GEO DataSets

Analysis of myeloma-patient whole bone marrow (BM) aspirates after immediate RNA fixation or after delayed fixation (up to 660 min). Aspiration interrupts the natural BM interactions. Results provide insight into the molecular pathways regulated by intercellular interactions within myelomatous BM.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 10 individual, 2 protocol, 9 time sets

Platform:

GPL6244

Series:

GSE36036

26 Samples

Download data: CEL

(Submitter supplied) Gene expression profile (GEP) was analyzed in bone marrow (BM) samples from patients with leukemia or leukemic phase of lymphoma at different time points following aspiration. Among numerous changes in GEP evolved over time a discrete subset of > 60 genes exhibited prompt and sustained switch in expression consistently. Similar results were discovered recently in BM samples from patients with multiple myeloma (GSE36036). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

17 Samples

Download data: CEL

(Submitter supplied) Background. Multiple myeloma (MM) cells depend on the bone marrow (BM) niche for growth and survival. However, the tumor genes regulated by the niche are largely unknown. Design and Methods. BM aspiration samples were obtained from MM-patients with a high tumor load. Gene expression profile (GEP) was recorded immediately following aspiration and at subsequent time points. Identification of niche-regulated genes relied on spontaneous gene modulation following loss of niche regulation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4007 GDS4008

Platform:

GPL6244

32 Samples

Download data: CEL

Analysis of cultured myeloma bone marrow (BM) cells fixed immediately following spread from the bottom well or after maintenance in suspension (delayed fixation for 60, 120 minutes). Results provide insight into molecular mechanisms involved in contact versus contactless growth in myeloma.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 individual, 2 protocol, 3 time sets

Platform:

GPL6244

Series:

GSE36036

4 Samples

Download data: CEL

(Submitter supplied) We report specific signatures of up or down regulated genes form each of the stimuli comparing to the untreated situation. These signatures are semmed to be in link with the specific bone marrow or lymphnode niches organisaton observed during the pathological course of follicular lymphomas.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

25 Samples

Download data: TXT

(Submitter supplied) GEP on Affymetrix U133+2.0 microarrays was performed on ex vivo cell-sorted FL B cells from infiltrated human BM samples, according to the CD20hiCD44loCD38posIgDnegCD138negCD34neg phenotype.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

5 Samples

Download data: CEL

(Submitter supplied) GEP on Affymetrix U133+2.0 microarrays was performed on in vitro expanded stromal cells

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

16 Samples

Download data: CEL

(Submitter supplied) Neuroblastoma (NB) is the most common extra cranial solid tumor in infants. Although several risk factors including patient age, disease stage and genetic abnormalities, such as MYCN amplification and 11q deletion, have been shown to predict outcome, the mechanisms responsible for the heterogeneous clinical behavior of this tumor, ranging from spontaneous regression to rapid progression of disease and patient’s death, remain largely unknown. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

40 Samples

Download data: TXT

(Submitter supplied) To determine the molecular mechanisms involved in the compromised erythropoiesis of ESAM-KO mice, Lin- FCgRII/III-/Lo CD41Lo c-Kit+ Sca1- endoglin+ CD150+ cells, which contain mostly BFU-E and CFU-E, were sorted from 5-FU-treated WT and ESAM-KO mice, and were subjected to microarray analyses.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

2 Samples

Download data: TXT

(Submitter supplied) To analyze the role of VEGF-C in the adult bone marrow vascular niche after irradiation

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

4 Samples

Download data: MTX, TSV

(Submitter supplied) To analyze the role of endothelial derived VEGF-C in the adult bone marrow vascular niche

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

3 Samples

Download data: MTX, TSV

(Submitter supplied) To analyze the role of VEGF-C in the adult bone marrow, we analyzed the bone marrow stromal fraction on LepR+ cells and endothelial cells to further dissect the source of VEGF-C in the adult bone marrow.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

2 Samples

Download data: CSV, MTX, TSV