GEO DataSets

Analysis of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, and Renal) from the NCI-60 panel. Results provide insight into molecular mechanisms underlying the various cancer types.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 59 cell line, 27 disease state, 9 tissue sets

Platform:

GPL570

Series:

GSE32474

174 Samples

Download data: CEL

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4296

Platform:

GPL570

174 Samples

Download data: CEL

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5188

178 Samples

Download data: CEL

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

132 Samples

Download data: TXT

(Submitter supplied) We present here a new expression profiling study of the 60 cell lines of the National Cancer Institute (NCI) Developmental Therapeutics program (DTP) drug screen (NCI-60) using the 41,000-probe Agilent Whole Human Genome Oligo Microarray. The expression levels of ∼21,000 genes were measured.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6848

132 Samples

Download data: TXT

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel Keywords: cell_type_comparison_design; disease state; cell line; tissue type

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

300 Samples

Download data: CEL, EXP

(Submitter supplied) Comparison between cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel Keywords: cell_type_comparison_design; disease state; cell line; tissue type

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

120 Samples

Download data: CEL

(Submitter supplied) Because most potential molecular markers and targets are proteins, proteomic profiling is expected to yield more direct answers to functional and pharmacological questions than does transcriptional profiling. To aid in such studies, we have developed a protocol for making reverse-phase protein lysate microarrays with larger numbers of spots than previously feasible. Our first application of these arrays was to profiling of the 60 human cancer cell lines (NCI-60) used by the National Cancer Institute to screen compounds for anticancer activity. more...

Organism:

Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL4081

176 Samples

Download data

(Submitter supplied) Methylation assay of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

61 Samples

Download data: IDAT, TXT

(Submitter supplied) To check whether mRNA level change for the changed proteins in protein level.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

18 Samples

Download data: SF

(Submitter supplied) USP7 is a deubiquitinase enzyme that removes polyubiquitin chains form a number of substrates including MDM2, p53 and NF-κB. In this study we assessed the impact of the USP7 inhibitor HBX41,108 on lipopolysaccharide (LPS) induded transcriptional responses in murine bone marrow derived macrophages.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

6 Samples

Download data: TXT

(Submitter supplied) The biological functions of nuclear topoisomerase I (Top1) have been difficult to study because knocking out TOP1 is lethal in metazoans. To reveal the functions of human Top1, we have generated stable Top1siRNA cell lines from colon and breast carcinomas (HCT116-siTop1 and MCF-7-siTop1, respectively). In those cells, Top2 compensates for Top1 deficiency. A prominent feature of the siTop1 cells is genomic instability, with chromosomal aberrations and histone gamma-H2AX foci associated with replication. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

12 Samples

Download data: CEL

(Submitter supplied) We aimed to define epithelial-specific genes in the kidney. In the developing mouse kidney at E12.5 epithelial cells are restricted to the ureteric bud, while mesenchymal cells surrounding the ureteric bud are non-epithelial. The mouse renal epithelial cell line mIMCD-3 was used to represent kidney epithelia in vitro. Gene expression was analyzed using Affymetrix microarrays in ureteric bud stalks, ureteric bud tips, and mIMCD-3 cells and compared to metanephric mesenchyme.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

7 Samples

Download data: CEL

(Submitter supplied) The specialized corneal epithelium requires differentiated properties, specific for its role at the anterior surface of the eye, thus tight maintenance of the differentiated qualities of the corneal epithelial is essential. Our studies have focused on pinin (PNN), an exon junction component (EJC) that has dramatic implications on corneal epithelial cell differentiation and may act as a stabilizer of the corneal epithelial cell phenotype. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

32 Samples

Download data: XLSX

(Submitter supplied) In this experiment, we sought to identify the distribution of USP7 on chromatin relative to other PRC1 components

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL11154

1 Sample

Download data: BW

(Submitter supplied) To understand the extent of Smad-mediated gene regulation in the colon, we isolated colon epithelium from Smad4ΔLrig1 and from Smad4+ control mice (either mice lacking a CreERT allele and treated with tamoxifen, or mice bearing a CreERT allele but treated with vehicle only) and analyzed the colonic epithelium by RNAseq. The ability of TGFβ1 and/or BMP2 to block TNF-mediated induction of Ccl20 from our study suggests that these Smad-mediated pathways may act as gatekeepers for induction of other inflammation-associated genes. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21493 GPL17021

30 Samples

Download data: TXT

(Submitter supplied) Pnn depletion in developing mouse corneal epithelium led to disrupted alternative splicing of multiple ESRP-regulated epithelial-type exons. In human corneal epithelial cells (HCET), ESRP1 and PNN displayed close localization in and around nuclear speckles and their physical association in protein complexes was identified. In this study, gene expression profiling was performed to identify PNN- and ESRP1-regulated alternative pre-mRNA splicing in human corneal epithelial cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL16254 GPL16238

48 Samples

Download data: CEL

(Submitter supplied) The role of SPROUTY2 (SPRY2) in human colon cancer is controversial. Our data support a tumorigenic action of SPRY2. We use microarrays to identify SPRY2 target genes in human SW480 ADH colon carcinoma cell line.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16987

12 Samples

Download data: CEL

(Submitter supplied) The Grainyhead family of transcription factors controls morphogenesis and differentiation of epithelial cell layers in multicellular organisms by regulating cell junction- and proliferation-related genes. Grainyhead-like 2 (Grhl2) is expressed in developing mouse lung epithelium and is required for normal lung organogenesis. The specific epithelial cells expressing Grhl2 and the genes regulated by Grhl2 in normal lungs are mostly unknown. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5113

Platform:

GPL6246

5 Samples

Download data: CEL

Analysis of MLE-15 lung epithelial cells depleted for Grainyhead-like 2. Results provide insight into the role of Grainyhead-like 2 in the morphogenesis and differentiation of lung epithelial cells.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol sets

Platform:

GPL6246

Series:

GSE40729

5 Samples

Download data: CEL