GEO DataSets

Analysis of HepG2 transformants expressing: wildtype thyroid hormone receptors (TRs), hepatocellular carcinoma (HCC)-TR mutants, or renal clear cell carcinoma (RCCC)-TR mutants, in the presence of hormone agonist T3 thyronine. Results provide insight into a unique regulatory repertoire for RCCCs.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 7 genotype/variation sets

Platform:

GPL6244

Series:

GSE29159

42 Samples

Download data: CEL

(Submitter supplied) Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that regulate a diverse array of biological activities, including metabolism, homeostasis, and development. TRs also serve as tumor suppressors, and aberrant TR function (via mutation, deletion, or altered expression) is associated with a spectrum of both neoplastic and endocrine diseases. A particularly high frequency of TR mutations has been reported in renal clear cell carcinoma (RCCC) and in hepatocellular carcinoma (HCC). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3945

Platform:

GPL6244

42 Samples

Download data: CEL

(Submitter supplied) Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that control multiple aspects of physiology and development. TRs are expressed in vertebrates as a series of distinct isoforms that exert distinct biological roles. We wished to determine if the two most widely expressed isoforms, TRa1 and TRb1, exert their different biological effects by regulating different sets of target genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

18 Samples

Download data: CEL

(Submitter supplied) Objective: Thyroid hormone receptors (TRs) are ligand-dependent transcription factors with a major impact on erythroid cell development. Here we investigated TR activity on red cell gene expression and identified TR target genes. The impact of the TR target gene GAR22 (growth arrest specific 2 [GAS2]-related gene on chromosome 22) on red cell differentiation was determined. Methods: SCF/Epo dependent red cell progenitors were differentiated in vitro in the presence or absence of thyroid hormone. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

13 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) Analysis of T3 response in HepG2-TRbeta cells transfected with siRNA (siCtrl or siKLF9) at gene expression level.The hypothesis tested in the present study was that TR/KLF9 axis is responsible for many of T3 downstream efects. Results provide information of the changr in T3 response after KLF9 knockdown.response

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

18 Samples

Download data: TXT