GEO DataSets

Analysis of pancreatic β-TC3 insulinoma cell line subjected to serum deprivation in the presence of high-density lipoproteins (HDLs). Results provide insight into the molecular mechanisms underlying the HDL protective effect on pancreatic β-cells in response to stress.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 2 stress sets

Platform:

GPL1261

Series:

GSE17647

24 Samples

Download data: CEL

(Submitter supplied) High-density lipoproteins (HDLs) protect pancreatic β cells against apoptosis. This property might be related to the increased risk to develop diabetes in patients with low HDL blood levels. However, the mechanisms by which HDLs protect β cells are poorly characterized. Here we use a transcriptomic approach to identify genes differentially modulated by HDLs in β cells subjected to apoptotic stimuli.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4026

Platform:

GPL1261

24 Samples

Download data: CEL

(Submitter supplied) Eukaryotic translation initiation factor 4E (eIF4E)–binding protein 1 (4E-BP1) inhibits cap-dependent translation in eukaryotes by competing with eIF4G for an interaction with eIF4E. Phos-phorylation at Ser-83 of 4E-BP1 occurs during mitosis through the activity of cyclin-dependent kinase 1 (CDK1)/cyclin B rather than through canonical mTOR kinase activity. Here, we investi-gated the interaction of eIF4E with 4E-BP1 or eIF4G during interphase and mitosis. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

20 Samples

Download data: TXT

(Submitter supplied) Discodermolide treatment of A549 results in senescence. We compared cells resistant to disco-induced senescence to those that are sensitive to senescence induction. We also examined the gene expression of resistant (AD32) cells overexpressing 4E-BP1, a protein known to restore sensitivity to discodermolide in these cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

10 Samples

Download data: CEL