: GSE37897

ID:: 200037897

PubMed Full text in PMC Similar studies Analyze with GEO2R

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